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ONTOLOGY REPORT - ANNOTATIONS


Term:glutathione biosynthetic process
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Accession:GO:0006750 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
Synonyms:exact_synonym: glutathione anabolism;   glutathione biosynthesis;   glutathione formation;   glutathione synthesis
 xref: MetaCyc:GLUTATHIONESYN-PWY



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glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit involved_in
acts_upstream_of_or_within
ISO
IBA
IMP
IDA
(MGI:6201960|PMID:21873635)
(MGI:1858542|PMID:10805773)
(MGI:3607629|PMID:16081425)
MGI
RGD
GO_Central
PMID:10805773 PMID:16081425 PMID:16183645 PMID:21873635 GO_REF:0000096 MGI:1858542 MGI:3607629 MGI:4417868 MGI:4834177 MGI:6201960 RGD:1582661 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
(MGI:3607629|PMID:16081425)
(MGI:6201960|PMID:21873635)
MGI
RGD
GO_Central
PMID:16081425 PMID:16183645 PMID:21873635 GO_REF:0000096 MGI:3607629 MGI:4417868 MGI:4834177 MGI:6201960 RGD:1582661 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 involved_in IMP (MGI:5294309|PMID:12468440) UniProt PMID:12468440 MGI:5294309 NCBI chr10:75,561,076...75,586,193
Ensembl chr10:75,561,604...75,586,200
JBrowse link
G Ggt5 gamma-glutamyltransferase 5 acts_upstream_of_or_within IEA UniProt GO_REF:0000004 MGI:1354194 NCBI chr10:75,589,327...75,617,200
Ensembl chr10:75,589,340...75,617,200
JBrowse link
G Ggt6 gamma-glutamyltransferase 6 acts_upstream_of_or_within IEA UniProt GO_REF:0000004 MGI:1354194 NCBI chr11:72,435,247...72,438,566
Ensembl chr11:72,435,526...72,438,400
JBrowse link
G Ggt7 gamma-glutamyltransferase 7 acts_upstream_of_or_within IEA UniProt GO_REF:0000004 MGI:1354194 NCBI chr 2:155,490,379...155,514,891
Ensembl chr 2:155,490,379...155,518,237
JBrowse link
G Gss glutathione synthetase acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:6201960|PMID:21873635) RGD
GOC
MGI
PMID:10964706 PMID:21873635 GO_REF:0000096 MGI:4417868 MGI:6201960 RGD:1599340 NCBI chr 2:155,563,181...155,592,810
Ensembl chr 2:155,563,181...155,592,810
JBrowse link
G Hagh hydroxyacyl glutathione hydrolase acts_upstream_of_or_within
involved_in
IC
ISO
(MGI:48978|PMID:1914521) MGI PMID:1914521 GO_REF:0000096 MGI:4834177 MGI:48978 NCBI chr17:24,839,781...24,864,450
Ensembl chr17:24,840,143...24,864,450
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 3:51,636,912...51,682,675
Ensembl chr 3:51,660,360...51,682,677
JBrowse link
G Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 involved_in IDA (MGI:6478075|PMID:12614333) MGI PMID:12614333 MGI:6478075 NCBI chr19:28,835,135...28,913,960
Ensembl chr19:28,835,049...28,913,960
JBrowse link
G Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 involved_in IDA (MGI:6478075|PMID:12614333) MGI PMID:12614333 MGI:6478075 NCBI chr 2:102,658,239...102,790,784
Ensembl chr 2:102,658,659...102,790,784
JBrowse link
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in IMP (MGI:5616326|PMID:14978030) ParkinsonsUK-UCL PMID:14978030 MGI:5616326 NCBI chr 6:70,844,484...70,905,241
Ensembl chr 6:70,844,515...70,905,245
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 involved_in IMP (MGI:5616326|PMID:14978030) ParkinsonsUK-UCL PMID:14978030 MGI:5616326 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 acts_upstream_of_or_within IMP (MGI:3588610|PMID:16037214) MGI PMID:16037214 MGI:3588610 NCBI chr 3:50,364,936...50,499,087
Ensembl chr 3:49,892,526...50,443,614
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 29900
    cellular process 17658
      cellular metabolic process 10089
        cellular modified amino acid metabolic process 204
          glutathione metabolic process 81
            glutathione biosynthetic process 14
              negative regulation of glutathione biosynthetic process 0
              positive regulation of glutathione biosynthetic process 2
              regulation of glutathione biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 29900
    metabolic process 11255
      cellular metabolic process 10089
        cellular biosynthetic process 5502
          cellular nitrogen compound biosynthetic process 4483
            amide biosynthetic process 820
              peptide biosynthetic process 707
                nonribosomal peptide biosynthetic process 16
                  glutathione biosynthetic process 14
                    negative regulation of glutathione biosynthetic process 0
                    positive regulation of glutathione biosynthetic process 2
                    regulation of glutathione biosynthetic process + 3
paths to the root