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ONTOLOGY REPORT - ANNOTATIONS


Term:glutathione biosynthetic process
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Accession:GO:0006750 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
Synonyms:exact_synonym: glutathione anabolism;   glutathione biosynthesis;   glutathione formation;   glutathione synthesis
 xref: MetaCyc:GLUTATHIONESYN-PWY



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glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 involved_in TAS Reactome Reactome:R-HSA-174403 NCBI chr15:40,942,137...40,956,518
Ensembl chr15:40,952,962...40,956,512
JBrowse link
G CHAC2 ChaC glutathione specific gamma-glutamylcyclotransferase 2 involved_in TAS Reactome Reactome:R-HSA-174403 NCBI chr 2:53,767,783...53,775,196
Ensembl chr 2:53,767,804...53,775,196
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit involved_in
acts_upstream_of_or_within
IMP
ISO
IDA
IBA
IEA
(PMID:12663448)
(MGI:1858542|PMID:10805773)
(MGI:3607629|PMID:16081425)
(PMID:10395918), (PMID:8104187), (PMID:9675072)
(PMID:21873635)
UniProt
MGI
RGD
GO_Central
PMID:8104187 PMID:9675072 PMID:10395918 PMID:10805773 PMID:12663448 More... GO_REF:0000041 MGI:1858542 MGI:3607629 RGD:1582661 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit involved_in
acts_upstream_of_or_within
IDA
ISO
IEA
IMP
IBA
(PMID:10395918), (PMID:9675072)
(MGI:3607629|PMID:16081425)
(PMID:12081989)
(PMID:21873635)
UniProt
MGI
RGD
GO_Central
PMID:9675072 PMID:10395918 PMID:12081989 PMID:16081425 PMID:16183645 More... GO_REF:0000041 MGI:3607629 RGD:1582661 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GGT1 gamma-glutamyltransferase 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,594,811...24,629,005
JBrowse link
G GGT3P gamma-glutamyltransferase 3 pseudogene involved_in IEA UniProt GO_REF:0000043 NCBI chr22:18,773,689...18,791,961
Ensembl chr22:18,773,665...18,843,399
JBrowse link
G GGT5 gamma-glutamyltransferase 5 involved_in IEA UniProt GO_REF:0000043 NCBI chr22:24,219,654...24,245,142
Ensembl chr22:24,219,654...24,245,108
JBrowse link
G GGT6 gamma-glutamyltransferase 6 involved_in IEA UniProt GO_REF:0000043 NCBI chr17:4,556,927...4,560,920
Ensembl chr17:4,556,927...4,560,818
JBrowse link
G GGT7 gamma-glutamyltransferase 7 involved_in IEA UniProt GO_REF:0000043 NCBI chr20:34,844,720...34,872,857
Ensembl chr20:34,844,720...34,872,856
JBrowse link
G GSS glutathione synthetase involved_in IEA
ISO
GOC
InterPro
RGD
UniProt
PMID:10964706 GO_REF:0000002 GO_REF:0000041 GO_REF:0000108 RGD:1599340 NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027
JBrowse link
G HAGH hydroxyacylglutathione hydrolase involved_in IDA (PMID:8550579) UniProt PMID:8550579 NCBI chr16:1,807,629...1,827,194
Ensembl chr16:1,795,620...1,827,157
JBrowse link
G MGST2 microsomal glutathione S-transferase 2 involved_in IDA (PMID:8703034) UniProt PMID:8703034 NCBI chr 4:139,665,725...139,754,608
Ensembl chr 4:139,665,768...139,740,745
JBrowse link
G SLC1A1 solute carrier family 1 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:4,490,466...4,587,469
Ensembl chr 9:4,490,468...4,587,469
JBrowse link
G SLC1A2 solute carrier family 1 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:35,251,205...35,420,058
Ensembl chr11:35,251,205...35,420,063
JBrowse link
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:5616326|PMID:14978030) ParkinsonsUK-UCL PMID:14978030 MGI:5616326 NCBI chr 2:88,556,741...88,627,464
Ensembl chr 2:88,556,741...88,691,518
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC7A11 solute carrier family 7 member 11 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3588610|PMID:16037214) Ensembl
MGI
PMID:16037214 GO_REF:0000107 MGI:3588610 NCBI chr 4:138,164,097...138,242,349
Ensembl chr 4:138,164,097...138,242,349
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18539
    cellular process 17460
      cellular metabolic process 10810
        cellular modified amino acid metabolic process 210
          glutathione metabolic process 74
            glutathione biosynthetic process 17
              negative regulation of glutathione biosynthetic process 0
              positive regulation of glutathione biosynthetic process 2
              regulation of glutathione biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 18539
    metabolic process 11870
      cellular metabolic process 10810
        cellular biosynthetic process 6017
          cellular nitrogen compound biosynthetic process 4923
            amide biosynthetic process 875
              peptide biosynthetic process 742
                nonribosomal peptide biosynthetic process 19
                  glutathione biosynthetic process 17
                    negative regulation of glutathione biosynthetic process 0
                    positive regulation of glutathione biosynthetic process 2
                    regulation of glutathione biosynthetic process + 3
paths to the root