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ONTOLOGY REPORT - ANNOTATIONS

Term:glutathione biosynthetic process
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Accession:GO:0006750 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
Synonyms:exact_synonym: glutathione anabolism;   glutathione biosynthesis;   glutathione formation;   glutathione synthesis
 xref: MetaCyc:GLUTATHIONESYN-PWY


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glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 involved_in TAS Reactome Reactome:R-HSA-174403 NCBI chr15:40,953,471...40,956,512
Ensembl chr15:40,952,962...40,956,512 		JBrowse link
G CHAC2 ChaC glutathione specific gamma-glutamylcyclotransferase 2 involved_in TAS Reactome Reactome:R-HSA-174403 NCBI chr 2:53,767,783...53,775,196
Ensembl chr 2:53,767,804...53,775,196 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit acts_upstream_of_or_within
involved_in		 ISO
IBA
IEA
IMP
IDA		 (PMID:10805773)
(PMID:16081425)
(PMID:12663448)
(PMID:10395918), (PMID:8104187), (PMID:9675072)		 RGD
MGI
GO_Central
TreeGrafter
UniProt
InterPro
Ensembl		 PMID:8104187 PMID:9675072 PMID:10395918 PMID:10805773 PMID:12663448 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 RGD:1582661 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit acts_upstream_of_or_within
involved_in		 ISO
IBA
IDA
IEA
IMP		 (PMID:16081425)
(PMID:10395918), (PMID:9675072)
(PMID:12081989)		 RGD
MGI
GO_Central
UniProt
Ensembl
InterPro		 PMID:9675072 PMID:10395918 PMID:12081989 PMID:16081425 PMID:16183645 GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107 RGD:1582661 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456 		JBrowse link
G GGT1 gamma-glutamyltransferase 1 involved_in IEA
ISS		 UniProt GO_REF:0000024 GO_REF:0000043 NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,594,811...24,629,005 		JBrowse link
G GGT3P gamma-glutamyltransferase 3 pseudogene involved_in IEA UniProt GO_REF:0000043 NCBI chr22:18,773,689...18,791,961
Ensembl chr22:18,773,825...18,791,223 		JBrowse link
G GGT5 gamma-glutamyltransferase 5 involved_in IEA UniProt GO_REF:0000043 NCBI chr22:24,219,654...24,245,142
Ensembl chr22:24,219,654...24,245,108 		JBrowse link
G GGT6 gamma-glutamyltransferase 6 involved_in IEA UniProt GO_REF:0000043 NCBI chr17:4,556,140...4,560,577
Ensembl chr17:4,556,927...4,560,818 		JBrowse link
G GGT7 gamma-glutamyltransferase 7 involved_in IEA UniProt GO_REF:0000043 NCBI chr20:34,844,720...34,872,856
Ensembl chr20:34,844,720...34,872,856 		JBrowse link
G GSS glutathione synthetase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:81780|PMID:8660701) RGD
GOC
GOC
UniProt
InterPro		 PMID:8660701 PMID:10964706 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 GO_REF:0000108 MGI:81780 RGD:1599340 NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027 		JBrowse link
G HAGH hydroxyacylglutathione hydrolase involved_in IDA (PMID:8550579) UniProt PMID:8550579 NCBI chr16:1,807,629...1,827,194
Ensembl chr16:1,795,620...1,827,157 		JBrowse link
G MGST2 microsomal glutathione S-transferase 2 involved_in IDA (PMID:8703034) UniProt PMID:8703034 NCBI chr 4:139,665,819...139,754,618
Ensembl chr 4:139,665,768...139,740,745 		JBrowse link
G SLC1A1 solute carrier family 1 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:4,490,468...4,587,469
Ensembl chr 9:4,490,468...4,587,469 		JBrowse link
G SLC1A2 solute carrier family 1 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:35,251,205...35,420,507
Ensembl chr11:35,251,205...35,420,063 		JBrowse link
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:5616326|PMID:14978030) ParkinsonsUK-UCL PMID:14978030 MGI:5616326 NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC7A11 solute carrier family 7 member 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16037214) Ensembl
MGI		 PMID:16037214 GO_REF:0000107 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      biosynthetic process 9289
        amide biosynthetic process 170
          glutathione biosynthetic process 17
            negative regulation of glutathione biosynthetic process 0
            positive regulation of glutathione biosynthetic process 2
            regulation of glutathione biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      biosynthetic process 9289
        organic substance biosynthetic process 9224
          organonitrogen compound biosynthetic process 1908
            cellular modified amino acid biosynthetic process 48
              glutathione biosynthetic process 17
                negative regulation of glutathione biosynthetic process 0
                positive regulation of glutathione biosynthetic process 2
                regulation of glutathione biosynthetic process + 3
paths to the root