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ONTOLOGY REPORT - ANNOTATIONS

Term:glutathione biosynthetic process
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Accession:GO:0006750 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
Synonyms:exact_synonym: glutathione anabolism;   glutathione biosynthesis;   glutathione formation;   glutathione synthesis
 xref: MetaCyc:GLUTATHIONESYN-PWY


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glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 NCBI chr 6:55,248,437...55,264,187
Ensembl chr 6:55,235,542...55,263,728 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:16081425)
(PMID:10805773)		 RGD
MGI
TreeGrafter
Ensembl
UniProt
InterPro		 PMID:10805773 PMID:16081425 PMID:16183645 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 RGD:1582661 NCBI chr12:20,999,815...21,047,779
Ensembl chr12:21,000,792...21,047,779 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:16081425) RGD
MGI
TreeGrafter
UniProt
Ensembl
InterPro		 PMID:16081425 PMID:16183645 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 RGD:1582661 NCBI chr 6:55,204,602...55,244,217 JBrowse link
G GGT1 gamma-glutamyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:28,301,455...28,315,029 JBrowse link
G GGT7 gamma-glutamyltransferase 7 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 NCBI chr24:23,900,842...23,924,555
Ensembl chr24:23,901,045...23,997,286 		JBrowse link
G GSS glutathione synthetase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:81780|PMID:8660701) RGD
GOC
UniProt
InterPro		 PMID:8660701 PMID:10964706 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 MGI:81780 RGD:1599340 NCBI chr24:23,973,807...24,000,281
Ensembl chr24:23,901,045...23,997,286 		JBrowse link
G HAGH hydroxyacylglutathione hydrolase involved_in ISO (PMID:8550579) UniProt PMID:8550579 NCBI chr 6:39,076,364...39,105,646
Ensembl chr 6:39,084,513...39,105,592 		JBrowse link
G MGST2 microsomal glutathione S-transferase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:3,067,062...3,070,579 JBrowse link
G SLC1A1 solute carrier family 1 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:92,898,274...92,978,260
Ensembl chr 1:92,898,274...92,978,260 		JBrowse link
G SLC1A2 solute carrier family 1 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:32,565,258...32,717,052
Ensembl chr18:32,565,258...32,709,225 		JBrowse link
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:5616326|PMID:14978030) ParkinsonsUK-UCL PMID:14978030 MGI:5616326 NCBI chr17:37,886,397...37,950,671
Ensembl chr17:37,886,601...37,949,812 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr36:20,989,205...21,087,044
Ensembl chr36:20,989,360...21,012,524 		JBrowse link
regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC7A11 solute carrier family 7 member 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16037214) Ensembl
MGI		 PMID:16037214 GO_REF:0000107 NCBI chr19:4,289,792...4,379,060
Ensembl chr19:4,289,850...4,389,048 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17917
    metabolic process 10998
      biosynthetic process 7879
        amide biosynthetic process 143
          glutathione biosynthetic process 13
            negative regulation of glutathione biosynthetic process 0
            positive regulation of glutathione biosynthetic process 2
            regulation of glutathione biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 17917
    metabolic process 10998
      biosynthetic process 7879
        organic substance biosynthetic process 7821
          organonitrogen compound biosynthetic process 1906
            cellular modified amino acid biosynthetic process 41
              glutathione biosynthetic process 13
                negative regulation of glutathione biosynthetic process 0
                positive regulation of glutathione biosynthetic process 2
                regulation of glutathione biosynthetic process + 3
paths to the root