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ONTOLOGY REPORT - ANNOTATIONS

Term:glutathione biosynthetic process
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Accession:GO:0006750 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
Synonyms:exact_synonym: glutathione anabolism;   glutathione biosynthesis;   glutathione formation;   glutathione synthesis
 xref: MetaCyc:GLUTATHIONESYN-PWY;   Reactome:R-HSA-174403 "Glutathione synthesis and recycling"


show annotations for term's descendants           Sort by:
glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cryaa crystallin, alpha A acts_upstream_of_or_within ISO (PMID:22442691) RGD PMID:22442691 NCBI chr20:9,784,872...9,788,656
Ensembl chr20:9,784,857...9,788,654 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit acts_upstream_of_or_within
involved_in 		IMP
ISO
IEA
IBA
ISS 		MGI:2387010 (PMID:10805773), (PMID:16081425)
GO_REF:0000002
GO_REF:0000107
GO_REF:0000104
GO_REF:0000043
GO_REF:0000117
GO_REF:0000033
GO_REF:0000041
(PMID:10395918), (PMID:12663448), (PMID:8104187), (PMID:9675072)
GO_REF:0000024 		RGD
InterPro
Ensembl
UniProt
GO_Central		 PMID:8104187 PMID:9675072 PMID:10395918 PMID:10805773 PMID:12663448 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117, RGD:1582661 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit acts_upstream_of_or_within
involved_in 		IMP
ISO
IEA
IBA
ISS 		(PMID:16081425)
GO_REF:0000117
GO_REF:0000107
GO_REF:0000043
GO_REF:0000002
GO_REF:0000033
GO_REF:0000041
(PMID:10395918), (PMID:12081989), (PMID:9675072)
GO_REF:0000024 		RGD
UniProt
Ensembl
InterPro
GO_Central		 PMID:9675072 PMID:10395918 PMID:12081989 PMID:16081425 PMID:16183645 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107 GO_REF:0000117, RGD:1582661 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 involved_in IEA
ISO 		GO_REF:0000107
GO_REF:0000043
(PMID:12468440) 		Ensembl
UniProt
RGD		 PMID:12468440 GO_REF:0000043 GO_REF:0000107 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050 		JBrowse link
G Ggt5 gamma-glutamyltransferase 5 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:13,042,694...13,070,960
Ensembl chr20:13,042,696...13,070,892 		JBrowse link
G Ggt6 gamma-glutamyl transferase 6 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:57,550,447...57,553,461
Ensembl chr10:57,550,492...57,553,460 		JBrowse link
G Ggt7 gamma-glutamyltransferase 7 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:164,438,240...164,464,059
Ensembl chr 3:164,437,812...164,463,068 		JBrowse link
G Gss glutathione synthetase involved_in IDA
IEA 		GO_REF:0000041
GO_REF:0000043
GO_REF:0000002 		UniProt
InterPro
RGD		 PMID:10964706 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043, RGD:1599340 NCBI chr 3:164,508,005...164,538,343
Ensembl chr 3:164,508,005...164,538,306 		JBrowse link
G Hagh hydroxyacyl glutathione hydrolase involved_in IEA
ISO 		GO_REF:0000107
(PMID:8550579) 		Ensembl
RGD		 PMID:8550579 GO_REF:0000107 NCBI chr10:14,379,400...14,394,046
Ensembl chr10:14,382,410...14,394,043 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 involved_in ISO
IEA 		(PMID:8703034)
GO_REF:0000107 		RGD
Ensembl		 PMID:8703034 GO_REF:0000107 NCBI chr 2:137,821,787...137,866,664
Ensembl chr 2:137,836,140...137,866,661 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:12614333) 		Ensembl
RGD		 PMID:12614333 GO_REF:0000107 NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:235,963,437...236,045,469 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:12614333) 		Ensembl
RGD		 PMID:12614333 GO_REF:0000107 NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249 		JBrowse link
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (PMID:14978030) RGD PMID:14978030 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:14978030) 		Ensembl
RGD		 PMID:14978030 GO_REF:0000107 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO MGI:1857061 (PMID:16037214) RGD PMID:16037214 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    cellular process 18484
      metabolic process 11533
        modified amino acid metabolic process 201
          glutathione metabolic process 69
            glutathione biosynthetic process 15
              negative regulation of glutathione biosynthetic process 0
              positive regulation of glutathione biosynthetic process 2
              regulation of glutathione biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 19315
    cellular process 18484
      metabolic process 11533
        peptide metabolic process 61
          peptide biosynthetic process 29
            nonribosomal peptide biosynthetic process 17
              glutathione biosynthetic process 15
                negative regulation of glutathione biosynthetic process 0
                positive regulation of glutathione biosynthetic process 2
                regulation of glutathione biosynthetic process + 3
paths to the root