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ONTOLOGY REPORT - ANNOTATIONS


Term:glutathione biosynthetic process
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Accession:GO:0006750 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
Synonyms:exact_synonym: glutathione anabolism;   glutathione biosynthesis;   glutathione formation;   glutathione synthesis
 xref: MetaCyc:GLUTATHIONESYN-PWY


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glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit IMP
ISO
IBA
ISS
IEA
MGI:2387010 (MGI:1858542|PMID:10805773), (MGI:3607629|PMID:16081425)
(PMID:10395918), (PMID:12663448), (PMID:8104187), (PMID:9675072)
PMID:21873635
GO_REF:0000024
GO_REF:0000041
RGD
UniProt
PMID:8104187, PMID:9675072, PMID:10395918, PMID:10805773, PMID:12663448, PMID:16081425, PMID:16183645, PMID:21873635 GO_REF:0000024, GO_REF:0000041, MGI:1858542, MGI:3607629, RGD:1582661, RGD:13792537 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit IMP
ISO
IBA
ISS
IEA
(MGI:3607629|PMID:16081425)
(PMID:10395918), (PMID:12081989), (PMID:9675072)
PMID:21873635
GO_REF:0000024
GO_REF:0000041
RGD
UniProt
PMID:9675072, PMID:10395918, PMID:12081989, PMID:16081425, PMID:16183645, PMID:21873635 GO_REF:0000024, GO_REF:0000041, MGI:3607629, RGD:1582661, RGD:13792537 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 IEA
ISO
GO_REF:0000043
(MGI:5294309|PMID:12468440)
UniProt
RGD
PMID:12468440 GO_REF:0000043, MGI:5294309 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Ggt5 gamma-glutamyltransferase 5 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:13,988,444...14,001,296 JBrowse link
G Ggt6 gamma-glutamyl transferase 6 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:58,995,253...58,998,431
Ensembl chr10:58,995,556...58,998,033
JBrowse link
G Ggt7 gamma-glutamyltransferase 7 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:151,005,960...151,029,941
Ensembl chr 3:151,006,531...151,032,302
JBrowse link
G Gss glutathione synthetase IDA
IEA
GO_REF:0000041 UniProt PMID:10964706 GO_REF:0000041, RGD:1599340 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G Hagh hydroxyacyl glutathione hydrolase IEA
ISO
GO_REF:0000107
(PMID:8550579)
Ensembl
RGD
PMID:8550579 GO_REF:0000107 NCBI chr10:14,215,913...14,230,506
Ensembl chr10:14,216,155...14,230,515
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 ISO (PMID:8703034) RGD PMID:8703034 NCBI chr 2:140,708,396...140,727,381
Ensembl chr 2:140,708,397...140,727,281
JBrowse link
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO (MGI:5616326|PMID:14978030) RGD PMID:14978030 MGI:5616326 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 ISO (MGI:5616326|PMID:14978030) RGD PMID:14978030 MGI:5616326 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
regulation of glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc7a11 solute carrier family 7 member 11 ISO MGI:1857061 (MGI:3588610|PMID:16037214) RGD PMID:16037214 MGI:3588610 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      cellular metabolic process 11073
        cellular modified amino acid metabolic process 190
          glutathione metabolic process 68
            glutathione biosynthetic process 12
              negative regulation of glutathione biosynthetic process 0
              positive regulation of glutathione biosynthetic process 2
              regulation of glutathione biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      cellular metabolic process 11073
        cellular biosynthetic process 6056
          cellular nitrogen compound biosynthetic process 5075
            amide biosynthetic process 1232
              peptide biosynthetic process 1114
                nonribosomal peptide biosynthetic process 14
                  glutathione biosynthetic process 12
                    negative regulation of glutathione biosynthetic process 0
                    positive regulation of glutathione biosynthetic process 2
                    regulation of glutathione biosynthetic process + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.