Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:glutathione biosynthetic process
go back to main search page
Accession:GO:0006750 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
Synonyms:exact_synonym: glutathione anabolism;   glutathione biosynthesis;   glutathione formation;   glutathione synthesis
 xref: MetaCyc:GLUTATHIONESYN-PWY


show annotations for term's descendants           Sort by:
 
glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit acts_upstream_of_or_within
involved_in
IMP
ISO
IBA
IEA
ISS
MGI:2387010 (MGI:1858542|PMID:10805773), (MGI:3607629|PMID:16081425)
PMID:21873635
GO_REF:0000041
(PMID:10395918), (PMID:12663448), (PMID:8104187), (PMID:9675072)
GO_REF:0000024
RGD
UniProt
PMID:8104187 PMID:9675072 PMID:10395918 PMID:10805773 PMID:12663448 More... GO_REF:0000024 GO_REF:0000041 MGI:1858542 MGI:3607629, RGD:1582661, RGD:13792537 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit acts_upstream_of_or_within
involved_in
IMP
ISO
IEA
IBA
ISS
(MGI:3607629|PMID:16081425)
GO_REF:0000041
PMID:21873635
(PMID:10395918), (PMID:12081989), (PMID:9675072)
GO_REF:0000024
RGD
UniProt
PMID:9675072 PMID:10395918 PMID:12081989 PMID:16081425 PMID:16183645 More... GO_REF:0000024 GO_REF:0000041 MGI:3607629, RGD:1582661, RGD:13792537 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 involved_in IEA
ISO
GO_REF:0000043
(MGI:5294309|PMID:12468440)
UniProt
RGD
PMID:12468440 GO_REF:0000043 MGI:5294309 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Ggt5 gamma-glutamyltransferase 5 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:13,043,255...13,071,523 JBrowse link
G Ggt6 gamma-glutamyl transferase 6 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:57,052,025...57,054,502
Ensembl chr10:57,051,825...57,067,260
JBrowse link
G Ggt7 gamma-glutamyltransferase 7 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:143,978,073...144,004,597
Ensembl chr 3:143,978,082...144,001,492
JBrowse link
G Gss glutathione synthetase involved_in IDA
IEA
GO_REF:0000041 UniProt PMID:10964706 GO_REF:0000041, RGD:1599340 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
JBrowse link
G Hagh hydroxyacyl glutathione hydrolase involved_in IEA
ISO
GO_REF:0000107
(PMID:8550579)
Ensembl
RGD
PMID:8550579 GO_REF:0000107 NCBI chr10:13,874,883...13,889,527
Ensembl chr10:13,875,241...13,889,504
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 involved_in ISO (PMID:8703034) RGD PMID:8703034 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828
JBrowse link
G Slc1a1 solute carrier family 1 member 1 involved_in ISO (MGI:6478075|PMID:12614333) RGD PMID:12614333 MGI:6478075 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
JBrowse link
G Slc1a2 solute carrier family 1 member 2 involved_in ISO (MGI:6478075|PMID:12614333) RGD PMID:12614333 MGI:6478075 NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498
JBrowse link
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:5616326|PMID:14978030) RGD PMID:14978030 MGI:5616326 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 involved_in ISO (MGI:5616326|PMID:14978030) RGD PMID:14978030 MGI:5616326 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO MGI:1857061 (MGI:3588610|PMID:16037214) RGD PMID:16037214 MGI:3588610 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19494
    cellular process 18342
      cellular metabolic process 10718
        cellular modified amino acid metabolic process 202
          glutathione metabolic process 77
            glutathione biosynthetic process 14
              negative regulation of glutathione biosynthetic process 0
              positive regulation of glutathione biosynthetic process 2
              regulation of glutathione biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 19494
    metabolic process 11798
      cellular metabolic process 10718
        cellular biosynthetic process 5914
          cellular nitrogen compound biosynthetic process 4899
            amide biosynthetic process 1225
              peptide biosynthetic process 1106
                nonribosomal peptide biosynthetic process 16
                  glutathione biosynthetic process 14
                    negative regulation of glutathione biosynthetic process 0
                    positive regulation of glutathione biosynthetic process 2
                    regulation of glutathione biosynthetic process + 3
paths to the root