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ONTOLOGY REPORT - ANNOTATIONS


Term:glutathione metabolic process
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Accession:GO:0006749 term browser browse the term
Definition:The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
Synonyms:exact_synonym: glutathione metabolism
 narrow_synonym: oxidized glutathione reduction


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glutathione metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AC097845.1 RGD:13792537
G Cth cystathionine gamma-lyase JBrowse link 2 264,266,959 264,293,040 RGD:1600763
G Ctns cystinosin, lysosomal cystine transporter JBrowse link 10 59,749,250 59,772,475 RGD:1624291
G Ethe1 ETHE1, persulfide dioxygenase JBrowse link 1 81,457,008 81,472,061 RGD:1624291
RGD:13792537
G G6pd glucose-6-phosphate dehydrogenase JBrowse link X 156,274,800 156,293,935 RGD:1624291
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:1624291
G Gclm glutamate cysteine ligase, modifier subunit JBrowse link 2 225,827,504 225,847,876 RGD:1624291
G Glo1 glyoxalase 1 JBrowse link 20 9,273,589 9,291,608 RGD:1641958
RGD:1641959
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:1624364
RGD:1600115
RGD:13792537
RGD:1624291
G Gpx3 glutathione peroxidase 3 JBrowse link 10 40,247,436 40,255,423 RGD:1624364
G Gpx4 glutathione peroxidase 4 JBrowse link 7 12,516,357 12,519,154 RGD:1624364
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:1625133
RGD:13792537
RGD:1600115
G Gsta1 glutathione S-transferase alpha 1 JBrowse link 9 27,366,404 27,381,004 RGD:1624291
RGD:13792537
G Gsta2 glutathione S-transferase alpha 2 JBrowse link 8 85,640,081 85,645,621 RGD:13792537
G Gsta3 glutathione S-transferase alpha 3 JBrowse link 9 27,357,490 27,417,023 RGD:13792537
G Gsta4 glutathione S-transferase alpha 4 JBrowse link 8 85,497,557 85,514,732 RGD:1624291
RGD:13792537
G Gsta5 glutathione S-transferase alpha 5 JBrowse link 8 85,553,659 85,564,914 RGD:13792537
G Gsta6 glutathione S-transferase alpha 6 JBrowse link 9 27,475,273 27,533,939 RGD:1600115
RGD:13792537
G Gstk1 glutathione S-transferase kappa 1 JBrowse link 4 71,621,777 71,626,096 RGD:1624291
RGD:13792537
G Gstm1 glutathione S-transferase mu 1 JBrowse link 2 210,803,869 210,809,461 RGD:2302181
RGD:13792537
RGD:1624291
RGD:70307
G Gstm2 glutathione S-transferase mu 2 JBrowse link 2 210,778,041 210,782,807 RGD:2302181
RGD:1600115
RGD:13792537
RGD:1624291
G Gstm3 glutathione S-transferase mu 3 JBrowse link 2 210,685,204 210,688,273 RGD:1600115
RGD:13792537
RGD:1624291
G Gstm3l glutathione S-transferase mu 3-like JBrowse link 2 210,761,729 210,766,501 RGD:1624291
RGD:13792537
G Gstm4 glutathione S-transferase mu 4 JBrowse link 2 210,834,013 210,839,242 RGD:1624291
RGD:13792537
G Gstm5 glutathione S-transferase, mu 5 JBrowse link 2 210,685,338 210,688,133 RGD:1600115
RGD:13792537
RGD:1624291
G Gstm6 glutathione S-transferase, mu 6 JBrowse link 2 210,733,594 210,738,368 RGD:13792537
G Gstm6l glutathione S-transferase, mu 6-like JBrowse link 2 210,698,155 210,703,265 RGD:13792537
G Gstm7 glutathione S-transferase, mu 7 JBrowse link 2 210,720,719 210,726,179 RGD:13792537
RGD:1600115
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:1624291
RGD:13792537
G Gstt1 glutathione S-transferase theta 1 JBrowse link 20 13,799,102 13,816,527 RGD:8554299
RGD:13792537
RGD:1624291
G Gstt2 glutathione S-transferase, theta 2 JBrowse link 20 13,760,810 13,764,481 RGD:8553858
RGD:13792537
G Gstt3 glutathione S-transferase, theta 3 JBrowse link 20 13,817,795 13,825,475 RGD:13792537
G Gstt4 glutathione S-transferase, theta 4 JBrowse link 20 13,778,185 13,784,813 RGD:13792537
G Gstz1 glutathione S-transferase zeta 1 JBrowse link 6 111,176,798 111,187,246 RGD:1624291
RGD:13792537
G Hagh hydroxyacyl glutathione hydrolase JBrowse link 10 14,215,913 14,230,506 RGD:1641958
RGD:1641959
G Hbb hemoglobin subunit beta JBrowse link 1 168,971,269 168,972,680 RGD:2325281
G Hmgn5 high mobility group nucleosome binding domain 5 JBrowse link X 80,134,557 80,142,902 RGD:1624291
G Hpgds hematopoietic prostaglandin D synthase JBrowse link 4 95,945,356 95,970,666 RGD:13792537
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 JBrowse link 9 71,882,108 71,911,645 RGD:1624291
G LOC103694878 glutathione S-transferase theta-2-like RGD:13792537
G LOC103694879 glutathione S-transferase theta-2-like RGD:13792537
G LOC108348061 glutathione S-transferase alpha-3 JBrowse link 9 27,436,255 27,452,897 RGD:13792537
G Mgst1 microsomal glutathione S-transferase 1 JBrowse link 4 172,119,382 172,134,609 RGD:1624291
G Mmachc metabolism of cobalamin associated C JBrowse link 5 135,555,587 135,561,723 RGD:1624291
G Nat8 N-acetyltransferase 8 JBrowse link 4 117,525,963 117,527,443 RGD:1600115
RGD:1624291
G Nfe2l1 nuclear factor, erythroid 2-like 1 JBrowse link 10 84,686,762 84,699,313 RGD:1624291
G Oplah 5-oxoprolinase (ATP-hydrolysing) JBrowse link 7 117,353,951 117,394,205 RGD:13792537
G RGD1307603 similar to hypothetical protein MGC37914 JBrowse link 1 219,309,593 219,312,240 RGD:13792537
G RGD1562107 similar to class-alpha glutathione S-transferase JBrowse link 9 27,311,229 27,324,452 RGD:13792537
G Slc7a11 solute carrier family 7 member 11 JBrowse link 2 139,453,774 139,528,479 RGD:1624291
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:1624291
RGD:1600115
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:1624291
G Txnrd3 thioredoxin reductase 3 JBrowse link 4 121,612,332 121,650,543 RGD:1624291
glutathione biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:1582661
RGD:1624291
RGD:13792537
RGD:1600115
G Gclm glutamate cysteine ligase, modifier subunit JBrowse link 2 225,827,504 225,847,876 RGD:1582661
RGD:1624291
RGD:13792537
RGD:1600115
G Ggt1 gamma-glutamyltransferase 1 JBrowse link 20 14,019,723 14,045,781 RGD:1624291
G Ggt5 gamma-glutamyltransferase 5 JBrowse link 20 13,988,444 14,001,296 RGD:1600115
G Ggt6 gamma-glutamyl transferase 6 JBrowse link 10 58,995,253 58,998,431 RGD:1600115
G Ggt7 gamma-glutamyltransferase 7 JBrowse link 3 151,005,960 151,029,941 RGD:1600115
G Gss glutathione synthetase JBrowse link 3 151,076,254 151,106,557 RGD:1599340
RGD:1600115
G Hagh hydroxyacyl glutathione hydrolase JBrowse link 10 14,215,913 14,230,506 RGD:1600115
RGD:1624291
G Mgst2 microsomal glutathione S-transferase 2 JBrowse link 2 140,708,396 140,727,381 RGD:1624291
glutathione catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07044631.2 RGD:13792537
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 JBrowse link 3 111,160,205 111,163,425 RGD:13792537
G Chac2 ChaC cation transport regulator 2 JBrowse link 14 115,383,906 115,391,757 RGD:13792537
G Dpep1 dipeptidase 1 JBrowse link 19 55,973,447 55,998,830 RGD:1600115
RGD:1624291
G Ggt1 gamma-glutamyltransferase 1 JBrowse link 20 14,019,723 14,045,781 RGD:1600115
RGD:13792537
RGD:1624291
G Ggt5 gamma-glutamyltransferase 5 JBrowse link 20 13,988,444 14,001,296 RGD:1624291
RGD:13792537
G Ggt7 gamma-glutamyltransferase 7 JBrowse link 3 151,005,960 151,029,941 RGD:13792537
glutathione deglycation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:1624291
RGD:1600115
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 4 98,648,513 98,709,695 RGD:1624291
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:1624291
regulation of glutathione biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc7a11 solute carrier family 7 member 11 JBrowse link 2 139,453,774 139,528,479 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19678
    metabolic process 11954
      cellular metabolic process 10782
        cellular modified amino acid metabolic process 185
          glutathione metabolic process 66
            ascorbate glutathione cycle 0
            glutathione biosynthetic process + 12
            glutathione catabolic process 7
            glutathione deglycation 1
Path 2
Term Annotations click to browse term
  biological_process 19678
    cellular process 18452
      cellular metabolic process 10782
        cellular nitrogen compound metabolic process 6418
          cellular amide metabolic process 1421
            peptide metabolic process 1163
              glutathione metabolic process 66
                ascorbate glutathione cycle 0
                glutathione biosynthetic process + 12
                glutathione catabolic process 7
                glutathione deglycation 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.