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ONTOLOGY REPORT - ANNOTATIONS

Term:glutathione metabolic process
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Accession:GO:0006749 term browser browse the term
Definition:The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
Synonyms:exact_synonym: glutathione metabolism
 narrow_synonym: oxidized glutathione reduction


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glutathione metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arl6ip5 ADP-ribosylation factor like GTPase 6 interacting protein 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:5315599 (PMID:18799673), (PMID:22210510)		 Ensembl
RGD		 PMID:18799673 PMID:22210510 GO_REF:0000107 NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608 		JBrowse link
G Cth cystathionine gamma-lyase IMP RGD PMID:15683713 RGD:1600763 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Ctns cystinosin, lysosomal cystine transporter involved_in ISO (PMID:15956064) RGD PMID:15956064 NCBI chr10:57,801,551...57,817,213
Ensembl chr10:57,801,456...57,817,120 		JBrowse link
G Ethe1 ETHE1, persulfide dioxygenase involved_in ISO
IBA		 (PMID:23144459)
GO_REF:0000033		 RGD
GO_Central		 PMID:23144459 GO_REF:0000033 NCBI chr 1:80,184,037...80,199,092
Ensembl chr 1:80,183,894...80,199,052 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase involved_in
acts_upstream_of_or_within		 ISO (PMID:17516514), (PMID:2420826)
MGI:2183760 (PMID:12521604)		 RGD PMID:2420826 PMID:12521604 PMID:17516514 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit acts_upstream_of_or_within ISO MGI:2429419 (PMID:11118286) RGD PMID:11118286 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit acts_upstream_of_or_within ISO MGI:2447852 (PMID:12384496) RGD PMID:12384496 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Glo1 glyoxalase 1 IDA RGD PMID:8719777 PMID:8903102 RGD:1641958, RGD:1641959 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Gpx1 glutathione peroxidase 1 involved_in ISO
IBA
IEA		 (PMID:12829378)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:12829378 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsr glutathione-disulfide reductase involved_in IDA
IBA
IEA		 GO_REF:0000033
GO_REF:0000002		 GO_Central
InterPro
RGD		 PMID:237922 GO_REF:0000002 GO_REF:0000033, RGD:1625133 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:20606271)
(PMID:11851347)		 RGD PMID:11851347 PMID:20606271 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 involved_in ISO (PMID:10329152) RGD PMID:10329152 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182 		JBrowse link
G Gsta6 glutathione S-transferase alpha 6 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 9:23,743,262...23,806,260
Ensembl chr 9:23,744,288...23,801,131 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:12720545)		 GO_Central
RGD		 PMID:12720545 GO_REF:0000033 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 involved_in IMP
ISO
IDA		 (PMID:8373352)
PMID:10229687		 RGD PMID:8373352 PMID:12027896 PMID:10229687 RGD:2302181, RGD:70307 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 involved_in IMP
ISO		 (PMID:16549767), (PMID:2034681), (PMID:8373352) RGD PMID:2034681 PMID:8373352 PMID:16549767 PMID:12027896 RGD:2302181 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm4 glutathione S-transferase mu 4 involved_in ISO
IEA		 (PMID:8373352)
GO_REF:0000107		 RGD
Ensembl		 PMID:8373352 GO_REF:0000107 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 involved_in ISS
ISO		 GO_REF:0000024
(PMID:10587441), (PMID:8373352)		 UniProt
RGD		 PMID:8373352 PMID:10587441 GO_REF:0000024 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Gstm5l glutathione S-transferase, mu 5-like involved_in ISO (PMID:10587441) RGD PMID:10587441 NCBI chr 2:195,544,424...195,549,895
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm7 glutathione S-transferase, mu 7 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:195,566,701...195,572,149
Ensembl chr 2:195,566,701...195,572,203 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 involved_in IEA
IBA		 GO_REF:0000104
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468 		JBrowse link
G Gsto2 glutathione S-transferase omega 2 involved_in IEA
IBA		 GO_REF:0000104
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 NCBI chr 1:246,731,314...246,757,592
Ensembl chr 1:246,732,089...246,753,866 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:1540159)
(PMID:7982937)		 RGD PMID:1540159 PMID:7982937 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstp3 glutathione S-transferase pi 3 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 1:201,355,682...201,358,216
Ensembl chr 1:201,355,682...201,358,330 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 involved_in
acts_upstream_of_or_within		 IDA
ISO
IBA		 PMID:20097269
MGI:3828088 (PMID:12038961), (PMID:17827337), (PMID:8670055), (PMID:9854036)
GO_REF:0000033
(MGI:4836147|PMID:20097269)
(PMID:20097269), (PMID:9307035), (PMID:9434735)		 RGD
GO_Central		 PMID:8670055 PMID:9307035 PMID:9434735 PMID:9854036 PMID:12038961 More... GO_REF:0000033 MGI:4836147, RGD:8554299 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Gstt2 glutathione S-transferase theta 2 acts_upstream_of_or_within
involved_in		 IDA
IBA		 PMID:12038961
GO_REF:0000033		 GO_Central PMID:12038961 GO_REF:0000033, RGD:8553858 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288 		JBrowse link
G Gstt4 glutathione S-transferase, theta 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:12,835,178...12,842,306
Ensembl chr20:12,835,178...12,842,292 		JBrowse link
G Gstz1 glutathione S-transferase zeta 1 involved_in ISO
IBA		 (PMID:10739172)
GO_REF:0000033		 RGD
GO_Central		 PMID:10739172 GO_REF:0000033 NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284 		JBrowse link
G Hagh hydroxyacyl glutathione hydrolase involved_in IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:8719777 PMID:8903102 GO_REF:0000033, RGD:1641958, RGD:1641959 NCBI chr10:13,874,883...13,889,527
Ensembl chr10:13,875,241...13,889,504 		JBrowse link
G Hbb hemoglobin subunit beta IDA RGD PMID:19963409 RGD:2325281 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012 		JBrowse link
G Hmgn5 high mobility group nucleosome binding domain 5 acts_upstream_of_or_within ISO MGI:5588022 (PMID:24392144) RGD PMID:24392144 NCBI chr  X:74,085,871...74,094,488
Ensembl chr  X:74,085,875...74,094,441 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 acts_upstream_of_or_within ISO (PMID:12031902) RGD PMID:12031902 NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 acts_upstream_of_or_within ISO (PMID:10767383) RGD PMID:10767383 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892 		JBrowse link
G Mmachc metabolism of cobalamin associated C involved_in ISO (PMID:19801555), (PMID:22642810) RGD PMID:19801555 PMID:22642810 NCBI chr 5:130,166,056...130,172,735
Ensembl chr 5:130,166,451...130,172,601 		JBrowse link
G Nat8 N-acetyltransferase 8 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 4:118,279,521...118,284,671
Ensembl chr 4:118,270,954...118,281,763 		JBrowse link
G Ndp norrin cystine knot growth factor NDP acts_upstream_of_or_within ISO MGI:4414794 (PMID:30988181) RGD PMID:30988181 NCBI chr  X:5,796,487...5,820,934
Ensembl chr  X:5,796,487...5,820,934 		JBrowse link
G Nfe2l1 NFE2 like bZIP transcription factor 1 acts_upstream_of_or_within ISO MGI:3828165 (PMID:25092871) RGD PMID:25092871 NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318 		JBrowse link
G Nox1 NADPH oxidase 1 IMP RGD PMID:30653821 RGD:329970281 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Oplah 5-oxoprolinase (ATP-hydrolysing) involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:108,011,472...108,051,751
Ensembl chr 7:108,011,475...108,035,297 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:28886095)
MGI:2655190 (PMID:18799673), (PMID:22732503)		 RGD PMID:18799673 PMID:22732503 PMID:28886095 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO MGI:3608695 (PMID:17200146), (PMID:23085521) RGD PMID:17200146 PMID:23085521 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Sod1 superoxide dismutase 1 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:1857872 (PMID:16377630)		 UniProt
RGD		 PMID:16377630 GO_REF:0000024 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 acts_upstream_of_or_within ISO MGI:1857344 (PMID:10049502) RGD PMID:10049502 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Txnrd3 thioredoxin reductase 3 acts_upstream_of_or_within ISO (PMID:11259642) RGD PMID:11259642 NCBI chr 4:122,072,548...122,112,493
Ensembl chr 4:122,072,548...122,112,491 		JBrowse link
glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit acts_upstream_of_or_within
involved_in		 IMP
ISO
IBA
IEA
ISS		 MGI:2387010 (PMID:10805773), (PMID:16081425)
GO_REF:0000033
GO_REF:0000041
(PMID:10395918), (PMID:12663448), (PMID:8104187), (PMID:9675072)
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:8104187 PMID:9675072 PMID:10395918 PMID:10805773 PMID:12663448 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000041, RGD:1582661 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit acts_upstream_of_or_within
involved_in		 IMP
ISO
IBA
IEA
ISS		 (PMID:16081425)
GO_REF:0000033
GO_REF:0000041
(PMID:10395918), (PMID:12081989), (PMID:9675072)
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:9675072 PMID:10395918 PMID:12081989 PMID:16081425 PMID:16183645 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041, RGD:1582661 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 involved_in ISO
IEA		 (MGI:5294309|PMID:12468440)
GO_REF:0000107		 RGD
Ensembl		 PMID:12468440 GO_REF:0000107 MGI:5294309 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Ggt5 gamma-glutamyltransferase 5 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:13,043,255...13,071,523
Ensembl chr20:13,043,257...13,071,450 		JBrowse link
G Ggt6 gamma-glutamyl transferase 6 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:57,051,977...57,054,900
Ensembl chr10:57,051,825...57,067,260 		JBrowse link
G Ggt7 gamma-glutamyltransferase 7 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:143,978,073...144,004,597
Ensembl chr 3:143,978,082...144,001,492 		JBrowse link
G Gss glutathione synthetase acts_upstream_of_or_within
involved_in		 IDA
ISO
IEA		 (MGI:81780|PMID:8660701)
GO_REF:0000041		 RGD
UniProt		 PMID:8660701 PMID:10964706 GO_REF:0000041 MGI:81780, RGD:1599340 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198 		JBrowse link
G Hagh hydroxyacyl glutathione hydrolase involved_in IEA
ISO		 GO_REF:0000107
(PMID:8550579)		 Ensembl
RGD		 PMID:8550579 GO_REF:0000107 NCBI chr10:13,874,883...13,889,527
Ensembl chr10:13,875,241...13,889,504 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 involved_in ISO (PMID:8703034) RGD PMID:8703034 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 involved_in ISO (PMID:12614333) RGD PMID:12614333 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:12614333)		 Ensembl
RGD		 PMID:12614333 GO_REF:0000107 NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498 		JBrowse link
glutathione catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526 		JBrowse link
G Chac2 ChaC glutathione specific gamma-glutamylcyclotransferase 2 involved_in IEA
IBA		 GO_REF:0000104
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 NCBI chr14:104,720,754...104,728,305
Ensembl chr14:104,720,758...104,728,301 		JBrowse link
G Dpep1 dipeptidase 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:1203838|PMID:9560193)		 UniProt
RGD		 PMID:9560193 GO_REF:0000024 MGI:1203838 NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 involved_in ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:17924658), (PMID:21447318)
GO_REF:0000002
GO_REF:0000033		 UniProt
RGD
InterPro
GO_Central		 PMID:17924658 PMID:21447318 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Ggt5 gamma-glutamyltransferase 5 involved_in ISO
ISS
IBA		 (PMID:1676842), (PMID:21447318)
GO_REF:0000024
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:1676842 PMID:21447318 GO_REF:0000024 GO_REF:0000033 NCBI chr20:13,043,255...13,071,523
Ensembl chr20:13,043,257...13,071,450 		JBrowse link
G Ggt7 gamma-glutamyltransferase 7 involved_in IEA
IBA		 GO_REF:0000104
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 NCBI chr 3:143,978,073...144,004,597
Ensembl chr 3:143,978,082...144,001,492 		JBrowse link
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:5616326|PMID:14978030) RGD PMID:14978030 MGI:5616326 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 involved_in ISO (MGI:5616326|PMID:14978030) RGD PMID:14978030 MGI:5616326 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO MGI:1857061 (PMID:16037214) RGD PMID:16037214 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    metabolic process 12289
      amide metabolic process 439
        glutathione metabolic process 56
          ascorbate glutathione cycle 0
          glutathione biosynthetic process + 14
          glutathione catabolic process 6
Path 2
Term Annotations click to browse term
  biological_process 20115
    metabolic process 12289
      cellular metabolic process 10294
        cellular modified amino acid metabolic process 190
          glutathione metabolic process 56
            ascorbate glutathione cycle 0
            glutathione biosynthetic process + 14
            glutathione catabolic process 6
paths to the root