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ONTOLOGY REPORT - ANNOTATIONS


Term:NADP metabolic process
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Accession:GO:0006739 term browser browse the term
Definition:The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH.
Synonyms:exact_synonym: NADP metabolism;   NADPH metabolic process;   NADPH metabolism;   nicotinamide adenine dinucleotide phosphate metabolic process;   nicotinamide adenine dinucleotide phosphate metabolism;   oxidized NADP metabolic process;   oxidized NADP metabolism;   oxidized nicotinamide adenine dinucleotide phosphate metabolic process;   oxidized nicotinamide adenine dinucleotide phosphate metabolism;   reduced NADP metabolic process;   reduced NADP metabolism;   reduced nicotinamide adenine dinucleotide phosphate metabolic process;   reduced nicotinamide adenine dinucleotide phosphate metabolism
 related_synonym: NAD phosphorylation and dephosphorylation



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NADP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBR2 carbonyl reductase 2 acts_upstream_of_or_within ISO (MGI:2179664|PMID:11882650) MGI PMID:11882650 MGI:2179664 NCBI chr12:973,780...976,017
Ensembl chr12:973,760...976,017
JBrowse link
G CYB5R4 cytochrome b5 reductase 4 ISO NADPH oxidation RGD PMID:11913972 RGD:632262 NCBI chr 1:53,092,006...53,191,216
Ensembl chr 1:53,092,036...53,191,212
JBrowse link
G DCXR dicarbonyl and L-xylulose reductase involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr12:978,131...980,042
Ensembl chr12:978,139...982,259
JBrowse link
G FMO2 flavin containing dimethylaniline monoxygenase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:63,812,016...63,857,608
Ensembl chr 9:63,812,492...63,852,085
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:125,029,147...125,041,040
Ensembl chr  X:125,029,150...125,041,040
JBrowse link
G GCK glucokinase acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3691164|PMID:9873043) MGI
Ensembl
PMID:9873043 GO_REF:0000107 MGI:3691164 NCBI chr18:50,979,167...51,024,500
Ensembl chr18:50,979,167...51,029,844
JBrowse link
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase ISO RGD PMID:6813321 RGD:1641956 NCBI chr 6:69,666,348...69,700,303
Ensembl chr 6:69,666,601...69,700,298
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,609...55,675,554
JBrowse link
G MDH1 malate dehydrogenase 1 involved_in ISO (PMID:34547241) ComplexPortal PMID:34547241 NCBI chr 3:78,247,229...78,263,085
Ensembl chr 3:78,244,999...78,268,600
JBrowse link
G ME1 malic enzyme 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:82,799,878...82,989,895
Ensembl chr 1:82,799,684...82,991,085
JBrowse link
G MYL7 myosin light chain 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:51,026,436...51,028,917
Ensembl chr18:50,979,167...51,029,844
JBrowse link
G NOCT nocturnin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:87,885,411...87,909,231
Ensembl chr 8:87,885,420...87,909,241
JBrowse link
G PC pyruvate carboxylase involved_in ISO (PMID:34547241) ComplexPortal PMID:34547241 NCBI chr 2:5,566,608...5,587,797
Ensembl chr 2:5,518,517...5,587,797
JBrowse link
G PGD phosphogluconate dehydrogenase ISO RGD PMID:6813321 RGD:1641956 NCBI chr 6:70,675,751...70,692,697
Ensembl chr 6:70,675,815...70,692,679
JBrowse link
G TP53I3 tumor protein p53 inducible protein 3 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 3:114,599,285...114,605,455
Ensembl chr 3:114,600,224...114,605,448
JBrowse link
NADP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6PD glucose-6-phosphate dehydrogenase acts_upstream_of_or_within ISO (MGI:1349468|PMID:3377761), (MGI:2387959|PMID:10627286), (MGI:3607389|PMID:14757696), (MGI:3694178|PMID:15998684), (MGI:49164|PMID:1953691), (MGI:85983|PMID:9067418)
(MGI:3522057|PMID:15271799)
(MGI:1097071|PMID:9330624), (MGI:1202104|PMID:9539108), (MGI:1261671|PMID:9627357), (MGI:54902|PMID:7439685), (MGI:87492|PMID:9169132)
MGI PMID:1953691 PMID:3377761 PMID:7439685 PMID:9067418 PMID:9169132 More... MGI:1097071 MGI:1202104 MGI:1261671 MGI:1349468 MGI:2387959 MGI:3522057 MGI:3607389 MGI:3694178 MGI:49164 MGI:54902 MGI:85983 MGI:87492 NCBI chr  X:125,029,147...125,041,040
Ensembl chr  X:125,029,150...125,041,040
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 ISO RGD PMID:21641335 RGD:11522736 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,609...55,675,554
JBrowse link
G NADK NAD kinase involved_in IBA
IEA
ISO
(PMID:21873635) GO_Central
GO_Central
InterPro
RGD
InterPro
PMID:21873635 PMID:22550069 GO_REF:0000002 RGD:13703105 NCBI chr 6:63,846,650...63,864,137
Ensembl chr 6:63,846,655...63,863,946
JBrowse link
G NADK2 NAD kinase 2, mitochondrial involved_in IEA UniProt
UniProt
InterPro
GO_REF:0000002 GO_REF:0000104 NCBI chr16:21,507,422...21,557,312
Ensembl chr16:21,506,769...21,557,274
JBrowse link
NADP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NUDT12 nudix hydrolase 12 involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
(PMID:21873635)
(PMID:12790796)
GO_Central
Ensembl
GO_Central
MGI
PMID:12790796 PMID:21873635 GO_REF:0000107 NCBI chr 2:109,044,946...109,059,721
Ensembl chr 2:109,045,592...109,059,616
JBrowse link
G NUDT13 nudix hydrolase 13 involved_in ISO (MGI:6368098|PMID:28755312) UniProt PMID:28755312 MGI:6368098 NCBI chr14:75,918,056...75,958,187
Ensembl chr14:75,918,171...75,958,178
JBrowse link
G NUDT17 nudix hydrolase 17 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 4:99,472,347...99,477,953
Ensembl chr 4:99,472,350...99,477,944
JBrowse link
NADPH oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FDX1 ferredoxin 1 ISO RGD PMID:10525147 RGD:727285 NCBI chr 9:38,376,147...38,399,026
Ensembl chr 9:38,375,984...38,404,832
JBrowse link
G FDXR ferredoxin reductase ISO RGD PMID:10525147 RGD:727285 NCBI chr12:6,372,224...6,382,769
Ensembl chr12:6,372,009...6,382,769
JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 involved_in IDA
IEA
(PMID:15144220) BHF-UCL
BHF-UCL
Ensembl
Ensembl
PMID:15144220 GO_REF:0000107 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076
JBrowse link
G FMO2 flavin containing dimethylaniline monoxygenase 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 9:63,812,016...63,857,608
Ensembl chr 9:63,812,492...63,852,085
JBrowse link
G FMO5 flavin containing dimethylaniline monoxygenase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:100,336,769...100,372,744
Ensembl chr 4:100,336,980...100,374,367
JBrowse link
G KCNAB2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 involved_in ISO PMID:18672894 UniProt PMID:18672894 RGD:10047329 NCBI chr 6:66,928,374...67,016,846
Ensembl chr 6:66,928,381...67,016,845
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 ISO RGD PMID:29444417 RGD:25823192 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590
JBrowse link
G PRDX5 peroxiredoxin 5 involved_in ISO (PMID:10751410) UniProt PMID:10751410 NCBI chr 2:7,798,672...7,801,955
Ensembl chr 2:7,798,670...7,802,952
JBrowse link
G TXNRD1 thioredoxin reductase 1 ISO RGD PMID:19054767 RGD:5133716 NCBI chr 5:80,170,334...80,213,889
Ensembl chr 5:80,172,260...80,236,219
JBrowse link
NADPH regeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:53,748,585...53,794,777
Ensembl chr 7:53,748,653...53,794,706
JBrowse link
G ALDH1L2 aldehyde dehydrogenase 1 family member L2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:79,492,672...79,558,702
Ensembl chr 5:79,492,750...79,558,701
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:125,029,147...125,041,040
Ensembl chr  X:125,029,150...125,041,040
JBrowse link
G NNT nicotinamide nucleotide transhydrogenase ISO RGD PMID:22198343 RGD:13513982 NCBI chr16:28,157,192...28,248,732
Ensembl chr16:28,157,318...28,250,961
JBrowse link
negative regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TP53 tumor protein p53 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
JBrowse link
pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6PD glucose-6-phosphate dehydrogenase involved_in ISO
IEA
RGD
UniProt
Ensembl
PMID:2843500 GO_REF:0000041 GO_REF:0000107 GO_REF:0000117 RGD:1599574 NCBI chr  X:125,029,147...125,041,040
Ensembl chr  X:125,029,150...125,041,040
JBrowse link
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2668276|PMID:12831846) UniProt
UniProt
InterPro
MGI
PMID:12831846 GO_REF:0000002 GO_REF:0000041 GO_REF:0000117 MGI:2668276 NCBI chr 6:69,666,348...69,700,303
Ensembl chr 6:69,666,601...69,700,298
JBrowse link
G PGD phosphogluconate dehydrogenase involved_in ISS
IEA
ISO
UniProt
UniProt
InterPro
RGD
PMID:2843500 GO_REF:0000002 GO_REF:0000024 GO_REF:0000041 GO_REF:0000043 RGD:1599574 NCBI chr 6:70,675,751...70,692,697
Ensembl chr 6:70,675,815...70,692,679
JBrowse link
G PGLS 6-phosphogluconolactonase involved_in IEA UniProt
InterPro
UniProt
GO_REF:0000002 GO_REF:0000041 NCBI chr 2:60,186,690...60,198,037
Ensembl chr 2:60,187,747...60,197,648
JBrowse link
G PRPS1 phosphoribosyl pyrophosphate synthetase 1 involved_in ISO (MGI:5602900|PMID:24855946) MGI PMID:24855946 MGI:5602900 NCBI chr  X:88,074,861...88,101,925
Ensembl chr  X:88,074,965...88,101,910
JBrowse link
G PRPS2 phosphoribosyl pyrophosphate synthetase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:9,505,034...9,531,044
Ensembl chr  X:9,503,953...9,530,086
Ensembl chr  X:9,503,953...9,530,086
JBrowse link
G RBKS ribokinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:111,328,758...111,426,173
Ensembl chr 3:111,328,750...111,426,908
JBrowse link
G RPE ribulose-5-phosphate-3-epimerase involved_in IEA
ISO
InterPro
InterPro
RGD
PMID:2843500 GO_REF:0000002 RGD:1599574 NCBI chr15:112,723,318...112,748,337 JBrowse link
G RPIA ribose 5-phosphate isomerase A involved_in ISO
IEA
RGD
Ensembl
UniProt
PMID:2843500 GO_REF:0000041 GO_REF:0000107 RGD:1599574 NCBI chr 3:57,355,973...57,386,948
Ensembl chr 3:57,355,975...57,386,939
JBrowse link
G TALDO1 transaldolase 1 involved_in IEA
ISS
ISO
UniProt
UniProt
InterPro
RGD
PMID:2843500 GO_REF:0000002 GO_REF:0000024 GO_REF:0000041 GO_REF:0000043 RGD:1599574 NCBI chr 2:464,781...472,836
Ensembl chr 2:464,728...472,835
JBrowse link
G TKT transketolase involved_in ISO
IEA
RGD
Ensembl
Ensembl
PMID:2843500 GO_REF:0000107 RGD:1599574 NCBI chr13:35,348,921...35,377,518
Ensembl chr13:35,348,915...35,377,587
JBrowse link
pentose-phosphate shunt, non-oxidative branch term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RPE ribulose-5-phosphate-3-epimerase involved_in IBA
ISO
(PMID:21873635) GO_Central
GO_Central
RGD
PMID:3079759 PMID:21873635 RGD:1641816 NCBI chr15:112,723,318...112,748,337 JBrowse link
G RPIA ribose 5-phosphate isomerase A involved_in IEA
IBA
ISO
(PMID:21873635) InterPro
GO_Central
InterPro
RGD
GO_Central
PMID:3079759 PMID:21873635 GO_REF:0000002 RGD:1641816 NCBI chr 3:57,355,973...57,386,948
Ensembl chr 3:57,355,975...57,386,939
JBrowse link
G SHPK sedoheptulokinase involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr12:49,713,224...49,732,319
Ensembl chr12:49,712,177...49,732,246
JBrowse link
G TALDO1 transaldolase 1 ISO RGD PMID:3079759 PMID:8477719 RGD:1641803 RGD:1641816 NCBI chr 2:464,781...472,836
Ensembl chr 2:464,728...472,835
JBrowse link
G TKT transketolase involved_in ISO
IBA
(PMID:21873635) RGD
GO_Central
PMID:3079759 PMID:16116031 PMID:21873635 RGD:1580394 RGD:1641816 NCBI chr13:35,348,921...35,377,518
Ensembl chr13:35,348,915...35,377,587
JBrowse link
pentose-phosphate shunt, oxidative branch term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6PD glucose-6-phosphate dehydrogenase involved_in ISO
IEA
RGD
Ensembl
Ensembl
PMID:9794092 GO_REF:0000107 RGD:1641793 NCBI chr  X:125,029,147...125,041,040
Ensembl chr  X:125,029,150...125,041,040
JBrowse link
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase involved_in IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr 6:69,666,348...69,700,303
Ensembl chr 6:69,666,601...69,700,298
JBrowse link
G PGD phosphogluconate dehydrogenase involved_in IBA
IEA
ISO
(PMID:21873635) GO_Central
GO_Central
Ensembl
RGD
Ensembl
PMID:9794092 PMID:21873635 GO_REF:0000107 RGD:1641793 NCBI chr 6:70,675,751...70,692,697
Ensembl chr 6:70,675,815...70,692,679
JBrowse link
G PGLS 6-phosphogluconolactonase ISO RGD PMID:971315 RGD:2311501 NCBI chr 2:60,186,690...60,198,037
Ensembl chr 2:60,187,747...60,197,648
JBrowse link
regulation of NADP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HNF1A HNF1 homeobox A ISO RGD PMID:20841353 RGD:150540305 NCBI chr14:40,868,819...40,888,322
Ensembl chr14:40,868,676...40,888,328
JBrowse link
G ME1 malic enzyme 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 1:82,799,878...82,989,895
Ensembl chr 1:82,799,684...82,991,085
JBrowse link
G ME2 malic enzyme 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 1:100,419,404...100,475,778
Ensembl chr 1:100,419,760...100,476,733
JBrowse link
regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 ISO RGD PMID:16234247 RGD:1625062 NCBI chr 9:133,231,451...133,278,396
Ensembl chr 9:133,231,451...133,278,396
JBrowse link
G PGAM1 phosphoglycerate mutase 1 involved_in ISO (PMID:12189148) UniProt PMID:12189148 NCBI chr14:108,822,782...108,832,818
Ensembl chr14:108,822,812...108,833,058
JBrowse link
G TIGAR TP53 induced glycolysis regulatory phosphatase involved_in IBA
IEA
(PMID:21873635) GO_Central
GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 5:66,044,679...66,067,571
Ensembl chr 5:66,044,686...66,067,377
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17430
    metabolic process 10973
      cellular metabolic process 9229
        cellular aromatic compound metabolic process 5490
          purine-containing compound metabolic process 500
            purine nucleotide metabolic process 464
              NADP metabolic process 46
                NADP biosynthetic process 4
                NADP catabolic process 3
                NADPH oxidation 9
                NADPH regeneration + 19
                regulation of NADP metabolic process + 7
Path 2
Term Annotations click to browse term
  biological_process 17430
    metabolic process 10973
      organic substance metabolic process 10533
        organic cyclic compound metabolic process 5689
          nucleobase-containing compound metabolic process 5277
            nucleobase-containing small molecule metabolic process 591
              nucleoside phosphate metabolic process 526
                nucleotide metabolic process 520
                  pyridine nucleotide metabolic process 79
                    nicotinamide nucleotide metabolic process 79
                      NADP metabolic process 46
                        NADP biosynthetic process 4
                        NADP catabolic process 3
                        NADPH oxidation 9
                        NADPH regeneration + 19
                        regulation of NADP metabolic process + 7
paths to the root