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ONTOLOGY REPORT - ANNOTATIONS


Term:NADP metabolic process
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Accession:GO:0006739 term browser browse the term
Definition:The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH.
Synonyms:exact_synonym: NADP metabolism;   NADPH metabolic process;   NADPH metabolism;   nicotinamide adenine dinucleotide phosphate metabolic process;   nicotinamide adenine dinucleotide phosphate metabolism;   oxidized NADP metabolic process;   oxidized NADP metabolism;   oxidized nicotinamide adenine dinucleotide phosphate metabolic process;   oxidized nicotinamide adenine dinucleotide phosphate metabolism;   reduced NADP metabolic process;   reduced NADP metabolism;   reduced nicotinamide adenine dinucleotide phosphate metabolic process;   reduced nicotinamide adenine dinucleotide phosphate metabolism
 related_synonym: NAD phosphorylation and dephosphorylation


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NADP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYB5R4 cytochrome b5 reductase 4 ISO NADPH oxidation RGD PMID:11913972 RGD:632262 NCBI chr 6:83,859,689...83,967,423
Ensembl chr 6:83,859,656...83,967,423
JBrowse link
G DCXR dicarbonyl and L-xylulose reductase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2179664|PMID:11882650) Ensembl
MGI
PMID:11882650 GO_REF:0000107 MGI:2179664 NCBI chr17:82,035,858...82,037,697
Ensembl chr17:82,035,136...82,037,709
JBrowse link
G FMO2 flavin containing dimethylaniline monoxygenase 2 involved_in IDA (PMID:11744609) BHF-UCL PMID:11744609 NCBI chr 1:171,185,208...171,212,686
Ensembl chr 1:171,185,249...171,212,686
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase involved_in IDA (PMID:15858258) UniProt PMID:15858258 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GCK glucokinase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3691164|PMID:9873043) Ensembl
MGI
PMID:9873043 GO_REF:0000107 MGI:3691164 NCBI chr 7:44,143,213...44,189,439
Ensembl chr 7:44,143,213...44,198,170
JBrowse link
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase ISO RGD PMID:6813321 RGD:1641956 NCBI chr 1:9,234,767...9,271,337
Ensembl chr 1:9,234,774...9,271,337
JBrowse link
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:208,236,227...208,255,071
Ensembl chr 2:208,236,229...208,266,074
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477
JBrowse link
G NOCT nocturnin involved_in IDA (PMID:31147539) UniProt PMID:31147539 NCBI chr 4:139,015,781...139,045,939
Ensembl chr 4:139,015,781...139,045,939
JBrowse link
G NOX1 NADPH oxidase 1 involved_in IC (PMID:10485709) BHF-UCL PMID:10485709 NCBI chr  X:100,843,324...100,874,359
Ensembl chr  X:100,843,324...100,874,359
JBrowse link
G PGD phosphogluconate dehydrogenase ISO RGD PMID:6813321 RGD:1641956 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
JBrowse link
G TP53I3 tumor protein p53 inducible protein 3 involved_in IDA (PMID:19349281) UniProt PMID:19349281 NCBI chr 2:24,077,428...24,085,767
Ensembl chr 2:24,077,433...24,085,861
JBrowse link
NADP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6PD glucose-6-phosphate dehydrogenase acts_upstream_of_or_within ISO (MGI:1097071|PMID:9330624), (MGI:1202104|PMID:9539108), (MGI:1261671|PMID:9627357), (MGI:54902|PMID:7439685), (MGI:87492|PMID:9169132)
(MGI:3522057|PMID:15271799)
(MGI:1349468|PMID:3377761), (MGI:2387959|PMID:10627286), (MGI:3607389|PMID:14757696), (MGI:3694178|PMID:15998684), (MGI:49164|PMID:1953691), (MGI:85983|PMID:9067418)
MGI PMID:1953691 PMID:3377761 PMID:7439685 PMID:9067418 PMID:9169132 More... MGI:1097071 MGI:1202104 MGI:1261671 MGI:1349468 MGI:2387959 MGI:3522057 MGI:3607389 MGI:3694178 MGI:49164 MGI:54902 MGI:85983 MGI:87492 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 involved_in IEA
ISO
Ensembl
RGD
PMID:21641335 GO_REF:0000107 RGD:11522736 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477
JBrowse link
G NADK NAD kinase involved_in IBA
ISO
IEA
(PMID:21873635) GO_Central
RGD
InterPro
PMID:21873635 PMID:22550069 GO_REF:0000002 RGD:13703105 NCBI chr 1:1,751,232...1,780,509
Ensembl chr 1:1,751,232...1,780,457
JBrowse link
G NADK2 NAD kinase 2, mitochondrial involved_in IEA InterPro
UniProt
GO_REF:0000002 GO_REF:0000104 NCBI chr 5:36,192,589...36,242,279
Ensembl chr 5:36,192,589...36,242,279
JBrowse link
NADP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NUDT12 nudix hydrolase 12 involved_in
acts_upstream_of_or_within
IBA
IDA
(PMID:21873635)
(PMID:12790796)
GO_Central
MGI
PMID:12790796 PMID:21873635 NCBI chr 5:103,548,855...103,562,805
Ensembl chr 5:103,548,855...103,562,790
JBrowse link
G NUDT13 nudix hydrolase 13 involved_in ISS UniProt GO_REF:0000024 NCBI chr10:73,110,455...73,131,827
Ensembl chr10:73,110,375...73,131,828
JBrowse link
G NUDT17 nudix hydrolase 17 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:145,844,985...145,848,954
Ensembl chr 1:145,845,630...145,848,954
JBrowse link
NADPH oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FDX1 ferredoxin 1 ISO RGD PMID:10525147 RGD:727285 NCBI chr11:110,429,948...110,464,884
Ensembl chr11:110,429,948...110,464,884
JBrowse link
G FDXR ferredoxin reductase ISO RGD PMID:10525147 RGD:727285 NCBI chr17:74,862,497...74,872,994
Ensembl chr17:74,862,497...74,873,031
JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 involved_in IDA (PMID:15144220) BHF-UCL PMID:15144220 NCBI chr 1:171,248,473...171,285,978
Ensembl chr 1:171,248,471...171,285,978
JBrowse link
G FMO2 flavin containing dimethylaniline monoxygenase 2 involved_in IDA (PMID:15144220), (PMID:9804831) UniProt PMID:9804831 PMID:15144220 NCBI chr 1:171,185,208...171,212,686
Ensembl chr 1:171,185,249...171,212,686
JBrowse link
G FMO5 flavin containing dimethylaniline monoxygenase 5 involved_in IDA (PMID:26771671) UniProt PMID:26771671 NCBI chr 1:147,183,963...147,225,798
Ensembl chr 1:147,175,351...147,243,050
JBrowse link
G KCNAB2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr 1:5,992,639...6,101,186
Ensembl chr 1:5,990,927...6,101,193
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 involved_in IEA
ISO
Ensembl
RGD
PMID:29444417 GO_REF:0000107 RGD:25823192 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G PRDX5 peroxiredoxin 5 involved_in IDA (PMID:10751410) UniProt PMID:10751410 NCBI chr11:64,318,121...64,321,811
Ensembl chr11:64,318,121...64,321,811
JBrowse link
G TXNRD1 thioredoxin reductase 1 ISO RGD PMID:19054767 RGD:5133716 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
NADPH regeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6PD glucose-6-phosphate dehydrogenase involved_in IMP (PMID:17516514) BHF-UCL PMID:17516514 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G NNT nicotinamide nucleotide transhydrogenase involved_in IBA
ISO
(PMID:21873635) GO_Central
RGD
PMID:21873635 PMID:22198343 RGD:13513982 NCBI chr 5:43,601,092...43,707,396
Ensembl chr 5:43,602,692...43,707,405
JBrowse link
negative regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TP53 tumor protein p53 involved_in IMP (PMID:21336310) CACAO PMID:21336310 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DERA deoxyribose-phosphate aldolase involved_in TAS Reactome Reactome:R-HSA-71336 NCBI chr12:15,911,332...16,037,381
Ensembl chr12:15,911,302...16,037,381
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase involved_in IEA
ISO
IDA
(PMID:2297768) UniProt
RGD
BHF-UCL
PMID:2297768 PMID:2843500 GO_REF:0000041 RGD:1599574 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase acts_upstream_of_or_within ISO (MGI:2668276|PMID:12831846) MGI PMID:12831846 MGI:2668276 NCBI chr 1:9,234,767...9,271,337
Ensembl chr 1:9,234,774...9,271,337
JBrowse link
G PGD phosphogluconate dehydrogenase involved_in IEA
ISO
ISS
UniProt
RGD
PMID:2843500 GO_REF:0000024 GO_REF:0000041 RGD:1599574 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
JBrowse link
G PGLS 6-phosphogluconolactonase involved_in IEA
TAS
IDA
(PMID:10518023) UniProt
Reactome
PMID:10518023 GO_REF:0000041 Reactome:R-HSA-71336 NCBI chr19:17,511,649...17,521,291
Ensembl chr19:17,511,636...17,521,288
JBrowse link
G RBKS ribokinase involved_in TAS Reactome Reactome:R-HSA-71336 NCBI chr 2:27,781,379...27,890,387
Ensembl chr 2:27,781,379...27,890,681
JBrowse link
G RPE ribulose-5-phosphate-3-epimerase involved_in IDA
ISO
IEA
(PMID:20923965) UniProt
RGD
InterPro
PMID:2843500 PMID:20923965 GO_REF:0000002 RGD:1599574 NCBI chr 2:210,002,628...210,023,363
Ensembl chr 2:210,002,565...210,022,260
JBrowse link
G RPIA ribose 5-phosphate isomerase A involved_in TAS
ISO
Reactome
RGD
PMID:2843500 RGD:1599574 Reactome:R-HSA-71336 NCBI chr 2:88,691,673...88,750,929
Ensembl chr 2:88,691,673...88,750,929
JBrowse link
G SHPK sedoheptulokinase involved_in TAS Reactome Reactome:R-HSA-71336 NCBI chr17:3,608,240...3,636,250
Ensembl chr17:3,608,240...3,636,250
JBrowse link
G TALDO1 transaldolase 1 involved_in IEA
ISO
UniProt
RGD
PMID:2843500 GO_REF:0000041 RGD:1599574 NCBI chr11:747,464...765,012
Ensembl chr11:747,415...765,012
JBrowse link
G TKT transketolase involved_in IDA
ISO
(PMID:20667822) UniProt
RGD
PMID:2843500 PMID:20667822 RGD:1599574 NCBI chr 3:53,224,712...53,256,052
Ensembl chr 3:53,224,712...53,256,052
JBrowse link
pentose-phosphate shunt, non-oxidative branch term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RPE ribulose-5-phosphate-3-epimerase involved_in IBA
ISO
(PMID:21873635) GO_Central
RGD
PMID:3079759 PMID:21873635 RGD:1641816 NCBI chr 2:210,002,628...210,023,363
Ensembl chr 2:210,002,565...210,022,260
JBrowse link
G RPEL1 ribulose-5-phosphate-3-epimerase like 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:103,245,887...103,248,016
Ensembl chr10:103,245,887...103,248,016
JBrowse link
G RPIA ribose 5-phosphate isomerase A involved_in IBA
ISO
(PMID:21873635) GO_Central
RGD
PMID:3079759 PMID:21873635 RGD:1641816 NCBI chr 2:88,691,673...88,750,929
Ensembl chr 2:88,691,673...88,750,929
JBrowse link
G SHPK sedoheptulokinase involved_in ISS UniProt GO_REF:0000024 NCBI chr17:3,608,240...3,636,250
Ensembl chr17:3,608,240...3,636,250
JBrowse link
G TALDO1 transaldolase 1 involved_in IBA
ISO
(PMID:21873635) GO_Central
RGD
PMID:3079759 PMID:8477719 PMID:21873635 RGD:1641803 RGD:1641816 NCBI chr11:747,464...765,012
Ensembl chr11:747,415...765,012
JBrowse link
G TKT transketolase involved_in IBA
ISO
NAS
(PMID:21873635)
(PMID:9357955)
GO_Central
RGD
UniProt
PMID:3079759 PMID:9357955 PMID:16116031 PMID:21873635 RGD:1580394 RGD:1641816 NCBI chr 3:53,224,712...53,256,052
Ensembl chr 3:53,224,712...53,256,052
JBrowse link
pentose-phosphate shunt, oxidative branch term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6PD glucose-6-phosphate dehydrogenase involved_in IMP
ISO
(PMID:2420826) BHF-UCL
RGD
PMID:2420826 PMID:9794092 RGD:1641793 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase involved_in IMP (PMID:18628520), (PMID:23132696) UniProt PMID:18628520 PMID:23132696 NCBI chr 1:9,234,767...9,271,337
Ensembl chr 1:9,234,774...9,271,337
JBrowse link
G PGD phosphogluconate dehydrogenase involved_in IDA
ISO
IBA
(PMID:3858849)
(PMID:21873635)
UniProt
RGD
GO_Central
PMID:3858849 PMID:9794092 PMID:21873635 RGD:1641793 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
JBrowse link
G PGLS 6-phosphogluconolactonase involved_in IBA
ISO
(PMID:21873635) GO_Central
RGD
PMID:971315 PMID:21873635 RGD:2311501 NCBI chr19:17,511,649...17,521,291
Ensembl chr19:17,511,636...17,521,288
JBrowse link
regulation of NADP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ME1 malic enzyme 1 involved_in IMP (PMID:23334421) CACAO PMID:23334421 NCBI chr 6:83,210,402...83,431,078
Ensembl chr 6:83,210,402...83,431,051
JBrowse link
G ME2 malic enzyme 2 involved_in IMP (PMID:23334421) CACAO PMID:23334421 NCBI chr18:50,878,702...50,954,257
Ensembl chr18:50,879,080...50,954,257
JBrowse link
regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 ISO RGD PMID:16234247 RGD:1625062 NCBI chr 1:209,686,179...209,734,929
Ensembl chr 1:209,686,178...209,734,949
JBrowse link
G PGAM1 phosphoglycerate mutase 1 involved_in IDA (PMID:12189148) UniProt PMID:12189148 NCBI chr10:97,426,191...97,433,444
Ensembl chr10:97,426,191...97,433,444
JBrowse link
G TIGAR TP53 induced glycolysis regulatory phosphatase involved_in IMP
IBA
(PMID:25928429)
(PMID:21873635)
UniProt
GO_Central
PMID:21873635 PMID:25928429 NCBI chr12:4,321,213...4,360,028
Ensembl chr12:4,307,763...4,360,028
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18537
    metabolic process 11867
      NADP metabolic process 41
        NADP biosynthetic process 4
        NADP catabolic process 3
        NADPH oxidation 9
        NADPH regeneration + 17
        regulation of NADP metabolic process + 6
paths to the root