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ONTOLOGY REPORT - ANNOTATIONS

Term:NADP metabolic process
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Accession:GO:0006739 term browser browse the term
Definition:The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH.
Synonyms:exact_synonym: NADP metabolism;   NADPH metabolic process;   NADPH metabolism;   nicotinamide adenine dinucleotide phosphate metabolic process;   nicotinamide adenine dinucleotide phosphate metabolism;   oxidized NADP metabolic process;   oxidized NADP metabolism;   oxidized nicotinamide adenine dinucleotide phosphate metabolic process;   oxidized nicotinamide adenine dinucleotide phosphate metabolism;   reduced NADP metabolic process;   reduced NADP metabolism;   reduced nicotinamide adenine dinucleotide phosphate metabolic process;   reduced nicotinamide adenine dinucleotide phosphate metabolism
 related_synonym: NAD phosphorylation and dephosphorylation


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NADP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYB5R4 cytochrome b5 reductase 4 ISO NADPH oxidation RGD PMID:11913972 RGD:632262 NCBI chr12:44,170,571...44,247,494
Ensembl chr12:44,141,582...44,247,493 		JBrowse link
G DCXR dicarbonyl and L-xylulose reductase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11882650) Ensembl
MGI		 PMID:11882650 GO_REF:0000107 NCBI chr 9:289,864...291,518
Ensembl chr 9:289,889...291,480 		JBrowse link
G FMO2 flavin containing dimethylaniline monoxygenase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:27,634,624...27,659,111
Ensembl chr 7:27,634,900...27,659,037 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:122,217,317...122,231,862
Ensembl chr  X:122,205,683...122,231,678 		JBrowse link
G GCK glucokinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9873043) Ensembl
MGI		 PMID:9873043 GO_REF:0000107
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase ISO RGD PMID:6813321 RGD:1641956 NCBI chr 5:62,548,136...62,577,346
Ensembl chr 5:62,548,221...62,608,964 		JBrowse link
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr37:16,512,027...16,531,269
Ensembl chr37:16,512,770...16,531,219 		JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 3:53,070,462...53,077,566
Ensembl chr 3:53,070,695...53,087,496 		JBrowse link
G MDH1 malate dehydrogenase 1 involved_in ISO (PMID:34547241) ComplexPortal PMID:34547241 NCBI chr10:63,316,818...63,334,556
Ensembl chr10:63,316,831...63,361,735 		JBrowse link
G ME1 malic enzyme 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:43,623,413...43,793,590
Ensembl chr12:43,624,945...43,828,775 		JBrowse link
G NOCT nocturnin involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:3,587,769...3,612,184
Ensembl chr19:3,588,695...3,609,307 		JBrowse link
G PC pyruvate carboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:50,406,994...50,507,677
Ensembl chr18:50,412,272...50,507,669 		JBrowse link
G PGD phosphogluconate dehydrogenase ISO RGD PMID:6813321 RGD:1641956 NCBI chr 2:85,393,526...85,408,714
Ensembl chr 2:85,393,819...85,408,272 		JBrowse link
G TP53I3 tumor protein p53 inducible protein 3 involved_in ISO (PMID:19349281) UniProt PMID:19349281 NCBI chr17:18,560,123...18,566,588
Ensembl chr17:18,560,240...18,565,958 		JBrowse link
NADP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6PD glucose-6-phosphate dehydrogenase acts_upstream_of_or_within ISO (PMID:7439685), (PMID:9169132), (PMID:9330624), (PMID:9539108), (PMID:9627357)
(PMID:15271799)
(PMID:10627286), (PMID:14757696), (PMID:15998684), (PMID:1953691), (PMID:3377761), (PMID:9067418)		 MGI PMID:1953691 PMID:3377761 PMID:7439685 PMID:9067418 PMID:9169132 More... NCBI chr  X:122,217,317...122,231,862
Ensembl chr  X:122,205,683...122,231,678 		JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 ISO RGD PMID:21641335 RGD:11522736 NCBI chr 3:53,070,462...53,077,566
Ensembl chr 3:53,070,695...53,087,496 		JBrowse link
G NADK NAD kinase involved_in ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:22550069 GO_REF:0000002 GO_REF:0000118 RGD:13703105 NCBI chr 5:56,743,920...56,774,578
Ensembl chr 5:56,745,869...56,774,529 		JBrowse link
G NADK2 NAD kinase 2, mitochondrial involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 NCBI chr 4:72,297,480...72,341,176
Ensembl chr 4:72,297,114...72,339,460 		JBrowse link
NADP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NUDT12 nudix hydrolase 12 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12790796) MGI
TreeGrafter
Ensembl		 PMID:12790796 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:7,693,903...7,708,930
Ensembl chr 3:7,696,505...7,724,769 		JBrowse link
G NUDT13 nudix hydrolase 13 involved_in ISO (MGI:6368098|PMID:28755312) UniProt PMID:28755312 MGI:6368098 NCBI chr 4:23,695,183...23,712,301
Ensembl chr 4:23,695,266...23,711,937 		JBrowse link
G NUDT17 nudix hydrolase 17 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:58,648,234...58,653,222
Ensembl chr17:58,648,272...58,650,757 		JBrowse link
NADPH oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FDX1 ferredoxin 1 ISO RGD PMID:10525147 RGD:727285 NCBI chr 5:22,452,011...22,485,581
Ensembl chr 5:22,451,209...22,485,395 		JBrowse link
G FDXR ferredoxin reductase ISO RGD PMID:10525147 RGD:727285 NCBI chr 9:5,567,411...5,577,427
Ensembl chr 9:5,567,328...5,577,277 		JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 involved_in ISO (PMID:15144220) BHF-UCL PMID:15144220 NCBI chr 7:27,599,230...27,623,081
Ensembl chr 7:27,599,267...27,618,237 		JBrowse link
G FMO2 flavin containing dimethylaniline monoxygenase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:27,634,624...27,659,111
Ensembl chr 7:27,634,900...27,659,037 		JBrowse link
G FMO5 flavin containing dimethylaniline monoxygenase 5 involved_in ISO (PMID:26771671) UniProt PMID:26771671 NCBI chr17:57,665,879...57,698,540
Ensembl chr17:57,666,762...57,697,982 		JBrowse link
G KCNAB2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 involved_in ISO PMID:18672894 UniProt PMID:18672894 RGD:10047329 NCBI chr 5:59,936,432...60,021,945
Ensembl chr 5:59,936,528...60,021,957 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 ISO RGD PMID:29444417 RGD:25823192 NCBI chr 5:79,979,593...79,990,875
Ensembl chr 5:79,978,865...79,989,860 		JBrowse link
G PRDX5 peroxiredoxin 5 involved_in ISO (PMID:10751410) UniProt PMID:10751410 NCBI chr18:52,750,977...52,754,432 JBrowse link
G TXNRD1 thioredoxin reductase 1 ISO RGD PMID:19054767 RGD:5133716 NCBI chr10:33,904,065...34,021,549
Ensembl chr10:33,886,343...34,021,696 		JBrowse link
NADPH regeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 involved_in ISO (PMID:19933275)
PMID:1848231		 UniProt PMID:1848231 PMID:19933275 RGD:632027 NCBI chr20:52,722...99,180
Ensembl chr20:61,349...99,160 		JBrowse link
G ALDH1L2 aldehyde dehydrogenase 1 family member L2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:33,310,523...33,365,677
Ensembl chr10:33,310,558...33,365,228 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:122,217,317...122,231,862
Ensembl chr  X:122,205,683...122,231,678 		JBrowse link
G NNT nicotinamide nucleotide transhydrogenase involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:22198343 GO_REF:0000118 RGD:13513982 NCBI chr 4:66,348,222...66,437,889
Ensembl chr 4:66,349,318...66,442,841 		JBrowse link
negative regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDOB aldolase, fructose-bisphosphate B involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:58,150,621...58,166,266
Ensembl chr11:58,150,967...58,176,319 		JBrowse link
G TP53 tumor protein p53 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109 		JBrowse link
pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACACB acetyl-CoA carboxylase beta ISO RGD PMID:31709908 RGD:329901803 NCBI chr26:17,763,531...17,895,319
Ensembl chr26:17,747,362...17,894,400 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase involved_in ISO
IEA		 RGD
Ensembl
UniProt		 PMID:2843500 GO_REF:0000041 GO_REF:0000107 GO_REF:0000117 RGD:1599574 NCBI chr  X:122,217,317...122,231,862
Ensembl chr  X:122,205,683...122,231,678 		JBrowse link
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12831846) InterPro
MGI
UniProt		 PMID:12831846 GO_REF:0000002 GO_REF:0000041 GO_REF:0000117 NCBI chr 5:62,548,136...62,577,346
Ensembl chr 5:62,548,221...62,608,964 		JBrowse link
G PGD phosphogluconate dehydrogenase involved_in ISO
IEA		 RGD
UniProt
InterPro		 PMID:2843500 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 RGD:1599574 NCBI chr 2:85,393,526...85,408,714
Ensembl chr 2:85,393,819...85,408,272 		JBrowse link
G PGLS 6-phosphogluconolactonase involved_in IEA Ensembl
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000107 NCBI chr20:45,293,970...45,301,074
Ensembl chr20:45,294,008...45,301,038 		JBrowse link
G PRPS1 phosphoribosyl pyrophosphate synthetase 1 involved_in ISO (PMID:24855946) MGI PMID:24855946 NCBI chr  X:81,150,537...81,171,521
Ensembl chr  X:81,150,536...81,212,689 		JBrowse link
G PRPS2 phosphoribosyl pyrophosphate synthetase 2 involved_in ISO (PMID:24855946) MGI PMID:24855946 NCBI chr  X:9,281,686...9,326,551
Ensembl chr  X:9,281,730...9,418,289 		JBrowse link
G RBKS ribokinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:21,793,882...21,944,839
Ensembl chr17:21,795,203...21,944,805 		JBrowse link
G RPE ribulose-5-phosphate-3-epimerase involved_in ISO
IEA		 RGD
InterPro		 PMID:2843500 GO_REF:0000002 RGD:1599574 NCBI chr37:17,866,729...17,882,702 JBrowse link
G RPIA ribose 5-phosphate isomerase A involved_in ISO
IEA		 RGD
UniProt
Ensembl		 PMID:2843500 GO_REF:0000041 GO_REF:0000107 RGD:1599574 NCBI chr17:37,640,740...37,671,308 JBrowse link
G TALDO1 transaldolase 1 involved_in ISO
IEA		 RGD
UniProt
InterPro		 PMID:2843500 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 RGD:1599574 NCBI chr18:25,764,138...25,772,043 JBrowse link
G TKT transketolase involved_in ISO
IEA		 RGD
Ensembl		 PMID:2843500 GO_REF:0000107 RGD:1599574 NCBI chr20:36,690,540...36,705,980
Ensembl chr20:36,681,531...36,742,199 		JBrowse link
pentose-phosphate shunt, non-oxidative branch term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RPE ribulose-5-phosphate-3-epimerase involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:3079759 GO_REF:0000118 RGD:1641816 NCBI chr37:17,866,729...17,882,702 JBrowse link
G RPIA ribose 5-phosphate isomerase A involved_in ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:3079759 GO_REF:0000002 GO_REF:0000118 RGD:1641816 NCBI chr17:37,640,740...37,671,308 JBrowse link
G SHPK sedoheptulokinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:47,445,969...47,486,756 JBrowse link
G TALDO1 transaldolase 1 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:3079759 PMID:8477719 GO_REF:0000118 RGD:1641803 RGD:1641816 NCBI chr18:25,764,138...25,772,043 JBrowse link
G TKT transketolase involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:3079759 PMID:16116031 GO_REF:0000118 RGD:1580394 RGD:1641816 NCBI chr20:36,690,540...36,705,980
Ensembl chr20:36,681,531...36,742,199 		JBrowse link
pentose-phosphate shunt, oxidative branch term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6PD glucose-6-phosphate dehydrogenase involved_in ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:9794092 GO_REF:0000107 GO_REF:0000118 RGD:1641793 NCBI chr  X:122,217,317...122,231,862
Ensembl chr  X:122,205,683...122,231,678 		JBrowse link
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:62,548,136...62,577,346
Ensembl chr 5:62,548,221...62,608,964 		JBrowse link
G PGD phosphogluconate dehydrogenase involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:9794092 GO_REF:0000118 RGD:1641793 NCBI chr 2:85,393,526...85,408,714
Ensembl chr 2:85,393,819...85,408,272 		JBrowse link
G PGLS 6-phosphogluconolactonase ISO RGD PMID:971315 RGD:2311501 NCBI chr20:45,293,970...45,301,074
Ensembl chr20:45,294,008...45,301,038 		JBrowse link
positive regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TIGAR TP53 induced glycolysis regulatory phosphatase involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:40,521,751...40,549,304
Ensembl chr27:40,523,314...40,549,332 		JBrowse link
regulation of NADP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HNF1A HNF1 homeobox A ISO RGD PMID:20841353 RGD:150540305 NCBI chr26:16,805,690...16,826,065
Ensembl chr26:16,805,690...16,824,790 		JBrowse link
G ME1 malic enzyme 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:43,623,413...43,793,590
Ensembl chr12:43,624,945...43,828,775 		JBrowse link
G ME2 malic enzyme 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:23,985,482...24,032,642
Ensembl chr 1:23,985,994...24,025,747 		JBrowse link
regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 ISO RGD PMID:16234247 RGD:1625062 NCBI chr 7:8,344,380...8,409,901
Ensembl chr 7:8,344,447...8,409,897 		JBrowse link
G PGAM1 phosphoglycerate mutase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:10,720,235...10,727,709
Ensembl chr28:10,720,094...10,930,286 		JBrowse link
G TIGAR TP53 induced glycolysis regulatory phosphatase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr27:40,521,751...40,549,304
Ensembl chr27:40,523,314...40,549,332 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17917
    metabolic process 10998
      organic substance metabolic process 10554
        organonitrogen compound metabolic process 5384
          purine-containing compound metabolic process 586
            purine nucleotide metabolic process 551
              NADP metabolic process 47
                NADP biosynthetic process 4
                NADP catabolic process 3
                NADPH oxidation 9
                NADPH regeneration + 21
                regulation of NADP metabolic process + 8
Path 2
Term Annotations click to browse term
  biological_process 17917
    metabolic process 10998
      organic substance metabolic process 10554
        organic cyclic compound metabolic process 5907
          nucleobase-containing compound metabolic process 5439
            nucleobase-containing small molecule metabolic process 682
              nucleoside phosphate metabolic process 615
                nucleotide metabolic process 608
                  pyridine nucleotide metabolic process 197
                    nicotinamide nucleotide metabolic process 197
                      NADP metabolic process 47
                        NADP biosynthetic process 4
                        NADP catabolic process 3
                        NADPH oxidation 9
                        NADPH regeneration + 21
                        regulation of NADP metabolic process + 8
paths to the root