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ONTOLOGY REPORT - ANNOTATIONS


Term:NADP metabolic process
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Accession:GO:0006739 term browser browse the term
Definition:The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH.
Synonyms:exact_synonym: NADP metabolism;   NADPH metabolic process;   NADPH metabolism;   nicotinamide adenine dinucleotide phosphate metabolic process;   nicotinamide adenine dinucleotide phosphate metabolism;   oxidized NADP metabolic process;   oxidized NADP metabolism;   oxidized nicotinamide adenine dinucleotide phosphate metabolic process;   oxidized nicotinamide adenine dinucleotide phosphate metabolism;   reduced NADP metabolic process;   reduced NADP metabolism;   reduced nicotinamide adenine dinucleotide phosphate metabolic process;   reduced nicotinamide adenine dinucleotide phosphate metabolism
 related_synonym: NAD phosphorylation and dephosphorylation



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NADP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYB5R4 cytochrome b5 reductase 4 ISO NADPH oxidation RGD PMID:11913972 RGD:632262 NCBI chr12:44,170,571...44,247,494
Ensembl chr12:44,141,582...44,247,493
JBrowse link
G DCXR dicarbonyl and L-xylulose reductase acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2179664|PMID:11882650) MGI
Ensembl
PMID:11882650 GO_REF:0000107 MGI:2179664 NCBI chr 9:289,864...291,518
Ensembl chr 9:289,889...291,480
JBrowse link
G FMO2 flavin containing dimethylaniline monoxygenase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:27,634,624...27,659,111
Ensembl chr 7:27,634,900...27,659,037
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase involved_in ISO (PMID:15858258) UniProt PMID:15858258 NCBI chr  X:122,217,317...122,231,862
Ensembl chr  X:122,205,683...122,231,678
JBrowse link
G GCK glucokinase acts_upstream_of_or_within ISO (MGI:3691164|PMID:9873043) MGI PMID:9873043 MGI:3691164
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase ISO RGD PMID:6813321 RGD:1641956 NCBI chr 5:62,548,136...62,577,346
Ensembl chr 5:62,548,221...62,608,964
JBrowse link
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr37:16,512,027...16,531,269
Ensembl chr37:16,512,770...16,531,219
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:53,070,462...53,077,566
Ensembl chr 3:53,070,695...53,087,496
JBrowse link
G MDH1 malate dehydrogenase 1 involved_in ISO (PMID:34547241) ComplexPortal PMID:34547241 NCBI chr10:63,316,818...63,334,556
Ensembl chr10:63,316,831...63,361,735
JBrowse link
G ME1 malic enzyme 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:43,623,413...43,793,590
Ensembl chr12:43,624,945...43,828,775
JBrowse link
G NOCT nocturnin involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:3,587,769...3,612,184
Ensembl chr19:3,588,695...3,609,307
JBrowse link
G PC pyruvate carboxylase involved_in ISO (PMID:34547241) ComplexPortal PMID:34547241 NCBI chr18:50,406,994...50,507,677
Ensembl chr18:50,412,272...50,507,669
JBrowse link
G PGD phosphogluconate dehydrogenase ISO RGD PMID:6813321 RGD:1641956 NCBI chr 2:85,393,526...85,408,714
Ensembl chr 2:85,393,819...85,408,272
JBrowse link
G TP53I3 tumor protein p53 inducible protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:18,560,123...18,566,588
Ensembl chr17:18,560,240...18,565,958
JBrowse link
NADP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6PD glucose-6-phosphate dehydrogenase acts_upstream_of_or_within ISO (MGI:1349468|PMID:3377761), (MGI:2387959|PMID:10627286), (MGI:3607389|PMID:14757696), (MGI:3694178|PMID:15998684), (MGI:49164|PMID:1953691), (MGI:85983|PMID:9067418)
(MGI:1097071|PMID:9330624), (MGI:1202104|PMID:9539108), (MGI:1261671|PMID:9627357), (MGI:54902|PMID:7439685), (MGI:87492|PMID:9169132)
(MGI:3522057|PMID:15271799)
MGI PMID:1953691 PMID:3377761 PMID:7439685 PMID:9067418 PMID:9169132 More... MGI:1097071 MGI:1202104 MGI:1261671 MGI:1349468 MGI:2387959 MGI:3522057 MGI:3607389 MGI:3694178 MGI:49164 MGI:54902 MGI:85983 MGI:87492 NCBI chr  X:122,217,317...122,231,862
Ensembl chr  X:122,205,683...122,231,678
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 ISO RGD PMID:21641335 RGD:11522736 NCBI chr 3:53,070,462...53,077,566
Ensembl chr 3:53,070,695...53,087,496
JBrowse link
G NADK NAD kinase involved_in ISO
IEA
IBA
(PMID:21873635) RGD
InterPro
GO_Central
PMID:21873635 PMID:22550069 GO_REF:0000002 RGD:13703105 NCBI chr 5:56,743,920...56,774,578
Ensembl chr 5:56,745,869...56,774,529
JBrowse link
G NADK2 NAD kinase 2, mitochondrial involved_in IEA UniProt
InterPro
UniProt
InterPro
GO_REF:0000002 GO_REF:0000104 NCBI chr 4:72,297,480...72,341,176
Ensembl chr 4:72,297,114...72,339,460
JBrowse link
NADP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NUDT12 nudix hydrolase 12 involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
(PMID:21873635)
(PMID:12790796)
GO_Central
Ensembl
MGI
PMID:12790796 PMID:21873635 GO_REF:0000107 NCBI chr 3:7,693,903...7,708,930
Ensembl chr 3:7,696,505...7,724,769
JBrowse link
G NUDT13 nudix hydrolase 13 involved_in ISO (MGI:6368098|PMID:28755312) UniProt PMID:28755312 MGI:6368098 NCBI chr 4:23,695,183...23,712,301
Ensembl chr 4:23,695,266...23,711,937
JBrowse link
G NUDT17 nudix hydrolase 17 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:58,648,234...58,653,222
Ensembl chr17:58,648,272...58,650,757
JBrowse link
NADPH oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FDX1 ferredoxin 1 ISO RGD PMID:10525147 RGD:727285 NCBI chr 5:22,452,011...22,485,581
Ensembl chr 5:22,451,209...22,485,395
JBrowse link
G FDXR ferredoxin reductase ISO RGD PMID:10525147 RGD:727285 NCBI chr 9:5,567,411...5,577,427
Ensembl chr 9:5,567,328...5,577,277
JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 7:27,599,230...27,623,081
Ensembl chr 7:27,599,267...27,618,237
JBrowse link
G FMO2 flavin containing dimethylaniline monoxygenase 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 7:27,634,624...27,659,111
Ensembl chr 7:27,634,900...27,659,037
JBrowse link
G FMO5 flavin containing dimethylaniline monoxygenase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:57,665,879...57,698,540
Ensembl chr17:57,666,762...57,697,982
JBrowse link
G KCNAB2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 involved_in ISO PMID:18672894 UniProt PMID:18672894 RGD:10047329 NCBI chr 5:59,936,432...60,021,945
Ensembl chr 5:59,936,528...60,021,957
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 ISO RGD PMID:29444417 RGD:25823192 NCBI chr 5:79,979,593...79,990,875
Ensembl chr 5:79,978,865...79,989,860
JBrowse link
G PRDX5 peroxiredoxin 5 involved_in ISO (PMID:10751410) UniProt PMID:10751410 NCBI chr18:52,750,977...52,754,432 JBrowse link
G TXNRD1 thioredoxin reductase 1 ISO RGD PMID:19054767 RGD:5133716 NCBI chr10:33,904,065...34,021,549
Ensembl chr10:33,886,343...34,021,696
JBrowse link
NADPH regeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 involved_in ISO (PMID:19933275)
PMID:1848231
UniProt PMID:1848231 PMID:19933275 RGD:632027 NCBI chr20:52,722...99,180
Ensembl chr20:61,349...99,160
JBrowse link
G ALDH1L2 aldehyde dehydrogenase 1 family member L2 involved_in ISO (PMID:21238436)
(MGI:6489626|PMID:33168096)
UniProt PMID:21238436 PMID:33168096 MGI:6489626 NCBI chr10:33,310,523...33,365,677
Ensembl chr10:33,310,558...33,365,228
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase involved_in ISO (PMID:17516514) BHF-UCL PMID:17516514 NCBI chr  X:122,217,317...122,231,862
Ensembl chr  X:122,205,683...122,231,678
JBrowse link
G NNT nicotinamide nucleotide transhydrogenase involved_in ISO
IBA
(PMID:21873635) RGD
GO_Central
PMID:21873635 PMID:22198343 RGD:13513982 NCBI chr 4:66,348,222...66,437,889
Ensembl chr 4:66,349,318...66,442,841
JBrowse link
negative regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TP53 tumor protein p53 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109
JBrowse link
pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6PD glucose-6-phosphate dehydrogenase involved_in ISO
IEA
RGD
UniProt
UniProt
PMID:2843500 GO_REF:0000041 GO_REF:0000117 RGD:1599574 NCBI chr  X:122,217,317...122,231,862
Ensembl chr  X:122,205,683...122,231,678
JBrowse link
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2668276|PMID:12831846) UniProt
UniProt
InterPro
MGI
PMID:12831846 GO_REF:0000002 GO_REF:0000041 GO_REF:0000117 MGI:2668276 NCBI chr 5:62,548,136...62,577,346
Ensembl chr 5:62,548,221...62,608,964
JBrowse link
G PGD phosphogluconate dehydrogenase involved_in ISO
IEA
RGD
UniProt
InterPro
PMID:2843500 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 RGD:1599574 NCBI chr 2:85,393,526...85,408,714
Ensembl chr 2:85,393,819...85,408,272
JBrowse link
G PGLS 6-phosphogluconolactonase involved_in IEA Ensembl
UniProt
InterPro
GO_REF:0000002 GO_REF:0000041 GO_REF:0000107 NCBI chr20:45,293,970...45,301,074
Ensembl chr20:45,294,008...45,301,038
JBrowse link
G PRPS1 phosphoribosyl pyrophosphate synthetase 1 involved_in ISO (MGI:5602900|PMID:24855946) MGI PMID:24855946 MGI:5602900 NCBI chr  X:81,150,537...81,171,521
Ensembl chr  X:81,150,536...81,212,689
JBrowse link
G PRPS2 phosphoribosyl pyrophosphate synthetase 2 involved_in ISO (MGI:5602900|PMID:24855946) MGI PMID:24855946 MGI:5602900 NCBI chr  X:9,281,686...9,326,551
Ensembl chr  X:9,281,730...9,418,289
JBrowse link
G RBKS ribokinase involved_in ISO (MGI:7261130|PMID:13405914) MGI PMID:13405914 MGI:7261130 NCBI chr17:21,793,882...21,944,839
Ensembl chr17:21,795,203...21,944,805
JBrowse link
G RPE ribulose-5-phosphate-3-epimerase involved_in ISO
IEA
RGD
InterPro
InterPro
PMID:2843500 GO_REF:0000002 RGD:1599574 NCBI chr37:17,866,729...17,882,702 JBrowse link
G RPIA ribose 5-phosphate isomerase A involved_in ISO
IEA
RGD
UniProt
Ensembl
PMID:2843500 GO_REF:0000041 GO_REF:0000107 RGD:1599574 NCBI chr17:37,640,740...37,671,308 JBrowse link
G TALDO1 transaldolase 1 involved_in ISO
IEA
RGD
UniProt
Ensembl
InterPro
UniProt
PMID:2843500 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107 RGD:1599574 NCBI chr18:25,764,138...25,772,043 JBrowse link
G TKT transketolase involved_in ISO (MGI:7257768|PMID:5360673), (MGI:7261130|PMID:13405914)
(PMID:20667822)
RGD
MGI
UniProt
PMID:2843500 PMID:5360673 PMID:13405914 PMID:20667822 MGI:7257768 MGI:7261130 RGD:1599574 NCBI chr20:36,690,540...36,705,980
Ensembl chr20:36,681,531...36,742,199
JBrowse link
pentose-phosphate shunt, non-oxidative branch term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RPE ribulose-5-phosphate-3-epimerase involved_in IBA
ISO
(PMID:21873635) GO_Central
RGD
PMID:3079759 PMID:21873635 RGD:1641816 NCBI chr37:17,866,729...17,882,702 JBrowse link
G RPIA ribose 5-phosphate isomerase A involved_in IBA
IEA
ISO
(PMID:21873635) GO_Central
InterPro
InterPro
RGD
PMID:3079759 PMID:21873635 GO_REF:0000002 RGD:1641816 NCBI chr17:37,640,740...37,671,308 JBrowse link
G SHPK sedoheptulokinase involved_in ISO (MGI:5428058|PMID:22682222) UniProt PMID:22682222 MGI:5428058 NCBI chr 9:47,445,969...47,486,756 JBrowse link
G TALDO1 transaldolase 1 involved_in IBA
ISO
(PMID:21873635) GO_Central
GO_Central
RGD
PMID:3079759 PMID:8477719 PMID:21873635 RGD:1641803 RGD:1641816 NCBI chr18:25,764,138...25,772,043 JBrowse link
G TKT transketolase involved_in ISO
IBA
(PMID:21873635) RGD
GO_Central
PMID:3079759 PMID:16116031 PMID:21873635 RGD:1580394 RGD:1641816 NCBI chr20:36,690,540...36,705,980
Ensembl chr20:36,681,531...36,742,199
JBrowse link
pentose-phosphate shunt, oxidative branch term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6PD glucose-6-phosphate dehydrogenase involved_in ISO
IEA
RGD
Ensembl
PMID:9794092 GO_REF:0000107 RGD:1641793 NCBI chr  X:122,217,317...122,231,862
Ensembl chr  X:122,205,683...122,231,678
JBrowse link
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 5:62,548,136...62,577,346
Ensembl chr 5:62,548,221...62,608,964
JBrowse link
G PGD phosphogluconate dehydrogenase involved_in IBA
ISO
(PMID:21873635) GO_Central
RGD
PMID:9794092 PMID:21873635 RGD:1641793 NCBI chr 2:85,393,526...85,408,714
Ensembl chr 2:85,393,819...85,408,272
JBrowse link
G PGLS 6-phosphogluconolactonase involved_in IBA
ISO
(PMID:21873635) GO_Central
RGD
PMID:971315 PMID:21873635 RGD:2311501 NCBI chr20:45,293,970...45,301,074
Ensembl chr20:45,294,008...45,301,038
JBrowse link
regulation of NADP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HNF1A HNF1 homeobox A ISO RGD PMID:20841353 RGD:150540305 NCBI chr26:16,805,690...16,826,065
Ensembl chr26:16,805,690...16,824,790
JBrowse link
G ME1 malic enzyme 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:43,623,413...43,793,590
Ensembl chr12:43,624,945...43,828,775
JBrowse link
G ME2 malic enzyme 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 1:23,985,482...24,032,642
Ensembl chr 1:23,985,994...24,025,747
JBrowse link
regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 ISO RGD PMID:16234247 RGD:1625062 NCBI chr 7:8,344,380...8,409,901
Ensembl chr 7:8,344,447...8,409,897
JBrowse link
G PGAM1 phosphoglycerate mutase 1 involved_in ISO (PMID:12189148) UniProt PMID:12189148 NCBI chr28:10,720,235...10,727,709
Ensembl chr28:10,720,094...10,930,286
JBrowse link
G TIGAR TP53 induced glycolysis regulatory phosphatase involved_in IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr27:40,521,751...40,549,304
Ensembl chr27:40,523,314...40,549,332
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17341
    metabolic process 11294
      cellular metabolic process 9483
        cellular aromatic compound metabolic process 5578
          purine-containing compound metabolic process 538
            purine nucleotide metabolic process 502
              NADP metabolic process 45
                NADP biosynthetic process 4
                NADP catabolic process 3
                NADPH oxidation 9
                NADPH regeneration + 19
                regulation of NADP metabolic process + 7
Path 2
Term Annotations click to browse term
  biological_process 17341
    metabolic process 11294
      organic substance metabolic process 10869
        organic cyclic compound metabolic process 5775
          nucleobase-containing compound metabolic process 5362
            nucleobase-containing small molecule metabolic process 635
              nucleoside phosphate metabolic process 567
                nucleotide metabolic process 561
                  pyridine nucleotide metabolic process 77
                    nicotinamide nucleotide metabolic process 77
                      NADP metabolic process 45
                        NADP biosynthetic process 4
                        NADP catabolic process 3
                        NADPH oxidation 9
                        NADPH regeneration + 19
                        regulation of NADP metabolic process + 7
paths to the root