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ONTOLOGY REPORT - ANNOTATIONS


Term:NADP metabolic process
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Accession:GO:0006739 term browser browse the term
Definition:The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH.
Synonyms:exact_synonym: NADP metabolism;   NADPH metabolic process;   NADPH metabolism;   nicotinamide adenine dinucleotide phosphate metabolic process;   nicotinamide adenine dinucleotide phosphate metabolism;   oxidized NADP metabolic process;   oxidized NADP metabolism;   oxidized nicotinamide adenine dinucleotide phosphate metabolic process;   oxidized nicotinamide adenine dinucleotide phosphate metabolism;   reduced NADP metabolic process;   reduced NADP metabolism;   reduced nicotinamide adenine dinucleotide phosphate metabolic process;   reduced nicotinamide adenine dinucleotide phosphate metabolism
 related_synonym: NAD phosphorylation and dephosphorylation



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NADP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cryzl2 crystallin zeta like 2 involved_in ISO (PMID:19349281) RGD PMID:19349281 NCBI chr13:69,612,605...69,655,018
Ensembl chr13:69,620,792...69,652,475
JBrowse link
G Cyb5r4 cytochrome b5 reductase 4 IDA NADPH oxidation RGD PMID:11913972 RGD:632262 NCBI chr 8:87,975,596...88,048,356
Ensembl chr 8:87,981,116...88,045,832
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase acts_upstream_of_or_within ISO (MGI:2179664|PMID:11882650) RGD PMID:11882650 MGI:2179664 NCBI chr10:106,006,404...106,008,294 JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 involved_in ISO (PMID:11744609) RGD PMID:11744609 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase involved_in ISO
ISS
(PMID:15858258)
GO_REF:0000024
RGD
UniProt
PMID:15858258 GO_REF:0000024 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gck glucokinase acts_upstream_of_or_within ISO (MGI:3691164|PMID:9873043) RGD PMID:9873043 MGI:3691164 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) IDA RGD PMID:6813321 RGD:1641956 NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171
JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Mdh1 malate dehydrogenase 1 involved_in ISO (PMID:34547241) RGD PMID:34547241 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
JBrowse link
G Me1 malic enzyme 1 involved_in ISO
IEA
(PMID:34547241)
GO_REF:0000107
RGD
Ensembl
PMID:34547241 GO_REF:0000107 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Noct nocturnin involved_in ISS
ISO
GO_REF:0000024
(PMID:31147539)
UniProt
RGD
PMID:31147539 GO_REF:0000024 NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
JBrowse link
G Pc pyruvate carboxylase involved_in ISO
IEA
(PMID:34547241)
GO_REF:0000107
RGD
Ensembl
PMID:34547241 GO_REF:0000107 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
JBrowse link
G Pgd phosphogluconate dehydrogenase IDA RGD PMID:6813321 RGD:1641956 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 involved_in ISO (PMID:19349281) RGD PMID:19349281 NCBI chr 6:27,818,327...27,827,030 JBrowse link
NADP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pd glucose-6-phosphate dehydrogenase acts_upstream_of_or_within ISO MGI:2182739 (MGI:1097071|PMID:9330624), (MGI:1202104|PMID:9539108), (MGI:1261671|PMID:9627357), (MGI:1349468|PMID:3377761), (MGI:2387959|PMID:10627286), (MGI:3522057|PMID:15271799), (MGI:3607389|PMID:14757696), (MGI:3694178|PMID:15998684), (MGI:49164|PMID:1953691), (MGI:54902|PMID:7439685), (MGI:85983|PMID:9067418), (MGI:87492|PMID:9169132) RGD PMID:1953691 PMID:3377761 PMID:7439685 PMID:9067418 PMID:9169132 More... MGI:1097071 MGI:1202104 MGI:1261671 MGI:1349468 MGI:2387959 MGI:3522057 MGI:3607389 MGI:3694178 MGI:49164 MGI:54902 MGI:85983 MGI:87492 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 IMP RGD PMID:21641335 RGD:11522736 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Nadk NAD kinase involved_in IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:22550069 PMID:21873635 RGD:13703105, RGD:13792537 NCBI chr 5:166,145,708...166,176,328
Ensembl chr 5:166,145,481...166,176,322
JBrowse link
G Nadk2 NAD kinase 2, mitochondrial involved_in IEA GO_REF:0000104
GO_REF:0000002
UniProt
InterPro
GO_REF:0000002 GO_REF:0000104 NCBI chr 2:58,117,674...58,159,815
Ensembl chr 2:58,117,674...58,159,808
JBrowse link
NADP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nudt12 nudix hydrolase 12 involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:12790796)
PMID:21873635
RGD PMID:12790796 PMID:21873635 RGD:13792537 NCBI chr 9:98,741,627...98,755,039
Ensembl chr 9:98,742,360...98,755,039
JBrowse link
G Nudt13 nudix hydrolase 13 involved_in ISO (MGI:6368098|PMID:28755312) RGD PMID:28755312 MGI:6368098 NCBI chr15:4,001,787...4,022,404
Ensembl chr15:4,001,794...4,022,293
JBrowse link
G Nudt17 nudix hydrolase 17 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:184,241,468...184,243,960
Ensembl chr 2:184,241,468...184,243,960
JBrowse link
NADPH oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fdx1 ferredoxin 1 IDA RGD PMID:10525147 RGD:727285 NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414
JBrowse link
G Fdxr ferredoxin reductase IDA RGD PMID:10525147 RGD:727285 NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 involved_in ISO (PMID:15144220) RGD PMID:15144220 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:15144220), (PMID:9804831)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:9804831 PMID:15144220 GO_REF:0000024 GO_REF:0000107 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 involved_in ISS
ISO
GO_REF:0000024
(PMID:26771671)
UniProt
RGD
PMID:26771671 GO_REF:0000024 NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693
JBrowse link
G Kcnab2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 involved_in IDA PMID:18672894 UniProt PMID:18672894 RGD:10047329 NCBI chr 5:162,899,511...162,988,057
Ensembl chr 5:162,901,896...162,988,243
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 IDA RGD PMID:29444417 RGD:25823192 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Prdx5 peroxiredoxin 5 involved_in ISO (PMID:10751410) RGD PMID:10751410 NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268
JBrowse link
G Txnrd1 thioredoxin reductase 1 IDA RGD PMID:19054767 RGD:5133716 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
NADPH regeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 involved_in ISO
IDA
(PMID:19933275)
PMID:1848231
RGD PMID:19933275 PMID:1848231 RGD:632027 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465
JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 involved_in ISO (PMID:21238436)
(MGI:6489626|PMID:33168096)
RGD PMID:21238436 PMID:33168096 MGI:6489626 NCBI chr 7:20,254,196...20,305,793
Ensembl chr 7:20,254,233...20,305,776
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase involved_in ISO (PMID:17516514) RGD PMID:17516514 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase involved_in IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:22198343 PMID:21873635 RGD:13513982, RGD:13792537 NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823
JBrowse link
negative regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 involved_in ISO (PMID:21336310) RGD PMID:21336310 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pd glucose-6-phosphate dehydrogenase involved_in IDA
ISO
(PMID:2297768) RGD PMID:2297768 PMID:2843500 RGD:1599574 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) acts_upstream_of_or_within ISO (MGI:2668276|PMID:12831846) RGD PMID:12831846 MGI:2668276 NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171
JBrowse link
G Kif1b kinesin family member 1B involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:159,607,697...159,742,778
Ensembl chr 5:159,561,271...159,742,778
JBrowse link
G Pgd phosphogluconate dehydrogenase involved_in IDA
IEA
ISS
GO_REF:0000041
GO_REF:0000024
UniProt
RGD
PMID:2843500 GO_REF:0000024 GO_REF:0000041, RGD:1599574 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
JBrowse link
G Pgls 6-phosphogluconolactonase involved_in ISO
IEA
(PMID:10518023)
GO_REF:0000041
RGD
UniProt
PMID:10518023 GO_REF:0000041 NCBI chr16:18,300,317...18,305,803
Ensembl chr16:18,300,317...18,305,803
JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 involved_in ISO (MGI:5602900|PMID:24855946) RGD PMID:24855946 MGI:5602900 NCBI chr  X:104,132,139...104,154,191
Ensembl chr  X:104,132,141...104,154,187
JBrowse link
G Prps2 phosphoribosyl pyrophosphate synthetase 2 involved_in ISO (MGI:5602900|PMID:24855946) RGD PMID:24855946 MGI:5602900 NCBI chr  X:26,975,915...27,013,184
Ensembl chr  X:26,976,061...27,013,181
JBrowse link
G Rbks ribokinase involved_in ISO (MGI:7261130|PMID:13405914) RGD PMID:13405914 MGI:7261130 NCBI chr 6:24,747,651...24,824,290
Ensembl chr 6:24,747,293...24,824,290
JBrowse link
G Rpe ribulose-5-phosphate-3-epimerase involved_in IDA
ISO
(MGI:7257768|PMID:5360673)
(PMID:20923965)
RGD PMID:5360673 PMID:20923965 PMID:2843500 MGI:7257768, RGD:1599574 NCBI chr 9:68,191,027...68,211,295
Ensembl chr 9:68,191,292...68,211,591
JBrowse link
G Rpia ribose 5-phosphate isomerase A involved_in IDA
ISO
(MGI:7257768|PMID:5360673) RGD PMID:5360673 PMID:2843500 MGI:7257768, RGD:1599574 NCBI chr 4:102,723,712...102,749,374
Ensembl chr 4:102,723,712...102,749,355
JBrowse link
G Taldo1 transaldolase 1 involved_in IDA
IEA
ISO
GO_REF:0000041
(MGI:3851036|PMID:19436114), (MGI:7257768|PMID:5360673), (MGI:7261130|PMID:13405914)
(MGI:7257768|PMID:5360673), (MGI:7261130|PMID:13405914)
UniProt
RGD
PMID:5360673 PMID:13405914 PMID:19436114 PMID:2843500 GO_REF:0000041 MGI:3851036 MGI:7257768 MGI:7261130, RGD:1599574 NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974
JBrowse link
G Tkt transketolase involved_in IDA
IEA
ISO
GO_REF:0000107
(MGI:7257768|PMID:5360673), (MGI:7261130|PMID:13405914)
(PMID:20667822)
Ensembl
RGD
PMID:5360673 PMID:13405914 PMID:20667822 PMID:2843500 GO_REF:0000107 MGI:7257768 MGI:7261130, RGD:1599574 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
JBrowse link
pentose-phosphate shunt, non-oxidative branch term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpe ribulose-5-phosphate-3-epimerase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:3079759 PMID:21873635 RGD:1641816, RGD:13792537 NCBI chr 9:68,191,027...68,211,295
Ensembl chr 9:68,191,292...68,211,591
JBrowse link
G Rpia ribose 5-phosphate isomerase A involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:3079759 PMID:21873635 RGD:1641816, RGD:13792537 NCBI chr 4:102,723,712...102,749,374
Ensembl chr 4:102,723,712...102,749,355
JBrowse link
G Shpk sedoheptulokinase involved_in ISO (MGI:5428058|PMID:22682222) RGD PMID:22682222 MGI:5428058 NCBI chr10:57,817,551...57,841,981
Ensembl chr10:57,817,629...57,841,980
JBrowse link
G Taldo1 transaldolase 1 involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:8477719 PMID:21873635 PMID:3079759 RGD:1641803, RGD:13792537, RGD:1641816 NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974
JBrowse link
G Tkt transketolase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:16116031 PMID:21873635 PMID:3079759 RGD:1580394, RGD:13792537, RGD:1641816 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
JBrowse link
pentose-phosphate shunt, oxidative branch term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pd glucose-6-phosphate dehydrogenase involved_in IMP
IBA
ISO
PMID:21873635
MGI:2182739 (MGI:5446538|PMID:22829586), (MGI:7257767|PMID:12466018)
(PMID:2420826)
RGD PMID:2420826 PMID:12466018 PMID:22829586 PMID:9794092 PMID:21873635 MGI:5446538 MGI:7257767, RGD:1641793, RGD:13792537 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) involved_in ISO
IBA
(PMID:18628520), (PMID:23132696)
PMID:21873635
RGD PMID:18628520 PMID:23132696 PMID:21873635 RGD:13792537 NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171
JBrowse link
G Pgd phosphogluconate dehydrogenase involved_in IMP
IBA
ISO
PMID:21873635
(MGI:7257767|PMID:12466018), (MGI:7257768|PMID:5360673), (MGI:7257880|PMID:7496990)
(PMID:3858849)
RGD PMID:3858849 PMID:5360673 PMID:7496990 PMID:12466018 PMID:9794092 More... MGI:7257767 MGI:7257768 MGI:7257880, RGD:1641793, RGD:13792537 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
JBrowse link
G Pgls 6-phosphogluconolactonase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:971315 PMID:21873635 RGD:2311501, RGD:13792537 NCBI chr16:18,300,317...18,305,803
Ensembl chr16:18,300,317...18,305,803
JBrowse link
regulation of NADP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnf1a HNF1 homeobox A IMP RGD PMID:20841353 RGD:150540305 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
JBrowse link
G Me1 malic enzyme 1 involved_in ISO
IEA
(PMID:23334421)
GO_REF:0000107
RGD
Ensembl
PMID:23334421 GO_REF:0000107 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Me2 malic enzyme 2 involved_in ISO (PMID:23334421) RGD PMID:23334421 NCBI chr18:67,350,833...67,400,987
Ensembl chr18:67,355,795...67,400,987
JBrowse link
regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 IDA RGD PMID:16234247 RGD:1625062 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Pgam1 phosphoglycerate mutase 1 involved_in ISO (PMID:12189148) RGD PMID:12189148 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452
JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase involved_in ISO
IBA
(PMID:25928429)
PMID:21873635
RGD PMID:25928429 PMID:21873635 RGD:13792537 NCBI chr 4:159,927,138...159,946,094
Ensembl chr 4:159,927,139...159,946,029
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19876
    metabolic process 12192
      cellular metabolic process 10295
        cellular aromatic compound metabolic process 5990
          purine-containing compound metabolic process 590
            purine nucleotide metabolic process 554
              NADP metabolic process 47
                NADP biosynthetic process 4
                NADP catabolic process 3
                NADPH oxidation 9
                NADPH regeneration + 20
                regulation of NADP metabolic process + 7
Path 2
Term Annotations click to browse term
  biological_process 19876
    metabolic process 12192
      organic substance metabolic process 11723
        organic cyclic compound metabolic process 6236
          nucleobase-containing compound metabolic process 5756
            nucleobase-containing small molecule metabolic process 691
              nucleoside phosphate metabolic process 617
                nucleotide metabolic process 607
                  pyridine nucleotide metabolic process 80
                    nicotinamide nucleotide metabolic process 80
                      NADP metabolic process 47
                        NADP biosynthetic process 4
                        NADP catabolic process 3
                        NADPH oxidation 9
                        NADPH regeneration + 20
                        regulation of NADP metabolic process + 7
paths to the root