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ONTOLOGY REPORT - ANNOTATIONS

Term:NADH metabolic process
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Accession:GO:0006734 term browser browse the term
Definition:The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
Synonyms:exact_synonym: NADH metabolism;   reduced NAD metabolic process;   reduced NAD metabolism;   reduced nicotinamide adenine dinucleotide metabolic process;   reduced nicotinamide adenine dinucleotide metabolism


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NADH metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DLST dihydrolipoamide S-succinyltransferase ISO RGD PMID:9405249 RGD:1359804 NCBI chr14:74,881,916...74,903,743
Ensembl chr14:74,881,891...74,903,743 		JBrowse link
G GPD1 glycerol-3-phosphate dehydrogenase 1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:12351438 GO_REF:0000107 RGD:2303499 NCBI chr12:50,104,008...50,111,313
Ensembl chr12:50,103,982...50,111,313 		JBrowse link
G GPD1L glycerol-3-phosphate dehydrogenase 1 like acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:4943631|PMID:19745168) MGI
Ensembl		 PMID:19745168 GO_REF:0000107 MGI:4943631 NCBI chr 3:32,106,620...32,168,709
Ensembl chr 3:32,105,689...32,168,709 		JBrowse link
G GPD2 glycerol-3-phosphate dehydrogenase 2 ISO RGD PMID:12351438 RGD:2303499 NCBI chr 2:156,400,281...156,586,403
Ensembl chr 2:156,435,290...156,613,735 		JBrowse link
G IDH3A isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha ISO RGD PMID:938457 RGD:2306828 NCBI chr15:78,149,362...78,171,945
Ensembl chr15:78,131,498...78,171,945 		JBrowse link
G IDH3B isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta involved_in IEA
ISO		 Ensembl
Ensembl
RGD		 PMID:938457 GO_REF:0000107 RGD:2306828 NCBI chr20:2,658,395...2,664,216
Ensembl chr20:2,658,395...2,664,219 		JBrowse link
G IDH3G isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma ISO RGD PMID:938457 RGD:2306828 NCBI chr  X:153,785,768...153,794,375
Ensembl chr  X:153,785,766...153,794,512 		JBrowse link
G MDH1 malate dehydrogenase 1 involved_in ISO
IDA
IBA		 (PMID:34547241)
(PMID:21873635)		 RGD
ComplexPortal
GO_Central
GO_Central		 PMID:12351438 PMID:21873635 PMID:34547241 RGD:2303499 NCBI chr 2:63,588,963...63,607,197
Ensembl chr 2:63,588,609...63,607,197 		JBrowse link
G MDH1B malate dehydrogenase 1B involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 2:206,737,763...206,765,328
Ensembl chr 2:206,737,763...206,765,328 		JBrowse link
G MDH2 malate dehydrogenase 2 involved_in IEA
ISO		 Ensembl
Ensembl
RGD		 PMID:12351438 GO_REF:0000107 RGD:2303499 NCBI chr 7:76,048,106...76,067,508
Ensembl chr 7:76,048,051...76,067,508 		JBrowse link
G ME1 malic enzyme 1 involved_in IDA (PMID:34547241) ComplexPortal PMID:34547241 NCBI chr 6:83,210,402...83,431,051
Ensembl chr 6:83,210,402...83,431,051 		JBrowse link
G NUDT12 nudix hydrolase 12 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 5:103,548,855...103,562,789
Ensembl chr 5:103,548,855...103,562,790 		JBrowse link
G NUDT13 nudix hydrolase 13 involved_in ISS
IEA		 UniProt
Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr10:73,110,455...73,131,823
Ensembl chr10:73,110,375...73,131,828 		JBrowse link
G NUDT17 nudix hydrolase 17 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 1:145,845,630...145,848,954
Ensembl chr 1:145,845,630...145,848,954 		JBrowse link
G OGDH oxoglutarate dehydrogenase involved_in IEA
ISO		 Ensembl
Ensembl
RGD		 PMID:9712727 GO_REF:0000107 RGD:2306877 NCBI chr 7:44,606,627...44,709,066
Ensembl chr 7:44,606,572...44,709,066 		JBrowse link
G PC pyruvate carboxylase involved_in IDA (PMID:34547241) ComplexPortal PMID:34547241 NCBI chr11:66,848,420...66,958,383
Ensembl chr11:66,848,417...66,958,386 		JBrowse link
G VCP valosin containing protein involved_in IMP (PMID:23498975) ParkinsonsUK-UCL
ParkinsonsUK-UCL		 PMID:23498975 NCBI chr 9:35,056,064...35,072,625
Ensembl chr 9:35,053,928...35,072,668 		JBrowse link
canonical glycolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDOA aldolase, fructose-bisphosphate A involved_in ISO (MGI:5819300|PMID:28049690) MGI PMID:28049690 MGI:5819300 NCBI chr16:30,053,151...30,070,414
Ensembl chr16:30,053,090...30,070,420
Ensembl chr16:30,053,090...30,070,420
Ensembl chr16:30,053,090...30,070,420 		JBrowse link
G ENO1 enolase 1 involved_in IMP
IDA		 (PMID:3529090)
(PMID:29775581)		 CAFA
CAFA
UniProt
UniProt		 PMID:3529090 PMID:29775581 NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190 		JBrowse link
G ENO2 enolase 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr12:6,914,580...6,923,697
Ensembl chr12:6,913,745...6,923,698 		JBrowse link
G ENO3 enolase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:4,948,710...4,957,129
Ensembl chr17:4,948,092...4,957,131 		JBrowse link
G FOXK1 forkhead box K1 acts_upstream_of IDA (PMID:30700909) UniProt
UniProt		 PMID:30700909 NCBI chr 7:4,682,295...4,771,442
Ensembl chr 7:4,682,295...4,771,442 		JBrowse link
G FOXK2 forkhead box K2 acts_upstream_of
involved_in		 ISS
IEA		 UniProt
Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:82,519,732...82,604,602
Ensembl chr17:82,519,713...82,644,662 		JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase involved_in ISO (MGI:2651735|PMID:12581789)
(MGI:6106926|PMID:28918937), (MGI:6861792|PMID:10777777)		 MGI PMID:10777777 PMID:12581789 PMID:28918937 MGI:2651735 MGI:6106926 MGI:6861792 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374 		JBrowse link
G GCK glucokinase involved_in TAS Reactome
Reactome		 Reactome:R-HSA-70171 NCBI chr 7:44,143,213...44,189,439
Ensembl chr 7:44,143,213...44,198,170 		JBrowse link
G HK1 hexokinase 1 involved_in TAS
IEA		 Reactome
Ensembl
Reactome		 GO_REF:0000107 Reactome:R-HSA-70171 NCBI chr10:69,270,000...69,401,882
Ensembl chr10:69,269,984...69,401,884 		JBrowse link
G HK2 hexokinase 2 involved_in TAS Reactome
Reactome		 Reactome:R-HSA-70171 NCBI chr 2:74,834,127...74,893,359
Ensembl chr 2:74,834,127...74,893,359 		JBrowse link
G HK3 hexokinase 3 involved_in TAS Reactome
Reactome		 Reactome:R-HSA-70171 NCBI chr 5:176,880,869...176,899,346
Ensembl chr 5:176,880,869...176,899,346 		JBrowse link
G PFKL phosphofructokinase, liver type involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr21:44,300,053...44,327,373
Ensembl chr21:44,300,051...44,327,376 		JBrowse link
G PFKM phosphofructokinase, muscle involved_in
acts_upstream_of_or_within		 IBA
ISO
IEA		 (PMID:21873635)
(MGI:4356361|PMID:19696889)		 GO_Central
MGI
GO_Central
Ensembl		 PMID:19696889 PMID:21873635 GO_REF:0000107 MGI:4356361 NCBI chr12:48,105,353...48,146,404
Ensembl chr12:48,105,139...48,146,404 		JBrowse link
G PFKP phosphofructokinase, platelet involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr10:3,067,548...3,136,805
Ensembl chr10:3,066,333...3,137,718 		JBrowse link
G PGAM2 phosphoglycerate mutase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:44,062,727...44,065,567
Ensembl chr 7:44,062,727...44,065,567 		JBrowse link
G PGK1 phosphoglycerate kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:78,104,248...78,129,295
Ensembl chr  X:77,910,739...78,129,295 		JBrowse link
G PKM pyruvate kinase M1/2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:72,199,029...72,231,591
Ensembl chr15:72,199,029...72,231,819 		JBrowse link
G TPI1 triosephosphate isomerase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:6,867,420...6,870,948
Ensembl chr12:6,867,119...6,870,948 		JBrowse link
glucose catabolic process to lactate via pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LDHA lactate dehydrogenase A acts_upstream_of_or_within ISO (MGI:62497|PMID:8224816) MGI PMID:8224816 MGI:62497 NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425 		JBrowse link
G TIGAR TP53 induced glycolysis regulatory phosphatase acts_upstream_of
involved_in		 ISO
IEA		 (MGI:4867601|PMID:20935145) MGI
Ensembl		 PMID:20935145 GO_REF:0000107 MGI:4867601 NCBI chr12:4,321,213...4,360,028
Ensembl chr12:4,307,763...4,360,028 		JBrowse link
G TP53 tumor protein p53 acts_upstream_of
involved_in		 ISO
IEA		 (MGI:4867601|PMID:20935145) MGI
Ensembl		 PMID:20935145 GO_REF:0000107 MGI:4867601 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
glycerophosphate shuttle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPD1 glycerol-3-phosphate dehydrogenase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:1927687|PMID:11147825) Ensembl
Ensembl
MGI		 PMID:11147825 GO_REF:0000107 MGI:1927687 NCBI chr12:50,104,008...50,111,313
Ensembl chr12:50,103,982...50,111,313 		JBrowse link
G GPD2 glycerol-3-phosphate dehydrogenase 2 involved_in TAS Reactome
Reactome		 Reactome:R-HSA-188467 NCBI chr 2:156,400,281...156,586,403
Ensembl chr 2:156,435,290...156,613,735 		JBrowse link
NADH oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDOB aldolase, fructose-bisphosphate B involved_in IDA (PMID:17576770) BHF-UCL
BHF-UCL		 PMID:17576770 NCBI chr 9:101,420,560...101,435,774
Ensembl chr 9:101,420,560...101,449,664 		JBrowse link
G GPD1 glycerol-3-phosphate dehydrogenase 1 involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 (PMID:21873635)
(MGI:1927687|PMID:11147825)		 GO_Central
Ensembl
GO_Central
MGI
RGD		 PMID:9550546 PMID:11147825 PMID:21873635 GO_REF:0000107 MGI:1927687 RGD:1641824 NCBI chr12:50,104,008...50,111,313
Ensembl chr12:50,103,982...50,111,313 		JBrowse link
G GPD1L glycerol-3-phosphate dehydrogenase 1 like NOT|involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 3:32,106,620...32,168,709
Ensembl chr 3:32,105,689...32,168,709 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 involved_in ISO
IEA		 RGD
Ensembl
Ensembl		 PMID:29389585 GO_REF:0000107 RGD:25823193 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial involved_in IEA
ISO		 Ensembl
Ensembl
RGD		 PMID:19635791 GO_REF:0000107 RGD:7242950 NCBI chr14:24,094,171...24,104,125
Ensembl chr14:24,094,053...24,110,598 		JBrowse link
negative regulation of glucose catabolic process to lactate via pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC25A12 solute carrier family 25 member 12 involved_in IEA
ISO		 Ensembl
Ensembl
RGD		 PMID:19764902 GO_REF:0000107 RGD:13628741 NCBI chr 2:171,783,405...171,894,244
Ensembl chr 2:171,783,405...171,999,859 		JBrowse link
G TIGAR TP53 induced glycolysis regulatory phosphatase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:4867601|PMID:20935145) Ensembl
Ensembl
MGI		 PMID:20935145 GO_REF:0000107 MGI:4867601 NCBI chr12:4,321,213...4,360,028
Ensembl chr12:4,307,763...4,360,028 		JBrowse link
G TP53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:4867601|PMID:20935145) Ensembl
MGI
Ensembl		 PMID:20935145 GO_REF:0000107 MGI:4867601 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
positive regulation of glucose catabolic process to lactate via pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTN3 actinin alpha 3 involved_in ISS
IEA		 UniProt
UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr11:66,546,395...66,563,334
Ensembl chr11:66,546,395...66,563,334 		JBrowse link
G MIR210 microRNA 210 involved_in IMP (PMID:20436681) ARUK-UCL PMID:20436681 NCBI chr11:568,089...568,198
Ensembl chr11:568,089...568,198 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19643
    metabolic process 13096
      NADH metabolic process 44
        NADH oxidation + 6
        NADH regeneration + 18
        glucose catabolic process to lactate via pyruvate + 6
        sulphoglycolysis 0
paths to the root