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ONTOLOGY REPORT - ANNOTATIONS


Term:one-carbon metabolic process
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Accession:GO:0006730 term browser browse the term
Definition:The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
Synonyms:exact_synonym: one carbon metabolism;   one-carbon transfer metabolic process;   one-carbon transfer metabolism
 alt_id: GO:0019753;   GO:0019754
 xref: UM-BBD_pathwayID:C1cyc


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one-carbon metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHCY adenosylhomocysteinase involved_in IEA UniProt GO_REF:0000043 NCBI chr20:34,235,012...34,311,976
Ensembl chr20:34,280,268...34,311,802
JBrowse link
G AHCYL1 adenosylhomocysteinase like 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:109,984,765...110,023,742
Ensembl chr 1:109,984,765...110,023,742
JBrowse link
G AHCYL2 adenosylhomocysteinase like 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 7:129,225,030...129,430,211
Ensembl chr 7:129,225,023...129,430,211
JBrowse link
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 3:126,103,565...126,197,758
Ensembl chr 3:126,103,562...126,197,994
JBrowse link
G ALDH1L2 aldehyde dehydrogenase 1 family member L2 involved_in IEA UniProt GO_REF:0000043 NCBI chr12:105,019,784...105,084,609
Ensembl chr12:105,019,784...105,107,643
JBrowse link
G CA1 carbonic anhydrase 1 involved_in IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr 8:85,327,608...85,378,113
Ensembl chr 8:85,327,608...85,379,014
JBrowse link
G CA10 carbonic anhydrase 10 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:51,630,313...52,160,023
Ensembl chr17:51,630,313...52,160,017
JBrowse link
G CA11 carbonic anhydrase 11 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr19:48,637,946...48,646,187
Ensembl chr19:48,637,946...48,646,187
JBrowse link
G CA12 carbonic anhydrase 12 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:63,321,378...63,381,846
Ensembl chr15:63,321,378...63,381,846
JBrowse link
G CA13 carbonic anhydrase 13 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:85,245,458...85,284,073
Ensembl chr 8:85,220,587...85,284,073
JBrowse link
G CA14 carbonic anhydrase 14 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:150,257,258...150,265,862
Ensembl chr 1:150,257,251...150,265,078
JBrowse link
G CA2 carbonic anhydrase 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:85,464,007...85,481,493
Ensembl chr 8:85,463,968...85,481,493
JBrowse link
G CA3 carbonic anhydrase 3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:85,438,859...85,449,040
Ensembl chr 8:85,373,436...85,449,040
JBrowse link
G CA4 carbonic anhydrase 4 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:60,149,942...60,179,021
Ensembl chr17:60,149,942...60,170,899
JBrowse link
G CA5A carbonic anhydrase 5A involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:87,881,549...87,936,575
Ensembl chr16:87,881,546...87,936,580
JBrowse link
G CA5B carbonic anhydrase 5B involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:15,738,270...15,788,411
Ensembl chr  X:15,688,830...15,788,411
JBrowse link
G CA6 carbonic anhydrase 6 involved_in IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr 1:8,945,868...8,975,092
Ensembl chr 1:8,945,867...8,975,092
JBrowse link
G CA7 carbonic anhydrase 7 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:66,844,414...66,854,149
Ensembl chr16:66,844,414...66,854,153
JBrowse link
G CA8 carbonic anhydrase 8 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:60,185,412...60,281,400
Ensembl chr 8:60,185,412...60,281,400
JBrowse link
G CA9 carbonic anhydrase 9 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:35,673,809...35,681,159
Ensembl chr 9:35,673,918...35,681,159
JBrowse link
G DHFR dihydrofolate reductase involved_in IEA UniProt GO_REF:0000043 NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983
JBrowse link
G DHFR2 dihydrofolate reductase 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 3:94,057,922...94,063,389
Ensembl chr 3:94,047,836...94,063,389
JBrowse link
G DHFRP1 dihydrofolate reductase pseudogene 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr18:26,167,862...26,171,357
Ensembl chr18:26,170,726...26,171,284
JBrowse link
G FPGS folylpolyglutamate synthase involved_in IEA UniProt GO_REF:0000043 NCBI chr 9:127,802,858...127,814,520
Ensembl chr 9:127,794,597...127,814,327
JBrowse link
G GNMT glycine N-methyltransferase involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:3842675|PMID:17937387)
GO_Central
MGI
PMID:17937387 PMID:21873635 MGI:3842675 NCBI chr 6:42,960,754...42,963,880
Ensembl chr 6:42,960,754...42,963,880
JBrowse link
G MAT1A methionine adenosyltransferase 1A involved_in IEA UniProt GO_REF:0000043 NCBI chr10:80,271,820...80,289,658
Ensembl chr10:80,271,820...80,289,658
JBrowse link
G MAT2A methionine adenosyltransferase 2A involved_in IEA UniProt GO_REF:0000043 NCBI chr 2:85,539,168...85,545,281
Ensembl chr 2:85,539,168...85,545,281
JBrowse link
G MAT2B methionine adenosyltransferase 2B involved_in IEA UniProt GO_REF:0000043 NCBI chr 5:163,503,064...163,519,354
Ensembl chr 5:163,503,114...163,519,354
JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in IMP
ISO
(PMID:25633902) BHF-UCL
RGD
PMID:14597174 PMID:25633902 RGD:1302361 NCBI chr14:64,388,353...64,460,025
Ensembl chr14:64,388,031...64,463,457
JBrowse link
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:150,865,684...151,101,887
Ensembl chr 6:150,865,549...151,101,887
Ensembl chr 6:150,865,549...151,101,887
JBrowse link
G MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:74,123,273...74,303,099
Ensembl chr 4:74,114,174...74,303,099
JBrowse link
G SFXN1 sideroflexin 1 acts_upstream_of IDA (PMID:30442778) UniProt PMID:30442778 NCBI chr 5:175,478,560...175,529,742
Ensembl chr 5:175,477,062...175,529,742
JBrowse link
G SFXN3 sideroflexin 3 acts_upstream_of IDA (PMID:30442778) UniProt PMID:30442778 NCBI chr10:101,031,234...101,041,243
Ensembl chr10:101,031,234...101,041,244
JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:18,327,873...18,363,560
Ensembl chr17:18,327,860...18,363,563
JBrowse link
G SHMT2 serine hydroxymethyltransferase 2 involved_in IDA
IBA
(PMID:11516159), (PMID:29180469), (PMID:29364879), (PMID:29452640)
(PMID:21873635)
UniProt
GO_Central
PMID:11516159 PMID:21873635 PMID:29180469 PMID:29364879 PMID:29452640 NCBI chr12:57,229,685...57,234,935
Ensembl chr12:57,229,573...57,234,935
JBrowse link
tetrahydrofolate interconversion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DMGDH dimethylglycine dehydrogenase ISO RGD PMID:6163778 RGD:7245485 NCBI chr 5:78,997,564...79,069,674
Ensembl chr 5:78,997,564...79,236,038
JBrowse link
G FTCD formimidoyltransferase cyclodeaminase involved_in IEA UniProt GO_REF:0000041 NCBI chr21:46,135,981...46,156,482
Ensembl chr21:46,136,262...46,155,579
Ensembl chr21:46,136,262...46,155,579
JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISS
IBA
IDA
IEA
(PMID:21873635)
(PMID:1881876)
BHF-UCL
GO_Central
UniProt
PMID:1881876 PMID:21873635 GO_REF:0000024 GO_REF:0000041 NCBI chr14:64,388,353...64,460,025
Ensembl chr14:64,388,031...64,463,457
JBrowse link
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like involved_in IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000041 NCBI chr 6:150,865,684...151,101,887
Ensembl chr 6:150,865,549...151,101,887
Ensembl chr 6:150,865,549...151,101,887
JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:74,198,591...74,217,565
Ensembl chr 2:74,198,610...74,217,565
Ensembl chr 2:74,198,610...74,217,565
JBrowse link
G MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like involved_in IEA
IBA
ISO
(PMID:21873635) UniProt
GO_Central
RGD
PMID:21163947 PMID:21873635 GO_REF:0000041 RGD:7244288 NCBI chr 4:74,123,273...74,303,099
Ensembl chr 4:74,114,174...74,303,099
JBrowse link
G MTHFR methylenetetrahydrofolate reductase involved_in IDA
IBA
IEA
IMP
IGI
(PMID:12673793)
(PMID:21873635)
(PMID:12673793), (PMID:25736335)
(PMID:10551815)
BHF-UCL
GO_Central
UniProt
PMID:10551815 PMID:12673793 PMID:21873635 PMID:25736335 GO_REF:0000041 NCBI chr 1:11,785,723...11,806,103
Ensembl chr 1:11,785,723...11,806,455
Ensembl chr 1:11,785,723...11,806,455
JBrowse link
G MTHFS methenyltetrahydrofolate synthetase involved_in IMP
IBA
(PMID:12764149)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:12764149 PMID:21873635 NCBI chr15:79,843,547...79,897,285
Ensembl chr15:79,833,585...79,897,379
JBrowse link
G SARDH sarcosine dehydrogenase ISO RGD PMID:6163778 RGD:7245485 NCBI chr 9:133,663,074...133,739,958
Ensembl chr 9:133,663,560...133,739,955
JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 involved_in IBA
IEA
IDA
(PMID:21873635)
(PMID:24698160)
GO_Central
UniProt
BHF-UCL
PMID:21873635 PMID:24698160 GO_REF:0000041 NCBI chr17:18,327,873...18,363,560
Ensembl chr17:18,327,860...18,363,563
JBrowse link
G SHMT2 serine hydroxymethyltransferase 2 involved_in IBA
IEA
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000041 NCBI chr12:57,229,685...57,234,935
Ensembl chr12:57,229,573...57,234,935
JBrowse link
G TYMS thymidylate synthetase involved_in IDA (PMID:15093541) BHF-UCL PMID:15093541 NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 18673
    metabolic process 12207
      cellular metabolic process 11228
        one-carbon metabolic process 42
          serine-isocitrate lyase pathway 0
          tetrahydrofolate interconversion 12
paths to the root