Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:tetrahydrobiopterin biosynthetic process
go back to main search page
Accession:GO:0006729 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine.
Synonyms:exact_synonym: 5,6,7,8-tetrahydrobiopterin biosynthetic process;   tetrahydrobiopterin anabolism;   tetrahydrobiopterin biosynthesis;   tetrahydrobiopterin formation;   tetrahydrobiopterin synthesis


show annotations for term's descendants           Sort by:
 
tetrahydrobiopterin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHFR dihydrofolate reductase involved_in IMP
ISS
(PMID:23707606) BHF-UCL PMID:23707606 GO_REF:0000024 NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983
JBrowse link
G DHFRP1 dihydrofolate reductase pseudogene 1 involved_in IMP
ISS
(PMID:23707606) BHF-UCL PMID:23707606 GO_REF:0000024 NCBI chr18:26,167,862...26,171,357
Ensembl chr18:26,170,726...26,171,284
JBrowse link
G GCH1 GTP cyclohydrolase 1 involved_in IBA
IMP
IDA
(PMID:21873635)
(PMID:17101830), (PMID:19666465)
(PMID:7678411), (PMID:9445252)
GO_Central
BHF-UCL
UniProt
PMID:7678411 PMID:9445252 PMID:17101830 PMID:19666465 PMID:21873635 NCBI chr14:54,842,016...54,902,826
Ensembl chr14:54,842,008...54,902,826
JBrowse link
G PCBD1 pterin-4 alpha-carbinolamine dehydratase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr10:70,882,280...70,888,565
Ensembl chr10:70,882,280...70,888,565
JBrowse link
G PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 5:134,905,131...134,962,644
Ensembl chr 5:134,905,120...135,007,959
JBrowse link
G PTS 6-pyruvoyltetrahydropterin synthase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1328867|PMID:9894812) UniProt
MGI
PMID:9894812 GO_REF:0000041 MGI:1328867 NCBI chr11:112,226,428...112,233,973
Ensembl chr11:112,226,367...112,269,955
JBrowse link
G QDPR quinoid dihydropteridine reductase involved_in IBA
ISO
(PMID:21873635) GO_Central
RGD
PMID:660556 PMID:9235988 PMID:21873635 RGD:4139903 RGD:5128582 NCBI chr 4:17,486,395...17,512,090
Ensembl chr 4:17,460,261...17,512,206
JBrowse link
G SPR sepiapterin reductase involved_in IBA
ISO
TAS
(PMID:21873635)
(PMID:1883349)
GO_Central
RGD
UniProt
PMID:1883349 PMID:2179471 PMID:21873635 RGD:1600056 NCBI chr 2:72,887,408...72,892,158
Ensembl chr 2:72,887,382...72,892,158
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18537
    cellular process 17456
      cellular metabolic process 10809
        heterocycle metabolic process 5952
          pteridine-containing compound metabolic process 37
            pteridine-containing compound biosynthetic process 15
              tetrahydrobiopterin biosynthetic process 8
Path 2
Term Annotations click to browse term
  biological_process 18537
    metabolic process 11867
      organic substance metabolic process 11374
        organic hydroxy compound metabolic process 597
          alcohol metabolic process 388
            polyol metabolic process 130
              diol metabolic process 30
                tetrahydrobiopterin metabolic process 9
                  tetrahydrobiopterin biosynthetic process 8
paths to the root