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Term:tetrahydrobiopterin biosynthetic process
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Accession:GO:0006729 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine.
Synonyms:exact_synonym: 5,6,7,8-tetrahydrobiopterin biosynthetic process;   tetrahydrobiopterin anabolism;   tetrahydrobiopterin biosynthesis;   tetrahydrobiopterin formation;   tetrahydrobiopterin synthesis

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tetrahydrobiopterin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHFR dihydrofolate reductase involved_in ISO (PMID:23707606)
BHF-UCL PMID:19666465 PMID:23707606 MGI:5645206 NCBI chr 5:34,663,210...34,689,467
Ensembl chr 5:34,938,548...34,967,003
JBrowse link
G GCH1 GTP cyclohydrolase 1 involved_in ISO (PMID:7678411), (PMID:9445252)
(PMID:17101830), (PMID:19666465)
PMID:7678411 PMID:9445252 PMID:17101830 PMID:19666465 NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393
JBrowse link
G PTS 6-pyruvoyltetrahydropterin synthase acts_upstream_of_or_within ISO (MGI:1328867|PMID:9894812) MGI PMID:9894812 MGI:1328867 NCBI chr11:107,107,114...107,114,594
Ensembl chr11:110,949,708...110,957,599
JBrowse link
G QDPR quinoid dihydropteridine reductase involved_in ISO PMID:1898002 RGD
PMID:660556 PMID:1898002 PMID:9235988 RGD:4139903 RGD:5128582 RGD:8553309 NCBI chr 4:11,906,439...11,932,311
Ensembl chr 4:17,199,772...17,225,667
JBrowse link
G SPR sepiapterin reductase ISO RGD PMID:2179471 RGD:1600056 NCBI chr2A:72,939,621...72,944,669
Ensembl chr2A:74,433,056...74,438,105
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12656
    cellular process 11789
      cellular metabolic process 7257
        heterocycle metabolic process 3834
          pteridine-containing compound metabolic process 22
            pteridine-containing compound biosynthetic process 10
              tetrahydrobiopterin biosynthetic process 5
Path 2
Term Annotations click to browse term
  biological_process 12656
    metabolic process 7929
      organic substance metabolic process 7641
        organic hydroxy compound metabolic process 424
          alcohol metabolic process 263
            polyol metabolic process 91
              diol metabolic process 22
                tetrahydrobiopterin metabolic process 5
                  tetrahydrobiopterin biosynthetic process 5
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