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ONTOLOGY REPORT - ANNOTATIONS

Term:tetrahydrobiopterin biosynthetic process
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Accession:GO:0006729 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine.
Synonyms:exact_synonym: 5,6,7,8-tetrahydrobiopterin biosynthetic process;   tetrahydrobiopterin anabolism;   tetrahydrobiopterin biosynthesis;   tetrahydrobiopterin formation;   tetrahydrobiopterin synthesis


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tetrahydrobiopterin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07068905.1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 8:817,915...819,124 JBrowse link
G Dhfr dihydrofolate reductase involved_in ISO (PMID:23707606)
(MGI:5645206|PMID:19666465)		 RGD PMID:19666465 PMID:23707606 MGI:5645206 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in ISO
IEA
IBA		 (PMID:17101830), (PMID:19666465), (PMID:7678411), (PMID:9445252)
GO_REF:0000043
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:7678411 PMID:9445252 PMID:17101830 PMID:19666465 GO_REF:0000033 GO_REF:0000043 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Pcbd1 pterin-4 alpha-carbinolamine dehydratase 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:29,037,545...29,044,322
Ensembl chr20:28,953,864...29,044,292
Ensembl chr20:28,953,864...29,044,292 		JBrowse link
G Pcbd2 pterin-4 alpha-carbinolamine dehydratase 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:8,845,161...8,896,343
Ensembl chr17:8,845,084...8,910,539 		JBrowse link
G Pts 6-pyruvoyl-tetrahydropterin synthase involved_in
acts_upstream_of_or_within		 TAS
IEA
ISO		 GO_REF:0000041
(PMID:9894812)		 UniProt
RGD		 PMID:9894812 PMID:1939130 GO_REF:0000041, RGD:68294 NCBI chr 8:50,870,838...50,877,869
Ensembl chr 8:50,870,841...50,877,869 		JBrowse link
G Qdpr quinoid dihydropteridine reductase involved_in TAS
IDA
IMP
IEA
IBA		 PMID:1898002
GO_REF:0000043
GO_REF:0000118
GO_REF:0000033		 UniProt
TreeGrafter
GO_Central
RGD		 PMID:3680258 PMID:660556 PMID:9235988 PMID:1898002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000118, RGD:729701, RGD:4139903, RGD:5128582, RGD:8553309 NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854 		JBrowse link
G Spr sepiapterin reductase involved_in TAS
IMP
IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central
RGD		 PMID:2201030 PMID:2179471 GO_REF:0000033 GO_REF:0000118, RGD:70022, RGD:1600056 NCBI chr 4:117,671,948...117,676,292
Ensembl chr 4:117,671,949...117,675,678 		JBrowse link
G Spr-ps1 sepiapterin reductase, pseudogene 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:117,689,458...117,693,286
Ensembl chr 4:117,689,458...117,692,891 		JBrowse link
G Txndc15 thioredoxin domain containing 15 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:8,898,074...8,910,538
Ensembl chr17:8,845,084...8,910,539 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    cellular process 18769
      cellular metabolic process 10279
        cellular aromatic compound metabolic process 5937
          pteridine-containing compound metabolic process 34
            pteridine-containing compound biosynthetic process 17
              tetrahydrobiopterin biosynthetic process 10
Path 2
Term Annotations click to browse term
  biological_process 20292
    metabolic process 11720
      organic substance metabolic process 11221
        organic hydroxy compound metabolic process 610
          alcohol metabolic process 395
            alcohol biosynthetic process 165
              polyol biosynthetic process 73
                diol biosynthetic process 27
                  tetrahydrobiopterin biosynthetic process 10
paths to the root