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ONTOLOGY REPORT - ANNOTATIONS


Term:mineralocorticoid biosynthetic process
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Accession:GO:0006705 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
Synonyms:exact_synonym: mineralocorticoid anabolism;   mineralocorticoid biosynthesis;   mineralocorticoid formation;   mineralocorticoid synthesis



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mineralocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 involved_in TAS Reactome Reactome:R-HSA-193993 NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843
JBrowse link
G CYP21A1P cytochrome P450 family 21 subfamily A member 1, pseudogene ISO 11-deoxycorticosterone RGD PMID:19665544 RGD:4891164 NCBI chr 6:32,005,636...32,008,909
Ensembl chr 6:32,005,636...32,008,451
JBrowse link
G CYP21A2 cytochrome P450 family 21 subfamily A member 2 involved_in TAS Reactome Reactome:R-HSA-193993 NCBI chr 6:32,038,415...32,041,644
Ensembl chr 6:32,038,327...32,041,644
JBrowse link
aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1H calcium voltage-gated channel subunit alpha1 H involved_in IMP (PMID:19342457) UniProt PMID:19342457 NCBI chr16:1,153,106...1,221,769
Ensembl chr16:1,153,106...1,221,771
JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 involved_in IDA
IMP
IBA
(PMID:2256920)
(PMID:19342457)
(PMID:21873635)
BHF-UCL
UniProt
GO_Central
PMID:2256920 PMID:19342457 PMID:21873635 NCBI chr 8:142,872,357...142,879,825
Ensembl chr 8:142,872,356...142,879,846
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 involved_in
acts_upstream_of_or_within
IBA
ISO
IMP
IDA
(PMID:21873635)
(MGI:50073|PMID:1686470), (MGI:80407|PMID:8645611)
(PMID:19342457)
(PMID:1741400), (PMID:2256920), (PMID:23322723)
GO_Central
MGI
UniProt
PMID:1686470 PMID:1741400 PMID:2256920 PMID:8645611 PMID:19342457 More... MGI:50073 MGI:80407 NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843
JBrowse link
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr 6:55,753,653...55,875,590
Ensembl chr 6:55,753,653...55,875,590
JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in IDA (PMID:16981135) UniProt PMID:16981135 NCBI chr11:11,963,036...12,009,827
Ensembl chr11:11,956,207...12,009,769
JBrowse link
G REST RE1 silencing transcription factor involved_in IMP (PMID:19342457) UniProt PMID:19342457 NCBI chr 4:56,907,900...56,935,847
Ensembl chr 4:56,907,876...56,966,808
JBrowse link
positive regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP6 bone morphogenetic protein 6 involved_in IDA (PMID:16527843) UniProt PMID:16527843 NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728
JBrowse link
G DAB2 DAB adaptor protein 2 ISO RGD PMID:17303656 RGD:7243836 NCBI chr 5:39,460,870...39,462,304
Ensembl chr 5:39,371,675...39,462,300
JBrowse link
G DAB2 DAB adaptor protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:39,371,677...39,424,980
Ensembl chr 5:39,371,675...39,462,300
JBrowse link
G WNT4 Wnt family member 4 involved_in IDA (PMID:16981135) UniProt PMID:16981135 NCBI chr 1:22,117,308...22,143,981
Ensembl chr 1:22,117,313...22,143,969
JBrowse link
regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCN2 chloride voltage-gated channel 2 involved_in IMP (PMID:29403011) UniProt PMID:29403011 NCBI chr 3:184,346,185...184,361,605
Ensembl chr 3:184,346,185...184,361,650
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18605
    cellular process 17543
      cellular metabolic process 10867
        cellular hormone metabolic process 152
          mineralocorticoid metabolic process 18
            mineralocorticoid biosynthetic process 14
              aldosterone biosynthetic process + 12
Path 2
Term Annotations click to browse term
  biological_process 18605
    metabolic process 11952
      organic substance metabolic process 11461
        organic substance biosynthetic process 6147
          lipid biosynthetic process 749
            steroid biosynthetic process 190
              steroid hormone biosynthetic process 49
                mineralocorticoid biosynthetic process 14
                  aldosterone biosynthetic process + 12
paths to the root