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ONTOLOGY REPORT - ANNOTATIONS


Term:glucocorticoid biosynthetic process
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Accession:GO:0006704 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
Synonyms:exact_synonym: glucocorticoid anabolism;   glucocorticoid biosynthesis;   glucocorticoid formation;   glucocorticoid synthesis



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glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRH corticotropin releasing hormone acts_upstream_of_or_within ISO (MGI:1860037|PMID:10861000) MGI PMID:10861000 MGI:1860037 NCBI chr 4:68,481,696...68,486,122
Ensembl chr 4:68,484,053...68,486,121
JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 involved_in IBA
IEA
GO_Central
TreeGrafter
GO_REF:0000033 GO_REF:0000118 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 involved_in IEA
IBA
TreeGrafter
GO_Central
GO_REF:0000033 GO_REF:0000118 NCBI chr 4:1,365,725...1,373,138 JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:77279|PMID:7588219) MGI
UniProt
PMID:7588219 GO_REF:0000041 MGI:77279 NCBI chr14:113,805,616...113,820,445
Ensembl chr14:113,805,611...113,812,041
JBrowse link
G CYP21A1 cytochrome P450 family 21 subfamily A member 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:24,086,138...24,089,364
Ensembl chr 7:24,086,218...24,089,370
JBrowse link
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:55,110,546...55,130,328
Ensembl chr17:55,110,590...55,130,363
JBrowse link
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:120,809,886...120,852,196
Ensembl chr15:120,809,959...120,852,192
JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:23,053,129...23,058,865
Ensembl chr 5:23,053,892...23,058,470
JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 ISO RGD PMID:12460758 RGD:1625060 NCBI chr 9:133,231,451...133,278,396
Ensembl chr 9:133,231,451...133,278,396
JBrowse link
cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1H calcium voltage-gated channel subunit alpha1 H involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:40,637,420...40,694,616
Ensembl chr 3:40,637,427...40,695,177
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 involved_in
NOT|involved_in
ISO (PMID:19342457)
(PMID:9703385)
UniProt
BHF-UCL
PMID:9703385 PMID:19342457 NCBI chr 4:1,365,725...1,373,138 JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:15,750,487...15,762,982
Ensembl chr17:15,749,835...15,761,195
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:25,344,924...25,468,430
Ensembl chr 7:25,344,822...25,470,470
JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:47,385,244...47,444,664
Ensembl chr 2:47,385,192...47,444,660
JBrowse link
G LOC100621006 RE1-silencing transcription factor-like involved_in ISS UniProt GO_REF:0000024 NCBI chr 8:56,048,280...56,215,011
Ensembl chr 8:56,035,150...56,215,013
JBrowse link
G REST RE1 silencing transcription factor involved_in ISS UniProt GO_REF:0000024 NCBI chr 8:56,035,182...56,061,140
Ensembl chr 8:56,035,150...56,215,013
JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3696486|PMID:17234593) MGI
Ensembl
PMID:17234593 GO_REF:0000107 MGI:3696486 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,508...104,384,547
JBrowse link
positive regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT4 Wnt family member 4 involved_in ISO (PMID:16981135) UniProt PMID:16981135 NCBI chr 6:80,110,238...80,138,165 JBrowse link
regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DGKQ diacylglycerol kinase theta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:313,325...325,089
Ensembl chr 8:313,329...325,095
JBrowse link
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:69,666,348...69,700,303
Ensembl chr 6:69,666,601...69,700,298
JBrowse link
regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR3C1 nuclear receptor subfamily 3 group C member 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:74913|PMID:7628695) MGI
Ensembl
PMID:7628695 GO_REF:0000107 MGI:74913 NCBI chr 2:144,822,937...144,956,451
Ensembl chr 2:144,822,939...144,956,451
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17774
    metabolic process 10318
      organic substance metabolic process 9876
        organic cyclic compound metabolic process 5562
          steroid metabolic process 314
            glucocorticoid metabolic process 30
              glucocorticoid biosynthetic process 20
                cortisol biosynthetic process + 10
                negative regulation of glucocorticoid biosynthetic process + 6
                positive regulation of glucocorticoid biosynthetic process + 1
                regulation of glucocorticoid biosynthetic process + 10
Path 2
Term Annotations click to browse term
  biological_process 17774
    metabolic process 10318
      primary metabolic process 8977
        lipid metabolic process 1350
          lipid biosynthetic process 671
            steroid biosynthetic process 164
              steroid hormone biosynthetic process 42
                glucocorticoid biosynthetic process 20
                  cortisol biosynthetic process + 10
                  negative regulation of glucocorticoid biosynthetic process + 6
                  positive regulation of glucocorticoid biosynthetic process + 1
                  regulation of glucocorticoid biosynthetic process + 10
paths to the root