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ONTOLOGY REPORT - ANNOTATIONS

Term:glucocorticoid biosynthetic process
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Accession:GO:0006704 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
Synonyms:exact_synonym: glucocorticoid anabolism;   glucocorticoid biosynthesis;   glucocorticoid formation;   glucocorticoid synthesis
 xref: Reactome:R-HSA-194002 "Glucocorticoid biosynthesis"

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glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:10861000) MGI
Ensembl		 PMID:10861000 GO_REF:0000107 NCBI chrNW_004624744:25,194,458...25,196,658
Ensembl chrNW_004624744:25,194,495...25,196,488 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 ISO RGD PMID:12460758 RGD:1625060 NCBI chrNW_004624807:2,260,702...2,293,962
Ensembl chrNW_004624807:2,261,006...2,293,804 		JBrowse link
G LOC101700018 sterol 26-hydroxylase, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624823:6,199,807...6,258,273
Ensembl chrNW_004624823:6,200,047...6,258,001 		JBrowse link
G LOC101700701 cytochrome P450 11B1, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624735:13,701,382...13,708,750 JBrowse link
G LOC101700851 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624802:10,176,865...10,181,725
Ensembl chrNW_004624802:10,176,919...10,181,657 		JBrowse link
G LOC101701311 cytochrome P450 11B1, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624735:13,726,649...13,734,536 JBrowse link
G LOC101704598 cholesterol side-chain cleavage enzyme, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624781:288,594...298,876
Ensembl chrNW_004624781:288,594...300,429 		JBrowse link
G LOC101716773 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624790:2,183,079...2,200,219
Ensembl chrNW_004624790:2,182,598...2,200,425 		JBrowse link
G LOC101726496 steroid 17-alpha-hydroxylase/17,20 lyase acts_upstream_of_or_within ISO (PMID:7588219) MGI PMID:7588219 NCBI chrNW_004624831:2,155,851...2,166,621
Ensembl chrNW_004624831:2,157,048...2,166,539 		JBrowse link
cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in ISO (PMID:19342457) UniProt PMID:19342457 RGD:4891166 NCBI chrNW_004624913:1,926,405...1,952,426
Ensembl chrNW_004624913:1,891,156...1,949,633 		JBrowse link
G LOC101700701 cytochrome P450 11B1, mitochondrial NOT|involved_in ISO (PMID:9703385)
(PMID:19342457)		 BHF-UCL
UniProt		 PMID:9703385 PMID:19342457 NCBI chrNW_004624735:13,701,382...13,708,750 JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chrNW_004624741:7,706,205...7,717,677
Ensembl chrNW_004624741:7,706,236...7,719,484 		JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chrNW_004624850:3,324,553...3,481,439
Ensembl chrNW_004624850:3,322,782...3,481,512 		JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO (PMID:16981135) UniProt PMID:16981135 NCBI chrNW_004624766:4,042,307...4,085,613
Ensembl chrNW_004624766:4,041,816...4,085,209 		JBrowse link
G Rest RE1 silencing transcription factor involved_in ISO (PMID:19342457) UniProt PMID:19342457 RGD:4891166 NCBI chrNW_004624761:12,464,243...12,495,294 JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 acts_upstream_of_or_within ISO (PMID:17234593) MGI PMID:17234593 NCBI chrNW_004624772:12,099,523...12,127,437
Ensembl chrNW_004624772:12,099,435...12,127,737 		JBrowse link
positive regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt4 Wnt family member 4 involved_in ISO (PMID:16981135) UniProt PMID:16981135 NCBI chrNW_004624764:6,913,027...6,934,650
Ensembl chrNW_004624764:6,921,811...6,933,392 		JBrowse link
regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgkq diacylglycerol kinase theta involved_in ISO (PMID:24369117) ParkinsonsUK-UCL PMID:24369117 NCBI chrNW_004624755:26,179,099...26,197,764
Ensembl chrNW_004624755:26,179,162...26,189,901 		JBrowse link
G H6pd hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase involved_in ISO (PMID:18628520), (PMID:23132696)
(PMID:16356929)		 UniProt PMID:16356929 PMID:18628520 PMID:23132696 NCBI chrNW_004624818:3,025,323...3,052,486
Ensembl chrNW_004624818:3,025,252...3,051,260 		JBrowse link
regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3 group C member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7628695) Ensembl
MGI		 PMID:7628695 GO_REF:0000107 NCBI chrNW_004624774:2,496,276...2,603,894
Ensembl chrNW_004624774:2,495,304...2,602,632 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17640
    cellular process 17222
      metabolic process 11022
        primary metabolic process 9867
          lipid metabolic process 1260
            steroid metabolic process 284
              glucocorticoid metabolic process 27
                glucocorticoid biosynthetic process 19
                  cortisol biosynthetic process + 9
                  negative regulation of glucocorticoid biosynthetic process + 5
                  positive regulation of glucocorticoid biosynthetic process + 1
                  regulation of glucocorticoid biosynthetic process + 9
Path 2
Term Annotations click to browse term
  biological_process 17640
    cellular process 17222
      metabolic process 11022
        primary metabolic process 9867
          lipid metabolic process 1260
            steroid metabolic process 284
              steroid biosynthetic process 155
                steroid hormone biosynthetic process 39
                  glucocorticoid biosynthetic process 19
                    cortisol biosynthetic process + 9
                    negative regulation of glucocorticoid biosynthetic process + 5
                    positive regulation of glucocorticoid biosynthetic process + 1
                    regulation of glucocorticoid biosynthetic process + 9
paths to the root