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ONTOLOGY REPORT - ANNOTATIONS


Term:C21-steroid hormone biosynthetic process
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Accession:GO:0006700 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.
Synonyms:exact_synonym: C21-steroid hormone anabolism;   C21-steroid hormone biosynthesis;   C21-steroid hormone formation;   C21-steroid hormone synthesis



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C21-steroid hormone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1B1 aldo-keto reductase family 1 member B involved_in TAS Reactome Reactome:R-HSA-196108 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 involved_in
acts_upstream_of_or_within
IDA
ISO
IEA
TAS
IBA
(PMID:11502818), (PMID:18182448), (PMID:21636783)
(MGI:68080|PMID:7527351)
pregnenolone
(PMID:21873635)
UniProt
MGI
RGD
InterPro
Reactome
GO_Central
PMID:7527351 PMID:11502818 PMID:18182448 PMID:19665544 PMID:21636783 More... GO_REF:0000002 MGI:68080 RGD:4891164 Reactome:R-HSA-196108 NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646
JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 involved_in IBA
IDA
(PMID:21873635)
(PMID:2256920)
GO_Central
BHF-UCL
PMID:2256920 PMID:21873635 NCBI chr 8:142,872,357...142,879,825
Ensembl chr 8:142,872,356...142,879,846
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 involved_in IBA
IDA
(PMID:21873635)
(PMID:2256920)
GO_Central
BHF-UCL
PMID:2256920 PMID:21873635 NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843
JBrowse link
G CYP21A1P cytochrome P450 family 21 subfamily A member 1, pseudogene ISO RGD PMID:9408081 RGD:1298842 NCBI chr 6:32,005,636...32,008,909
Ensembl chr 6:32,005,636...32,008,451
JBrowse link
G HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 ISO RGD PMID:1985917 RGD:632871 NCBI chr 1:119,414,931...119,423,034
Ensembl chr 1:119,414,931...119,423,035
JBrowse link
G TSPO translocator protein involved_in TAS Reactome Reactome:R-HSA-196108 NCBI chr22:43,151,559...43,163,242
Ensembl chr22:43,151,547...43,163,242
JBrowse link
aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1H calcium voltage-gated channel subunit alpha1 H involved_in IMP (PMID:19342457) UniProt PMID:19342457 NCBI chr16:1,153,106...1,221,769
Ensembl chr16:1,153,106...1,221,771
JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 involved_in IDA
IMP
IBA
(PMID:2256920)
(PMID:19342457)
(PMID:21873635)
BHF-UCL
UniProt
GO_Central
PMID:2256920 PMID:19342457 PMID:21873635 NCBI chr 8:142,872,357...142,879,825
Ensembl chr 8:142,872,356...142,879,846
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 involved_in
acts_upstream_of_or_within
IBA
ISO
IMP
IDA
(PMID:21873635)
(MGI:50073|PMID:1686470), (MGI:80407|PMID:8645611)
(PMID:19342457)
(PMID:1741400), (PMID:2256920), (PMID:23322723)
GO_Central
MGI
UniProt
PMID:1686470 PMID:1741400 PMID:2256920 PMID:8645611 PMID:19342457 More... MGI:50073 MGI:80407 NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843
JBrowse link
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr 6:55,753,653...55,875,590
Ensembl chr 6:55,753,653...55,875,590
JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in IDA (PMID:16981135) UniProt PMID:16981135 NCBI chr11:11,963,036...12,009,827
Ensembl chr11:11,956,207...12,009,769
JBrowse link
G REST RE1 silencing transcription factor involved_in IMP (PMID:19342457) UniProt PMID:19342457 NCBI chr 4:56,907,900...56,935,847
Ensembl chr 4:56,907,876...56,966,808
JBrowse link
positive regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP6 bone morphogenetic protein 6 involved_in IDA (PMID:16527843) UniProt PMID:16527843 NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728
JBrowse link
G DAB2 DAB adaptor protein 2 ISO RGD PMID:17303656 RGD:7243836 NCBI chr 5:39,460,870...39,462,304
Ensembl chr 5:39,371,675...39,462,300
JBrowse link
G WNT4 Wnt family member 4 involved_in IDA (PMID:16981135) UniProt PMID:16981135 NCBI chr 1:22,117,308...22,143,981
Ensembl chr 1:22,117,313...22,143,969
JBrowse link
positive regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin involved_in TAS (PMID:10822232) GO_Central PMID:10822232 NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha involved_in IEA
ISO
Ensembl
RGD
PMID:20133449 GO_REF:0000107 RGD:10059648 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FSHB follicle stimulating hormone subunit beta involved_in TAS (PMID:14557487) BHF-UCL PMID:14557487 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261
JBrowse link
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 ISO RGD PMID:1955079 RGD:1625116 NCBI chr 1:119,507,203...119,515,058
Ensembl chr 1:119,507,198...119,515,054
JBrowse link
G LHB luteinizing hormone subunit beta involved_in TAS (PMID:14557487) BHF-UCL PMID:14557487 NCBI chr19:49,015,980...49,017,091
Ensembl chr19:49,015,980...49,017,091
JBrowse link
G SCP2 sterol carrier protein 2 involved_in IDA (PMID:1703300) UniProt PMID:1703300 NCBI chr 1:52,927,276...53,051,698
Ensembl chr 1:52,927,276...53,051,698
JBrowse link
G STARD3 StAR related lipid transfer domain containing 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3039987|PMID:14963026) Ensembl
MGI
PMID:14963026 GO_REF:0000107 MGI:3039987 NCBI chr17:39,637,144...39,664,201
Ensembl chr17:39,637,090...39,664,201
JBrowse link
regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCN2 chloride voltage-gated channel 2 involved_in IMP (PMID:29403011) UniProt PMID:29403011 NCBI chr 3:184,346,185...184,361,605
Ensembl chr 3:184,346,185...184,361,650
JBrowse link
regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DGKQ diacylglycerol kinase theta involved_in IMP (PMID:24369117) ParkinsonsUK-UCL PMID:24369117 NCBI chr 4:958,887...973,569
Ensembl chr 4:958,887...986,895
JBrowse link
G EGR1 early growth response 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G MIR125A microRNA 125a ISO RGD PMID:23045399 RGD:26884342 NCBI chr19:51,693,254...51,693,339
Ensembl chr19:51,693,254...51,693,339
JBrowse link
G MIR455 microRNA 455 ISO RGD PMID:23045399 RGD:26884342 NCBI chr 9:114,209,434...114,209,529
Ensembl chr 9:114,209,434...114,209,529
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18536
    cellular process 17455
      cellular metabolic process 10809
        cellular biosynthetic process 6017
          C21-steroid hormone biosynthetic process 27
            aldosterone biosynthetic process + 11
            progesterone biosynthetic process + 11
Path 2
Term Annotations click to browse term
  biological_process 18536
    metabolic process 11867
      primary metabolic process 10543
        lipid metabolic process 1431
          lipid biosynthetic process 739
            steroid biosynthetic process 189
              steroid hormone biosynthetic process 48
                C21-steroid hormone biosynthetic process 27
                  aldosterone biosynthetic process + 11
                  progesterone biosynthetic process + 11
paths to the root