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ONTOLOGY REPORT - ANNOTATIONS

Term:bile acid biosynthetic process
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Accession:GO:0006699 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
Synonyms:exact_synonym: bile acid anabolism;   bile acid biosynthesis;   bile acid formation;   bile acid synthesis
 xref: Reactome:R-HSA-192105 "Synthesis of bile acids and bile salts"
 only_in_taxon: NCBITaxon:6072 ! Eumetazoa


show annotations for term's descendants           Sort by:
bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd3 ATP binding cassette subfamily D member 3 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:25168382)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:25168382 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020 		JBrowse link
G Acox2 acyl-CoA oxidase 2 involved_in ISO
IEA
ISS 		(PMID:27884763)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:27884763 GO_REF:0000024 GO_REF:0000107 NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160 		JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:7508385)
GO_REF:0000107
GO_REF:0000002 		RGD
Ensembl
InterPro		 PMID:7508385 GO_REF:0000002 GO_REF:0000107 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372 		JBrowse link
G Amacr alpha-methylacyl-CoA racemase involved_in IDA
IEA 		GO_REF:0000041 UniProt
RGD		 PMID:11964182 GO_REF:0000041, RGD:704372 NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255 		JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase involved_in ISO
IEA 		(PMID:12810727), (PMID:8034703)
GO_REF:0000107 		RGD
Ensembl		 PMID:8034703 PMID:12810727 GO_REF:0000107 NCBI chr 5:68,647,166...68,656,137
Ensembl chr 5:63,850,705...63,860,685 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 involved_in IEA
ISS
ISO 		GO_REF:0000041
GO_REF:0000024
(PMID:11412116), (PMID:9660774)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:9660774 PMID:11412116 GO_REF:0000024 GO_REF:0000041 GO_REF:0000107 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 involved_in ISO
IBA 		(PMID:10748047)
GO_REF:0000033 		RGD
GO_Central		 PMID:10748047 GO_REF:0000033 NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 involved_in TAS
IEA
IBA
IDA
ISO 		GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
GO_REF:0000041
PMID:1694852
(PMID:19965590) 		Ensembl
InterPro
GO_Central
UniProt
RGD		 PMID:19965590 PMID:2335522 PMID:1694852 GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107, RGD:70535, RGD:70534 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 involved_in TAS
ISO
IBA
IEA 		(PMID:10748047)
GO_REF:0000033
GO_REF:0000041
GO_REF:0000107 		RGD
GO_Central
UniProt
Ensembl		 PMID:10748047 PMID:12029625 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107, RGD:1298868 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 involved_in ISO (PMID:14643796)
(PMID:12393855) 		RGD PMID:12393855 PMID:14643796 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 acts_upstream_of_or_within ISO
IEA 		MGI:3769404 (PMID:22912762)
GO_REF:0000107 		RGD
Ensembl		 PMID:22912762 GO_REF:0000107 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Hnf1a HNF1 homeobox A acts_upstream_of_or_within ISO
IEA 		MGI:2384427 (PMID:11279518)
GO_REF:0000107 		RGD
Ensembl		 PMID:11279518 GO_REF:0000107 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104 		JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 involved_in ISO
IEA
ISS 		(PMID:12917011)
GO_REF:0000107
GO_REF:0000024
GO_REF:0000041 		RGD
Ensembl
UniProt		 PMID:12917011 GO_REF:0000024 GO_REF:0000041 GO_REF:0000107 NCBI chr  X:21,089,142...21,091,603
Ensembl chr  X:21,089,122...21,109,488 		JBrowse link
G Pex2 peroxisomal biogenesis factor 2 acts_upstream_of_or_within ISO MGI:2180128 (PMID:14673138) RGD PMID:14673138 NCBI chr 2:97,957,479...97,973,767
Ensembl chr 2:96,045,958...96,073,404 		JBrowse link
G Slc27a2 solute carrier family 27 member 2 involved_in ISO
IEA 		(PMID:11980911)
GO_REF:0000107 		RGD
Ensembl		 PMID:11980911 GO_REF:0000107 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208 		JBrowse link
G Slc27a5 solute carrier family 27 member 5 involved_in ISO
IEA 		(PMID:11980911)
GO_REF:0000107 		RGD
Ensembl		 PMID:11980911 GO_REF:0000107 NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172 		JBrowse link
G Star steroidogenic acute regulatory protein IDA RGD PMID:15382124 RGD:1600081 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
negative regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf19 fibroblast growth factor 19 involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:12815072)
GO_REF:0000107
MGI:1928271 (PMID:23747249) 		RGD
Ensembl		 PMID:12815072 PMID:23747249 GO_REF:0000107 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287 		JBrowse link
G Malrd1 MAM and LDL receptor class A domain containing 1 acts_upstream_of_or_within ISO
IEA 		MGI:1096383|MGI:2154956 (PMID:23747249)
GO_REF:0000107 		RGD
Ensembl		 PMID:23747249 GO_REF:0000107 NCBI chr17:78,418,819...79,131,015
Ensembl chr17:78,418,819...79,131,016 		JBrowse link
G Mir33 microRNA 33 involved_in ISO (PMID:23536474) RGD PMID:23536474 NCBI chr 7:113,713,855...113,713,923
Ensembl chr 7:113,713,855...113,713,923 		JBrowse link
G Prox1 prospero homeobox 1 involved_in ISO
IEA 		(PMID:16488887)
GO_REF:0000107 		RGD
Ensembl		 PMID:16488887 GO_REF:0000107 NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183 		JBrowse link
positive regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 involved_in IEA
ISS
ISO 		GO_REF:0000107
GO_REF:0000024
(PMID:18565334), (PMID:19721697) 		Ensembl
UniProt
RGD		 PMID:18565334 PMID:19721697 GO_REF:0000024 GO_REF:0000107 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Star steroidogenic acute regulatory protein involved_in ISO (PMID:18403318) RGD PMID:18403318 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 involved_in ISO
IEA 		(PMID:18403318)
GO_REF:0000107 		RGD
Ensembl		 PMID:18403318 GO_REF:0000107 NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024 		JBrowse link
regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D involved_in ISO (PMID:18599737) RGD PMID:18599737 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 involved_in ISO
IDA
IEA 		(PMID:19965590)
PMID:1694852
GO_REF:0000107 		RGD
Ensembl		 PMID:19965590 PMID:1694852 GO_REF:0000107, RGD:70534 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 involved_in ISO
ISS
IEA
IBA 		(PMID:17623664), (PMID:20683963)
GO_REF:0000024
GO_REF:0000107
GO_REF:0000033
(PMID:10809780) 		RGD
UniProt
Ensembl
GO_Central		 PMID:10809780 PMID:17623664 PMID:20683963 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242 		JBrowse link
G Sirt1 sirtuin 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:20375098) 		Ensembl
RGD		 PMID:20375098 GO_REF:0000107 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      metabolic process 12158
        primary metabolic process 10727
          lipid metabolic process 1485
            steroid metabolic process 374
              bile acid metabolic process 43
                bile acid biosynthetic process 26
                  negative regulation of bile acid biosynthetic process 4
                  positive regulation of bile acid biosynthetic process 3
                  regulation of bile acid biosynthetic process + 11
Path 2
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      metabolic process 12158
        small molecule metabolic process 1944
          organic acid metabolic process 1062
            oxoacid metabolic process 1040
              carboxylic acid metabolic process 1025
                carboxylic acid biosynthetic process 357
                  monocarboxylic acid biosynthetic process 246
                    bile acid biosynthetic process 26
                      negative regulation of bile acid biosynthetic process 4
                      positive regulation of bile acid biosynthetic process 3
                      regulation of bile acid biosynthetic process + 11
paths to the root