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ONTOLOGY REPORT - ANNOTATIONS


Term:bile acid biosynthetic process
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Accession:GO:0006699 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
Synonyms:exact_synonym: bile acid anabolism;   bile acid biosynthesis;   bile acid formation;   bile acid synthesis



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bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd3 ATP binding cassette subfamily D member 3 involved_in ISO
ISS
(MGI:5613029|PMID:25168382)
GO_REF:0000024
RGD
UniProt
PMID:25168382 GO_REF:0000024 MGI:5613029 NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020
JBrowse link
G Acox2 acyl-CoA oxidase 2 involved_in ISO
IEA
ISS
(PMID:27884763)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:27884763 GO_REF:0000024 GO_REF:0000107 NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 involved_in
acts_upstream_of_or_within
ISO
IEA
(PMID:7508385)
GO_REF:0000107
GO_REF:0000002
RGD
Ensembl
InterPro
PMID:7508385 GO_REF:0000002 GO_REF:0000107 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372
JBrowse link
G Amacr alpha-methylacyl-CoA racemase involved_in IDA
IEA
GO_REF:0000041 UniProt
RGD
PMID:11964182 GO_REF:0000041, RGD:704372 NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255
JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase involved_in ISO (PMID:12810727), (PMID:8034703) RGD PMID:8034703 PMID:12810727 NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 involved_in IEA
ISS
ISO
GO_REF:0000041
GO_REF:0000024
(PMID:11412116), (PMID:9660774)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:9660774 PMID:11412116 GO_REF:0000024 GO_REF:0000041 GO_REF:0000107 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 involved_in ISO
IBA
(PMID:10748047)
GO_REF:0000033
(MGI:1859119|PMID:10748047)
RGD
GO_Central
PMID:10748047 GO_REF:0000033 MGI:1859119 NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775
JBrowse link
G Cyp51 cytochrome P450, family 51 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 involved_in TAS
IBA
IEA
IDA
ISO
GO_REF:0000033
GO_REF:0000041
PMID:1694852
(PMID:19965590)
GO_Central
UniProt
RGD
PMID:19965590 PMID:2335522 PMID:1694852 GO_REF:0000033 GO_REF:0000041, RGD:70535, RGD:70534 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 involved_in TAS
IEA
IBA
ISO
GO_REF:0000118
GO_REF:0000033
(MGI:1859119|PMID:10748047)
GO_REF:0000041
GO_REF:0000107
TreeGrafter
GO_Central
RGD
UniProt
Ensembl
PMID:10748047 PMID:12029625 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 GO_REF:0000118 MGI:1859119, RGD:1298868 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 involved_in ISO (PMID:14643796)
(MGI:3588413|PMID:12393855)
RGD PMID:12393855 PMID:14643796 MGI:3588413 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 acts_upstream_of_or_within
involved_in
ISO
IEA
MGI:3769404 (MGI:5447601|PMID:22912762)
GO_REF:0000107
RGD
Ensembl
PMID:22912762 GO_REF:0000107 MGI:5447601 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
JBrowse link
G Hnf1a HNF1 homeobox A acts_upstream_of_or_within ISO MGI:2384427 (MGI:1933035|PMID:11279518) RGD PMID:11279518 MGI:1933035 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 involved_in ISO
IEA
ISS
(PMID:12917011)
GO_REF:0000107
GO_REF:0000024
GO_REF:0000041
RGD
Ensembl
UniProt
PMID:12917011 GO_REF:0000024 GO_REF:0000041 GO_REF:0000107 NCBI chr  X:21,089,142...21,091,603
Ensembl chr  X:21,089,122...21,109,488
JBrowse link
G Pex2 peroxisomal biogenesis factor 2 acts_upstream_of_or_within ISO MGI:2180128 (MGI:3027293|PMID:14673138) RGD PMID:14673138 MGI:3027293 NCBI chr 2:96,050,380...96,072,928
Ensembl chr 2:96,045,958...96,073,404
JBrowse link
G Slc27a2 solute carrier family 27 member 2 involved_in ISO
IEA
(PMID:11980911)
GO_REF:0000107
RGD
Ensembl
PMID:11980911 GO_REF:0000107 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
JBrowse link
G Slc27a5 solute carrier family 27 member 5 involved_in ISO (PMID:11980911) RGD PMID:11980911 NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172
JBrowse link
G Star steroidogenic acute regulatory protein IDA RGD PMID:15382124 RGD:1600081 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
negative regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf19 fibroblast growth factor 19 involved_in
acts_upstream_of_or_within
ISO (PMID:12815072)
MGI:1928271 (MGI:5501367|PMID:23747249)
RGD PMID:12815072 PMID:23747249 MGI:5501367 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G Malrd1 MAM and LDL receptor class A domain containing 1 acts_upstream_of_or_within ISO MGI:1096383|MGI:2154956 (MGI:5501367|PMID:23747249) RGD PMID:23747249 MGI:5501367 NCBI chr17:78,418,819...79,131,015
Ensembl chr17:78,418,819...79,131,016
JBrowse link
G Mir33 microRNA 33 involved_in ISO (PMID:23536474) RGD PMID:23536474 NCBI chr 7:113,713,855...113,713,923
Ensembl chr 7:113,713,855...113,713,923
JBrowse link
G Prox1 prospero homeobox 1 involved_in ISO (PMID:16488887) RGD PMID:16488887 NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183
JBrowse link
positive regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:3819720|PMID:18565334), (MGI:4360821|PMID:19721697)
Ensembl
UniProt
RGD
PMID:18565334 PMID:19721697 GO_REF:0000024 GO_REF:0000107 MGI:3819720 MGI:4360821 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
JBrowse link
G Star steroidogenic acute regulatory protein involved_in ISO (PMID:18403318) RGD PMID:18403318 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 involved_in ISO (PMID:18403318) RGD PMID:18403318 NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024
JBrowse link
regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D involved_in ISO (PMID:18599737) RGD PMID:18599737 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 involved_in ISO
IDA
(PMID:19965590)
PMID:1694852
RGD PMID:19965590 PMID:1694852 RGD:70534 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 involved_in ISO
ISS
IEA
IBA
(PMID:17623664), (PMID:20683963)
GO_REF:0000024
(MGI:1858658|PMID:10809780)
GO_REF:0000107
GO_REF:0000118
GO_REF:0000033
RGD
UniProt
Ensembl
TreeGrafter
GO_Central
PMID:10809780 PMID:17623664 PMID:20683963 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 MGI:1858658 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA
(MGI:5014028|PMID:20375098)
GO_REF:0000107
RGD
Ensembl
PMID:20375098 GO_REF:0000107 MGI:5014028 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20335
    metabolic process 11743
      organic substance metabolic process 11237
        organic hydroxy compound metabolic process 611
          bile acid metabolic process 44
            bile acid biosynthetic process 27
              negative regulation of bile acid biosynthetic process 4
              positive regulation of bile acid biosynthetic process 3
              regulation of bile acid biosynthetic process + 11
Path 2
Term Annotations click to browse term
  biological_process 20335
    cellular process 18799
      cellular metabolic process 10298
        organic acid metabolic process 1074
          oxoacid metabolic process 1056
            carboxylic acid metabolic process 1037
              carboxylic acid biosynthetic process 331
                monocarboxylic acid biosynthetic process 228
                  bile acid biosynthetic process 27
                    negative regulation of bile acid biosynthetic process 4
                    positive regulation of bile acid biosynthetic process 3
                    regulation of bile acid biosynthetic process + 11
paths to the root