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ONTOLOGY REPORT - ANNOTATIONS


Term:leukotriene metabolic process
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Accession:GO:0006691 term browser browse the term
Definition:The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
Synonyms:exact_synonym: leukotriene metabolism
 never_in_taxon: NCBITaxon:4751 ! Fungi



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leukotriene metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc10 ATP binding cassette subfamily C member 10 involved_in ISO (PMID:23087055) RGD PMID:23087055 NCBI chr 9:14,657,242...14,677,178
Ensembl chr 9:14,657,264...14,677,178
JBrowse link
G Alox5 arachidonate 5-lipoxygenase acts_upstream_of_or_within ISO MGI:1857125 (PMID:11867678) RGD PMID:11867678 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Cpa1 carboxypeptidase A1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 4:59,257,417...59,263,544
Ensembl chr 4:59,257,417...59,263,544
JBrowse link
G Cyp4f5 cytochrome P450, family 4, subfamily f, polypeptide 5 IMP RGD PMID:12646265 RGD:1299398 NCBI chr 7:11,544,040...11,558,982
Ensembl chr 7:11,544,082...11,558,978
JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 IMP RGD PMID:12646265 RGD:1299398 NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782
JBrowse link
G Dpep1 dipeptidase 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:1203838|PMID:9560193), (MGI:2669357|PMID:12738806)
UniProt
RGD
PMID:9560193 PMID:12738806 GO_REF:0000024 MGI:1203838 MGI:2669357 NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257
JBrowse link
G Dpep2 dipeptidase 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:2669357|PMID:12738806)
UniProt
RGD
PMID:12738806 GO_REF:0000024 MGI:2669357 NCBI chr19:33,883,557...33,896,487
Ensembl chr19:33,885,478...33,891,954
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 involved_in ISO (PMID:21447318) RGD PMID:21447318 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Lta4h leukotriene A4 hydrolase IDA RGD PMID:3995081 RGD:2316605 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
JBrowse link
G Ltc4s leukotriene C4 synthase involved_in
acts_upstream_of_or_within
ISO (PMID:9153254)
(PMID:8706658)
RGD PMID:8706658 PMID:9153254 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
JBrowse link
G Mgst3l1 microsomal glutathione S-transferase 3 like 1 involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr14:19,525,509...19,526,128
Ensembl chr14:19,525,558...19,526,016
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 acts_upstream_of_or_within ISO MGI:1934143 (PMID:11867678) RGD PMID:11867678 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Tlr2 toll-like receptor 2 IDA RGD PMID:21765618 RGD:7241098 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 IDA RGD PMID:21765618 RGD:7241098 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
leukotriene A4 biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:24282679), (PMID:31664810)
(MGI:6392995|PMID:31642348)
UniProt
Ensembl
RGD
PMID:24282679 PMID:31642348 PMID:31664810 GO_REF:0000024 GO_REF:0000107 MGI:6392995 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
leukotriene A4 metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type involved_in
NOT|involved_in
ISO
ISS
(PMID:8250832)
GO_REF:0000024
(PMID:1851637)
RGD
UniProt
PMID:1851637 PMID:8250832 GO_REF:0000024 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
JBrowse link
leukotriene B4 catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 involved_in IDA
IBA
PMID:14634044
GO_REF:0000033
PMID:10486137
GO_Central PMID:14634044 PMID:10486137 GO_REF:0000033, RGD:2301710, RGD:2301713 NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 involved_in ISO (PMID:11461919), (PMID:9675028) RGD PMID:9675028 PMID:11461919 NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940
JBrowse link
G Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 involved_in IDA
IBA
PMID:9344476
GO_REF:0000033
PMID:14634044
GO_Central PMID:9344476 PMID:14634044 GO_REF:0000033, RGD:15090848, RGD:2301710 NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506
JBrowse link
G Cyp4f40 cytochrome P450, family 4, subfamily f, polypeptide 40 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:11,691,648...11,707,437
Ensembl chr 7:11,692,086...11,706,229
JBrowse link
leukotriene B4 metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 involved_in ISO
ISS
IEA
(MGI:3640626|PMID:16380383)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:16380383 GO_REF:0000024 GO_REF:0000107 MGI:3640626 NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940
JBrowse link
G Ptgr1 prostaglandin reductase 1 involved_in ISS
IDA
ISO
GO_REF:0000024
(PMID:8394361)
UniProt
RGD
PMID:8394361 PMID:9667737 GO_REF:0000024, RGD:401959219 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
JBrowse link
leukotriene biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase acts_upstream_of_or_within
involved_in
TAS
ISO
ISS
(PMID:19075240)
(MGI:1933116|PMID:7809134)
GO_REF:0000024
(PMID:21233389), (PMID:24893149)
RGD
UniProt
PMID:7809134 PMID:19075240 PMID:21233389 PMID:24893149 PMID:3417684 GO_REF:0000024 MGI:1933116, RGD:632194 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
MGI:2156546 (PMID:19075240), (PMID:9091580)
GO_REF:0000033
(PMID:2300173)
RGD
GO_Central
PMID:2300173 PMID:9091580 PMID:19075240 PMID:2300173 PMID:19075240 GO_REF:0000033, RGD:69749, RGD:2313889 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
JBrowse link
G Fcer1a Fc epsilon receptor Ia acts_upstream_of_or_within ISO (PMID:9000133) RGD PMID:9000133 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351
JBrowse link
G Lta4h leukotriene A4 hydrolase involved_in ISO
IBA
ISS
(PMID:11675384), (PMID:15078870), (PMID:9774412)
GO_REF:0000033
GO_REF:0000024
RGD
GO_Central
UniProt
PMID:9774412 PMID:11675384 PMID:15078870 GO_REF:0000024 GO_REF:0000033 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
JBrowse link
G Ltc4s leukotriene C4 synthase involved_in TAS
IEA
IBA
IDA
GO_REF:0000104
GO_REF:0000033
UniProt
GO_Central
RGD
PMID:12767051 PMID:14637132 GO_REF:0000033 GO_REF:0000104, RGD:724432, RGD:2302289 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 involved_in ISO
IBA
(PMID:23409838), (PMID:8703034), (PMID:9092565)
GO_REF:0000033
RGD
GO_Central
PMID:8703034 PMID:9092565 PMID:23409838 GO_REF:0000033 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 involved_in ISO (PMID:9278457) RGD PMID:9278457 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411
JBrowse link
G Pla2g1b phospholipase A2 group IB involved_in ISO (PMID:16005851) RGD PMID:16005851 NCBI chr12:41,142,193...41,151,967
Ensembl chr12:41,142,200...41,153,226
JBrowse link
G Pla2g4a phospholipase A2 group 4A involved_in ISO
IEA
(PMID:18451993)
GO_REF:0000043
GO_REF:0000107
(MGI:1100763|PMID:9403693)
RGD
UniProt
Ensembl
PMID:9403693 PMID:18451993 GO_REF:0000043 GO_REF:0000107 MGI:1100763 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Pla2g5 phospholipase A2, group V involved_in IDA
IEA
ISO
GO_REF:0000107
(PMID:20432503)
Ensembl
RGD
PMID:20432503 PMID:11106649 GO_REF:0000107, RGD:2303037 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658
JBrowse link
G Prg3 proteoglycan 3, pro eosinophil major basic protein 2 involved_in ISO (PMID:10318872) RGD PMID:10318872 NCBI chr 3:70,071,970...70,078,103
Ensembl chr 3:70,072,497...70,078,102
JBrowse link
G Syk spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2384078 (PMID:9000133)
Ensembl
RGD
PMID:9000133 GO_REF:0000107 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link
leukotriene D4 biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ggt1 gamma-glutamyltransferase 1 involved_in ISO (PMID:14754911), (PMID:21447318) RGD PMID:14754911 PMID:21447318 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Ggt5 gamma-glutamyltransferase 5 involved_in
acts_upstream_of_or_within
ISO
IBA
IEA
ISS
(PMID:1676842), (PMID:21447318)
MGI:2182354 (PMID:12163373), (PMID:9774450)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024
RGD
GO_Central
Ensembl
UniProt
PMID:1676842 PMID:9774450 PMID:12163373 PMID:21447318 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr20:13,043,255...13,071,523
Ensembl chr20:13,043,257...13,071,450
JBrowse link
leukotriene D4 catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpep1 dipeptidase 1 involved_in ISO
ISS
(PMID:32325220)
GO_REF:0000024
RGD
UniProt
PMID:32325220 GO_REF:0000024 NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257
JBrowse link
G Dpep2 dipeptidase 2 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:32325220)
UniProt
Ensembl
RGD
PMID:32325220 GO_REF:0000024 GO_REF:0000107 NCBI chr19:33,883,557...33,896,487
Ensembl chr19:33,885,478...33,891,954
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19872
    metabolic process 11602
      cellular metabolic process 9669
        organic acid metabolic process 1025
          oxoacid metabolic process 1014
            carboxylic acid metabolic process 999
              icosanoid metabolic process 143
                leukotriene metabolic process 30
                  leukotriene A4 metabolic process + 2
                  leukotriene B4 metabolic process + 5
                  leukotriene D4 metabolic process + 4
                  leukotriene biosynthetic process + 14
                  leukotriene catabolic process + 6
paths to the root