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ONTOLOGY REPORT - ANNOTATIONS


Term:leukotriene metabolic process
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Accession:GO:0006691 term browser browse the term
Definition:The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
Synonyms:exact_synonym: leukotriene metabolism


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leukotriene metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc10 ATP binding cassette subfamily C member 10 involved_in ISO
IEA
(PMID:23087055)
GO_REF:0000107
RGD
Ensembl
PMID:23087055 GO_REF:0000107 NCBI chr 9:17,041,351...17,061,263
Ensembl chr 9:17,041,389...17,063,780
JBrowse link
G Alox5 arachidonate 5-lipoxygenase acts_upstream_of_or_within ISO MGI:1857125 (MGI:2176389|PMID:11867678) RGD PMID:11867678 MGI:2176389 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Cpa1 carboxypeptidase A1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 4:57,952,982...57,959,109
Ensembl chr 4:57,952,982...57,959,109
JBrowse link
G Cyp4f5 cytochrome P450, family 4, subfamily f, polypeptide 5 IMP RGD PMID:12646265 RGD:1299398 NCBI chr 7:14,559,806...14,574,345
Ensembl chr 7:14,529,482...14,574,361
JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 IMP RGD PMID:12646265 RGD:1299398 NCBI chr 7:15,198,950...15,225,547
Ensembl chr 7:15,198,940...15,225,410
JBrowse link
G Dpep1 dipeptidase 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:1203838|PMID:9560193), (MGI:2669357|PMID:12738806)
UniProt
RGD
PMID:9560193 PMID:12738806 GO_REF:0000024 MGI:1203838 MGI:2669357 NCBI chr19:55,973,447...55,998,830
Ensembl chr19:55,982,740...55,998,208
JBrowse link
G Dpep2 dipeptidase 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:2669357|PMID:12738806)
UniProt
RGD
PMID:12738806 GO_REF:0000024 MGI:2669357 NCBI chr19:37,964,098...37,975,154
Ensembl chr19:37,964,105...37,970,537
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 involved_in ISO (PMID:21447318) RGD PMID:21447318 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Lta4h leukotriene A4 hydrolase IDA RGD PMID:3995081 RGD:2316605 NCBI chr 7:34,288,333...34,320,243
Ensembl chr 7:34,288,365...34,320,235
JBrowse link
G Ltc4s leukotriene C4 synthase acts_upstream_of_or_within
involved_in
ISO (PMID:8706658), (PMID:9153254)
(MGI:81677|PMID:8706658)
RGD PMID:8706658 PMID:9153254 MGI:81677 NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 acts_upstream_of_or_within ISO MGI:1934143 (MGI:2176389|PMID:11867678) RGD PMID:11867678 MGI:2176389 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Tlr2 toll-like receptor 2 IDA RGD PMID:21765618 RGD:7241098 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 IDA RGD PMID:21765618 RGD:7241098 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
leukotriene A4 biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase involved_in ISO
ISS
IEA
(PMID:24282679), (PMID:31664810)
GO_REF:0000024
GO_REF:0000107
(MGI:6392995|PMID:31642348)
RGD
UniProt
Ensembl
PMID:24282679 PMID:31642348 PMID:31664810 GO_REF:0000024 GO_REF:0000107 MGI:6392995 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
leukotriene A4 metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type involved_in
NOT|involved_in
ISO
ISS
(PMID:8250832)
GO_REF:0000024
(PMID:1851637)
RGD
UniProt
PMID:1851637 PMID:8250832 GO_REF:0000024 NCBI chr10:56,851,734...56,864,049
Ensembl chr10:56,851,734...56,864,005
JBrowse link
leukotriene B4 catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 involved_in IDA
IBA
PMID:10486137
PMID:21873635
PMID:14634044
UniProt
GO_Central
PMID:10486137, PMID:21873635, PMID:10486137, PMID:14634044, PMID:21873635, PMID:14634044 RGD:2301713, RGD:13792537, RGD:2301713, RGD:2301710, RGD:13792537, RGD:2301710 NCBI chr 7:15,179,472...15,191,113
Ensembl chr 7:15,179,467...15,190,796
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr16:19,501,680...19,528,935
Ensembl chr16:19,410,810...19,528,999
JBrowse link
G Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 involved_in IDA
IBA
PMID:14634044
PMID:9344476
PMID:21873635
UniProt
GO_Central
PMID:14634044, PMID:14634044, PMID:9344476, PMID:21873635, PMID:21873635, PMID:9344476 RGD:2301710, RGD:2301710, RGD:15090848, RGD:13792537, RGD:13792537, RGD:15090848 NCBI chr 7:14,891,062...14,907,250
Ensembl chr 7:14,891,001...14,907,305
JBrowse link
G Cyp4f40 cytochrome P450, family 4, subfamily f, polypeptide 40 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 7:14,865,941...14,880,084
Ensembl chr 7:14,865,941...14,880,084
JBrowse link
leukotriene B4 metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgr1 prostaglandin reductase 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
leukotriene biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase involved_in
acts_upstream_of_or_within
TAS
ISO
ISS
(MGI:1933116|PMID:7809134)
MGI:1933120 (MGI:3821938|PMID:19075240), (MGI:86611|PMID:9091580)
GO_REF:0000024
(PMID:21233389), (PMID:24893149)
MGI:1933120 (MGI:1933116|PMID:7809134), (MGI:3821938|PMID:19075240), (MGI:86611|PMID:9091580)
RGD
UniProt
PMID:7809134 PMID:9091580 PMID:19075240 PMID:21233389 PMID:24893149, PMID:3417684 GO_REF:0000024 MGI:1933116 MGI:3821938 MGI:86611, RGD:632194 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
MGI:2156546 (MGI:3821938|PMID:19075240), (MGI:86611|PMID:9091580)
PMID:21873635
(PMID:2300173)
RGD PMID:2300173 PMID:9091580 PMID:19075240, PMID:2300173, PMID:21873635, PMID:21873635, PMID:19075240 MGI:3821938 MGI:86611, RGD:69749, RGD:13792537, RGD:13792537, RGD:2313889 NCBI chr12:6,854,930...6,879,112
Ensembl chr12:6,854,920...6,879,154
JBrowse link
G Fcer1a Fc fragment of IgE receptor Ia acts_upstream_of_or_within ISO (MGI:85068|PMID:9000133) RGD PMID:9000133 MGI:85068 NCBI chr13:91,727,253...91,737,106
Ensembl chr13:91,730,925...91,737,053
JBrowse link
G Lta4h leukotriene A4 hydrolase involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:11675384), (PMID:15078870), (PMID:9774412)
UniProt
RGD
PMID:9774412 PMID:11675384 PMID:15078870, PMID:21873635, PMID:21873635 GO_REF:0000024, RGD:13792537, RGD:13792537 NCBI chr 7:34,288,333...34,320,243
Ensembl chr 7:34,288,365...34,320,235
JBrowse link
G Ltc4s leukotriene C4 synthase involved_in TAS
IBA
IDA
PMID:21873635 RGD
GO_Central
PMID:12767051, PMID:21873635, PMID:21873635, PMID:14637132 RGD:724432, RGD:13792537, RGD:13792537, RGD:2302289 NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 involved_in ISO
IBA
(PMID:23409838), (PMID:8703034), (PMID:9092565)
PMID:21873635
RGD PMID:8703034 PMID:9092565 PMID:23409838, PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 2:140,708,396...140,727,381
Ensembl chr 2:140,708,397...140,727,281
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 involved_in ISO (PMID:9278457) RGD PMID:9278457 NCBI chr13:85,601,499...85,622,392
Ensembl chr13:85,601,499...85,622,314
JBrowse link
G Pla2g1b phospholipase A2 group IB involved_in ISO (PMID:16005851) RGD PMID:16005851 NCBI chr12:46,879,346...46,890,234
Ensembl chr12:46,879,343...46,889,082
JBrowse link
G Pla2g4a phospholipase A2 group IVA involved_in ISO
IEA
(PMID:18451993)
(MGI:1100763|PMID:9403693)
GO_REF:0000107
RGD
Ensembl
PMID:9403693 PMID:18451993 GO_REF:0000107 MGI:1100763 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Pla2g5 phospholipase A2, group V involved_in IDA
ISO
(PMID:20432503) RGD PMID:20432503, PMID:11106649 RGD:2303037 NCBI chr 5:157,247,601...157,268,968
Ensembl chr 5:157,247,781...157,268,903
JBrowse link
G Prg3 proteoglycan 3, pro eosinophil major basic protein 2 involved_in ISO (PMID:10318872) RGD PMID:10318872 NCBI chr 3:72,395,194...72,401,254
Ensembl chr 3:72,395,218...72,401,318
JBrowse link
G Syk spleen associated tyrosine kinase acts_upstream_of_or_within
involved_in
IEA
ISO
GO_REF:0000107
MGI:2384078 (MGI:85068|PMID:9000133)
Ensembl
RGD
PMID:9000133 GO_REF:0000107 MGI:85068 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
leukotriene D4 biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07044631.2 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 Ensembl chr20:13,988,442...14,001,269 JBrowse link
G Ggt1 gamma-glutamyltransferase 1 involved_in ISO (PMID:14754911), (PMID:21447318) RGD PMID:14754911 PMID:21447318 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Ggt5 gamma-glutamyltransferase 5 acts_upstream_of_or_within
involved_in
ISO
IBA
ISS
(PMID:1676842), (PMID:21447318)
MGI:2182354 (MGI:1306746|PMID:9774450), (MGI:2384601|PMID:12163373)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:1676842 PMID:9774450 PMID:12163373 PMID:21447318, PMID:21873635, PMID:21873635 GO_REF:0000024 MGI:1306746 MGI:2384601, RGD:13792537, RGD:13792537 NCBI chr20:13,988,444...14,001,296 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20082
    metabolic process 12142
      cellular metabolic process 11078
        organic acid metabolic process 1018
          oxoacid metabolic process 980
            carboxylic acid metabolic process 961
              icosanoid metabolic process 139
                leukotriene metabolic process 30
                  leukotriene A4 metabolic process + 2
                  leukotriene B4 metabolic process + 5
                  leukotriene D4 metabolic process + 3
                  leukotriene biosynthetic process + 15
                  leukotriene catabolic process + 4
paths to the root