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ONTOLOGY REPORT - ANNOTATIONS

Term:leukotriene metabolic process
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Accession:GO:0006691 term browser browse the term
Definition:The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
Synonyms:exact_synonym: leukotriene metabolism
 never_in_taxon: NCBITaxon:4751 ! Fungi


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leukotriene metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc10 ATP binding cassette subfamily C member 10 involved_in ISO (PMID:23087055) RGD PMID:23087055 NCBI chr 9:14,657,242...14,677,178
Ensembl chr 9:14,657,264...14,677,178 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase acts_upstream_of_or_within ISO MGI:1857125 (MGI:2176389|PMID:11867678) RGD PMID:11867678 MGI:2176389 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Cpa1 carboxypeptidase A1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 4:59,257,417...59,263,544
Ensembl chr 4:59,257,417...59,263,544 		JBrowse link
G Cyp4f5 cytochrome P450, family 4, subfamily f, polypeptide 5 IMP RGD PMID:12646265 RGD:1299398 NCBI chr 7:11,544,040...11,558,982
Ensembl chr 7:11,544,082...11,558,978 		JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 IMP RGD PMID:12646265 RGD:1299398 NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782 		JBrowse link
G Dpep1 dipeptidase 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:1203838|PMID:9560193), (MGI:2669357|PMID:12738806)		 UniProt
RGD		 PMID:9560193 PMID:12738806 GO_REF:0000024 MGI:1203838 MGI:2669357 NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257 		JBrowse link
G Dpep2 dipeptidase 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:2669357|PMID:12738806)		 UniProt
RGD		 PMID:12738806 GO_REF:0000024 MGI:2669357 NCBI chr19:33,883,557...33,896,487
Ensembl chr19:33,885,478...33,891,954 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 involved_in ISO (PMID:21447318) RGD PMID:21447318 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Lta4h leukotriene A4 hydrolase IDA RGD PMID:3995081 RGD:2316605 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600 		JBrowse link
G Ltc4s leukotriene C4 synthase acts_upstream_of_or_within
involved_in		 ISO (MGI:81677|PMID:8706658)
(PMID:8706658)
(PMID:9153254)		 RGD PMID:8706658 PMID:9153254 MGI:81677 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 acts_upstream_of_or_within ISO MGI:1934143 (MGI:2176389|PMID:11867678) RGD PMID:11867678 MGI:2176389 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Tlr2 toll-like receptor 2 IDA RGD PMID:21765618 RGD:7241098 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 IDA RGD PMID:21765618 RGD:7241098 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
leukotriene A4 biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:24282679), (PMID:31664810)
(MGI:6392995|PMID:31642348)		 UniProt
Ensembl
RGD		 PMID:24282679 PMID:31642348 PMID:31664810 GO_REF:0000024 GO_REF:0000107 MGI:6392995 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
leukotriene A4 metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type involved_in
NOT|involved_in		 ISO
ISS		 (PMID:8250832)
GO_REF:0000024
(PMID:1851637)		 RGD
UniProt		 PMID:1851637 PMID:8250832 GO_REF:0000024 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
leukotriene B4 catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 involved_in IDA PMID:14634044
PMID:10486137		 UniProt PMID:14634044 PMID:10486137 RGD:2301710, RGD:2301713 NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046 		JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 involved_in ISO (PMID:11461919), (PMID:9675028) RGD PMID:9675028 PMID:11461919 NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940 		JBrowse link
G Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 involved_in IDA PMID:9344476
PMID:14634044		 UniProt PMID:9344476 PMID:14634044 RGD:15090848, RGD:2301710 NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506 		JBrowse link
leukotriene B4 metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 involved_in ISO
ISS
IEA		 (MGI:3640626|PMID:16380383)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:16380383 GO_REF:0000024 GO_REF:0000107 MGI:3640626 NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940 		JBrowse link
G Ptgr1 prostaglandin reductase 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:8394361)		 UniProt
RGD		 PMID:8394361 GO_REF:0000024 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666 		JBrowse link
leukotriene biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase acts_upstream_of_or_within
involved_in		 TAS
ISO
ISS		 (MGI:3821938|PMID:19075240)
(MGI:1933116|PMID:7809134)
GO_REF:0000024
(PMID:21233389), (PMID:24893149)		 RGD
UniProt		 PMID:7809134 PMID:19075240 PMID:21233389 PMID:24893149 PMID:3417684 GO_REF:0000024 MGI:1933116 MGI:3821938, RGD:632194 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein involved_in
acts_upstream_of_or_within		 IDA
IBA
ISO		 PMID:21873635
MGI:2156546 (MGI:3821938|PMID:19075240), (MGI:86611|PMID:9091580)
(PMID:2300173)		 RGD PMID:2300173 PMID:9091580 PMID:19075240 PMID:2300173 PMID:21873635 More... MGI:3821938 MGI:86611, RGD:69749, RGD:13792537, RGD:2313889 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986 		JBrowse link
G Fcer1a Fc epsilon receptor Ia acts_upstream_of_or_within ISO (MGI:85068|PMID:9000133) RGD PMID:9000133 MGI:85068 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351 		JBrowse link
G Lta4h leukotriene A4 hydrolase involved_in ISO
IBA
ISS		 (PMID:11675384), (PMID:15078870), (PMID:9774412)
PMID:21873635
GO_REF:0000024		 RGD
UniProt		 PMID:9774412 PMID:11675384 PMID:15078870 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600 		JBrowse link
G Ltc4s leukotriene C4 synthase involved_in TAS
IEA
IBA
IDA		 GO_REF:0000043
PMID:21873635		 UniProt
RGD		 PMID:12767051 PMID:21873635 PMID:14637132 GO_REF:0000043, RGD:724432, RGD:13792537, RGD:2302289 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 involved_in ISO
IBA		 (PMID:23409838), (PMID:8703034), (PMID:9092565)
PMID:21873635		 RGD PMID:8703034 PMID:9092565 PMID:23409838 PMID:21873635 RGD:13792537 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 involved_in ISO (PMID:9278457) RGD PMID:9278457 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411 		JBrowse link
G Pla2g1b phospholipase A2 group IB involved_in ISO (PMID:16005851) RGD PMID:16005851 NCBI chr12:41,142,193...41,151,967
Ensembl chr12:41,142,200...41,153,226 		JBrowse link
G Pla2g4a phospholipase A2 group IVA involved_in ISO (PMID:18451993)
(MGI:1100763|PMID:9403693)		 RGD PMID:9403693 PMID:18451993 MGI:1100763 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Pla2g5 phospholipase A2, group V involved_in IDA
ISO		 (PMID:20432503) RGD PMID:20432503 PMID:11106649 RGD:2303037 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658 		JBrowse link
G Prg3 proteoglycan 3, pro eosinophil major basic protein 2 involved_in ISO (PMID:10318872) RGD PMID:10318872 NCBI chr 3:70,071,970...70,078,103
Ensembl chr 3:70,072,497...70,078,102 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2384078 (MGI:85068|PMID:9000133)		 Ensembl
RGD		 PMID:9000133 GO_REF:0000107 MGI:85068 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
leukotriene D4 biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ggt1 gamma-glutamyltransferase 1 involved_in ISO (PMID:14754911), (PMID:21447318) RGD PMID:14754911 PMID:21447318 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Ggt5 gamma-glutamyltransferase 5 involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA
ISS		 (PMID:1676842), (PMID:21447318)
GO_REF:0000107
MGI:2182354 (MGI:1306746|PMID:9774450), (MGI:2384601|PMID:12163373)
PMID:21873635
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:1676842 PMID:9774450 PMID:12163373 PMID:21447318 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:1306746 MGI:2384601, RGD:13792537 NCBI chr20:13,043,255...13,071,523
Ensembl chr20:13,043,257...13,071,450 		JBrowse link
leukotriene D4 catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpep1 dipeptidase 1 involved_in ISO
ISS		 (PMID:32325220)
GO_REF:0000024		 RGD
UniProt		 PMID:32325220 GO_REF:0000024 NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257 		JBrowse link
G Dpep2 dipeptidase 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:32325220)		 UniProt
RGD		 PMID:32325220 GO_REF:0000024 NCBI chr19:33,883,557...33,896,487
Ensembl chr19:33,885,478...33,891,954 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19746
    metabolic process 12044
      cellular metabolic process 9531
        organic acid metabolic process 1055
          oxoacid metabolic process 1044
            carboxylic acid metabolic process 1029
              icosanoid metabolic process 135
                leukotriene metabolic process 28
                  leukotriene A4 metabolic process + 2
                  leukotriene B4 metabolic process + 4
                  leukotriene D4 metabolic process + 4
                  leukotriene biosynthetic process + 14
                  leukotriene catabolic process + 5
paths to the root