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ONTOLOGY REPORT - ANNOTATIONS

Term:sphingomyelin catabolic process
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Accession:GO:0006685 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.
Synonyms:exact_synonym: sphingomyelin breakdown;   sphingomyelin catabolism;   sphingomyelin degradation


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sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd1 sphingomyelin phosphodiesterase 1 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:18815062), (PMID:20807762), (PMID:22573858)
PMID:21873635
(MGI:5529577|PMID:23973266)		 RGD PMID:18815062 PMID:20807762 PMID:22573858 PMID:23973266 PMID:21873635 MGI:5529577, RGD:13792537 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5529577|PMID:23973266)
GO_REF:0000107
(MGI:1202145|PMID:9520418)
(PMID:10608884), (PMID:14741383)		 RGD
Ensembl		 PMID:9520418 PMID:10608884 PMID:14741383 PMID:23973266 GO_REF:0000107 MGI:1202145 MGI:5529577 NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:14741383)
(MGI:5529577|PMID:23973266)		 Ensembl
RGD		 PMID:14741383 PMID:23973266 GO_REF:0000107 MGI:5529577 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Smpd4 sphingomyelin phosphodiesterase 4 involved_in ISO
IBA		 (PMID:16517606), (PMID:25180167)
PMID:21873635
(MGI:6450503|PMID:25180167)		 RGD PMID:16517606 PMID:25180167 PMID:21873635 MGI:6450503, RGD:13792537 NCBI chr11:83,362,534...83,386,257
Ensembl chr11:83,362,534...83,386,250 		JBrowse link
G Smpd5 sphingomyelin phosphodiesterase 5 involved_in ISO (MGI:6450238|PMID:21183079) RGD PMID:21183079 MGI:6450238 NCBI chr 7:108,009,182...108,011,767
Ensembl chr 7:108,009,173...108,011,763 		JBrowse link
G Smpdl3a sphingomyelin phosphodiesterase, acid-like 3A NOT|involved_in ISO
ISS		 (PMID:26783088)
GO_REF:0000024		 RGD
UniProt		 PMID:26783088 GO_REF:0000024 NCBI chr20:37,132,592...37,155,567
Ensembl chr20:37,132,592...37,155,567 		JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:144,944,618...144,966,703
Ensembl chr 5:144,944,636...144,966,720 		JBrowse link
positive regulation of sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4947032|PMID:21177474)		 UniProt
RGD		 PMID:21177474 GO_REF:0000024 MGI:4947032 NCBI chr10:104,242,223...104,246,589
Ensembl chr10:104,242,223...104,246,589 		JBrowse link
G Prkcd protein kinase C, delta involved_in ISO
IEA		 (PMID:19279011)
GO_REF:0000107		 RGD
Ensembl		 PMID:19279011 GO_REF:0000107 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19818
    metabolic process 12096
      nitrogen compound metabolic process 8258
        amide metabolic process 1656
          sphingomyelin metabolic process 20
            sphingomyelin catabolic process 9
              positive regulation of sphingomyelin catabolic process 2
              regulation of sphingomyelin catabolic process + 2
Path 2
Term Annotations click to browse term
  biological_process 19818
    metabolic process 12096
      primary metabolic process 8928
        lipid metabolic process 1448
          cellular lipid metabolic process 1052
            membrane lipid metabolic process 200
              sphingolipid metabolic process 151
                sphingomyelin metabolic process 20
                  sphingomyelin catabolic process 9
                    positive regulation of sphingomyelin catabolic process 2
                    regulation of sphingomyelin catabolic process + 2
paths to the root