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ONTOLOGY REPORT - ANNOTATIONS

Term:sphingomyelin metabolic process
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Accession:GO:0006684 term browser browse the term
Definition:The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine.
Synonyms:exact_synonym: sphingomyelin metabolism


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sphingomyelin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3718765|PMID:17488728)		 UniProt
RGD		 PMID:17488728 GO_REF:0000024 MGI:3718765 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537 		JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in ISS
ISO		 GO_REF:0000024
(PMID:12671034), (PMID:12885774), (PMID:28292932)		 UniProt
RGD		 PMID:12671034 PMID:12885774 PMID:28292932 GO_REF:0000024 NCBI chr10:104,242,169...104,247,185
Ensembl chr10:104,242,223...104,246,589 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within		 ISS
ISO
IBA		 GO_REF:0000024
(PMID:10823942)
GO_REF:0000033
(MGI:6450311|PMID:21550973)		 UniProt
RGD
GO_Central		 PMID:10823942 PMID:21550973 GO_REF:0000024 GO_REF:0000033 MGI:6450311 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Smpd5 sphingomyelin phosphodiesterase 5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:108,009,182...108,011,767
Ensembl chr 7:108,009,173...108,011,763 		JBrowse link
positive regulation of sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4947032|PMID:21177474)		 UniProt
RGD		 PMID:21177474 GO_REF:0000024 MGI:4947032 NCBI chr10:104,242,169...104,247,185
Ensembl chr10:104,242,223...104,246,589 		JBrowse link
G Prkcd protein kinase C, delta involved_in ISO
IEA		 (PMID:19279011)
GO_REF:0000107		 RGD
Ensembl		 PMID:19279011 GO_REF:0000107 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
sphingomyelin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 involved_in ISO (PMID:23560799) RGD PMID:23560799 NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988 		JBrowse link
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 acts_upstream_of ISO MGI:1913862 (PMID:31880535) RGD PMID:31880535 NCBI chr 9:48,243,365...48,253,316
Ensembl chr 9:48,237,572...48,253,211 		JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
MGI:2137691|MGI:2181669|MGI:6382064 (PMID:31880535)		 Ensembl
RGD		 PMID:31880535 GO_REF:0000107 NCBI chr10:83,590,052...83,596,035
Ensembl chr10:83,590,071...83,598,620 		JBrowse link
G Osbp oxysterol binding protein involved_in ISO (PMID:12023275) RGD PMID:12023275 NCBI chr 1:208,888,697...208,918,511
Ensembl chr 1:208,887,895...208,918,506 		JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:25667419)		 Ensembl
RGD		 PMID:25667419 GO_REF:0000107 NCBI chr10:44,775,910...44,849,990
Ensembl chr10:44,775,911...44,850,013 		JBrowse link
G Sgms1 sphingomyelin synthase 1 involved_in ISO
IBA
ISS		 (PMID:14685263), (PMID:14976195), (PMID:17982138)
GO_REF:0000033
(MGI:6221394|PMID:27892528)
GO_REF:0000024		 RGD
GO_Central
HGNC-UCL		 PMID:14685263 PMID:14976195 PMID:17982138 PMID:27892528 GO_REF:0000024 GO_REF:0000033 MGI:6221394 NCBI chr 1:229,996,673...230,259,591
Ensembl chr 1:229,998,119...230,259,603 		JBrowse link
G Sgms2 sphingomyelin synthase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
(PMID:25667419)
GO_REF:0000033
(MGI:6221394|PMID:27892528)
(PMID:14685263), (PMID:17982138)		 Ensembl
RGD
GO_Central		 PMID:14685263 PMID:17982138 PMID:25667419 PMID:27892528 GO_REF:0000033 GO_REF:0000107 MGI:6221394 NCBI chr 2:219,889,809...219,967,704
Ensembl chr 2:219,893,572...219,967,546 		JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 involved_in
acts_upstream_of_or_within		 ISO (MGI:5749304|PMID:26301690)
MGI:3815115 (PMID:16216550)		 RGD PMID:16216550 PMID:26301690 MGI:5749304 NCBI chr17:11,877,249...11,916,295
Ensembl chr17:11,877,249...11,916,295 		JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3815117 (PMID:16216550)		 Ensembl
RGD		 PMID:16216550 GO_REF:0000107 NCBI chr 6:106,948,682...107,031,532
Ensembl chr 6:106,950,949...107,031,542 		JBrowse link
G Vapa VAMP associated protein A involved_in ISO (PMID:12023275) RGD PMID:12023275 NCBI chr 9:105,177,904...105,208,400
Ensembl chr 9:105,177,907...105,207,847 		JBrowse link
sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd1 sphingomyelin phosphodiesterase 1 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:18815062), (PMID:20807762), (PMID:22573858)
(PMID:23973266)
GO_REF:0000033		 RGD
GO_Central		 PMID:18815062 PMID:20807762 PMID:22573858 PMID:23973266 GO_REF:0000033 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:10608884), (PMID:14741383)
(PMID:23973266)
GO_REF:0000107
(MGI:1202145|PMID:9520418)		 RGD
Ensembl		 PMID:9520418 PMID:10608884 PMID:14741383 PMID:23973266 GO_REF:0000107 MGI:1202145 NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:23973266)
(PMID:14741383)		 Ensembl
RGD		 PMID:14741383 PMID:23973266 GO_REF:0000107 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Smpd4 sphingomyelin phosphodiesterase 4 involved_in ISO
IBA		 (PMID:16517606), (PMID:25180167)
GO_REF:0000033
(MGI:6450503|PMID:25180167)		 RGD
GO_Central		 PMID:16517606 PMID:25180167 GO_REF:0000033 MGI:6450503 NCBI chr11:83,362,534...83,386,257
Ensembl chr11:83,362,534...83,386,250 		JBrowse link
G Smpd5 sphingomyelin phosphodiesterase 5 involved_in ISO (MGI:6450238|PMID:21183079) RGD PMID:21183079 MGI:6450238 NCBI chr 7:108,009,182...108,011,767
Ensembl chr 7:108,009,173...108,011,763 		JBrowse link
G Smpdl3a sphingomyelin phosphodiesterase, acid-like 3A NOT|involved_in ISO
ISS		 (PMID:26783088)
GO_REF:0000024		 RGD
UniProt		 PMID:26783088 GO_REF:0000024 NCBI chr20:37,132,592...37,155,567
Ensembl chr20:37,132,592...37,155,567 		JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:144,944,618...144,966,703
Ensembl chr 5:144,944,636...144,966,720 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    metabolic process 12289
      amide metabolic process 439
        sphingomyelin metabolic process 20
          sphingomyelin biosynthetic process 10
          sphingomyelin catabolic process + 9
Path 2
Term Annotations click to browse term
  biological_process 20115
    metabolic process 12289
      primary metabolic process 10923
        lipid metabolic process 1460
          cellular lipid metabolic process 1068
            membrane lipid metabolic process 209
              sphingolipid metabolic process 157
                sphingomyelin metabolic process 20
                  sphingomyelin biosynthetic process 10
                  sphingomyelin catabolic process + 9
paths to the root