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ONTOLOGY REPORT - ANNOTATIONS


Term:sphingomyelin metabolic process
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Accession:GO:0006684 term browser browse the term
Definition:The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine.
Synonyms:exact_synonym: sphingomyelin metabolism


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sphingomyelin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 ISS
ISO
GO_REF:0000024
(PMID:12671034), (PMID:12885774), (PMID:28292932)
UniProt
RGD
PMID:12671034, PMID:12885774, PMID:28292932 GO_REF:0000024 NCBI chr10:108,095,131...108,099,483
Ensembl chr10:108,095,131...108,099,483
JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:46,212,070...46,215,183
Ensembl chr20:46,211,892...46,215,120
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 IBA
ISO
ISS
PMID:21873635
(MGI:MGI:1858672|PMID:10823942), (MGI:MGI:6450311|PMID:21550973)
GO_REF:0000024
RGD
UniProt
PMID:10823942, PMID:21550973, PMID:21873635 GO_REF:0000024, MGI:MGI:1858672, MGI:MGI:6450311, RGD:13792537 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link
G Smpd5 sphingomyelin phosphodiesterase 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:117,351,694...117,354,241
Ensembl chr 7:117,351,648...117,354,084
JBrowse link
positive regulation of sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 ISS
ISO
GO_REF:0000024
(MGI:MGI:4947032|PMID:21177474)
UniProt
RGD
PMID:21177474 GO_REF:0000024, MGI:MGI:4947032 NCBI chr10:108,095,131...108,099,483
Ensembl chr10:108,095,131...108,099,483
JBrowse link
G Prkcd protein kinase C, delta ISO
IEA
(PMID:19279011)
GO_REF:0000107
RGD
Ensembl
PMID:19279011 GO_REF:0000107 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
sphingomyelin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 ISO MGI:MGI:1913862 (MGI:MGI:6393026|PMID:31880535) RGD PMID:31880535 MGI:MGI:6393026 NCBI chr 9:53,110,628...53,120,454
Ensembl chr 9:53,111,371...53,118,613
JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 ISO MGI:MGI:2137691|MGI:MGI:2181669|MGI:MGI:6382064 (MGI:MGI:6393026|PMID:31880535) RGD PMID:31880535 MGI:MGI:6393026 NCBI chr10:86,545,910...86,554,478
Ensembl chr10:86,547,339...86,554,478
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase ISO (MGI:MGI:5707904|PMID:25667419) RGD PMID:25667419 MGI:MGI:5707904 NCBI chr10:46,339,821...46,404,640
Ensembl chr10:46,339,821...46,404,642
JBrowse link
G Sgms1 sphingomyelin synthase 1 ISS
ISO
IBA
GO_REF:0000024
(MGI:MGI:6221394|PMID:27892528)
(PMID:14685263), (PMID:14976195), (PMID:17982138)
PMID:21873635
HGNC
RGD
PMID:14685263, PMID:14976195, PMID:17982138, PMID:27892528, PMID:21873635 GO_REF:0000024, MGI:MGI:6221394, RGD:13792537 NCBI chr 1:250,692,448...250,951,685
Ensembl chr 1:250,691,370...250,951,697
JBrowse link
G Sgms2 sphingomyelin synthase 2 IEA
ISO
IBA
GO_REF:0000107
(MGI:MGI:5707904|PMID:25667419), (MGI:MGI:6221394|PMID:27892528)
(PMID:14685263), (PMID:17982138)
PMID:21873635
Ensembl
RGD
PMID:14685263, PMID:17982138, PMID:25667419, PMID:27892528, PMID:21873635 GO_REF:0000107, MGI:MGI:5707904, MGI:MGI:6221394, RGD:13792537 NCBI chr 2:236,458,276...236,530,667
Ensembl chr 2:236,458,279...236,480,502
JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 ISO MGI:MGI:3815115 (MGI:MGI:3814228|PMID:16216550), (MGI:MGI:5749304|PMID:26301690) RGD PMID:16216550, PMID:26301690 MGI:MGI:3814228, MGI:MGI:5749304 NCBI chr17:11,856,525...11,895,566
Ensembl chr17:11,856,525...11,895,566
JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 ISO MGI:MGI:3815117 (MGI:MGI:3814228|PMID:16216550) RGD PMID:16216550 MGI:MGI:3814228 NCBI chr 6:111,334,408...111,417,960
Ensembl chr 6:111,339,136...111,417,954
JBrowse link
sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:108,095,131...108,099,483
Ensembl chr10:108,095,131...108,099,483
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 ISO
IBA
(PMID:18815062)
(MGI:MGI:5529577|PMID:23973266)
PMID:21873635
RGD PMID:18815062, PMID:23973266, PMID:21873635 MGI:MGI:5529577, RGD:13792537 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524
JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 ISO (MGI:MGI:5529577|PMID:23973266) RGD PMID:23973266 MGI:MGI:5529577 NCBI chr20:46,212,070...46,215,183
Ensembl chr20:46,211,892...46,215,120
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 ISO
IEA
(MGI:MGI:5529577|PMID:23973266)
GO_REF:0000107
RGD
Ensembl
PMID:23973266 GO_REF:0000107, MGI:MGI:5529577 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link
G Smpd4 sphingomyelin phosphodiesterase 4 IBA
ISO
PMID:21873635
(MGI:MGI:6450503|PMID:25180167)
(PMID:16517606), (PMID:25180167)
RGD PMID:16517606, PMID:25180167, PMID:21873635 MGI:MGI:6450503, RGD:13792537 NCBI chr11:87,522,971...87,546,687
Ensembl chr11:87,522,971...87,546,687
JBrowse link
G Smpd5 sphingomyelin phosphodiesterase 5 ISO (MGI:MGI:6450238|PMID:21183079) RGD PMID:21183079 MGI:MGI:6450238 NCBI chr 7:117,351,694...117,354,241
Ensembl chr 7:117,351,648...117,354,084
JBrowse link
G Smpdl3a sphingomyelin phosphodiesterase, acid-like 3A NOT ISO
ISS
(PMID:26783088)
GO_REF:0000024
RGD
UniProt
PMID:26783088 GO_REF:0000024 NCBI chr20:40,779,022...40,800,842
Ensembl chr20:40,778,927...40,800,868
JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:150,925,150...150,946,994
Ensembl chr 5:150,925,370...150,949,931
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    cellular process 18788
      cellular metabolic process 11067
        cellular lipid metabolic process 1056
          phospholipid metabolic process 415
            sphingomyelin metabolic process 16
              sphingomyelin biosynthetic process 7
              sphingomyelin catabolic process + 9
Path 2
Term Annotations click to browse term
  biological_process 20015
    metabolic process 12259
      organic substance metabolic process 11639
        lipid metabolic process 1378
          cellular lipid metabolic process 1056
            membrane lipid metabolic process 187
              sphingolipid metabolic process 137
                sphingomyelin metabolic process 16
                  sphingomyelin biosynthetic process 7
                  sphingomyelin catabolic process + 9
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.