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ONTOLOGY REPORT - ANNOTATIONS


Term:sphingomyelin metabolic process
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Accession:GO:0006684 term browser browse the term
Definition:The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine.
Synonyms:exact_synonym: sphingomyelin metabolism


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sphingomyelin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:3718765|PMID:17488728)
UniProt
RGD
PMID:17488728 GO_REF:0000024 MGI:3718765 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537
JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in ISS
ISO
GO_REF:0000024
(PMID:12671034), (PMID:12885774), (PMID:28292932)
UniProt
RGD
PMID:12671034 PMID:12885774 PMID:28292932 GO_REF:0000024 NCBI chr10:104,242,223...104,246,589
Ensembl chr10:104,242,223...104,246,589
JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within
IBA
ISO
ISS
PMID:21873635
(MGI:1858672|PMID:10823942)
(MGI:6450311|PMID:21550973)
GO_REF:0000024
RGD
UniProt
PMID:10823942 PMID:21550973 PMID:21873635 GO_REF:0000024 MGI:1858672 MGI:6450311, RGD:13792537 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749
JBrowse link
G Smpd5 sphingomyelin phosphodiesterase 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:108,009,182...108,011,767
Ensembl chr 7:108,009,173...108,011,763
JBrowse link
positive regulation of sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in ISS
ISO
GO_REF:0000024
(MGI:4947032|PMID:21177474)
UniProt
RGD
PMID:21177474 GO_REF:0000024 MGI:4947032 NCBI chr10:104,242,223...104,246,589
Ensembl chr10:104,242,223...104,246,589
JBrowse link
G Prkcd protein kinase C, delta involved_in IEA
ISO
GO_REF:0000107
(PMID:19279011)
Ensembl
RGD
PMID:19279011 GO_REF:0000107 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
sphingomyelin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 involved_in ISO (PMID:23560799) RGD PMID:23560799 NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988
JBrowse link
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 acts_upstream_of ISO MGI:1913862 (MGI:6393026|PMID:31880535) RGD PMID:31880535 MGI:6393026 NCBI chr 9:48,243,365...48,253,316
Ensembl chr 9:48,237,572...48,253,211
JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 involved_in
acts_upstream_of
IEA
ISO
GO_REF:0000107
MGI:2137691|MGI:2181669|MGI:6382064 (MGI:6393026|PMID:31880535)
Ensembl
RGD
PMID:31880535 GO_REF:0000107 MGI:6393026 NCBI chr10:83,590,052...83,598,620
Ensembl chr10:83,590,071...83,598,620
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase acts_upstream_of_or_within ISO (MGI:5707904|PMID:25667419) RGD PMID:25667419 MGI:5707904 NCBI chr10:44,775,910...44,849,990
Ensembl chr10:44,775,911...44,850,013
JBrowse link
G Sgms1 sphingomyelin synthase 1 involved_in IBA
ISO
ISS
PMID:21873635
(MGI:6221394|PMID:27892528)
GO_REF:0000024
(PMID:14685263), (PMID:14976195), (PMID:17982138)
RGD
HGNC-UCL
PMID:14685263 PMID:14976195 PMID:17982138 PMID:27892528 PMID:21873635 GO_REF:0000024 MGI:6221394, RGD:13792537 NCBI chr 1:229,996,673...230,259,591
Ensembl chr 1:229,998,119...230,259,603
JBrowse link
G Sgms2 sphingomyelin synthase 2 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
(MGI:6221394|PMID:27892528)
(MGI:5707904|PMID:25667419)
(PMID:14685263), (PMID:17982138)
PMID:21873635
Ensembl
RGD
PMID:14685263 PMID:17982138 PMID:25667419 PMID:27892528 PMID:21873635 GO_REF:0000107 MGI:5707904 MGI:6221394, RGD:13792537 NCBI chr 2:219,889,809...219,967,704
Ensembl chr 2:219,893,572...219,967,546
JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 involved_in
acts_upstream_of_or_within
ISO (MGI:5749304|PMID:26301690)
MGI:3815115 (MGI:3814228|PMID:16216550)
RGD PMID:16216550 PMID:26301690 MGI:3814228 MGI:5749304 NCBI chr17:11,877,249...11,916,295
Ensembl chr17:11,877,249...11,916,295
JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 acts_upstream_of_or_within ISO MGI:3815117 (MGI:3814228|PMID:16216550) RGD PMID:16216550 MGI:3814228 NCBI chr 6:106,948,681...107,031,584
Ensembl chr 6:106,950,949...107,031,542
JBrowse link
sphingomyelin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:104,242,223...104,246,589
Ensembl chr10:104,242,223...104,246,589
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:18815062), (PMID:20807762), (PMID:22573858)
(MGI:5529577|PMID:23973266)
PMID:21873635
RGD PMID:18815062 PMID:20807762 PMID:22573858 PMID:23973266 PMID:21873635 MGI:5529577, RGD:13792537 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 acts_upstream_of_or_within ISO (MGI:5529577|PMID:23973266) RGD PMID:23973266 MGI:5529577 NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:5529577|PMID:23973266)
Ensembl
RGD
PMID:23973266 GO_REF:0000107 MGI:5529577 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749
JBrowse link
G Smpd4 sphingomyelin phosphodiesterase 4 involved_in IBA
ISO
PMID:21873635
(MGI:6450503|PMID:25180167)
(PMID:16517606), (PMID:25180167)
RGD PMID:16517606 PMID:25180167 PMID:21873635 MGI:6450503, RGD:13792537 NCBI chr11:83,362,534...83,386,257
Ensembl chr11:83,362,534...83,386,250
JBrowse link
G Smpd5 sphingomyelin phosphodiesterase 5 involved_in ISO (MGI:6450238|PMID:21183079) RGD PMID:21183079 MGI:6450238 NCBI chr 7:108,009,182...108,011,767
Ensembl chr 7:108,009,173...108,011,763
JBrowse link
G Smpdl3a sphingomyelin phosphodiesterase, acid-like 3A NOT|involved_in ISO
ISS
(PMID:26783088)
GO_REF:0000024
RGD
UniProt
PMID:26783088 GO_REF:0000024 NCBI chr20:37,132,592...37,155,567
Ensembl chr20:37,132,592...37,155,567
JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:144,944,618...144,966,703
Ensembl chr 5:144,944,636...144,966,720
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    cellular process 18340
      cellular metabolic process 10721
        cellular lipid metabolic process 1019
          phospholipid metabolic process 377
            sphingomyelin metabolic process 18
              sphingomyelin biosynthetic process 8
              sphingomyelin catabolic process + 9
Path 2
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      organic substance metabolic process 11335
        lipid metabolic process 1364
          cellular lipid metabolic process 1019
            membrane lipid metabolic process 187
              sphingolipid metabolic process 141
                sphingomyelin metabolic process 18
                  sphingomyelin biosynthetic process 8
                  sphingomyelin catabolic process + 9
paths to the root