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ONTOLOGY REPORT - ANNOTATIONS

Term:glucosylceramide metabolic process
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Accession:GO:0006678 term browser browse the term
Definition:The chemical reactions and pathways involving glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. They are neutral glycolipids containing equimolar amounts of fatty acid, glucose, and sphingosine or a sphingosine derivative.
Synonyms:exact_synonym: glucosylceramide metabolism


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glucosylceramide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GBA1 glucosylceramidase beta 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3762988|PMID:17954912), (MGI:3795074|PMID:18346921) MGI
Ensembl		 PMID:17954912 PMID:18346921 GO_REF:0000107 MGI:3762988 MGI:3795074 NCBI chr 1:155,234,452...155,244,627
Ensembl chr 1:155,234,452...155,244,699 		JBrowse link
G PSAP prosaposin acts_upstream_of_or_within ISO (MGI:3711591|PMID:17353235) MGI PMID:17353235 MGI:3711591 NCBI chr10:71,816,298...71,851,251
Ensembl chr10:71,816,298...71,851,251 		JBrowse link
glucosylceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FA2H fatty acid 2-hydroxylase involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr16:74,712,969...74,774,820
Ensembl chr16:74,712,955...74,774,831 		JBrowse link
G UGCG UDP-glucose ceramide glucosyltransferase involved_in IEA
IDA
IBA		 (PMID:8643456)
(PMID:21873635)		 Ensembl
UniProt
GO_Central		 PMID:8643456 PMID:21873635 GO_REF:0000107 NCBI chr 9:111,896,814...111,935,369
Ensembl chr 9:111,896,814...111,935,369 		JBrowse link
glucosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GBA1 glucosylceramidase beta 1 involved_in IDA
IBA
IMP
IEA		 (PMID:16293621), (PMID:24211208), (PMID:9201993)
(PMID:21873635)
(PMID:19279011), (PMID:21700325), (PMID:24022302)		 UniProt
GO_Central
ParkinsonsUK-UCL
Ensembl		 PMID:9201993 PMID:16293621 PMID:19279011 PMID:21700325 PMID:21873635 More... GO_REF:0000107 NCBI chr 1:155,234,452...155,244,627
Ensembl chr 1:155,234,452...155,244,699 		JBrowse link
G GBA2 glucosylceramidase beta 2 involved_in IMP
IDA
IEA		 (PMID:30308956)
(PMID:17080196)		 UniProt
InterPro
Ensembl		 PMID:17080196 PMID:30308956 GO_REF:0000002 GO_REF:0000107 NCBI chr 9:35,736,866...35,749,228
Ensembl chr 9:35,736,866...35,749,228 		JBrowse link
G GBA3 glucosylceramidase beta 3 (gene/pseudogene) NOT|involved_in IDA
IMP		 (PMID:20728381)
(PMID:26724485)
(PMID:17595169)		 UniProt PMID:17595169 PMID:20728381 PMID:26724485 NCBI chr 4:22,692,937...22,819,569
Ensembl chr 4:22,692,914...22,819,575 		JBrowse link
negative regulation of glucosylceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 involved_in NAS (PMID:11165240) UniProt PMID:11165240 NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374 		JBrowse link
positive regulation of glucosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKCD protein kinase C delta involved_in IMP (PMID:19279011) BHF-UCL PMID:19279011 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19566
    metabolic process 12606
      nitrogen compound metabolic process 10074
        amide metabolic process 1338
          ceramide metabolic process 109
            glycosylceramide metabolic process 18
              glucosylceramide metabolic process 8
                glucosylceramide biosynthetic process + 3
                glucosylceramide catabolic process + 4
Path 2
Term Annotations click to browse term
  biological_process 19566
    metabolic process 12606
      primary metabolic process 10633
        lipid metabolic process 1502
          cellular lipid metabolic process 1094
            membrane lipid metabolic process 217
              glycolipid metabolic process 111
                glycosphingolipid metabolic process 67
                  glycosylceramide metabolic process 18
                    glucosylceramide metabolic process 8
                      glucosylceramide biosynthetic process + 3
                      glucosylceramide catabolic process + 4
paths to the root