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ONTOLOGY REPORT - ANNOTATIONS

Term:ceramide metabolic process
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Accession:GO:0006672 term browser browse the term
Definition:The chemical reactions and pathways involving ceramides, any N-acylated sphingoid.
Synonyms:exact_synonym: ceramide metabolism

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ceramide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA12 ATP binding cassette subfamily A member 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:100,759,196...100,972,307
Ensembl chr10:100,759,225...100,888,912 		JBrowse link
G ACER1 alkaline ceramidase 1 involved_in IEA InterPro GO_REF:0000002 Ensembl chr 6:5,949,734...5,955,689 JBrowse link
G ACER2 alkaline ceramidase 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr12:60,286,802...60,323,359
Ensembl chr12:60,283,174...60,321,817 		JBrowse link
G ACER3 alkaline ceramidase 3 involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:68,072,323...68,228,036
Ensembl chr 1:68,072,544...68,227,736 		JBrowse link
G ASAH2 N-acylsphingosine amidohydrolase 2 involved_in IEA UniProt GO_REF:0000117 NCBI chr 9:80,409,649...80,501,527
Ensembl chr 9:80,409,478...80,476,731 		JBrowse link
G CERK ceramide kinase involved_in ISO (PMID:19501188) UniProt PMID:19501188 NCBI chr19:29,183,324...29,236,857 JBrowse link
G CERK ceramide kinase involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr19:29,179,686...29,236,734 JBrowse link
G CERT1 ceramide transporter 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19139267) Ensembl
MGI		 PMID:19139267 GO_REF:0000107 NCBI chr 4:69,696,926...69,843,000
Ensembl chr 4:69,708,205...69,842,338 		JBrowse link
G CLN8 CLN8 transmembrane ER and ERGIC protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:1,424,402...1,445,505
Ensembl chr 8:1,433,953...1,445,021 		JBrowse link
G FUT7 fucosyltransferase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:1,158,353...1,160,913 JBrowse link
G HTRA2 HtrA serine peptidase 2 ISO C2 ceramide RGD PMID:22296759 RGD:5688365 NCBI chr14:32,745,436...32,749,176
Ensembl chr14:32,743,708...32,748,577 		JBrowse link
G LOC103233751 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 involved_in ISO (PMID:17604274), (PMID:7721776), (PMID:9737988) BHF-UCL PMID:7721776 PMID:9737988 PMID:17604274 NCBI chr 6:5,495,756...5,504,981
Ensembl chr 6:5,496,283...5,497,407 		JBrowse link
G ORMDL1 ORMDL sphingolipid biosynthesis regulator 1 involved_in IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr10:75,291,320...75,305,412
Ensembl chr10:75,287,780...75,305,001 		JBrowse link
G ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 involved_in IEA UniProt
TreeGrafter		 GO_REF:0000104 GO_REF:0000118 NCBI chr11:51,768,533...51,771,461
Ensembl chr11:51,768,642...51,770,998 		JBrowse link
G ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 involved_in IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr16:66,243,503...66,249,800
Ensembl chr16:66,243,539...66,250,167 		JBrowse link
G PLA2G15 phospholipase A2 group XV acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11790796) MGI
TreeGrafter		 PMID:11790796 GO_REF:0000118 NCBI chr 5:59,160,396...59,184,472
Ensembl chr 5:59,160,100...59,177,709 		JBrowse link
G PLPP1 phospholipid phosphatase 1 involved_in ISO PMID:8663293
PMID:10359651
(PMID:9305923), (PMID:9705349)
(MGI:6383560|PMID:10359651)		 UniProt PMID:8663293 PMID:9305923 PMID:9705349 PMID:10359651 MGI:6383560 RGD:15090855 RGD:15090857 NCBI chr 4:51,667,336...51,777,016
Ensembl chr 4:51,667,684...51,776,981 		JBrowse link
G PLPP2 phospholipid phosphatase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:15,326...26,759
Ensembl chr 6:14,945...26,703 		JBrowse link
G PLPP3 phospholipid phosphatase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:76,382,041...76,466,497
Ensembl chr20:76,382,079...76,477,847 		JBrowse link
G PSAP prosaposin acts_upstream_of_or_within ISO (PMID:15345707)
(PMID:17353235)		 MGI PMID:15345707 PMID:17353235 NCBI chr 9:59,440,327...59,474,773
Ensembl chr 9:59,440,311...59,474,986 		JBrowse link
G SGPL1 sphingosine-1-phosphate lyase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:60,425,703...60,487,196
Ensembl chr 9:60,424,305...60,487,146 		JBrowse link
G SMPD1 sphingomyelin phosphodiesterase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23046545) Ensembl
MGI		 PMID:23046545 GO_REF:0000107 NCBI chr 1:58,431,677...58,436,233
Ensembl chr 1:58,432,068...58,436,236 		JBrowse link
G SMPD2 sphingomyelin phosphodiesterase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:64,424,236...64,427,435
Ensembl chr13:64,424,250...64,427,366 		JBrowse link
G SMPD3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22383528), (PMID:23046545) Ensembl
MGI		 PMID:22383528 PMID:23046545 GO_REF:0000107 NCBI chr 5:58,965,965...59,057,823
Ensembl chr 5:59,029,093...59,059,577 		JBrowse link
G TM9SF2 transmembrane 9 superfamily member 2 involved_in ISO (PMID:30660999) UniProt PMID:30660999 NCBI chr 3:78,143,850...78,217,461
Ensembl chr 3:78,144,078...78,216,828 		JBrowse link
ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGK acylglycerol kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15252046) Ensembl
TreeGrafter
MGI		 PMID:15252046 GO_REF:0000107 GO_REF:0000118 NCBI chr21:110,302,439...110,404,733
Ensembl chr21:110,337,966...110,403,436 		JBrowse link
G ALOX12B arachidonate 12-lipoxygenase, 12R type involved_in ISO (MGI:3789553|PMID:17403930) UniProt PMID:17403930 MGI:3789553 NCBI chr16:7,454,950...7,470,949
Ensembl chr16:7,455,044...7,469,934 		JBrowse link
G ALOXE3 arachidonate epidermal lipoxygenase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22832496) Ensembl
MGI		 PMID:22832496 GO_REF:0000107 NCBI chr16:7,478,775...7,500,931
Ensembl chr16:7,478,793...7,500,428 		JBrowse link
G ASAH1 N-acylsphingosine amidohydrolase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:16,151,974...16,181,726
Ensembl chr 8:16,151,247...16,181,155 		JBrowse link
G ASAH2 N-acylsphingosine amidohydrolase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:80,409,649...80,501,527
Ensembl chr 9:80,409,478...80,476,731 		JBrowse link
G CERS1 ceramide synthase 1 involved_in ISO (MGI:5008665|PMID:21625621), (MGI:6380950|PMID:30605666)
(MGI:3696321|PMID:16951403), (MGI:3764760|PMID:17977534), (MGI:5755322|PMID:26620563)
(PMID:12105227), (PMID:12869556), (PMID:15823095), (PMID:17548428), (PMID:18541923), (PMID:22922758), (PMID:24782409)		 UniProt PMID:12105227 PMID:12869556 PMID:15823095 PMID:16951403 PMID:17548428 More... MGI:3696321 MGI:3764760 MGI:5008665 MGI:5755322 MGI:6380950 NCBI chr 6:17,331,021...17,351,542 JBrowse link
G CERS1 ceramide synthase 1 involved_in IEA Ensembl
TreeGrafter
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 Ensembl chr 6:17,331,107...17,351,496 JBrowse link
G CERS2 ceramide synthase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15823095) Ensembl
TreeGrafter
MGI
UniProt
InterPro		 PMID:15823095 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118
G CERS3 ceramide synthase 3 involved_in IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000117 GO_REF:0000118 NCBI chr29:18,883,532...19,016,790
Ensembl chr29:18,929,866...18,974,662 		JBrowse link
G CERS4 ceramide synthase 4 involved_in
acts_upstream_of_or_within		 ISO (PMID:17977534), (PMID:29632068)
(PMID:12912983), (PMID:15823095)		 UniProt
MGI		 PMID:12912983 PMID:15823095 PMID:17977534 PMID:29632068
G CERS5 ceramide synthase 5 involved_in IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000117 GO_REF:0000118 NCBI chr11:46,360,078...46,400,746
Ensembl chr11:46,359,966...46,400,554 		JBrowse link
G CERS6 ceramide synthase 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15823095) Ensembl
TreeGrafter
MGI
UniProt
InterPro		 PMID:15823095 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chr10:53,972,795...54,299,721
Ensembl chr10:53,972,376...54,294,224 		JBrowse link
G CYP4F22 cytochrome P450 family 4 subfamily F member 22 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:14,111,406...14,153,617
Ensembl chr 6:14,126,086...14,152,447 		JBrowse link
G DEGS1 delta 4-desaturase, sphingolipid 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:22984457) MGI
TreeGrafter		 PMID:22984457 GO_REF:0000118 NCBI chr25:5,589,530...5,603,261
Ensembl chr25:5,589,383...5,603,227 		JBrowse link
G DEGS2 delta 4-desaturase, sphingolipid 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr24:78,114,950...78,128,766
Ensembl chr24:78,115,292...78,127,831 		JBrowse link
G ELOVL1 ELOVL fatty acid elongase 1 involved_in ISO (MGI:5532629|PMID:23689133) UniProt PMID:23689133 MGI:5532629 NCBI chr20:89,444,146...89,448,802 JBrowse link
G FA2H fatty acid 2-hydroxylase involved_in ISO (PMID:15337768)
(MGI:6245295|PMID:22517924)		 UniProt PMID:15337768 PMID:22517924 MGI:6245295 NCBI chr 5:52,930,289...52,993,751
Ensembl chr 5:52,930,833...52,992,499 		JBrowse link
G GBA1 glucosylceramidase beta 1 involved_in ISO (PMID:19279011) BHF-UCL PMID:19279011 NCBI chr20:8,598,110...8,631,517
Ensembl chr20:8,598,628...8,630,990 		JBrowse link
G LOC119623630 lysosomal acid glucosylceramidase involved_in IEA Ensembl GO_REF:0000107
G MECR mitochondrial trans-2-enoyl-CoA reductase acts_upstream_of
involved_in		 ISO
IEA		 (PMID:37653044) UniProt
Ensembl		 PMID:37653044 GO_REF:0000107 NCBI chr20:103,591,944...103,630,253
Ensembl chr20:103,591,944...103,629,102 		JBrowse link
G P2RX1 purinergic receptor P2X 1 acts_upstream_of_or_within ISO (PMID:16325464) MGI PMID:16325464 NCBI chr16:3,377,526...3,399,374
Ensembl chr16:3,377,483...3,398,360 		JBrowse link
G P2RX7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO (PMID:16325464) MGI PMID:16325464 NCBI chr11:116,505,975...116,560,151
Ensembl chr11:116,529,346...116,563,059 		JBrowse link
G PNPLA1 patatin like phospholipase domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:35,808,652...35,854,069
Ensembl chr17:35,814,590...35,851,985 		JBrowse link
G SAMD8 sterile alpha motif domain containing 8 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25667419)
(PMID:25605874)
(PMID:25605874), (PMID:25667419)		 Ensembl
TreeGrafter
MGI		 PMID:25605874 PMID:25667419 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:56,190,771...56,259,857
Ensembl chr 9:56,196,202...56,225,058 		JBrowse link
G SGMS1 sphingomyelin synthase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:25605874) MGI
TreeGrafter
Ensembl		 PMID:25605874 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:80,524,115...80,646,332
Ensembl chr 9:80,524,055...80,562,945 		JBrowse link
G SGMS2 sphingomyelin synthase 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:25605874) MGI
TreeGrafter		 PMID:25605874 GO_REF:0000118 NCBI chr 7:55,752,419...55,843,408
Ensembl chr 7:55,753,270...55,838,914 		JBrowse link
G SMPD1 sphingomyelin phosphodiesterase 1 involved_in ISO
IEA		 RGD
TreeGrafter
UniProt
Ensembl		 PMID:17261082 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 RGD:1601344 NCBI chr 1:58,431,677...58,436,233
Ensembl chr 1:58,432,068...58,436,236 		JBrowse link
G SMPD2 sphingomyelin phosphodiesterase 2 ISO RGD PMID:12473648 RGD:1581395 NCBI chr13:64,424,236...64,427,435
Ensembl chr13:64,424,250...64,427,366 		JBrowse link
G SMPD4 sphingomyelin phosphodiesterase 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr10:131,882...162,244
Ensembl chr10:136,784...163,555 		JBrowse link
G SPTLC1 serine palmitoyltransferase long chain base subunit 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:25691431)
(PMID:16216550)		 MGI
TreeGrafter		 PMID:16216550 PMID:25691431 GO_REF:0000118 NCBI chr12:102,475,437...102,551,401
Ensembl chr12:102,475,415...102,551,322 		JBrowse link
G SPTLC2 serine palmitoyltransferase long chain base subunit 2 acts_upstream_of_or_within ISO (PMID:25691431)
(PMID:16216550)		 MGI PMID:16216550 PMID:25691431 NCBI chr24:54,769,072...54,876,963 JBrowse link
G SPTLC2 serine palmitoyltransferase long chain base subunit 2 involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr24:54,769,340...54,823,210 JBrowse link
G SPTLC3 serine palmitoyltransferase long chain base subunit 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 2:41,900,389...42,067,842
Ensembl chr 2:41,900,447...42,070,112 		JBrowse link
G SPTSSA serine palmitoyltransferase small subunit A acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:25691431) MGI
TreeGrafter		 PMID:25691431 GO_REF:0000118 NCBI chr24:11,264,578...11,298,816
Ensembl chr24:11,266,343...11,298,668 		JBrowse link
G SPTSSB serine palmitoyltransferase small subunit B acts_upstream_of_or_within ISO (PMID:26438849) MGI PMID:26438849 NCBI chr15:29,468,155...29,502,387 JBrowse link
G SPTSSB serine palmitoyltransferase small subunit B involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 Ensembl chr15:29,494,628...29,502,375 JBrowse link
G TLCD3B TLC domain containing 3B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23275342) MGI
TreeGrafter		 PMID:23275342 GO_REF:0000118 NCBI chr 5:26,626,643...26,639,343
Ensembl chr 5:26,632,509...26,639,356 		JBrowse link
ceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACER1 alkaline ceramidase 1 involved_in
acts_upstream_of_or_within		 ISO (MGI:5800647|PMID:27126290)
(PMID:12783875)
(PMID:20207939)		 UniProt
MGI		 PMID:12783875 PMID:20207939 PMID:27126290 MGI:5800647 NCBI chr 6:5,949,286...5,978,282 JBrowse link
G ACER1 alkaline ceramidase 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 Ensembl chr 6:5,949,734...5,955,689 JBrowse link
G ACER2 alkaline ceramidase 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr12:60,286,802...60,323,359
Ensembl chr12:60,283,174...60,321,817 		JBrowse link
G ACER3 alkaline ceramidase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:68,072,323...68,228,036
Ensembl chr 1:68,072,544...68,227,736 		JBrowse link
G ASAH1 N-acylsphingosine amidohydrolase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:16,151,974...16,181,726
Ensembl chr 8:16,151,247...16,181,155 		JBrowse link
G ASAH2 N-acylsphingosine amidohydrolase 2 involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:80,409,649...80,501,527
Ensembl chr 9:80,409,478...80,476,731 		JBrowse link
G CEL carboxyl ester lipase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11733511) MGI
TreeGrafter		 PMID:11733511 GO_REF:0000118 NCBI chr12:5,053,817...5,077,487
Ensembl chr12:5,066,882...5,077,227 		JBrowse link
galactosylceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3GALT1 beta-1,3-galactosyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:52,792,505...53,368,536
Ensembl chr10:53,366,522...53,367,499 		JBrowse link
G B3GALT2 beta-1,3-galactosyltransferase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:36,234,882...36,246,827
Ensembl chr25:36,241,631...36,242,899 		JBrowse link
G B4GALT3 beta-1,4-galactosyltransferase 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:2,807,510...2,814,480
Ensembl chr20:2,807,895...2,814,476 		JBrowse link
G FA2H fatty acid 2-hydroxylase involved_in ISO PMID:17901466
(MGI:3696647|PMID:15658937)
(MGI:3826747|PMID:18815260)		 UniProt PMID:15658937 PMID:17901466 PMID:18815260 MGI:3696647 MGI:3826747 RGD:13825191 NCBI chr 5:52,930,289...52,993,751
Ensembl chr 5:52,930,833...52,992,499 		JBrowse link
G GAL3ST1 galactose-3-O-sulfotransferase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10727929) Ensembl
TreeGrafter
MGI		 PMID:10727929 GO_REF:0000107 GO_REF:0000118 NCBI chr19:13,431,245...13,451,189
Ensembl chr19:13,431,270...13,434,055 		JBrowse link
G UGT8 UDP glycosyltransferase 8 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 7:62,380,506...62,465,695
Ensembl chr 7:62,381,223...62,466,401 		JBrowse link
galactosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GALC galactosylceramidase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11371512) Ensembl
TreeGrafter
MGI
InterPro		 PMID:11371512 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr24:65,556,763...65,621,693
Ensembl chr24:65,558,074...65,621,258 		JBrowse link
G PSAP prosaposin acts_upstream_of_or_within ISO (PMID:11371512) MGI PMID:11371512 NCBI chr 9:59,440,327...59,474,773
Ensembl chr 9:59,440,311...59,474,986 		JBrowse link
galactosylceramide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GAL3ST1 galactose-3-O-sulfotransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:13,431,245...13,451,189
Ensembl chr19:13,431,270...13,434,055 		JBrowse link
ganglioside biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3GALT4 beta-1,3-galactosyltransferase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:38,798,224...38,799,910
Ensembl chr17:38,798,496...38,799,644 		JBrowse link
G B4GALNT1 beta-1,4-N-acetyl-galactosaminyltransferase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:10021458) MGI
TreeGrafter		 PMID:10021458 GO_REF:0000118 NCBI chr11:53,533,485...53,541,915
Ensembl chr11:53,530,886...53,540,178 		JBrowse link
G ST6GALNAC4 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr12:10,205,665...10,215,180
Ensembl chr12:10,205,705...10,214,688 		JBrowse link
G ST6GALNAC5 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:56,110,411...56,299,639
Ensembl chr20:56,113,473...56,131,866 		JBrowse link
G ST6GALNAC6 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10702226) Ensembl
TreeGrafter
MGI		 PMID:10702226 GO_REF:0000107 GO_REF:0000118 NCBI chr12:10,217,546...10,238,317
Ensembl chr12:10,218,036...10,238,350 		JBrowse link
G ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:10,966,738...11,039,014
Ensembl chr29:11,000,989...11,041,634 		JBrowse link
G ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:22,367,725...22,378,567
Ensembl chr18:22,369,107...22,376,818 		JBrowse link
G ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 involved_in ISO (PMID:10766765) BHF-UCL PMID:10766765 NCBI chr23:4,324,886...4,423,253
Ensembl chr23:4,325,373...4,423,109 		JBrowse link
G ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 involved_in ISO (MGI:2182536|PMID:11980897) BHF-UCL PMID:11980897 MGI:2182536 NCBI chr 9:17,269,548...17,400,860 JBrowse link
G ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 9:17,270,133...17,308,328 JBrowse link
ganglioside biosynthetic process via lactosylceramide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B4GALT5 beta-1,4-galactosyltransferase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:14,270,945...14,357,052
Ensembl chr 2:14,271,141...14,354,159 		JBrowse link
G B4GALT6 beta-1,4-galactosyltransferase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:49,037,348...49,101,769
Ensembl chr18:49,037,225...49,102,502 		JBrowse link
G ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 involved_in IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chr 8:127,885,018...127,929,865
Ensembl chr 8:127,885,031...127,906,059 		JBrowse link
G ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 involved_in IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chr 5:53,530,077...53,585,065
Ensembl chr 5:53,531,781...53,545,739 		JBrowse link
G ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 involved_in ISO (MGI:6467685|PMID:22735313) UniProt PMID:22735313 MGI:6467685 NCBI chr20:88,875,525...89,108,001 JBrowse link
G ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr20:88,876,461...88,911,367 JBrowse link
ganglioside catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GM2A GM2 ganglioside activator involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9223328) Ensembl
TreeGrafter
MGI
InterPro		 PMID:9223328 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr23:53,808,447...53,831,489 JBrowse link
G HEXA hexosaminidase subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8789434), (PMID:9645704)
(PMID:7937929), (PMID:9223328)		 Ensembl
TreeGrafter
MGI		 PMID:7937929 PMID:8789434 PMID:9223328 PMID:9645704 GO_REF:0000107 GO_REF:0000118 NCBI chr26:11,081,985...11,130,366
Ensembl chr26:11,082,468...11,116,075 		JBrowse link
G HEXB hexosaminidase subunit beta acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:10021458), (PMID:12657883), (PMID:12756243), (PMID:15748167), (PMID:9223328)
(PMID:8566348)
(PMID:8789434), (PMID:9645704)		 MGI
TreeGrafter		 PMID:8566348 PMID:8789434 PMID:9223328 PMID:9645704 PMID:10021458 More... GO_REF:0000118 NCBI chr 4:69,037,532...69,065,925
Ensembl chr 4:69,037,583...69,065,814 		JBrowse link
G LOC103232916 ganglioside GM2 activator involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:39,308,349...39,308,823 JBrowse link
G NEU1 neuraminidase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:40,158,530...40,162,254
Ensembl chr17:40,158,679...40,161,723 		JBrowse link
G NEU2 neuraminidase 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:119,064,910...119,069,595
Ensembl chr10:119,066,733...119,069,118 		JBrowse link
G NEU3 neuraminidase 3 involved_in ISO (PMID:10861246), (PMID:11298736), (PMID:15847605), (PMID:17334392)
(MGI:3040535|PMID:14970224), (MGI:3765376|PMID:17708748), (MGI:6478528|PMID:11696012)		 UniProt PMID:10861246 PMID:11298736 PMID:11696012 PMID:14970224 PMID:15847605 More... MGI:3040535 MGI:3765376 MGI:6478528 NCBI chr 1:66,220,472...66,243,163 JBrowse link
G NEU3 neuraminidase 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 Ensembl chr 1:66,221,012...66,243,919 JBrowse link
G NEU4 neuraminidase 4 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:127,845,536...127,852,873
Ensembl chr10:127,847,391...127,852,519 		JBrowse link
ganglioside metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 involved_in ISO (MGI:3718765|PMID:17488728) UniProt PMID:17488728 MGI:3718765 NCBI chr12:1,161,340...1,183,807
Ensembl chr12:1,162,865...1,183,113 		JBrowse link
G CLN6 CLN6 transmembrane ER protein involved_in ISO (PMID:16857350) UniProt PMID:16857350 NCBI chr26:15,259,186...15,278,249 JBrowse link
G CLN6 CLN6 transmembrane ER protein involved_in IEA Ensembl GO_REF:0000107 Ensembl chr26:15,266,732...15,278,418 JBrowse link
G GM2A GM2 ganglioside activator ISO RGD PMID:9770472 RGD:1598995 NCBI chr23:53,808,447...53,831,489 JBrowse link
G ITGB8 integrin subunit beta 8 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16251442) Ensembl
MGI		 PMID:16251442 GO_REF:0000107 NCBI chr21:37,811,811...37,896,539
Ensembl chr21:37,817,572...37,895,560 		JBrowse link
G NAGLU N-acetyl-alpha-glucosaminidase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21408219) Ensembl
MGI		 PMID:21408219 GO_REF:0000107 NCBI chr16:63,735,411...63,744,365 JBrowse link
glucosylceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FA2H fatty acid 2-hydroxylase involved_in ISO (MGI:5285470|PMID:21628453) UniProt PMID:21628453 MGI:5285470 NCBI chr 5:52,930,289...52,993,751
Ensembl chr 5:52,930,833...52,992,499 		JBrowse link
G UGCG UDP-glucose ceramide glucosyltransferase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr12:27,575,519...27,614,114
Ensembl chr12:27,574,970...27,613,811 		JBrowse link
glucosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GBA1 glucosylceramidase beta 1 involved_in ISO (MGI:6271235|PMID:24211208)
(PMID:19279011), (PMID:21700325), (PMID:24022302), (PMID:25584808)
(MGI:5141165|PMID:21700325), (MGI:5501380|PMID:23707074)
(PMID:16293621), (PMID:24211208), (PMID:9201993)		 UniProt
ParkinsonsUK-UCL		 PMID:9201993 PMID:16293621 PMID:19279011 PMID:21700325 PMID:23707074 More... MGI:5141165 MGI:5501380 MGI:6271235 NCBI chr20:8,598,110...8,631,517
Ensembl chr20:8,598,628...8,630,990 		JBrowse link
G GBA2 glucosylceramidase beta 2 involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr12:44,852,048...44,865,542
Ensembl chr12:44,852,203...44,868,652 		JBrowse link
G LOC119623630 lysosomal acid glucosylceramidase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118
glucosylceramide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GBA1 glucosylceramidase beta 1 acts_upstream_of_or_within ISO (PMID:17954912), (PMID:18346921) MGI PMID:17954912 PMID:18346921 NCBI chr20:8,598,110...8,631,517
Ensembl chr20:8,598,628...8,630,990 		JBrowse link
G LOC119623630 lysosomal acid glucosylceramidase involved_in IEA Ensembl GO_REF:0000107
G PSAP prosaposin acts_upstream_of_or_within ISO (PMID:17353235) MGI PMID:17353235 NCBI chr 9:59,440,327...59,474,773
Ensembl chr 9:59,440,311...59,474,986 		JBrowse link
glycosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLA galactosidase alpha acts_upstream_of_or_within ISO (PMID:10840053), (PMID:15629890)
(PMID:10841515), (PMID:11752062), (PMID:9122231)		 MGI PMID:9122231 PMID:10840053 PMID:10841515 PMID:11752062 PMID:15629890 NCBI chr  X:89,738,097...89,749,740
Ensembl chr  X:89,737,966...89,750,539 		JBrowse link
G LCT lactase involved_in ISO PMID:4752949 UniProt PMID:4752949 RGD:151356630 NCBI chr10:19,994,398...20,049,325
Ensembl chr10:19,994,384...20,049,097 		JBrowse link
G LOC103246284 cytosolic beta-glucosidase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr27:27,519,119...27,643,745
Ensembl chr27:27,519,783...27,643,340 		JBrowse link
glycosylceramide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ST6GALNAC3 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 involved_in ISO (PMID:17123352) BHF-UCL PMID:17123352 NCBI chr20:56,415,330...57,085,966 JBrowse link
G ST6GALNAC6 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:10,217,546...10,238,317
Ensembl chr12:10,218,036...10,238,350 		JBrowse link
lactosylceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B4GALT4 beta-1,4-galactosyltransferase 4 involved_in ISO (PMID:9792633) UniProt PMID:9792633 NCBI chr22:61,600,143...61,629,857
Ensembl chr22:61,604,044...61,630,420 		JBrowse link
G B4GALT6 beta-1,4-galactosyltransferase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:49,037,348...49,101,769
Ensembl chr18:49,037,225...49,102,502 		JBrowse link
negative regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ORMDL1 ORMDL sphingolipid biosynthesis regulator 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:25691431) MGI
Ensembl		 PMID:25691431 GO_REF:0000107 NCBI chr10:75,291,320...75,305,412
Ensembl chr10:75,287,780...75,305,001 		JBrowse link
G ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 acts_upstream_of_or_within ISO (PMID:25691431) MGI PMID:25691431 NCBI chr11:51,768,533...51,771,461
Ensembl chr11:51,768,642...51,770,998 		JBrowse link
G ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:25691431) MGI
Ensembl		 PMID:25691431 GO_REF:0000107 NCBI chr16:66,243,503...66,249,800
Ensembl chr16:66,243,539...66,250,167 		JBrowse link
G SPHK1 sphingosine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:45,290,147...45,295,175
Ensembl chr16:45,290,421...45,293,128 		JBrowse link
omega-hydroxyceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PNPLA1 patatin like phospholipase domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:35,808,652...35,854,069
Ensembl chr17:35,814,590...35,851,985 		JBrowse link
positive regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCN1 cellular communication network factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19364818) Ensembl
MGI		 PMID:19364818 GO_REF:0000107 NCBI chr20:47,783,270...47,786,216
Ensembl chr20:47,783,935...47,785,997 		JBrowse link
G ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in ISO (MGI:4947032|PMID:21177474) UniProt PMID:21177474 MGI:4947032 NCBI chr16:71,693,148...71,701,517
Ensembl chr16:71,693,851...71,699,926 		JBrowse link
G PLA2G6 phospholipase A2 group VI ISO RGD PMID:18936091 RGD:6482750 NCBI chr19:20,818,575...20,884,243 JBrowse link
G PLA2G6 phospholipase A2 group VI involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr19:20,834,479...20,890,380 JBrowse link
G PRKCD protein kinase C delta involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:14,561,401...14,592,877
Ensembl chr22:14,565,282...14,592,873 		JBrowse link
G SIRT3 sirtuin 3 involved_in ISO (MGI:5755322|PMID:26620563) UniProt PMID:26620563 MGI:5755322 NCBI chr 1:25,740...49,471
Ensembl chr 1:26,927...48,944 		JBrowse link
G SMPD3 sphingomyelin phosphodiesterase 3 ISO RGD PMID:20096352 RGD:10041064 NCBI chr 5:58,965,965...59,057,823
Ensembl chr 5:59,029,093...59,059,577 		JBrowse link
G SPHK2 sphingosine kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:41,865,921...41,881,889
Ensembl chr 6:41,867,139...41,881,268 		JBrowse link
G ZNF750 zinc finger protein 750 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:37115925) Ensembl
MGI		 PMID:37115925 GO_REF:0000107 NCBI chr16:74,720,080...74,731,951
Ensembl chr16:74,720,763...74,723,075 		JBrowse link
positive regulation of glucosylceramide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKCD protein kinase C delta involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:14,561,401...14,592,877
Ensembl chr22:14,565,282...14,592,873 		JBrowse link
regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ORMDL1 ORMDL sphingolipid biosynthesis regulator 1 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:31880535) UniProt
MGI
Ensembl		 PMID:31880535 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117 NCBI chr10:75,291,320...75,305,412
Ensembl chr10:75,287,780...75,305,001 		JBrowse link
G ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 involved_in IEA UniProt GO_REF:0000104 GO_REF:0000117 NCBI chr11:51,768,533...51,771,461
Ensembl chr11:51,768,642...51,770,998 		JBrowse link
G ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:31880535) Ensembl
MGI
UniProt		 PMID:31880535 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117 NCBI chr16:66,243,503...66,249,800
Ensembl chr16:66,243,539...66,250,167 		JBrowse link
G PAQR4 progestin and adipoQ receptor family member 4 involved_in ISO (PMID:32291319), (PMID:38961186) UniProt PMID:32291319 PMID:38961186 NCBI chr 5:2,708,807...2,713,104
Ensembl chr 5:2,709,245...2,713,256 		JBrowse link
G PRKCD protein kinase C delta involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:14,561,401...14,592,877
Ensembl chr22:14,565,282...14,592,873 		JBrowse link
G SAMD8 sterile alpha motif domain containing 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:56,190,771...56,259,857
Ensembl chr 9:56,196,202...56,225,058 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17080
    metabolic process 11165
      amide metabolic process 428
        ceramide metabolic process 114
          ceramide biosynthetic process + 74
          ceramide catabolic process + 25
          ganglioside metabolic process + 30
          glycosylceramide metabolic process + 18
          lactosylceramide metabolic process + 2
Path 2
Term Annotations click to browse term
  biological_process 17080
    metabolic process 11165
      primary metabolic process 9990
        lipid metabolic process 1308
          cellular lipid metabolic process 985
            membrane lipid metabolic process 211
              sphingolipid metabolic process 157
                ceramide metabolic process 114
                  ceramide biosynthetic process + 74
                  ceramide catabolic process + 25
                  ganglioside metabolic process + 30
                  glycosylceramide metabolic process + 18
                  lactosylceramide metabolic process + 2
paths to the root