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ONTOLOGY REPORT - ANNOTATIONS

Term:phosphatidylserine metabolic process
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Accession:GO:0006658 term browser browse the term
Definition:The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes.
Synonyms:exact_synonym: phosphatidylserine metabolism

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phosphatidylserine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase C, hepatic type IDA RGD PMID:2223857 RGD:1600650 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248 		JBrowse link
G Pla2g10 phospholipase A2, group X involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:2446974|PMID:12359733)
GO_REF:0000107
(PMID:12359733)		 UniProt
RGD
Ensembl		 PMID:12359733 GO_REF:0000024 GO_REF:0000107 MGI:2446974 NCBI chr10:1,509,732...1,520,970
Ensembl chr10:1,509,732...1,520,970 		JBrowse link
G Pla2g15 phospholipase A2, group XV involved_in ISS
ISO		 GO_REF:0000024
(PMID:29724779)		 UniProt
RGD		 PMID:29724779 GO_REF:0000024 NCBI chr19:38,129,666...38,146,958
Ensembl chr19:38,129,584...38,146,956 		JBrowse link
G Pla2g3 phospholipase A2, group III involved_in ISO (PMID:28947740) RGD PMID:28947740 NCBI chr14:83,724,828...83,730,614
Ensembl chr14:83,724,933...83,730,614 		JBrowse link
G Serinc1 serine incorporator 1 involved_in IDA PMID:16120614 HGNC-UCL PMID:16120614 RGD:8553290 NCBI chr20:38,966,016...38,985,056
Ensembl chr20:38,967,238...38,985,036 		JBrowse link
G Serinc2 serine incorporator 2 involved_in IDA PMID:16120614 HGNC-UCL PMID:16120614 RGD:8553290 NCBI chr 5:148,470,060...148,492,232
Ensembl chr 5:148,470,061...148,492,232 		JBrowse link
G Serinc3 serine incorporator 3 involved_in ISS PMID:16120614 HGNC-UCL PMID:16120614 RGD:8553290 NCBI chr 3:160,018,643...160,038,078
Ensembl chr 3:160,018,646...160,038,078 		JBrowse link
G Serinc5 serine incorporator 5 involved_in IDA
IEA		 PMID:16120614
GO_REF:0000002		 InterPro PMID:16120614 GO_REF:0000002, RGD:8553290 NCBI chr 2:22,195,507...22,310,289
Ensembl chr 2:22,195,600...22,310,312 		JBrowse link
phosphatidylserine acyl-chain remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lpcat3 lysophosphatidylcholine acyltransferase 3 involved_in ISO
ISS		 (PMID:18195019), (PMID:18772128), (PMID:18782225)
(MGI:6436389|PMID:18287005)
GO_REF:0000024		 RGD
UniProt		 PMID:18195019 PMID:18287005 PMID:18772128 PMID:18782225 GO_REF:0000024 MGI:6436389 NCBI chr 4:157,181,722...157,222,997
Ensembl chr 4:157,181,795...157,222,996 		JBrowse link
G Lpcat4 lysophosphatidylcholine acyltransferase 4 involved_in ISO (PMID:18458083) RGD PMID:18458083 NCBI chr 3:103,725,762...103,733,888
Ensembl chr 3:103,726,238...103,733,354 		JBrowse link
G Mboat1 membrane bound O-acyltransferase domain containing 1 involved_in ISO (PMID:18772128) RGD PMID:18772128 NCBI chr17:36,061,775...36,177,457
Ensembl chr17:36,061,775...36,177,457 		JBrowse link
G Mboat2 membrane bound O-acyltransferase domain containing 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:18772128)		 UniProt
RGD		 PMID:18772128 GO_REF:0000024 NCBI chr 6:44,009,872...44,135,501
Ensembl chr 6:44,009,872...44,131,387 		JBrowse link
G Pla2g2f phospholipase A2, group IIF involved_in ISO (PMID:11112443) RGD PMID:11112443 NCBI chr 5:157,192,047...157,217,265
Ensembl chr 5:157,193,053...157,199,441 		JBrowse link
phosphatidylserine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plscr1 phospholipid scramblase 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5284813|PMID:12509439)		 Ensembl
RGD		 PMID:12509439 GO_REF:0000107 MGI:5284813 NCBI chr 8:99,625,523...99,645,882
Ensembl chr 8:99,625,545...99,725,217 		JBrowse link
G Ptdss1 phosphatidylserine synthase 1 involved_in ISO
IEA		 (PMID:19014349)
GO_REF:0000041		 RGD
UniProt		 PMID:19014349 GO_REF:0000041 NCBI chr 7:71,294,140...71,356,153
Ensembl chr 7:71,293,388...71,356,153 		JBrowse link
G Ptdss2 phosphatidylserine synthase 2 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:19014349)
MGI:2447151 (MGI:2446765|PMID:12361952)
GO_REF:0000041		 RGD
UniProt		 PMID:12361952 PMID:19014349 GO_REF:0000041 MGI:2446765 NCBI chr 1:214,122,981...214,148,011
Ensembl chr 1:214,123,044...214,149,729 		JBrowse link
G Slc27a1 solute carrier family 27 member 1 involved_in IBA
IEA
ISO		 PMID:21873635
GO_REF:0000107
(PMID:19523918)		 Ensembl
RGD		 PMID:19523918, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr16:19,997,823...20,016,193
Ensembl chr16:19,999,112...20,016,190 		JBrowse link
phosphatidylserine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd12 abhydrolase domain containing 12, lysophospholipase involved_in
acts_upstream_of_or_within		 IBA
ISO
ISS		 PMID:21873635
MGI:5487621 (MGI:5469248|PMID:23297193)
GO_REF:0000024
(PMID:30643283)		 RGD
UniProt		 PMID:23297193 PMID:30643283, PMID:21873635 GO_REF:0000024 MGI:5469248, RGD:13792537 NCBI chr 3:146,630,298...146,690,375
Ensembl chr 3:146,630,299...146,690,375 		JBrowse link
G Abhd12b abhydrolase domain containing 12B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:92,568,975...92,596,327
Ensembl chr 6:92,568,975...92,596,327 		JBrowse link
G Abhd16a abhydrolase domain containing 16A, phospholipase involved_in IEA
ISO
IBA
ISS		 GO_REF:0000107
(MGI:5779796|PMID:25580854)
PMID:21873635
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:25580854, PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:5779796, RGD:13792537 NCBI chr20:5,080,070...5,094,935
Ensembl chr20:5,080,070...5,094,935 		JBrowse link
G Abhd16b abhydrolase domain containing 16B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:176,985,900...176,987,797
Ensembl chr 3:176,985,900...176,987,796 		JBrowse link
regulation of phosphatidylserine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mfsd2a major facilitator superfamily domain containing 2A acts_upstream_of ISO (MGI:6196220|PMID:30074985) RGD PMID:30074985 MGI:6196220 NCBI chr 5:140,642,865...140,657,759
Ensembl chr 5:140,642,885...140,657,745 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19612
    metabolic process 11882
      cellular metabolic process 10839
        cellular modified amino acid metabolic process 200
          phosphatidylserine metabolic process 22
            negative regulation of phosphatidylserine metabolic process + 0
            phosphatidylserine acyl-chain remodeling 5
            phosphatidylserine biosynthetic process + 4
            phosphatidylserine catabolic process 4
            positive regulation of phosphatidylserine metabolic process + 0
            regulation of phosphatidylserine metabolic process + 1
Path 2
Term Annotations click to browse term
  biological_process 19612
    metabolic process 11882
      organic substance metabolic process 11417
        lipid metabolic process 1360
          cellular lipid metabolic process 1018
            glycerolipid metabolic process 390
              glycerophospholipid metabolic process 289
                phosphatidylserine metabolic process 22
                  negative regulation of phosphatidylserine metabolic process + 0
                  phosphatidylserine acyl-chain remodeling 5
                  phosphatidylserine biosynthetic process + 4
                  phosphatidylserine catabolic process 4
                  positive regulation of phosphatidylserine metabolic process + 0
                  regulation of phosphatidylserine metabolic process + 1
paths to the root