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ONTOLOGY REPORT - ANNOTATIONS

Term:phosphatidylserine metabolic process
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Accession:GO:0006658 term browser browse the term
Definition:The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes.
Synonyms:exact_synonym: phosphatidylserine metabolism


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phosphatidylserine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase C, hepatic type IDA RGD PMID:2223857 RGD:1600650 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Pla2g10 phospholipase A2, group X involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:12359733)
GO_REF:0000107
(MGI:2446974|PMID:12359733)		 UniProt
RGD
Ensembl		 PMID:12359733 GO_REF:0000024 GO_REF:0000107 MGI:2446974 NCBI chr10:1,597,761...1,610,822
Ensembl chr10:1,597,761...1,609,000 		JBrowse link
G Pla2g15 phospholipase A2, group XV involved_in ISS
ISO		 GO_REF:0000024
(PMID:29724779)		 UniProt
RGD		 PMID:29724779 GO_REF:0000024 NCBI chr19:34,050,685...34,068,070
Ensembl chr19:34,050,694...34,068,063 		JBrowse link
G Pla2g3 phospholipase A2, group III involved_in ISO (PMID:28947740) RGD PMID:28947740 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913 		JBrowse link
G Serinc1 serine incorporator 1 involved_in IDA PMID:16120614 HGNC-UCL PMID:16120614 RGD:8553290 NCBI chr20:36,850,062...36,896,691
Ensembl chr20:36,850,076...36,896,691 		JBrowse link
G Serinc2 serine incorporator 2 involved_in IDA PMID:16120614 HGNC-UCL PMID:16120614 RGD:8553290 NCBI chr 5:142,592,308...142,614,628
Ensembl chr 5:142,592,309...142,618,364 		JBrowse link
G Serinc5 serine incorporator 5 involved_in IDA PMID:16120614 HGNC-UCL PMID:16120614 RGD:8553290 NCBI chr 2:23,846,899...23,950,346
Ensembl chr 2:23,846,900...23,950,346 		JBrowse link
phosphatidylserine acyl-chain remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lpcat3 lysophosphatidylcholine acyltransferase 3 involved_in ISO
ISS		 (PMID:18195019), (PMID:18772128), (PMID:18782225)
(MGI:6436389|PMID:18287005)
GO_REF:0000024		 RGD
UniProt		 PMID:18195019 PMID:18287005 PMID:18772128 PMID:18782225 GO_REF:0000024 MGI:6436389 NCBI chr 4:157,468,397...157,509,889
Ensembl chr 4:157,468,290...157,509,880 		JBrowse link
G Lpcat4 lysophosphatidylcholine acyltransferase 4 involved_in ISO (PMID:18458083) RGD PMID:18458083 NCBI chr 3:99,044,729...99,052,963
Ensembl chr 3:99,044,729...99,052,875 		JBrowse link
G Mboat1 membrane bound O-acyltransferase domain containing 1 involved_in ISO (PMID:18772128) RGD PMID:18772128 NCBI chr17:34,331,413...34,445,088
Ensembl chr17:34,331,422...34,445,088 		JBrowse link
G Mboat2 membrane bound O-acyltransferase domain containing 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:18772128)		 UniProt
RGD		 PMID:18772128 GO_REF:0000024 NCBI chr 6:41,471,135...41,597,599
Ensembl chr 6:41,471,161...41,593,485 		JBrowse link
G Pla2g2f phospholipase A2, group IIF involved_in ISO (PMID:11112443) RGD PMID:11112443 NCBI chr 5:150,986,788...150,993,175
Ensembl chr 5:150,986,788...150,993,175 		JBrowse link
phosphatidylserine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plscr1 phospholipid scramblase 1 involved_in ISO (MGI:5284813|PMID:12509439) RGD PMID:12509439 MGI:5284813 NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692 		JBrowse link
G Ptdss1 phosphatidylserine synthase 1 involved_in ISO
IEA		 (PMID:19014349)
GO_REF:0000041		 RGD
UniProt		 PMID:19014349 GO_REF:0000041 NCBI chr 7:63,845,017...63,906,791
Ensembl chr 7:63,844,268...63,906,791 		JBrowse link
G Ptdss2 phosphatidylserine synthase 2 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:19014349)
GO_REF:0000041
MGI:2447151 (MGI:2446765|PMID:12361952)		 RGD
UniProt		 PMID:12361952 PMID:19014349 GO_REF:0000041 MGI:2446765 NCBI chr 1:196,241,439...196,267,632
Ensembl chr 1:196,241,494...196,267,685 		JBrowse link
G Slc27a1 solute carrier family 27 member 1 involved_in IBA
ISO		 PMID:21873635
(PMID:19523918)		 RGD PMID:19523918 PMID:21873635 RGD:13792537 NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063 		JBrowse link
phosphatidylserine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd12 abhydrolase domain containing 12, lysophospholipase involved_in
acts_upstream_of_or_within		 IBA
ISO
ISS		 PMID:21873635
MGI:5487621 (MGI:5469248|PMID:23297193)
GO_REF:0000024
(PMID:30643283)		 RGD
UniProt		 PMID:23297193 PMID:30643283 PMID:21873635 GO_REF:0000024 MGI:5469248, RGD:13792537 NCBI chr 3:139,659,315...139,719,529
Ensembl chr 3:139,659,317...139,719,564 		JBrowse link
G Abhd12b abhydrolase domain containing 12B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:88,668,748...88,696,166
Ensembl chr 6:88,668,642...88,696,458 		JBrowse link
G Abhd16a abhydrolase domain containing 16A, phospholipase involved_in IEA
ISS
IBA
ISO		 GO_REF:0000107
GO_REF:0000024
PMID:21873635
(MGI:5779796|PMID:25580854)		 Ensembl
UniProt
RGD		 PMID:25580854 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:5779796, RGD:13792537 NCBI chr20:3,719,089...3,733,952
Ensembl chr20:3,719,091...3,733,927 		JBrowse link
G Abhd16b abhydrolase domain containing 16B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:168,594,677...168,596,574
Ensembl chr 3:168,594,609...168,619,762 		JBrowse link
regulation of phosphatidylserine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mfsd2a MFSD2 lysolipid transporter A, lysophospholipid acts_upstream_of ISO (MGI:6196220|PMID:30074985) RGD PMID:30074985 MGI:6196220 NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19903
    metabolic process 12212
      cellular metabolic process 9633
        cellular modified amino acid metabolic process 126
          phosphatidylserine metabolic process 21
            negative regulation of phosphatidylserine metabolic process + 0
            phosphatidylserine acyl-chain remodeling 5
            phosphatidylserine biosynthetic process + 4
            phosphatidylserine catabolic process 4
            positive regulation of phosphatidylserine metabolic process + 0
            regulation of phosphatidylserine metabolic process + 1
Path 2
Term Annotations click to browse term
  biological_process 19903
    metabolic process 12212
      organic substance metabolic process 11753
        lipid metabolic process 1457
          cellular lipid metabolic process 1055
            glycerolipid metabolic process 391
              glycerophospholipid metabolic process 288
                phosphatidylserine metabolic process 21
                  negative regulation of phosphatidylserine metabolic process + 0
                  phosphatidylserine acyl-chain remodeling 5
                  phosphatidylserine biosynthetic process + 4
                  phosphatidylserine catabolic process 4
                  positive regulation of phosphatidylserine metabolic process + 0
                  regulation of phosphatidylserine metabolic process + 1
paths to the root