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ONTOLOGY REPORT - ANNOTATIONS

Term:phosphatidylcholine biosynthetic process
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Accession:GO:0006656 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
Synonyms:exact_synonym: phosphatidylcholine anabolism;   phosphatidylcholine biosynthesis;   phosphatidylcholine formation;   phosphatidylcholine synthesis


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phosphatidylcholine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A1 involved_in ISO
IEA		 (PMID:4335615)
GO_REF:0000107		 RGD
Ensembl		 PMID:4335615 GO_REF:0000107 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoa2 apolipoprotein A2 involved_in ISO (PMID:14967812) RGD PMID:14967812 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355 		JBrowse link
G Cept1 choline/ethanolamine phosphotransferase 1 acts_upstream_of_or_within ISO (MGI:4460850|PMID:20018880) RGD PMID:20018880 MGI:4460850 NCBI chr 2:193,994,220...194,036,141
Ensembl chr 2:193,993,447...194,035,578 		JBrowse link
G Chka choline kinase alpha involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
(PMID:34077757)
(MGI:3623691|PMID:16371353)
(PMID:19915674)		 UniProt
RGD		 PMID:16371353 PMID:19915674 PMID:34077757 GO_REF:0000024 MGI:3623691 NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516 		JBrowse link
G Chkb choline kinase beta acts_upstream_of_or_within ISO MGI:3578417 (MGI:3623691|PMID:16371353) RGD PMID:16371353 MGI:3623691 NCBI chr 7:120,500,960...120,504,359
Ensembl chr 7:120,500,984...120,504,461 		JBrowse link
G Chpt1 choline phosphotransferase 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:10893425)
(MGI:4460850|PMID:20018880)		 RGD PMID:10893425 PMID:20018880 MGI:4460850 NCBI chr 7:22,866,455...22,915,111
Ensembl chr 7:22,863,027...22,915,103 		JBrowse link
G Dhrs7b dehydrogenase/reductase 7B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:6103958|PMID:28930673)
GO_REF:0000107		 RGD
Ensembl		 PMID:28930673 GO_REF:0000107 MGI:6103958 NCBI chr10:45,504,344...45,537,094
Ensembl chr10:45,504,426...45,537,076 		JBrowse link
G Fabp5 fatty acid binding protein 5 acts_upstream_of_or_within ISO MGI:95476 (MGI:3045488|PMID:15164767) RGD PMID:15164767 MGI:3045488 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773 		JBrowse link
G Fgf7 fibroblast growth factor 7 IMP surfactant disaturated phosphatidylcholine (DSPC) synthesis RGD PMID:11316745 RGD:68696 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929 		JBrowse link
G Gpat4 glycerol-3-phosphate acyltransferase 4 involved_in ISO (PMID:18238778) RGD PMID:18238778 NCBI chr16:68,819,031...68,852,903
Ensembl chr16:68,819,079...68,852,901 		JBrowse link
G Lcat lecithin cholesterol acyltransferase involved_in ISO
IEA		 (PMID:11966470), (PMID:12354767)
GO_REF:0000107		 RGD
Ensembl		 PMID:11966470 PMID:12354767 GO_REF:0000107 NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231 		JBrowse link
G Lpcat1 lysophosphatidylcholine acyltransferase 1 acts_upstream_of ISO (MGI:4460850|PMID:20018880) RGD PMID:20018880 MGI:4460850 NCBI chr 1:29,766,070...29,816,401
Ensembl chr 1:29,766,071...29,816,401 		JBrowse link
G Lpcat3 lysophosphatidylcholine acyltransferase 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:157,468,397...157,509,889
Ensembl chr 4:157,468,290...157,509,880 		JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1A, choline acts_upstream_of_or_within
involved_in		 TAS
ISO
IDA
IMP		 MGI:2176050|MGI:3027956 (MGI:2159547|PMID:11829742), (MGI:3575987|PMID:15798219)
(MGI:2667298|PMID:12842190)
PMID:8381041
PMID:8185307
(PMID:10480912)		 RGD PMID:10480912 PMID:11829742 PMID:12842190 PMID:15798219 PMID:2166941 More... MGI:2159547 MGI:2667298 MGI:3575987, RGD:70012, RGD:729578, RGD:39458015, RGD:729598 NCBI chr11:68,313,860...68,357,828
Ensembl chr11:68,313,882...68,357,357 		JBrowse link
G Pcyt1b phosphate cytidylyltransferase 1B, choline involved_in ISO
ISS		 (PMID:10480912)
(MGI:2667298|PMID:12842190)
GO_REF:0000024		 RGD
UniProt		 PMID:10480912 PMID:12842190 GO_REF:0000024 MGI:2667298 NCBI chr  X:58,378,090...58,471,623
Ensembl chr  X:58,378,116...58,468,935 		JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase involved_in IDA
IBA
IEA		 PMID:21873635
GO_REF:0000041		 UniProt
RGD		 PMID:8344945 PMID:21873635 GO_REF:0000041, RGD:729486, RGD:13792537 NCBI chr10:44,775,910...44,849,990
Ensembl chr10:44,775,911...44,850,013 		JBrowse link
G Phka1 phosphorylase kinase regulatory subunit alpha 1 TAS RGD PMID:12401806 RGD:724642 NCBI chr  X:67,601,302...67,738,504
Ensembl chr  X:67,601,302...67,738,455 		JBrowse link
G Slc27a1 solute carrier family 27 member 1 involved_in ISO
IEA
IBA		 (PMID:19523918)
GO_REF:0000107
PMID:21873635		 RGD
Ensembl		 PMID:19523918 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063 		JBrowse link
CDP-choline pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cept1 choline/ethanolamine phosphotransferase 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:193,994,220...194,036,141
Ensembl chr 2:193,993,447...194,035,578 		JBrowse link
G Chka choline kinase alpha involved_in IBA
IEA		 PMID:21873635
GO_REF:0000108		 GOC PMID:21873635 GO_REF:0000108, RGD:13792537 NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516 		JBrowse link
G Chkb choline kinase beta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:120,500,960...120,504,359
Ensembl chr 7:120,500,984...120,504,461 		JBrowse link
G Chpt1 choline phosphotransferase 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:22,866,455...22,915,111
Ensembl chr 7:22,863,027...22,915,103 		JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1A, choline involved_in IDA
ISO		 PMID:19783652
(MGI:2667298|PMID:12842190)
PMID:8185307
(PMID:10480912)
PMID:8381041		 RGD PMID:10480912 PMID:12842190 PMID:19783652 PMID:8185307 PMID:8381041 MGI:2667298, RGD:8553740, RGD:39458015, RGD:729578 NCBI chr11:68,313,860...68,357,828
Ensembl chr11:68,313,882...68,357,357 		JBrowse link
G Pcyt1b phosphate cytidylyltransferase 1B, choline involved_in IEA
ISO
ISS		 GO_REF:0000107
GO_REF:0000002
(MGI:2667298|PMID:12842190)
GO_REF:0000024
(PMID:10480912)		 Ensembl
InterPro
RGD
UniProt		 PMID:10480912 PMID:12842190 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 MGI:2667298 NCBI chr  X:58,378,090...58,471,623
Ensembl chr  X:58,378,116...58,468,935 		JBrowse link
G Phka1 phosphorylase kinase regulatory subunit alpha 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr  X:67,601,302...67,738,504
Ensembl chr  X:67,601,302...67,738,455 		JBrowse link
negative regulation of phosphatidylcholine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lpcat1 lysophosphatidylcholine acyltransferase 1 acts_upstream_of_or_within ISO (MGI:4460850|PMID:20018880) RGD PMID:20018880 MGI:4460850 NCBI chr 1:29,766,070...29,816,401
Ensembl chr 1:29,766,071...29,816,401 		JBrowse link
positive regulation of phosphatidylcholine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl3 acyl-CoA synthetase long-chain family member 3 involved_in ISO
IEA		 (PMID:18003621)
GO_REF:0000107		 RGD
Ensembl		 PMID:18003621 GO_REF:0000107 NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627 		JBrowse link
G Capn2 calpain 2 IMP RGD PMID:9481489 RGD:13792658 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Rab38 RAB38, member RAS oncogene family IDA RGD PMID:28438206 RGD:13524861 NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924 		JBrowse link
regulation of phosphatidylcholine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fabp3 fatty acid binding protein 3 acts_upstream_of_or_within ISO MGI:101790 (MGI:3045488|PMID:15164767) RGD PMID:15164767 MGI:3045488 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19574
    metabolic process 11556
      organic substance metabolic process 10908
        organonitrogen compound metabolic process 5634
          organonitrogen compound biosynthetic process 2154
            phosphatidylcholine biosynthetic process 22
              CDP-choline pathway 7
              negative regulation of phosphatidylcholine biosynthetic process 1
              phosphatidylcholine biosynthesis from choline and CDP-diacylglycerol 0
              phosphatidylcholine biosynthesis from phosphatidylethanolamine 0
              phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via CDP-N-methylethanolamine 0
              phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine 0
              phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline 0
              phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine 0
              positive regulation of phosphatidylcholine biosynthetic process 3
              regulation of phosphatidylcholine biosynthetic process + 5
Path 2
Term Annotations click to browse term
  biological_process 19574
    metabolic process 11556
      cellular metabolic process 10142
        phosphorus metabolic process 2073
          phosphate-containing compound metabolic process 2045
            phospholipid metabolic process 352
              glycerophospholipid metabolic process 257
                phosphatidylcholine metabolic process 65
                  phosphatidylcholine biosynthetic process 22
                    CDP-choline pathway 7
                    negative regulation of phosphatidylcholine biosynthetic process 1
                    phosphatidylcholine biosynthesis from choline and CDP-diacylglycerol 0
                    phosphatidylcholine biosynthesis from phosphatidylethanolamine 0
                    phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via CDP-N-methylethanolamine 0
                    phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine 0
                    phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline 0
                    phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine 0
                    positive regulation of phosphatidylcholine biosynthetic process 3
                    regulation of phosphatidylcholine biosynthetic process + 5
paths to the root