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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylcholine biosynthetic process
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Accession:GO:0006656 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
Synonyms:exact_synonym: phosphatidylcholine anabolism;   phosphatidylcholine biosynthesis;   phosphatidylcholine formation;   phosphatidylcholine synthesis
 xref: Reactome:R-HSA-1483191 "Synthesis of PC"



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phosphatidylcholine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A1 involved_in ISO
IEA
(PMID:4335615)
GO_REF:0000107
RGD
Ensembl
PMID:4335615 GO_REF:0000107 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apoa2 apolipoprotein A2 involved_in ISO (PMID:14967812) RGD PMID:14967812 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
JBrowse link
G Cept1 choline/ethanolamine phosphotransferase 1 acts_upstream_of_or_within
involved_in
ISO (PMID:20018880)
(PMID:10191259), (PMID:37137909)
RGD PMID:10191259 PMID:20018880 PMID:37137909 NCBI chr 2:193,994,220...194,036,141
Ensembl chr 2:193,993,447...194,035,578
JBrowse link
G Chka choline kinase alpha involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(PMID:19915674), (PMID:23416529)
(PMID:16371353)
(PMID:34077757)
UniProt
RGD
PMID:16371353 PMID:19915674 PMID:23416529 PMID:34077757 GO_REF:0000024 NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516
JBrowse link
G Chkb choline kinase beta acts_upstream_of_or_within ISO MGI:3578417 (PMID:16371353) RGD PMID:16371353 NCBI chr 7:120,500,960...120,504,359
Ensembl chr 7:120,500,984...120,504,461
JBrowse link
G Chpt1 choline phosphotransferase 1 involved_in
acts_upstream_of_or_within
ISO (PMID:10893425)
(PMID:20018880)
RGD PMID:10893425 PMID:20018880 NCBI chr 7:22,866,455...22,915,111
Ensembl chr 7:22,863,027...22,915,103
JBrowse link
G Dhrs7b dehydrogenase/reductase 7B involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:28930673)
Ensembl
RGD
PMID:28930673 GO_REF:0000107 NCBI chr10:45,504,344...45,537,094
Ensembl chr10:45,504,426...45,537,076
JBrowse link
G Fabp5 fatty acid binding protein 5 acts_upstream_of_or_within ISO MGI:95476 (PMID:15164767) RGD PMID:15164767 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
JBrowse link
G Fgf7 fibroblast growth factor 7 IMP surfactant disaturated phosphatidylcholine (DSPC) synthesis RGD PMID:11316745 RGD:68696 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929
JBrowse link
G Gpat4 glycerol-3-phosphate acyltransferase 4 involved_in ISO (PMID:18238778) RGD PMID:18238778 NCBI chr16:68,819,031...68,852,903
Ensembl chr16:68,819,079...68,852,901
JBrowse link
G Lcat lecithin cholesterol acyltransferase involved_in ISO
IEA
(PMID:11966470), (PMID:12354767)
GO_REF:0000107
RGD
Ensembl
PMID:11966470 PMID:12354767 GO_REF:0000107 NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
JBrowse link
G Lpcat1 lysophosphatidylcholine acyltransferase 1 acts_upstream_of ISO (PMID:20018880) RGD PMID:20018880 NCBI chr 1:29,766,070...29,816,401
Ensembl chr 1:29,766,071...29,816,401
JBrowse link
G Lpcat3 lysophosphatidylcholine acyltransferase 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:157,468,397...157,509,889
Ensembl chr 4:157,468,290...157,509,880
JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1A, choline involved_in
acts_upstream_of_or_within
TAS
ISO
IDA
IMP
(PMID:12842190)
PMID:24275660
MGI:2176050|MGI:3027956 (PMID:11829742), (PMID:15798219)
PMID:8381041
PMID:8185307
(PMID:10480912)
RGD PMID:10480912 PMID:11829742 PMID:12842190 PMID:15798219 PMID:2166941 More... RGD:70012, RGD:405866193, RGD:729578, RGD:39458015, RGD:729598 NCBI chr11:68,313,860...68,357,828
Ensembl chr11:68,313,882...68,357,357
JBrowse link
G Pcyt1b phosphate cytidylyltransferase 1B, choline involved_in ISO
ISS
(PMID:10480912)
(PMID:12842190)
GO_REF:0000024
RGD
UniProt
PMID:10480912 PMID:12842190 GO_REF:0000024 NCBI chr  X:58,378,090...58,471,623
Ensembl chr  X:58,378,116...58,468,935
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase involved_in IDA
IBA
IEA
GO_REF:0000033
GO_REF:0000041
GO_Central
UniProt
RGD
PMID:8344945 GO_REF:0000033 GO_REF:0000041, RGD:729486 NCBI chr10:44,775,910...44,849,990
Ensembl chr10:44,775,911...44,850,013
JBrowse link
G Phka1 phosphorylase kinase regulatory subunit alpha 1 TAS RGD PMID:12401806 RGD:724642 NCBI chr  X:67,601,302...67,738,504
Ensembl chr  X:67,601,302...67,738,455
JBrowse link
CDP-choline pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cept1 choline/ethanolamine phosphotransferase 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:193,994,220...194,036,141
Ensembl chr 2:193,993,447...194,035,578
JBrowse link
G Chka choline kinase alpha involved_in IEA
IBA
GO_REF:0000108
GO_REF:0000033
GOC
GO_Central
GO_REF:0000033 GO_REF:0000108 NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516
JBrowse link
G Chkb choline kinase beta involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:120,500,960...120,504,359
Ensembl chr 7:120,500,984...120,504,461
JBrowse link
G Chpt1 choline phosphotransferase 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:22,866,455...22,915,111
Ensembl chr 7:22,863,027...22,915,103
JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1A, choline involved_in IDA
ISO
PMID:19783652
(PMID:12842190)
PMID:8185307
(PMID:10480912)
PMID:8381041
RGD PMID:10480912 PMID:12842190 PMID:19783652 PMID:8185307 PMID:8381041 RGD:8553740, RGD:39458015, RGD:729578 NCBI chr11:68,313,860...68,357,828
Ensembl chr11:68,313,882...68,357,357
JBrowse link
G Pcyt1b phosphate cytidylyltransferase 1B, choline involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:12842190)
GO_REF:0000002
GO_REF:0000024
(PMID:10480912)
Ensembl
RGD
InterPro
UniProt
PMID:10480912 PMID:12842190 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:58,378,090...58,471,623
Ensembl chr  X:58,378,116...58,468,935
JBrowse link
G Phka1 phosphorylase kinase regulatory subunit alpha 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr  X:67,601,302...67,738,504
Ensembl chr  X:67,601,302...67,738,455
JBrowse link
negative regulation of phosphatidylcholine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lpcat1 lysophosphatidylcholine acyltransferase 1 acts_upstream_of_or_within ISO (PMID:20018880) RGD PMID:20018880 NCBI chr 1:29,766,070...29,816,401
Ensembl chr 1:29,766,071...29,816,401
JBrowse link
positive regulation of phosphatidylcholine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl3 acyl-CoA synthetase long-chain family member 3 involved_in ISO
IEA
(PMID:18003621)
GO_REF:0000107
RGD
Ensembl
PMID:18003621 GO_REF:0000107 NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627
JBrowse link
G Capn2 calpain 2 IMP RGD PMID:9481489 RGD:13792658 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Rab38 RAB38, member RAS oncogene family IDA RGD PMID:28438206 RGD:13524861 NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924
JBrowse link
regulation of phosphatidylcholine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fabp3 fatty acid binding protein 3 acts_upstream_of_or_within ISO MGI:101790 (PMID:15164767) RGD PMID:15164767 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    cellular process 19525
      metabolic process 12160
        biosynthetic process 8651
          lipid biosynthetic process 731
            glycerolipid biosynthetic process 211
              glycerophospholipid biosynthetic process 162
                phosphatidylcholine biosynthetic process 21
                  CDP-choline pathway 7
                  negative regulation of phosphatidylcholine biosynthetic process 1
                  phosphatidylcholine biosynthesis from choline and CDP-diacylglycerol 0
                  phosphatidylcholine biosynthesis from phosphatidylethanolamine 0
                  phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via CDP-N-methylethanolamine 0
                  phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine 0
                  phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline 0
                  phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine 0
                  positive regulation of phosphatidylcholine biosynthetic process 3
                  regulation of phosphatidylcholine biosynthetic process + 5
Path 2
Term Annotations click to browse term
  biological_process 20536
    cellular process 19525
      metabolic process 12160
        primary metabolic process 10746
          lipid metabolic process 1458
            phospholipid metabolic process 381
              glycerophospholipid metabolic process 277
                phosphatidylcholine metabolic process 66
                  phosphatidylcholine biosynthetic process 21
                    CDP-choline pathway 7
                    negative regulation of phosphatidylcholine biosynthetic process 1
                    phosphatidylcholine biosynthesis from choline and CDP-diacylglycerol 0
                    phosphatidylcholine biosynthesis from phosphatidylethanolamine 0
                    phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via CDP-N-methylethanolamine 0
                    phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine 0
                    phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline 0
                    phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine 0
                    positive regulation of phosphatidylcholine biosynthetic process 3
                    regulation of phosphatidylcholine biosynthetic process + 5
paths to the root