ONTOLOGY REPORT - ANNOTATIONS
Term: fatty acid beta-oxidation
Accession: GO:0006635
browse the term
Definition: A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
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ABCD1
ATP binding cassette subfamily D member 1
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr X:128,152,697...128,171,007
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ABCD2
ATP binding cassette subfamily D member 2
involved_in
ISO
(PMID:21145416) (PMID:10196381) (MGI:5315378|PMID:10196381)
UniProt
PMID:10196381 PMID:21145416
MGI:5315378
NCBI chr11:35,818,451...35,884,696
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ABCD2
ATP binding cassette subfamily D member 2
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
Ensembl chr11:35,866,928...35,884,503
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ABCD3
ATP binding cassette subfamily D member 3
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr20:38,750,147...38,846,011
Ensembl chr20:38,748,787...38,845,989
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ABCD4
ATP binding cassette subfamily D member 4
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr24:51,497,440...51,516,919
Ensembl chr24:51,495,790...51,516,905
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ACAA1
acetyl-CoA acyltransferase 1
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr15:1,282,556...1,297,154
Ensembl chr15:1,282,650...1,297,832
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ACAA2
acetyl-CoA acyltransferase 2
ISO
RGD
PMID:11879205
RGD:2317624
NCBI chr18:31,152,067...31,181,020
Ensembl chr18:31,152,074...31,181,706
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ACADM
acyl-CoA dehydrogenase medium chain
involved_in
IEA
InterPro Ensembl
GO_REF:0000002 GO_REF:0000107
NCBI chr20:57,428,863...57,468,422
Ensembl chr20:57,428,472...57,468,359
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ACADVL
acyl-CoA dehydrogenase very long chain
ISO
RGD
PMID:8034667
RGD:631729
NCBI chr16:6,593,288...6,598,980
Ensembl chr16:6,593,287...6,598,979
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ACAT1
acetyl-CoA acetyltransferase 1
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 1:99,552,760...99,580,079
Ensembl chr 1:99,552,838...99,579,914
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ACAT2
acetyl-CoA acetyltransferase 2
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr13:87,363,527...87,378,002
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ACOX1
acyl-CoA oxidase 1
involved_in
IEA
UniProt
GO_REF:0000117
NCBI chr16:45,706,009...45,745,564
Ensembl chr16:45,706,360...45,740,247
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ACOX2
acyl-CoA oxidase 2
involved_in
ISO IEA
RGD InterPro
PMID:1400324 PMID:8654595
GO_REF:0000002 RGD:2299949 RGD:2299971
NCBI chr22:19,805,736...19,838,399
Ensembl chr22:19,804,440...19,838,374
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ACOXL
acyl-CoA oxidase like
involved_in
IEA
InterPro
GO_REF:0000002
Ensembl chr14:13,812,041...14,173,333
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ADIPOQ
adiponectin, C1Q and collagen domain containing
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:12151381)
Ensembl MGI
PMID:12151381
GO_REF:0000107
NCBI chr15:81,128,427...81,142,779
Ensembl chr15:81,129,795...81,147,391
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ALDH1L2
aldehyde dehydrogenase 1 family member L2
acts_upstream_of_or_within_positive_effect
ISO
(MGI:6489626|PMID:33168096)
UniProt
PMID:33168096
MGI:6489626
NCBI chr11:100,242,649...100,311,164
Ensembl chr11:100,247,262...100,298,621
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AUH
AU RNA binding methylglutaconyl-CoA hydratase
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr12:101,654,957...101,799,863
Ensembl chr12:101,653,386...101,799,792
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BDH2
3-hydroxybutyrate dehydrogenase 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 7:51,185,303...51,206,300
Ensembl chr 7:51,183,107...51,206,261
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CPT1A
carnitine palmitoyltransferase 1A
involved_in
ISO IEA
RGD UniProt
PMID:31901136 PMID:31953200
GO_REF:0000041 RGD:25823178 RGD:25823179
NCBI chr 1:5,704,275...5,784,077
Ensembl chr 1:5,730,853...5,784,337
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CPT1B
carnitine palmitoyltransferase 1B
involved_in
IEA
UniProt
GO_REF:0000041
NCBI chr19:33,044,272...33,055,197
Ensembl chr19:33,043,916...33,054,247
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CPT1C
carnitine palmitoyltransferase 1C
involved_in
IEA
UniProt
GO_REF:0000041
NCBI chr 6:42,865,706...42,885,359
Ensembl chr 6:42,866,921...42,885,185
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CPT2
carnitine palmitoyltransferase 2
involved_in
ISO IEA
RGD TreeGrafter Ensembl
PMID:10380116 PMID:10796071
GO_REF:0000107 GO_REF:0000118 RGD:21410186 RGD:2326088
NCBI chr20:79,710,638...79,728,100
Ensembl chr20:79,706,584...79,727,689
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CROT
carnitine O-octanoyltransferase
involved_in
IEA
UniProt Ensembl
GO_REF:0000041 GO_REF:0000107
NCBI chr21:61,531,263...61,584,448
Ensembl chr21:61,531,060...61,584,447
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DECR1
2,4-dienoyl-CoA reductase 1
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 8:85,086,843...85,129,267
Ensembl chr 8:85,086,874...85,129,160
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ECH1
enoyl-CoA hydratase 1
involved_in
IEA
UniProt
GO_REF:0000041
NCBI chr 6:33,439,490...33,449,349
Ensembl chr 6:33,439,682...33,449,272
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ECHDC1
ethylmalonyl-CoA decarboxylase 1
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr13:46,386,543...46,440,730
Ensembl chr13:46,398,058...46,439,533
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ECHDC2
enoyl-CoA hydratase domain containing 2
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr20:80,017,665...80,043,810
Ensembl chr20:80,017,421...80,044,670
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ECHS1
enoyl-CoA hydratase, short chain 1
involved_in
ISO
(PMID:26251176)
RGD UniProt
PMID:12379132 PMID:26251176
RGD:2317616
NCBI chr26:53,212,299...53,222,805
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ECHS1
enoyl-CoA hydratase, short chain 1
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
Ensembl chr26:53,210,972...53,222,782
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ECI1
enoyl-CoA delta isomerase 1
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:11916962)
Ensembl TreeGrafter MGI
PMID:11916962
GO_REF:0000107 GO_REF:0000118
NCBI chr 5:2,135,042...2,147,246
Ensembl chr 5:2,135,129...2,147,109
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ECI2
enoyl-CoA delta isomerase 2
ISO
RGD
PMID:11781327
RGD:2306199
NCBI chr17:68,034,906...68,054,825
Ensembl chr17:68,034,939...68,054,657
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EHHADH
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:17442273)
Ensembl TreeGrafter MGI UniProt
PMID:17442273
GO_REF:0000041 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118
NCBI chr15:4,164,795...4,228,593
Ensembl chr15:4,164,838...4,228,651
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HADH
hydroxyacyl-CoA dehydrogenase
involved_in
ISO IEA
RGD TreeGrafter Ensembl
PMID:17491019
GO_REF:0000107 GO_REF:0000118 RGD:2302227
NCBI chr 7:55,919,499...55,965,074
Ensembl chr 7:55,919,623...55,964,857
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HADHA
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:11390422)
RGD MGI UniProt Ensembl InterPro
PMID:1730633 PMID:11390422
GO_REF:0000002 GO_REF:0000041 GO_REF:0000107 GO_REF:0000117 RGD:1600572
NCBI chr14:81,411,620...81,468,415
Ensembl chr14:81,411,648...81,472,257
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HADHB
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
involved_in
ISO IEA
RGD TreeGrafter Ensembl
PMID:1730633
GO_REF:0000107 GO_REF:0000118 RGD:1600572
NCBI chr14:81,361,735...81,411,588
Ensembl chr14:81,361,612...81,411,432
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HSD17B10
hydroxysteroid 17-beta dehydrogenase 10
involved_in
ISO
(PMID:12917011)
UniProt
PMID:12917011
NCBI chr X:49,568,206...49,571,356
Ensembl chr X:49,567,267...49,571,292
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HSD17B4
hydroxysteroid 17-beta dehydrogenase 4
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:17442273)
UniProt MGI Ensembl
PMID:17442273
GO_REF:0000041 GO_REF:0000107
NCBI chr23:22,674,059...22,761,270
Ensembl chr23:22,674,072...22,762,056
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LEP
leptin
acts_upstream_of_or_within
ISO
(PMID:22958918)
MGI
PMID:22958918
NCBI chr21:97,056,913...97,071,161
Ensembl chr21:97,057,529...97,071,220
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LOC103235723
acetyl-CoA acetyltransferase, cytosolic-like
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 7:18,128,687...18,130,334
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MTLN
mitoregulin
involved_in
ISO
(PMID:32243843)
UniProt
PMID:32243843
NCBI chr14:13,595,687...13,596,974
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PEX2
peroxisomal biogenesis factor 2
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 8:72,513,975...72,532,399
Ensembl chr 8:72,514,307...72,517,003
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PEX5
peroxisomal biogenesis factor 5
acts_upstream_of_or_within
ISO
(PMID:17442273) (PMID:9288097)
MGI
PMID:9288097 PMID:17442273
NCBI chr11:7,255,078...7,286,500
Ensembl chr11:7,256,182...7,274,938
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PEX7
peroxisomal biogenesis factor 7
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:12915479)
Ensembl MGI
PMID:12915479
GO_REF:0000107
NCBI chr13:36,486,636...36,585,662
Ensembl chr13:36,485,513...36,585,736
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PPARD
peroxisome proliferator activated receptor delta
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr17:36,695,546...36,779,554
Ensembl chr17:36,695,494...36,779,577
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SCP2
sterol carrier protein 2
involved_in
ISO
PMID:9325339
UniProt
PMID:9325339
RGD:21201257
NCBI chr20:79,868,825...79,993,906
Ensembl chr20:79,865,332...79,993,835
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SESN2
sestrin 2
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:22958918)
Ensembl MGI
PMID:22958918
GO_REF:0000107
NCBI chr20:104,521,131...104,544,161
Ensembl chr20:104,521,132...104,544,001
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SLC25A17
solute carrier family 25 member 17
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr19:23,323,925...23,368,368
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SLC27A2
solute carrier family 27 member 2
involved_in
ISO
(PMID:10198260)
UniProt
PMID:10198260
NCBI chr26:33,080,844...33,134,467
Ensembl chr26:33,083,317...33,134,433
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ACAD11
acyl-CoA dehydrogenase family member 11
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr15:57,632,139...57,706,468
Ensembl chr15:57,626,742...57,707,504
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ACADL
acyl-CoA dehydrogenase long chain
involved_in
ISO
(PMID:15639194) (MGI:3526480|PMID:15639194)
RGD BHF-UCL
PMID:3968063 PMID:15639194
MGI:3526480 RGD:2317678
NCBI chr10:95,886,502...95,925,928
Ensembl chr10:95,887,465...95,925,578
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ACADM
acyl-CoA dehydrogenase medium chain
involved_in
ISO IEA
RGD Ensembl
PMID:3968063
GO_REF:0000107 RGD:2317678
NCBI chr20:57,428,863...57,468,422
Ensembl chr20:57,428,472...57,468,359
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ACADS
acyl-CoA dehydrogenase short chain
involved_in
ISO IEA
RGD TreeGrafter
PMID:3968063
GO_REF:0000118 RGD:2317678
NCBI chr11:116,083,156...116,096,554
Ensembl chr11:116,083,276...116,096,607
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ACADVL
acyl-CoA dehydrogenase very long chain
involved_in
ISO
(PMID:9599005) (PMID:7668252) (MGI:3526480|PMID:15639194)
UniProt BHF-UCL
PMID:7668252 PMID:9599005 PMID:15639194
MGI:3526480
NCBI chr16:6,593,288...6,598,980
Ensembl chr16:6,593,287...6,598,979
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ETFA
electron transfer flavoprotein subunit alpha
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr26:6,970,593...7,075,077
Ensembl chr26:6,970,584...7,076,049
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ETFB
electron transfer flavoprotein subunit beta
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 6:44,269,123...44,286,039
Ensembl chr 6:44,267,702...44,286,065
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ETFDH
electron transfer flavoprotein dehydrogenase
involved_in
ISO
(PMID:17412732)
BHF-UCL
PMID:17412732
NCBI chr 7:105,214,231...105,252,100
Ensembl chr 7:105,213,653...105,254,502
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GCDH
glutaryl-CoA dehydrogenase
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 6:11,572,512...11,588,108
Ensembl chr 6:11,572,540...11,588,224
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IVD
isovaleryl-CoA dehydrogenase
involved_in
ISO
(PMID:3597357)
BHF-UCL
PMID:3597357
NCBI chr26:42,592,387...42,605,931
Ensembl chr26:42,589,709...42,606,199
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ACOX1
acyl-CoA oxidase 1
involved_in
ISO IEA
RGD TreeGrafter InterPro Ensembl
PMID:1400324
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:2299949
NCBI chr16:45,706,009...45,745,564
Ensembl chr16:45,706,360...45,740,247
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ACOX2
acyl-CoA oxidase 2
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr22:19,805,736...19,838,399
Ensembl chr22:19,804,440...19,838,374
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ACOX3
acyl-CoA oxidase 3, pristanoyl
ISO
RGD
PMID:1400324 PMID:8026493 PMID:8654595
RGD:2299949 RGD:2299969 RGD:2299971
NCBI chr27:44,313,297...44,366,702
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ACOXL
acyl-CoA oxidase like
involved_in
IEA
TreeGrafter
GO_REF:0000118
Ensembl chr14:13,812,041...14,173,333
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CRAT
carnitine O-acetyltransferase
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:9,057,365...9,072,692
Ensembl chr12:9,058,824...9,072,813
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ACACB
acetyl-CoA carboxylase beta
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr11:104,325,250...104,488,567
Ensembl chr11:104,349,573...104,488,003
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AKT1
AKT serine/threonine kinase 1
involved_in
ISO
(PMID:16814735)
BHF-UCL
PMID:16814735
NCBI chr24:82,704,087...82,730,711
Ensembl chr24:82,704,068...82,727,698
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CNR1
cannabinoid receptor 1
ISO
RGD
PMID:19724020
RGD:2314644
NCBI chr13:12,626,259...12,653,253
Ensembl chr13:12,630,270...12,631,688
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DBI
diazepam binding inhibitor, acyl-CoA binding protein
ISO
RGD
PMID:11485163
RGD:2316274
NCBI chr10:10,956,529...10,962,135
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MFSD2A
MFSD2 lysolipid transporter A, lysophospholipid
acts_upstream_of_or_within involved_in
ISO IEA
(MGI:5474727|PMID:23209793)
ARUK-UCL Ensembl
PMID:23209793
GO_REF:0000107 MGI:5474727
NCBI chr20:92,926,217...92,941,191
Ensembl chr20:92,926,067...92,941,159
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PINK1
PTEN induced kinase 1
ISO
RGD
PMID:25421206
RGD:11560775
NCBI chr20:111,902,135...111,919,082
Ensembl chr20:111,902,765...111,919,069
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PLIN5
perilipin 5
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:4,251,316...4,262,656
Ensembl chr 6:4,251,751...4,261,126
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ETFBKMT
electron transfer flavoprotein subunit beta lysine methyltransferase
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr11:31,122,358...31,147,473
Ensembl chr11:31,134,559...31,147,174
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ABCD1
ATP binding cassette subfamily D member 1
involved_in
ISO
(MGI:3835692|PMID:18854420), (MGI:3836690|PMID:18723473), (MGI:6189665|PMID:23123468) (PMID:23123468)
UniProt
PMID:18723473 PMID:18854420 PMID:23123468
MGI:3835692 MGI:3836690 MGI:6189665
NCBI chr X:128,152,697...128,171,007
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ABCD2
ATP binding cassette subfamily D member 2
involved_in
ISO
(PMID:10196381) (PMID:18723473), (PMID:18854420) (MGI:3835692|PMID:18854420), (MGI:3836690|PMID:18723473)
UniProt
PMID:10196381 PMID:18723473 PMID:18854420
MGI:3835692 MGI:3836690
NCBI chr11:35,818,451...35,884,696
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ABCD2
ATP binding cassette subfamily D member 2
involved_in
IEA
Ensembl
GO_REF:0000107
Ensembl chr11:35,866,928...35,884,503
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ACSL5
acyl-CoA synthetase long chain family member 5
ISO
RGD
PMID:14711823
RGD:2312802
NCBI chr 9:105,259,546...105,311,500
Ensembl chr 9:105,257,429...105,311,690
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AKT2
AKT serine/threonine kinase 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:34,688,585...34,740,458
Ensembl chr 6:34,690,462...34,720,781
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CPT1A
carnitine palmitoyltransferase 1A
ISO
RGD
PMID:19302064
RGD:2311346
NCBI chr 1:5,704,275...5,784,077
Ensembl chr 1:5,730,853...5,784,337
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FABP1
fatty acid binding protein 1
ISO
peroxisomal
RGD
PMID:16262600
RGD:1626442
NCBI chr14:18,660,058...18,666,730
Ensembl chr14:18,659,836...18,667,127
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IRS1
insulin receptor substrate 1
involved_in
ISO
(PMID:16814735)
BHF-UCL
PMID:16814735
NCBI chr10:112,748,283...112,812,368
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IRS2
insulin receptor substrate 2
involved_in
ISO
(PMID:16814735)
BHF-UCL
PMID:16814735
NCBI chr 3:88,045,439...88,076,468
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MTLN
mitoregulin
involved_in
ISO
(MGI:6278482|PMID:29949755) (PMID:29949755)
UniProt
PMID:29949755
MGI:6278482
NCBI chr14:13,595,687...13,596,974
G
PLIN5
perilipin 5
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:4,251,316...4,262,656
Ensembl chr 6:4,251,751...4,261,126
G
TWIST1
twist family bHLH transcription factor 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr21:39,040,178...39,042,384
Ensembl chr21:39,040,547...39,041,146
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ABCB11
ATP binding cassette subfamily B member 11
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr10:54,458,283...54,575,943
Ensembl chr10:54,459,377...54,575,059
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ABCD1
ATP binding cassette subfamily D member 1
involved_in
ISO
(MGI:1095802|PMID:9256488), (MGI:1101351|PMID:9418970), (MGI:5635749|PMID:25255441), (MGI:87573|PMID:9126326) (PMID:25255441), (PMID:9126326), (PMID:9256488), (PMID:9418970)
UniProt
PMID:9126326 PMID:9256488 PMID:9418970 PMID:25255441
MGI:1095802 MGI:1101351 MGI:5635749 MGI:87573
NCBI chr X:128,152,697...128,171,007
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LONP2
lon peptidase 2, peroxisomal
involved_in
ISO
(PMID:22002062)
UniProt
PMID:22002062
NCBI chr 5:34,050,284...34,160,363
Ensembl chr 5:34,050,446...34,160,165
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MLYCD
malonyl-CoA decarboxylase
ISO
RGD
PMID:10516138
RGD:1600797
NCBI chr 5:69,312,978...69,329,346
Ensembl chr 5:69,313,062...69,329,102
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MTOR
mechanistic target of rapamycin kinase
ISO
RGD
PMID:17142137
RGD:1625611
NCBI chr20:120,522,667...120,678,988
Ensembl chr20:120,525,737...120,679,020
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TYSND1
trypsin like peroxisomal matrix peptidase 1
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 9:61,159,105...61,169,122
Ensembl chr 9:61,159,974...61,169,193
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ACOX1
acyl-CoA oxidase 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr16:45,706,009...45,745,564
Ensembl chr16:45,706,360...45,740,247
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