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ONTOLOGY REPORT - ANNOTATIONS

Term:fatty acid beta-oxidation
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Accession:GO:0006635 term browser browse the term
Definition:A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).


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fatty acid beta-oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCD1 ATP binding cassette subfamily D member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:121,545,690...121,564,117
Ensembl chr  X:121,545,586...121,563,186 		JBrowse link
G ABCD2 ATP binding cassette subfamily D member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:14,015,093...14,084,362
Ensembl chr27:14,015,091...14,163,312 		JBrowse link
G ABCD3 ATP binding cassette subfamily D member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:54,740,704...54,816,854
Ensembl chr 6:54,742,111...54,817,235 		JBrowse link
G ACAA1 acetyl-CoA acyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:7,889,481...7,901,324
Ensembl chr23:7,889,500...7,901,229 		JBrowse link
G ACAA2 acetyl-CoA acyltransferase 2 ISO RGD PMID:11879205 RGD:2317624 NCBI chr 7:79,028,636...79,057,720 JBrowse link
G ACADM acyl-CoA dehydrogenase medium chain involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 6:70,852,223...70,881,979
Ensembl chr 6:70,853,061...70,878,668 		JBrowse link
G ACADVL acyl-CoA dehydrogenase very long chain ISO RGD PMID:8034667 RGD:631729 NCBI chr 5:32,189,191...32,194,255
Ensembl chr 5:32,186,502...32,327,990 		JBrowse link
G ACOX1 acyl-CoA oxidase 1 involved_in IEA UniProt GO_REF:0000117 NCBI chr 9:4,658,692...4,682,667
Ensembl chr 9:4,658,090...4,679,096 		JBrowse link
G ACOX2 acyl-CoA oxidase 2 involved_in ISO
IEA		 RGD
InterPro		 PMID:1400324 PMID:8654595 GO_REF:0000002 RGD:2299949 RGD:2299971 NCBI chr20:32,110,788...32,141,751
Ensembl chr20:32,113,217...32,141,734 		JBrowse link
G ACOX3 acyl-CoA oxidase 3, pristanoyl involved_in IEA InterPro GO_REF:0000002 NCBI chr 3:60,154,012...60,205,696
Ensembl chr 3:60,153,775...60,203,554 		JBrowse link
G ACOXL acyl-CoA oxidase like involved_in IEA InterPro GO_REF:0000002 NCBI chr17:35,269,824...35,617,068
Ensembl chr17:35,269,501...35,617,335 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA		 (PMID:12151381) UniProt
MGI
Ensembl		 PMID:12151381 GO_REF:0000024 GO_REF:0000107 NCBI chr34:19,398,310...19,410,519
Ensembl chr34:19,354,825...19,409,844 		JBrowse link
G ALDH1L2 aldehyde dehydrogenase 1 family member L2 acts_upstream_of_or_within_positive_effect
involved_in		 ISO
IEA		 (MGI:6489626|PMID:33168096)
(PMID:33168096)		 UniProt
Ensembl		 PMID:33168096 GO_REF:0000107 MGI:6489626 NCBI chr10:33,310,523...33,365,677
Ensembl chr10:33,310,558...33,365,228 		JBrowse link
G BDH2 3-hydroxybutyrate dehydrogenase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr32:24,420,946...24,442,384
Ensembl chr32:24,420,951...24,442,384 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A involved_in ISO
IEA		 RGD
UniProt		 PMID:31901136 PMID:31953200 GO_REF:0000041 RGD:25823178 RGD:25823179 NCBI chr18:49,136,691...49,190,117
Ensembl chr18:49,136,691...49,190,117 		JBrowse link
G CPT1B carnitine palmitoyltransferase 1B involved_in IEA UniProt GO_REF:0000041 NCBI chr10:16,737,106...16,744,626
Ensembl chr10:16,737,289...16,744,624 		JBrowse link
G CPT1C carnitine palmitoyltransferase 1C involved_in IEA UniProt GO_REF:0000041 NCBI chr 1:106,826,207...106,847,117
Ensembl chr 1:106,826,303...106,846,446 		JBrowse link
G CPT2 carnitine palmitoyltransferase 2 involved_in ISO
IEA		 RGD
Ensembl
UniProt		 PMID:10380116 PMID:10796071 GO_REF:0000041 GO_REF:0000107 RGD:21410186 RGD:2326088 NCBI chr 5:55,718,209...55,786,175
Ensembl chr 5:55,718,510...55,744,809 		JBrowse link
G CROT carnitine O-octanoyltransferase involved_in IEA UniProt
Ensembl		 GO_REF:0000041 GO_REF:0000107 NCBI chr14:13,475,130...13,532,536
Ensembl chr14:13,475,235...13,532,536 		JBrowse link
G DECR1 2,4-dienoyl-CoA reductase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:35,495,348...35,544,955
Ensembl chr29:35,495,261...35,544,955 		JBrowse link
G ECHS1 enoyl-CoA hydratase, short chain 1 involved_in ISO (PMID:26251176) RGD
UniProt		 PMID:12379132 PMID:26251176 RGD:2317616 NCBI chr28:40,939,856...40,947,694
Ensembl chr28:40,939,961...40,946,167 		JBrowse link
G ECI1 enoyl-CoA delta isomerase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11916962) Ensembl
MGI		 PMID:11916962 GO_REF:0000107 NCBI chr 6:38,729,729...38,738,357
Ensembl chr 6:38,730,219...38,738,219 		JBrowse link
G ECI2 enoyl-CoA delta isomerase 2 ISO RGD PMID:11781327 RGD:2306199 NCBI chr35:4,349,075...4,368,219
Ensembl chr35:4,342,214...4,366,331 		JBrowse link
G EHHADH enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17442273) UniProt
MGI
Ensembl		 PMID:17442273 GO_REF:0000041 GO_REF:0000107 GO_REF:0000117 NCBI chr34:18,021,047...18,080,993
Ensembl chr34:18,022,353...18,080,903 		JBrowse link
G HADH hydroxyacyl-CoA dehydrogenase involved_in ISO
IEA		 RGD
Ensembl		 PMID:17491019 GO_REF:0000107 RGD:2302227 NCBI chr32:28,460,445...28,506,141
Ensembl chr32:28,460,193...28,531,280 		JBrowse link
G HADHA hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11390422) RGD
MGI
UniProt
InterPro
Ensembl		 PMID:1730633 PMID:11390422 GO_REF:0000002 GO_REF:0000041 GO_REF:0000107 GO_REF:0000117 RGD:1600572 NCBI chr17:20,307,207...20,355,659
Ensembl chr17:20,307,226...20,355,508 		JBrowse link
G HADHB hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta involved_in ISO (PMID:29915090) RGD
ComplexPortal		 PMID:1730633 PMID:29915090 RGD:1600572 NCBI chr17:20,355,778...20,399,869 JBrowse link
G HSD17B10 hydroxysteroid 17-beta dehydrogenase 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:45,165,272...45,167,683
Ensembl chr  X:45,165,272...45,167,574 		JBrowse link
G HSD17B4 hydroxysteroid 17-beta dehydrogenase 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17442273) Ensembl
MGI
UniProt		 PMID:17442273 GO_REF:0000041 GO_REF:0000107 NCBI chr11:8,717,182...8,810,716
Ensembl chr11:8,717,349...8,824,594 		JBrowse link
G LEP leptin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22958918) Ensembl
MGI		 PMID:22958918 GO_REF:0000107 NCBI chr14:8,115,396...8,130,946
Ensembl chr14:8,116,122...8,131,395 		JBrowse link
G LGALS4 galectin 4 involved_in IEA UniProt GO_REF:0000041 NCBI chr 1:114,281,737...114,300,709
Ensembl chr 1:114,281,803...114,291,209
Ensembl chr 1:114,281,803...114,291,209 		JBrowse link
G LOC119876011 delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial-like involved_in IEA UniProt GO_REF:0000041
G MTLN mitoregulin involved_in IEA Ensembl GO_REF:0000107
G PEX2 peroxisomal biogenesis factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:24,943,563...24,960,834 JBrowse link
G PEX5 peroxisomal biogenesis factor 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9288097)
(PMID:17442273)		 Ensembl
MGI		 PMID:9288097 PMID:17442273 GO_REF:0000107 NCBI chr27:37,843,218...37,860,664
Ensembl chr27:37,809,717...37,860,376 		JBrowse link
G PEX7 peroxisomal biogenesis factor 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12915479) Ensembl
MGI		 PMID:12915479 GO_REF:0000107 NCBI chr 1:29,337,362...29,423,608
Ensembl chr 1:29,337,386...29,418,126 		JBrowse link
G PPARD peroxisome proliferator activated receptor delta involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:4,492,867...4,579,340
Ensembl chr12:4,492,672...4,579,340 		JBrowse link
G SCP2 sterol carrier protein 2 involved_in ISO PMID:9325339 UniProt PMID:9325339 RGD:21201257 NCBI chr 5:55,860,053...55,971,657
Ensembl chr 5:55,860,549...55,964,014 		JBrowse link
G SESN2 sestrin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22958918) Ensembl
MGI		 PMID:22958918 GO_REF:0000107 NCBI chr 2:72,151,464...72,168,861
Ensembl chr 2:72,151,868...72,168,492 		JBrowse link
G SLC25A17 solute carrier family 25 member 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:24,417,294...24,462,057
Ensembl chr10:24,417,155...24,461,964 		JBrowse link
G SLC27A2 solute carrier family 27 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:16,155,932...16,196,919
Ensembl chr30:16,156,063...16,196,829 		JBrowse link
fatty acid beta-oxidation using acyl-CoA dehydrogenase term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAD11 acyl-CoA dehydrogenase family member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:29,537,049...29,645,338
Ensembl chr23:29,538,555...29,645,176 		JBrowse link
G ACADL acyl-CoA dehydrogenase long chain involved_in ISO (PMID:15639194)
(MGI:3526480|PMID:15639194)		 RGD
BHF-UCL		 PMID:3968063 PMID:15639194 MGI:3526480 RGD:2317678 NCBI chr37:18,028,244...18,073,975
Ensembl chr37:18,017,087...18,073,862 		JBrowse link
G ACADM acyl-CoA dehydrogenase medium chain involved_in ISO
IEA		 RGD
Ensembl		 PMID:3968063 GO_REF:0000107 RGD:2317678 NCBI chr 6:70,852,223...70,881,979
Ensembl chr 6:70,853,061...70,878,668 		JBrowse link
G ACADS acyl-CoA dehydrogenase short chain involved_in ISO
IEA		 RGD
Ensembl		 PMID:3968063 GO_REF:0000107 RGD:2317678 NCBI chr26:16,572,936...16,584,760
Ensembl chr26:16,572,947...16,584,194 		JBrowse link
G ACADVL acyl-CoA dehydrogenase very long chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:32,189,191...32,194,255
Ensembl chr 5:32,186,502...32,327,990 		JBrowse link
G ETFA electron transfer flavoprotein subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:39,848,241...39,925,809
Ensembl chr30:39,848,270...39,964,823 		JBrowse link
G ETFB electron transfer flavoprotein subunit beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:105,612,791...105,628,125 JBrowse link
G ETFDH electron transfer flavoprotein dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:55,752,170...55,781,118
Ensembl chr15:55,752,200...55,792,105 		JBrowse link
G GCDH glutaryl-CoA dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:49,284,341...49,290,456
Ensembl chr20:49,284,425...49,290,849 		JBrowse link
G IVD isovaleryl-CoA dehydrogenase involved_in ISO (PMID:3597357) BHF-UCL PMID:3597357 NCBI chr30:7,584,122...7,594,599
Ensembl chr30:7,584,086...7,594,150 		JBrowse link
fatty acid beta-oxidation using acyl-CoA oxidase term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOX1 acyl-CoA oxidase 1 involved_in ISO
IEA		 RGD
Ensembl
InterPro		 PMID:1400324 GO_REF:0000002 GO_REF:0000107 RGD:2299949 NCBI chr 9:4,658,692...4,682,667
Ensembl chr 9:4,658,090...4,679,096 		JBrowse link
G ACOX2 acyl-CoA oxidase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:32,110,788...32,141,751
Ensembl chr20:32,113,217...32,141,734 		JBrowse link
G ACOX3 acyl-CoA oxidase 3, pristanoyl involved_in ISO
IEA		 RGD
InterPro		 PMID:1400324 PMID:8026493 PMID:8654595 GO_REF:0000002 RGD:2299949 RGD:2299969 RGD:2299971 NCBI chr 3:60,154,012...60,205,696
Ensembl chr 3:60,153,775...60,203,554 		JBrowse link
G CRAT carnitine O-acetyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:54,566,708...54,580,301
Ensembl chr 9:54,566,407...54,580,025 		JBrowse link
negative regulation of fatty acid beta-oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACACB acetyl-CoA carboxylase beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:17,763,531...17,895,319
Ensembl chr26:17,747,362...17,894,400 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193 		JBrowse link
G CNR1 cannabinoid receptor 1 ISO RGD PMID:19724020 RGD:2314644 NCBI chr12:47,537,240...47,560,723
Ensembl chr12:47,509,583...47,560,983 		JBrowse link
G DBI diazepam binding inhibitor, acyl-CoA binding protein ISO RGD PMID:11485163 RGD:2316274 NCBI chr19:30,640,429...30,645,704
Ensembl chr19:30,640,429...30,646,405 		JBrowse link
G MFSD2A MFSD2 lysolipid transporter A, lysophospholipid acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5474727|PMID:23209793) ARUK-UCL
Ensembl		 PMID:23209793 GO_REF:0000107 MGI:5474727 NCBI chr15:2,966,433...2,979,030
Ensembl chr15:2,966,461...2,978,968 		JBrowse link
G PINK1 PTEN induced kinase 1 ISO RGD PMID:25421206 RGD:11560775 NCBI chr 2:78,276,091...78,293,761
Ensembl chr 2:78,277,077...78,294,123 		JBrowse link
G PLIN5 perilipin 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:55,181,171...55,189,369
Ensembl chr20:55,181,198...55,189,366 		JBrowse link
negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ETFBKMT electron transfer flavoprotein subunit beta lysine methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:17,103,168...17,110,405
Ensembl chr27:17,103,210...17,165,828 		JBrowse link
positive regulation of fatty acid beta-oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCD1 ATP binding cassette subfamily D member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:121,545,690...121,564,117
Ensembl chr  X:121,545,586...121,563,186 		JBrowse link
G ABCD2 ATP binding cassette subfamily D member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:14,015,093...14,084,362
Ensembl chr27:14,015,091...14,163,312 		JBrowse link
G ACSL5 acyl-CoA synthetase long chain family member 5 ISO RGD PMID:14711823 RGD:2312802 NCBI chr28:23,437,838...23,478,763
Ensembl chr28:23,440,387...23,478,762 		JBrowse link
G AKT2 AKT serine/threonine kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:113,359,038...113,407,119
Ensembl chr 1:113,359,575...113,407,131 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A ISO RGD PMID:19302064 RGD:2311346 NCBI chr18:49,136,691...49,190,117
Ensembl chr18:49,136,691...49,190,117 		JBrowse link
G FABP1 fatty acid binding protein 1 ISO peroxisomal RGD PMID:16262600 RGD:1626442 NCBI chr17:38,242,119...38,247,969
Ensembl chr17:38,242,119...38,247,962 		JBrowse link
G IRS1 insulin receptor substrate 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:39,624,554...39,687,991 JBrowse link
G IRS2 insulin receptor substrate 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:58,197,016...58,229,026
Ensembl chr22:58,223,387...58,227,535 		JBrowse link
G MTLN mitoregulin involved_in IEA Ensembl GO_REF:0000107
G PLIN5 perilipin 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:55,181,171...55,189,369
Ensembl chr20:55,181,198...55,189,366 		JBrowse link
G TWIST1 twist family bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107
regulation of fatty acid beta-oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr36:13,742,895...13,835,312
Ensembl chr36:13,746,964...13,834,974 		JBrowse link
G ABCD1 ATP binding cassette subfamily D member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:121,545,690...121,564,117
Ensembl chr  X:121,545,586...121,563,186 		JBrowse link
G LONP2 lon peptidase 2, peroxisomal involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:66,714,247...66,808,510
Ensembl chr 2:66,714,252...66,808,403 		JBrowse link
G MLYCD malonyl-CoA decarboxylase ISO RGD PMID:10516138 RGD:1600797 NCBI chr 5:68,385,058...68,399,965
Ensembl chr 5:68,384,618...68,399,965 		JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO RGD PMID:17142137 RGD:1625611 NCBI chr 2:84,818,893...84,939,283
Ensembl chr 2:84,787,708...84,939,114 		JBrowse link
G SAR1A secretion associated Ras related GTPase 1A involved_in ISO (PMID:22002062) UniProt PMID:22002062 NCBI chr 4:21,120,788...21,136,409
Ensembl chr 4:21,123,028...21,136,973 		JBrowse link
G TYSND1 trypsin like peroxisomal matrix peptidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:21,108,473...21,117,906 JBrowse link
very long-chain fatty acid beta-oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOX1 acyl-CoA oxidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:4,658,692...4,682,667
Ensembl chr 9:4,658,090...4,679,096 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17088
    cellular process 16614
      metabolic process 10876
        catabolic process 2441
          lipid catabolic process 323
            fatty acid catabolic process 96
              fatty acid beta-oxidation 70
                fatty acid beta-oxidation using acyl-CoA dehydrogenase + 11
                fatty acid beta-oxidation using acyl-CoA oxidase + 4
                fatty acid beta-oxidation, unsaturated, even number + 0
                fatty acid beta-oxidation, unsaturated, odd number 0
                negative regulation of fatty acid beta-oxidation + 8
                positive regulation of fatty acid beta-oxidation + 11
                regulation of fatty acid beta-oxidation + 24
Path 2
Term Annotations click to browse term
  biological_process 17088
    cellular process 16614
      metabolic process 10876
        small molecule metabolic process 1704
          organic acid metabolic process 906
            oxoacid metabolic process 899
              carboxylic acid metabolic process 884
                monocarboxylic acid metabolic process 603
                  fatty acid metabolic process 361
                    fatty acid oxidation 117
                      fatty acid beta-oxidation 70
                        fatty acid beta-oxidation using acyl-CoA dehydrogenase + 11
                        fatty acid beta-oxidation using acyl-CoA oxidase + 4
                        fatty acid beta-oxidation, unsaturated, even number + 0
                        fatty acid beta-oxidation, unsaturated, odd number 0
                        negative regulation of fatty acid beta-oxidation + 8
                        positive regulation of fatty acid beta-oxidation + 11
                        regulation of fatty acid beta-oxidation + 24
paths to the root