ONTOLOGY REPORT - ANNOTATIONS
Term: fatty acid beta-oxidation
Accession: GO:0006635
browse the term
Definition: A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
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ABCD1
ATP binding cassette subfamily D member 1
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr X:143,275,165...143,295,283
Ensembl chr X:153,162,412...153,182,424
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ABCD2
ATP binding cassette subfamily D member 2
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr12:49,082,122...49,158,524
Ensembl chr12:49,941,914...50,011,140
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ABCD3
ATP binding cassette subfamily D member 3
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 1:97,079,326...97,179,886
Ensembl chr 1:95,808,027...95,907,864
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ABCD4
ATP binding cassette subfamily D member 4
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr14:54,833,388...54,850,482
Ensembl chr14:73,684,109...73,701,344
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ACAA1
acetyl-CoA acyltransferase 1
involved_in
ISO
(PMID:2365812), (PMID:2882519) PMID:9325339
UniProt
PMID:2365812 PMID:2882519 PMID:9325339
RGD:21201257 RGD:8554082
NCBI chr 3:38,020,439...38,035,341
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ACAA2
acetyl-CoA acyltransferase 2
ISO
RGD
PMID:11879205
RGD:2317624
NCBI chr18:43,164,504...43,195,038
Ensembl chr18:46,512,374...46,542,737
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ACADM
acyl-CoA dehydrogenase medium chain
involved_in
IEA
Ensembl InterPro
GO_REF:0000002 GO_REF:0000107
NCBI chr 1:74,939,477...74,978,815
Ensembl chr 1:76,911,763...76,950,840
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ACADVL
acyl-CoA dehydrogenase very long chain
ISO
RGD
PMID:8034667
RGD:631729
NCBI chr17:7,249,717...7,255,165
Ensembl chr17:7,234,283...7,242,417
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ACAT1
acetyl-CoA acetyltransferase 1
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr11:103,008,564...103,034,697
Ensembl chr11:106,483,563...106,509,787
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ACAT2
acetyl-CoA acetyltransferase 2
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 6:157,644,894...157,661,965
Ensembl chr 6:162,656,497...162,673,606
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ACOX1
acyl-CoA oxidase 1
involved_in
IEA
UniProt
GO_REF:0000117
NCBI chr17:69,890,817...69,928,342
Ensembl chr17:75,445,923...75,479,571
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ACOX2
acyl-CoA oxidase 2
involved_in
ISO IEA
RGD InterPro
PMID:1400324 PMID:8654595
GO_REF:0000002 RGD:2299949 RGD:2299971
NCBI chr 3:58,442,532...58,474,601
Ensembl chr 3:59,852,771...59,884,548
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ACOXL
acyl-CoA oxidase like
involved_in
IEA
InterPro
GO_REF:0000002
NCBI chr2A:90,912,247...91,300,770
Ensembl chr2A:111,985,358...112,335,160
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ADIPOQ
adiponectin, C1Q and collagen domain containing
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:12151381)
Ensembl MGI
PMID:12151381
GO_REF:0000107
NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885
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ALDH1L2
aldehyde dehydrogenase 1 family member L2
acts_upstream_of_or_within_positive_effect involved_in
ISO IEA
(MGI:6489626|PMID:33168096) (PMID:33168096)
UniProt Ensembl
PMID:33168096
GO_REF:0000107 MGI:6489626
NCBI chr12:102,596,881...102,661,617
Ensembl chr12:105,997,045...106,056,607
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BDH2
3-hydroxybutyrate dehydrogenase 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 4:95,533,173...95,556,000
Ensembl chr 4:106,157,229...106,179,402
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CPT1A
carnitine palmitoyltransferase 1A
involved_in
ISO IEA
RGD UniProt
PMID:31901136 PMID:31953200
GO_REF:0000041 RGD:25823178 RGD:25823179
NCBI chr11:63,841,028...63,928,242
Ensembl chr11:67,144,736...67,205,481
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CPT1B
carnitine palmitoyltransferase 1B
involved_in
IEA
UniProt
GO_REF:0000041
NCBI chr22:30,815,073...30,825,341
Ensembl chr22:49,926,893...49,935,420
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CPT1C
carnitine palmitoyltransferase 1C
involved_in
IEA
UniProt
GO_REF:0000041
NCBI chr19:46,705,711...46,727,996
Ensembl chr19:55,626,831...55,647,394
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CPT2
carnitine palmitoyltransferase 2
involved_in
ISO IEA
RGD TreeGrafter UniProt Ensembl
PMID:10380116 PMID:10796071
GO_REF:0000041 GO_REF:0000107 GO_REF:0000118 RGD:21410186 RGD:2326088
NCBI chr 1:52,469,416...52,487,166
Ensembl chr 1:54,069,334...54,086,994
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CROT
carnitine O-octanoyltransferase
involved_in
IEA
UniProt Ensembl
GO_REF:0000041 GO_REF:0000107
NCBI chr 7:79,339,498...79,393,676
Ensembl chr 7:92,989,868...93,043,832
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DECR1
2,4-dienoyl-CoA reductase 1
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 8:86,690,816...86,755,379
Ensembl chr 8:88,642,172...88,693,224
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ECHDC1
ethylmalonyl-CoA decarboxylase 1
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 6:125,079,246...125,134,053
Ensembl chr 6:129,192,752...129,247,667
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ECHDC2
enoyl-CoA hydratase domain containing 2
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 1:52,163,918...52,195,629
Ensembl chr 1:53,766,197...53,792,248
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ECHS1
enoyl-CoA hydratase, short chain 1
involved_in
ISO IEA
RGD TreeGrafter Ensembl
PMID:12379132
GO_REF:0000107 GO_REF:0000118 RGD:2317616
Ensembl chr10:134,278,388...134,289,308
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ECI1
enoyl-CoA delta isomerase 1
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:11916962)
Ensembl TreeGrafter MGI
PMID:11916962
GO_REF:0000107 GO_REF:0000118
NCBI chr16:1,097,165...1,108,726
Ensembl chr16:2,339,864...2,351,385
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ECI2
enoyl-CoA delta isomerase 2
ISO
RGD
PMID:11781327
RGD:2306199
NCBI chr 6:3,948,748...3,968,634
Ensembl chr 6:4,137,353...4,157,538
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EHHADH
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:17442273)
Ensembl TreeGrafter MGI UniProt
PMID:17442273
GO_REF:0000041 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118
NCBI chr 3:182,228,520...182,319,339
Ensembl chr 3:190,704,695...190,796,075
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HADH
hydroxyacyl-CoA dehydrogenase
involved_in
ISO IEA
RGD TreeGrafter
PMID:17491019
GO_REF:0000118 RGD:2302227
NCBI chr 4:100,495,205...100,540,589
Ensembl chr 4:111,067,336...111,113,868
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HADHA
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:11390422)
RGD MGI UniProt InterPro Ensembl
PMID:1730633 PMID:11390422
GO_REF:0000002 GO_REF:0000041 GO_REF:0000107 GO_REF:0000117 RGD:1600572
NCBI chr2A:26,185,938...26,240,229
Ensembl chr2A:26,279,995...26,334,068
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HADHB
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
involved_in
ISO IEA
RGD TreeGrafter Ensembl
PMID:1730633
GO_REF:0000107 GO_REF:0000118 RGD:1600572
NCBI chr2A:26,240,365...26,285,982
Ensembl chr2A:26,334,043...26,379,059
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HSD17B10
hydroxysteroid 17-beta dehydrogenase 10
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr X:45,645,849...45,649,039
Ensembl chr X:53,754,164...53,757,643
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HSD17B4
hydroxysteroid 17-beta dehydrogenase 4
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:17442273)
Ensembl TreeGrafter MGI UniProt
PMID:17442273
GO_REF:0000041 GO_REF:0000107 GO_REF:0000118
NCBI chr 5:114,842,892...114,928,559
Ensembl chr 5:120,628,605...120,713,860
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LEP
leptin
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:22958918)
Ensembl MGI
PMID:22958918
GO_REF:0000107
NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519
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LOC100973698
trifunctional enzyme subunit alpha, mitochondrial-like
involved_in
IEA
UniProt InterPro
GO_REF:0000002 GO_REF:0000041 GO_REF:0000117
NCBI chr12:8,717,515...8,721,034
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LOC100980944
delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
involved_in
IEA
UniProt
GO_REF:0000041
NCBI chr19:35,909,348...35,925,686
Ensembl chr19:44,479,561...44,489,355
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LOC117976943
delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial-like
involved_in
IEA
UniProt
GO_REF:0000041
NCBI chr19:35,929,485...35,939,191
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MTLN
mitoregulin
involved_in
ISO
(PMID:32243843)
UniProt
PMID:32243843
NCBI chr2A:91,481,706...91,514,106
Ensembl chr2A:111,713,514...111,713,933
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PEX2
peroxisomal biogenesis factor 2
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 8:73,508,349...73,526,560
Ensembl chr 8:75,146,255...75,147,172
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PEX5
peroxisomal biogenesis factor 5
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:17442273) (PMID:9288097)
Ensembl MGI
PMID:9288097 PMID:17442273
GO_REF:0000107
NCBI chr12:7,318,637...7,340,428
Ensembl chr12:7,235,049...7,255,815
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PEX7
peroxisomal biogenesis factor 7
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:12915479)
Ensembl MGI
PMID:12915479
GO_REF:0000107
NCBI chr 6:134,582,933...134,675,388
Ensembl chr 6:138,672,179...138,762,830
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PPARD
peroxisome proliferator activated receptor delta
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:34,903,798...34,987,208
Ensembl chr 6:36,003,988...36,081,132
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SCP2
sterol carrier protein 2
involved_in
ISO
PMID:9325339
UniProt
PMID:9325339
RGD:21201257
NCBI chr 1:52,195,491...52,324,227
Ensembl chr 1:53,797,254...53,924,939
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SESN2
sestrin 2
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:22958918)
Ensembl MGI
PMID:22958918
GO_REF:0000107
NCBI chr 1:27,518,248...27,541,264
Ensembl chr 1:28,555,072...28,577,931
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SLC25A17
solute carrier family 25 member 17
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr22:21,665,210...21,714,596
Ensembl chr22:39,761,007...39,810,556
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SLC27A2
solute carrier family 27 member 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr15:29,130,262...29,182,752
Ensembl chr15:47,452,227...47,505,066
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ACAD11
acyl-CoA dehydrogenase family member 11
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 3:129,631,105...129,732,894
Ensembl chr 3:137,107,834...137,209,550
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ACADL
acyl-CoA dehydrogenase long chain
involved_in
ISO
(PMID:15639194) (MGI:3526480|PMID:15639194)
RGD BHF-UCL
PMID:3968063 PMID:15639194
MGI:3526480 RGD:2317678
NCBI chr2B:97,445,421...97,483,514
Ensembl chr2B:215,847,775...215,885,524
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ACADM
acyl-CoA dehydrogenase medium chain
involved_in
ISO IEA
RGD Ensembl
PMID:3968063
GO_REF:0000107 RGD:2317678
NCBI chr 1:74,939,477...74,978,815
Ensembl chr 1:76,911,763...76,950,840
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ACADS
acyl-CoA dehydrogenase short chain
involved_in
ISO IEA
RGD TreeGrafter Ensembl
PMID:3968063
GO_REF:0000107 GO_REF:0000118 RGD:2317678
NCBI chr12:118,309,303...118,323,489
Ensembl chr12:121,682,113...121,696,376
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ACADVL
acyl-CoA dehydrogenase very long chain
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr17:7,249,717...7,255,165
Ensembl chr17:7,234,283...7,242,417
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ETFA
electron transfer flavoprotein subunit alpha
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr15:55,128,686...55,227,369
Ensembl chr15:74,720,198...74,818,494
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ETFB
electron transfer flavoprotein subunit beta
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr19:48,281,101...48,301,527
Ensembl chr19:57,166,829...57,175,582
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ETFDH
electron transfer flavoprotein dehydrogenase
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 4:150,992,123...151,028,698
Ensembl chr 4:162,802,917...162,838,807
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GCDH
glutaryl-CoA dehydrogenase
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr19:12,452,779...12,461,757
Ensembl chr19:13,195,241...13,204,223
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IVD
isovaleryl-CoA dehydrogenase
involved_in
ISO
(PMID:3597357)
BHF-UCL
PMID:3597357
NCBI chr15:19,342,283...19,372,465
Ensembl chr15:37,596,688...37,609,902
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ACOX1
acyl-CoA oxidase 1
involved_in
ISO IEA
RGD TreeGrafter InterPro Ensembl
PMID:1400324
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:2299949
NCBI chr17:69,890,817...69,928,342
Ensembl chr17:75,445,923...75,479,571
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ACOX2
acyl-CoA oxidase 2
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 3:58,442,532...58,474,601
Ensembl chr 3:59,852,771...59,884,548
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ACOX3
acyl-CoA oxidase 3, pristanoyl
involved_in
ISO IEA
RGD TreeGrafter InterPro
PMID:1400324 PMID:8026493 PMID:8654595
GO_REF:0000002 GO_REF:0000118 RGD:2299949 RGD:2299969 RGD:2299971
Ensembl chr 4:8,432,788...8,494,157
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ACOXL
acyl-CoA oxidase like
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr2A:90,912,247...91,300,770
Ensembl chr2A:111,985,358...112,335,160
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CRAT
carnitine O-acetyltransferase
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 9:100,220,019...100,236,061
Ensembl chr 9:128,880,057...128,896,484
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ACACB
acetyl-CoA carboxylase beta
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:106,692,668...106,845,490
Ensembl chr12:110,086,374...110,239,847
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AKT1
AKT serine/threonine kinase 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756
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CNR1
cannabinoid receptor 1
ISO
RGD
PMID:19724020
RGD:2314644
NCBI chr 6:86,017,141...86,044,889
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DBI
diazepam binding inhibitor, acyl-CoA binding protein
ISO
RGD
PMID:11485163
RGD:2316274
NCBI chr2B:6,309,048...6,314,660
Ensembl chr2B:119,887,728...119,892,986
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MFSD2A
MFSD2 lysolipid transporter A, lysophospholipid
acts_upstream_of_or_within involved_in
ISO IEA
(MGI:5474727|PMID:23209793)
ARUK-UCL Ensembl
PMID:23209793
GO_REF:0000107 MGI:5474727
NCBI chr 1:39,244,438...39,259,156
Ensembl chr 1:40,569,706...40,584,438
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PINK1
PTEN induced kinase 1
ISO
RGD
PMID:25421206
RGD:11560775
NCBI chr 1:19,583,330...19,601,248
Ensembl chr 1:20,627,693...20,645,560
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PLIN5
perilipin 5
involved_in
ISO
(MGI:5559662|PMID:22675471), (MGI:5559666|PMID:21885430) (PMID:21885430), (PMID:22675471) (PMID:22532565) (MGI:5440401|PMID:22532565)
UniProt
PMID:21885430 PMID:22532565 PMID:22675471
MGI:5440401 MGI:5559662 MGI:5559666
NCBI chr19:3,542,675...3,555,611
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ETFBKMT
electron transfer flavoprotein subunit beta lysine methyltransferase
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:54,570,372...54,586,751
Ensembl chr12:57,161,781...57,172,705
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ABCD1
ATP binding cassette subfamily D member 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr X:143,275,165...143,295,283
Ensembl chr X:153,162,412...153,182,424
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ABCD2
ATP binding cassette subfamily D member 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:49,082,122...49,158,524
Ensembl chr12:49,941,914...50,011,140
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ACSL5
acyl-CoA synthetase long chain family member 5
ISO
RGD
PMID:14711823
RGD:2312802
NCBI chr10:108,965,559...109,019,240
Ensembl chr10:112,407,161...112,457,892
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AKT2
AKT serine/threonine kinase 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr19:37,275,799...37,331,971
Ensembl chr19:45,791,800...45,840,271
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CPT1A
carnitine palmitoyltransferase 1A
ISO
RGD
PMID:19302064
RGD:2311346
NCBI chr11:63,841,028...63,928,242
Ensembl chr11:67,144,736...67,205,481
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FABP1
fatty acid binding protein 1
ISO
peroxisomal
RGD
PMID:16262600
RGD:1626442
NCBI chr2A:87,256,032...87,303,505
Ensembl chr2A:89,165,315...89,170,448
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IRS1
insulin receptor substrate 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr2B:113,973,191...114,041,127
Ensembl chr2B:232,849,239...232,852,967
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IRS2
insulin receptor substrate 2
involved_in
ISO
(PMID:16814735)
BHF-UCL
PMID:16814735
NCBI chr13:90,886,095...90,917,724
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MTLN
mitoregulin
involved_in
ISO
(MGI:6278482|PMID:29949755) (PMID:29949755)
UniProt
PMID:29949755
MGI:6278482
NCBI chr2A:91,481,706...91,514,106
Ensembl chr2A:111,713,514...111,713,933
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PLIN5
perilipin 5
involved_in
ISO
PMID:22127648 (PMID:17130488) (MGI:3709110|PMID:17130488)
UniProt
PMID:17130488 PMID:22127648
MGI:3709110 RGD:8553692
NCBI chr19:3,542,675...3,555,611
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TWIST1
twist family bHLH transcription factor 1
involved_in
ISO
(PMID:20007935)
BHF-UCL
PMID:20007935
NCBI chr 7:19,761,041...19,765,665
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ABCB11
ATP binding cassette subfamily B member 11
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr2B:56,199,434...56,311,773
Ensembl chr2B:173,664,518...173,776,379
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ABCD1
ATP binding cassette subfamily D member 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr X:143,275,165...143,295,283
Ensembl chr X:153,162,412...153,182,424
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LONP2
lon peptidase 2, peroxisomal
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr16:28,513,060...28,628,181
Ensembl chr16:47,405,018...47,511,124
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MLYCD
malonyl-CoA decarboxylase
ISO
RGD
PMID:10516138
RGD:1600797
NCBI chr16:64,520,860...64,537,955
Ensembl chr16:83,912,793...83,929,162
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MTOR
mechanistic target of rapamycin kinase
ISO
RGD
PMID:17142137
RGD:1625611
NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841
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TYSND1
trypsin like peroxisomal matrix peptidase 1
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr10:66,609,736...66,619,838
Ensembl chr10:69,141,724...69,148,346
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ACOX1
acyl-CoA oxidase 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr17:69,890,817...69,928,342
Ensembl chr17:75,445,923...75,479,571
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