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ONTOLOGY REPORT - ANNOTATIONS

Term:protein retention in ER lumen
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Accession:GO:0006621 term browser browse the term
Definition:The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER.
Synonyms:broad_synonym: maintenance of protein location in ER lumen


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protein retention in ER lumen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKRD13C ankyrin repeat domain 13C involved_in IMP
IEA
IBA		 (PMID:20959461) BHF-UCL
TreeGrafter
GO_Central		 PMID:20959461 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:70,258,999...70,354,722
Ensembl chr 1:70,258,999...70,354,734 		JBrowse link
G GPAA1 glycosylphosphatidylinositol anchor attachment 1 involved_in NAS (PMID:12052837) UniProt PMID:12052837 NCBI chr 8:144,082,634...144,086,216
Ensembl chr 8:144,082,337...144,093,149 		JBrowse link
G GRIK5 glutamate ionotropic receptor kainate type subunit 5 involved_in ISO PMID:12878702 UniProt PMID:12878702 RGD:2316545 NCBI chr19:41,998,324...42,070,206
Ensembl chr19:41,998,321...42,070,206 		JBrowse link
G KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 involved_in IEA
IBA		 InterPro
GO_Central
TreeGrafter		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr19:48,382,575...48,397,412
Ensembl chr19:48,382,575...48,391,551 		JBrowse link
G KDELR2 KDEL endoplasmic reticulum protein retention receptor 2 involved_in IEA
IBA		 InterPro
TreeGrafter
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr 7:6,461,089...6,484,152
Ensembl chr 7:6,445,953...6,484,190 		JBrowse link
G KDELR3 KDEL endoplasmic reticulum protein retention receptor 3 involved_in IEA
IBA		 InterPro
TreeGrafter
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr22:38,468,096...38,483,447
Ensembl chr22:38,468,078...38,483,447 		JBrowse link
G OS9 OS9 endoplasmic reticulum lectin involved_in IDA (PMID:18417469) UniProt PMID:18417469 NCBI chr12:57,694,132...57,721,557
Ensembl chr12:57,693,841...57,728,342 		JBrowse link
G PDIA2 protein disulfide isomerase family A member 2 involved_in TAS (PMID:8561901) PINC PMID:8561901 NCBI chr16:283,164...287,215
Ensembl chr16:283,164...287,215 		JBrowse link
G RER1 retention in endoplasmic reticulum sorting receptor 1 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:2,391,841...2,405,436
Ensembl chr 1:2,391,775...2,405,442 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19770
    cellular process 18460
      maintenance of location in cell 249
        maintenance of protein location in cell 75
          maintenance of protein localization in organelle 47
            maintenance of protein localization in endoplasmic reticulum 15
              protein retention in ER lumen 9
Path 2
Term Annotations click to browse term
  biological_process 19770
    cellular process 18460
      cellular localization 3917
        cellular macromolecule localization 2907
          protein localization 2894
            maintenance of protein location 99
              maintenance of protein location in cell 75
                maintenance of protein localization in organelle 47
                  maintenance of protein localization in endoplasmic reticulum 15
                    protein retention in ER lumen 9
paths to the root