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ONTOLOGY REPORT - ANNOTATIONS


Term:SRP-dependent cotranslational protein targeting to membrane, translocation
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Accession:GO:0006616 term browser browse the term
Definition:The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.
Synonyms:exact_synonym: SRP-dependent cotranslational membrane targeting, translocation;   SRP-dependent cotranslational protein-membrane targeting, translocation;   translocation during SRP-dependent cotranslational protein targeting to membrane
 broad_synonym: ER translocation



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SRP-dependent cotranslational protein targeting to membrane, translocation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SEC61A1 SEC61 translocon subunit alpha 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr20:2,070,739...2,087,790
Ensembl chr20:2,070,248...2,087,789
JBrowse link
G SEC61B SEC61 translocon subunit beta involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr11:56,279,564...56,298,593
Ensembl chr11:56,251,636...56,286,291
JBrowse link
G SRP54 signal recognition particle 54 involved_in IBA
IDA
(PMID:21873635)
(PMID:8521805)
GO_Central
UniProt
PMID:8521805 PMID:21873635 NCBI chr 8:13,800,275...13,837,799
Ensembl chr 8:13,677,760...13,837,722
JBrowse link
G TRAM1 translocation associated membrane protein 1 involved_in IDA (PMID:8698819) WB PMID:8698819 NCBI chr29:19,669,622...19,703,707
Ensembl chr29:19,669,628...19,703,669
JBrowse link
G TRAM1L1 translocation associated membrane protein 1 like 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr32:36,487,648...36,489,596
Ensembl chr32:36,488,434...36,489,546
JBrowse link
G ZFAND2B zinc finger AN1-type containing 2B acts_upstream_of_or_within ISO (PMID:24160817) MGI PMID:24160817 NCBI chr37:25,757,454...25,760,366
Ensembl chr37:25,757,669...25,760,132
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 13875
    cellular process 13120
      transmembrane transport 1167
        protein transmembrane transport 45
          intracellular protein transmembrane transport 39
            SRP-dependent cotranslational protein targeting to membrane, translocation 6
Path 2
Term Annotations click to browse term
  biological_process 13875
    localization 5411
      macromolecule localization 2525
        protein localization 2166
          establishment of protein localization 1343
            protein transport 1218
              intracellular protein transport 703
                protein targeting 250
                  protein targeting to membrane 93
                    cotranslational protein targeting to membrane 16
                      SRP-dependent cotranslational protein targeting to membrane 15
                        SRP-dependent cotranslational protein targeting to membrane, translocation 6
paths to the root