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ONTOLOGY REPORT - ANNOTATIONS


Term:SRP-dependent cotranslational protein targeting to membrane, translocation
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Accession:GO:0006616 term browser browse the term
Definition:The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.
Synonyms:exact_synonym: SRP-dependent cotranslational membrane targeting, translocation;   SRP-dependent cotranslational protein-membrane targeting, translocation;   translocation during SRP-dependent cotranslational protein targeting to membrane
 broad_synonym: ER translocation


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SRP-dependent cotranslational protein targeting to membrane, translocation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sec61a1 SEC61 translocon subunit alpha 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:120,973,519...120,987,871
Ensembl chr 4:120,960,626...120,987,925
JBrowse link
G Sec61a2 SEC61 translocon subunit alpha 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:72,407,574...72,445,630
Ensembl chr17:72,407,671...72,434,494
JBrowse link
G Sec61b SEC61 translocon subunit beta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:61,773,594...61,781,804
Ensembl chr 5:61,773,594...61,781,804
JBrowse link
G Srp54a signal recognition particle 54A involved_in ISO
IBA
(PMID:8521805)
PMID:21873635
RGD PMID:8521805 PMID:21873635 RGD:13792537 NCBI chr 6:72,587,582...72,645,154
Ensembl chr 6:72,587,605...72,625,189
JBrowse link
G Tram1 translocation associated membrane protein 1 involved_in IEA
ISO
GO_REF:0000002
(PMID:8698819)
InterPro
RGD
PMID:8698819 GO_REF:0000002 NCBI chr 5:5,642,579...5,667,666
Ensembl chr 5:5,642,546...5,686,971
JBrowse link
G Tram1l1 translocation associated membrane protein 1-like 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:212,511,130...212,513,311 JBrowse link
G Tram2 translocation associated membrane protein 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:23,419,204...23,498,745
Ensembl chr 9:23,424,232...23,498,689
JBrowse link
G Zfand2b zinc finger AN1-type containing 2B acts_upstream_of_or_within ISO (PMID:24160817) RGD PMID:24160817 NCBI chr 9:76,665,466...76,668,447
Ensembl chr 9:76,665,546...76,668,445
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    cellular process 18340
      transmembrane transport 1582
        protein transmembrane transport 71
          intracellular protein transmembrane transport 62
            SRP-dependent cotranslational protein targeting to membrane, translocation 8
Path 2
Term Annotations click to browse term
  biological_process 19492
    localization 6447
      macromolecule localization 3001
        protein localization 2559
          establishment of protein localization 1696
            protein transport 1571
              intracellular protein transport 904
                protein targeting 316
                  protein targeting to membrane 126
                    cotranslational protein targeting to membrane 17
                      SRP-dependent cotranslational protein targeting to membrane 16
                        SRP-dependent cotranslational protein targeting to membrane, translocation 8
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