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ONTOLOGY REPORT - ANNOTATIONS

Term:SRP-dependent cotranslational protein targeting to membrane, translocation
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Accession:GO:0006616 term browser browse the term
Definition:The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.
Synonyms:exact_synonym: SRP-dependent cotranslational membrane targeting, translocation;   SRP-dependent cotranslational protein-membrane targeting, translocation;   translocation during SRP-dependent cotranslational protein targeting to membrane
 broad_synonym: ER translocation


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SRP-dependent cotranslational protein targeting to membrane, translocation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sec61a1 SEC61 translocon subunit alpha 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:120,973,519...120,987,871
Ensembl chr 4:120,960,626...120,987,925 		JBrowse link
G Sec61a2 SEC61 translocon subunit alpha 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:72,407,574...72,445,630
Ensembl chr17:72,407,671...72,434,494 		JBrowse link
G Sec61b SEC61 translocon subunit beta involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:61,773,594...61,781,804
Ensembl chr 5:61,773,594...61,781,804 		JBrowse link
G Srp54a signal recognition particle 54A involved_in ISO
IBA		 (PMID:8521805)
GO_REF:0000033		 RGD
GO_Central		 PMID:8521805 GO_REF:0000033 NCBI chr 6:72,587,584...72,626,878
Ensembl chr 6:72,587,605...72,625,189 		JBrowse link
G Tram1 translocation associated membrane protein 1 involved_in IEA
ISO		 GO_REF:0000002
(PMID:8698819)		 InterPro
RGD		 PMID:8698819 GO_REF:0000002 NCBI chr 5:5,642,579...5,667,666
Ensembl chr 5:5,642,546...5,686,971 		JBrowse link
G Tram2 translocation associated membrane protein 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:23,419,204...23,498,745
Ensembl chr 9:23,424,232...23,498,689 		JBrowse link
G Zfand2b zinc finger AN1-type containing 2B acts_upstream_of_or_within ISO (PMID:24160817) RGD PMID:24160817 NCBI chr 9:76,665,466...76,668,447
Ensembl chr 9:76,665,546...76,668,445 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    cellular process 18524
      transmembrane transport 1704
        protein transmembrane transport 83
          intracellular protein transmembrane transport 33
            SRP-dependent cotranslational protein targeting to membrane, translocation 7
Path 2
Term Annotations click to browse term
  biological_process 20115
    localization 5683
      macromolecule localization 3201
        cellular macromolecule localization 2712
          protein localization 2700
            establishment of protein localization 1768
              protein targeting 339
                protein targeting to membrane 127
                  cotranslational protein targeting to membrane 20
                    SRP-dependent cotranslational protein targeting to membrane 19
                      SRP-dependent cotranslational protein targeting to membrane, translocation 7
paths to the root