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ONTOLOGY REPORT - ANNOTATIONS


Term:SRP-dependent cotranslational protein targeting to membrane
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Accession:GO:0006614 term browser browse the term
Definition:The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
Synonyms:exact_synonym: SRP-dependent cotranslational membrane targeting;   SRP-dependent cotranslational protein-membrane targeting
 broad_synonym: ER translocation


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SRP-dependent cotranslational protein targeting to membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sec61a1 SEC61 translocon subunit alpha 1 acts_upstream_of_or_within ISO (PMID:22375059) MGI PMID:22375059 NCBI chrNW_004936798:578,090...587,010 JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator acts_upstream_of_or_within ISO (MGI:5494355|PMID:22375059)
(PMID:22375059)
MGI PMID:22375059 MGI:5494355 NCBI chrNW_004936564:4,182,330...4,221,927 JBrowse link
SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101965130 signal recognition particle 54 kDa protein involved_in ISO (PMID:16469117) UniProt PMID:16469117 NCBI chrNW_004936494:9,183,620...9,220,510 JBrowse link
SRP-dependent cotranslational protein targeting to membrane, translocation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101965130 signal recognition particle 54 kDa protein involved_in ISO (PMID:8521805) UniProt PMID:8521805 NCBI chrNW_004936494:9,183,620...9,220,510 JBrowse link
G Tram1 translocation associated membrane protein 1 involved_in ISO (PMID:8698819) WB PMID:8698819 NCBI chrNW_004936496:15,233,692...15,257,085 JBrowse link
G Zfand2b zinc finger AN1-type containing 2B acts_upstream_of_or_within ISO (PMID:24160817) MGI PMID:24160817 NCBI chrNW_004936569:1,625,712...1,628,533 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12170
    localization 4891
      cellular localization 2374
        intracellular transport 1080
          intracellular protein transport 555
            protein targeting 211
              protein targeting to ER 15
                SRP-dependent cotranslational protein targeting to membrane 5
                  SRP-dependent cotranslational protein targeting to membrane, docking 0
                  SRP-dependent cotranslational protein targeting to membrane, signal sequence processing 0
                  SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition 1
                  SRP-dependent cotranslational protein targeting to membrane, translocation 3
Path 2
Term Annotations click to browse term
  biological_process 12170
    localization 4891
      macromolecule localization 2248
        protein localization 1938
          establishment of protein localization 1125
            protein transport 998
              intracellular protein transport 555
                protein targeting 211
                  protein targeting to membrane 68
                    cotranslational protein targeting to membrane 6
                      SRP-dependent cotranslational protein targeting to membrane 5
                        SRP-dependent cotranslational protein targeting to membrane, docking 0
                        SRP-dependent cotranslational protein targeting to membrane, signal sequence processing 0
                        SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition 1
                        SRP-dependent cotranslational protein targeting to membrane, translocation 3
paths to the root