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ONTOLOGY REPORT - ANNOTATIONS


Term:SRP-dependent cotranslational protein targeting to membrane
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Accession:GO:0006614 term browser browse the term
Definition:The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
Synonyms:exact_synonym: SRP-dependent cotranslational membrane targeting;   SRP-dependent cotranslational protein-membrane targeting
 broad_synonym: ER translocation


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SRP-dependent cotranslational protein targeting to membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sec61a1 Sec61 alpha 1 subunit (S. cerevisiae) acts_upstream_of_or_within ISO (MGI:5494355|PMID:22375059) MGI PMID:22375059 MGI:5494355 NCBI chr 6:88,503,607...88,518,800
Ensembl chr 6:88,503,579...88,518,905
JBrowse link
G Sec63 SEC63-like (S. cerevisiae) involved_in
acts_upstream_of_or_within
IBA
ISO
IMP
(MGI:6201960|PMID:21873635)
(MGI:5494355|PMID:22375059)
GO_Central
MGI
PMID:21873635 PMID:22375059 MGI:5494355 MGI:6201960 NCBI chr10:42,761,496...42,832,514
Ensembl chr10:42,761,496...42,832,514
JBrowse link
G Srp14 signal recognition particle 14 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 2:118,475,843...118,479,696
Ensembl chr 2:118,475,850...118,479,711
JBrowse link
G Srp19 signal recognition particle 19 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr18:34,331,121...34,336,599
Ensembl chr18:34,330,847...34,336,599
JBrowse link
G Srp54a signal recognition particle 54A acts_upstream_of_or_within ISO MGI GO_REF:0000008 MGI:2154458 NCBI chr12:55,080,476...55,115,367
Ensembl chr12:55,080,262...55,115,367
JBrowse link
G Srp68 signal recognition particle 68 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr11:116,245,166...116,274,217
Ensembl chr11:116,245,166...116,274,217
JBrowse link
G Srp72 signal recognition particle 72 involved_in
acts_upstream_of_or_within
IBA
ISA
(MGI:6201960|PMID:21873635)
(MGI:1321354|PMID:9857079)
GO_Central
MGI
PMID:9857079 PMID:21873635 MGI:1321354 MGI:6201960 NCBI chr 5:76,974,701...76,999,935
Ensembl chr 5:76,974,683...76,999,937
JBrowse link
G Srp9 signal recognition particle 9 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 1:182,124,737...182,132,415
Ensembl chr 1:182,124,737...182,132,407
JBrowse link
G Srpr signal recognition particle receptor ('docking protein') involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 9:35,211,203...35,217,003
Ensembl chr 9:35,200,175...35,247,973
JBrowse link
G Ssr3 signal sequence receptor, gamma involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 3:65,379,657...65,392,553
Ensembl chr 3:65,379,655...65,392,623
JBrowse link
SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Srp19 signal recognition particle 19 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr18:34,331,121...34,336,599
Ensembl chr18:34,330,847...34,336,599
JBrowse link
G Srp54a signal recognition particle 54A involved_in ISO (PMID:16469117) UniProt PMID:16469117 NCBI chr12:55,080,476...55,115,367
Ensembl chr12:55,080,262...55,115,367
JBrowse link
SRP-dependent cotranslational protein targeting to membrane, translocation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gm10320 predicted pseudogene 10320 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr13:98,489,533...98,489,841
Ensembl chr13:98,489,348...98,492,001
JBrowse link
G Sec61a1 Sec61 alpha 1 subunit (S. cerevisiae) involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 6:88,503,607...88,518,800
Ensembl chr 6:88,503,579...88,518,905
JBrowse link
G Sec61a2 Sec61, alpha subunit 2 (S. cerevisiae) involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 2:5,870,977...5,895,432
Ensembl chr 2:5,870,987...5,895,432
JBrowse link
G Sec61b Sec61 beta subunit involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 4:47,474,661...47,483,233
Ensembl chr 4:47,474,658...47,483,242
JBrowse link
G Srp54a signal recognition particle 54A involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr12:55,080,476...55,115,367
Ensembl chr12:55,080,262...55,115,367
JBrowse link
G Srp54c signal recognition particle 54C involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr12:55,230,118...55,279,331
Ensembl chr12:55,230,168...55,263,836
JBrowse link
G Tram1 translocating chain-associating membrane protein 1 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 1:13,564,693...13,589,910
Ensembl chr 1:13,564,698...13,589,910
JBrowse link
G Tram1l1 translocation associated membrane protein 1-like 1 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 3:124,321,037...124,323,260
Ensembl chr 3:124,320,855...124,324,743
JBrowse link
G Tram2 translocating chain-associating membrane protein 2 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 1:21,001,397...21,079,225
Ensembl chr 1:20,996,299...21,079,229
JBrowse link
G Zfand2b zinc finger, AN1 type domain 2B acts_upstream_of_or_within ISO MGI GO_REF:0000008 MGI:2154458 NCBI chr 1:75,168,646...75,171,626
Ensembl chr 1:75,168,646...75,171,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28616
    localization 6381
      cellular localization 2927
        intracellular transport 1486
          intracellular protein transport 881
            protein targeting 305
              protein targeting to ER 40
                SRP-dependent cotranslational protein targeting to membrane 18
                  SRP-dependent cotranslational protein targeting to membrane, docking 0
                  SRP-dependent cotranslational protein targeting to membrane, signal sequence processing 0
                  SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition 2
                  SRP-dependent cotranslational protein targeting to membrane, translocation 10
Path 2
Term Annotations click to browse term
  biological_process 28616
    localization 6381
      macromolecule localization 3025
        protein localization 2584
          establishment of protein localization 1742
            protein transport 1615
              intracellular protein transport 881
                protein targeting 305
                  protein targeting to membrane 122
                    cotranslational protein targeting to membrane 19
                      SRP-dependent cotranslational protein targeting to membrane 18
                        SRP-dependent cotranslational protein targeting to membrane, docking 0
                        SRP-dependent cotranslational protein targeting to membrane, signal sequence processing 0
                        SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition 2
                        SRP-dependent cotranslational protein targeting to membrane, translocation 10
paths to the root