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ONTOLOGY REPORT - ANNOTATIONS


Term:SRP-dependent cotranslational protein targeting to membrane
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Accession:GO:0006614 term browser browse the term
Definition:The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
Synonyms:exact_synonym: SRP-dependent cotranslational membrane targeting;   SRP-dependent cotranslational protein-membrane targeting
 broad_synonym: ER translocation



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SRP-dependent cotranslational protein targeting to membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sec61a1 SEC61 translocon subunit alpha 1 acts_upstream_of_or_within ISO (MGI:5494355|PMID:22375059) MGI PMID:22375059 MGI:5494355 NCBI chr 6:88,480,589...88,495,782
Ensembl chr 6:88,480,561...88,495,887
JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator acts_upstream_of_or_within
involved_in
IMP
IBA
ISO
(MGI:5494355|PMID:22375059)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:21873635 PMID:22375059 MGI:5494355 MGI:6201960 NCBI chr10:42,637,492...42,708,510
Ensembl chr10:42,637,492...42,708,510
JBrowse link
G Srp14 signal recognition particle 14 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 2:118,306,324...118,310,177
Ensembl chr 2:118,306,331...118,310,192
JBrowse link
G Srp19 signal recognition particle 19 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr18:34,464,185...34,469,652
Ensembl chr18:34,463,900...34,469,652
JBrowse link
G Srp54a signal recognition particle 54A acts_upstream_of_or_within ISO MGI GO_REF:0000008 MGI:2154458 NCBI chr12:55,127,318...55,162,152
Ensembl chr12:55,127,047...55,162,152
JBrowse link
G Srp68 signal recognition particle 68 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr11:116,135,992...116,165,043
Ensembl chr11:116,135,992...116,165,043
JBrowse link
G Srp72 signal recognition particle 72 acts_upstream_of_or_within
involved_in
ISA
IBA
(MGI:1321354|PMID:9857079)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:9857079 PMID:21873635 MGI:1321354 MGI:6201960 NCBI chr 5:77,122,548...77,147,782
Ensembl chr 5:77,122,530...77,147,784
JBrowse link
G Srp9 signal recognition particle 9 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 1:181,952,302...181,959,980
Ensembl chr 1:181,952,302...181,959,972
JBrowse link
G Srpra signal recognition particle receptor alpha involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 9:35,122,499...35,128,299
Ensembl chr 9:35,111,471...35,159,269
JBrowse link
G Ssr3 signal sequence receptor, gamma involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 3:65,287,078...65,299,974
Ensembl chr 3:65,287,076...65,300,044
JBrowse link
SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Srp19 signal recognition particle 19 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr18:34,464,185...34,469,652
Ensembl chr18:34,463,900...34,469,652
JBrowse link
G Srp54a signal recognition particle 54A involved_in ISO (PMID:16469117) UniProt PMID:16469117 NCBI chr12:55,127,318...55,162,152
Ensembl chr12:55,127,047...55,162,152
JBrowse link
G Srpra signal recognition particle receptor alpha involved_in NAS (MGI:6869982|PMID:16439358) ComplexPortal PMID:16439358 MGI:6869982 NCBI chr 9:35,122,499...35,128,299
Ensembl chr 9:35,111,471...35,159,269
JBrowse link
G Srprb signal recognition particle receptor, B subunit involved_in NAS (MGI:6869982|PMID:16439358) ComplexPortal PMID:16439358 MGI:6869982 NCBI chr 9:103,065,232...103,079,264
Ensembl chr 9:103,065,231...103,079,336
JBrowse link
SRP-dependent cotranslational protein targeting to membrane, translocation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sec61a1 SEC61 translocon subunit alpha 1 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 6:88,480,589...88,495,782
Ensembl chr 6:88,480,561...88,495,887
JBrowse link
G Sec61a2 SEC61 translocon subunit alpha 2 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 2:5,875,788...5,900,199
Ensembl chr 2:5,875,798...5,900,243
JBrowse link
G Sec61b SEC61 translocon subunit beta involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 4:47,474,661...47,483,233
Ensembl chr 4:47,474,658...47,483,242
JBrowse link
G Sec61bl SEC61 translocon subunit beta like involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr13:98,625,867...98,626,349
Ensembl chr13:98,626,041...98,626,350
JBrowse link
G Srp54a signal recognition particle 54A involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr12:55,127,318...55,162,152
Ensembl chr12:55,127,047...55,162,152
JBrowse link
G Srp54c signal recognition particle 54C involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr12:55,276,896...55,326,120
Ensembl chr12:55,276,953...55,310,621
JBrowse link
G Tram1 translocating chain-associating membrane protein 1 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 1:13,634,917...13,660,134
Ensembl chr 1:13,634,922...13,660,134
JBrowse link
G Tram1l1 translocation associated membrane protein 1-like 1 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 3:124,114,686...124,116,909
Ensembl chr 3:124,114,504...124,118,392
JBrowse link
G Tram2 translocating chain-associating membrane protein 2 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 1:21,071,621...21,149,449
Ensembl chr 1:21,066,523...21,149,453
JBrowse link
G Zfand2b zinc finger, AN1 type domain 2B acts_upstream_of_or_within ISO MGI GO_REF:0000008 MGI:2154458 NCBI chr 1:75,145,290...75,148,270
Ensembl chr 1:75,145,290...75,148,273
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28558
    localization 5518
      establishment of localization 4809
        establishment of protein localization 1822
          protein targeting 325
            protein targeting to ER 45
              SRP-dependent cotranslational protein targeting to membrane 19
                SRP-dependent cotranslational protein targeting to membrane, docking 0
                SRP-dependent cotranslational protein targeting to membrane, signal sequence processing 0
                SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition 4
                SRP-dependent cotranslational protein targeting to membrane, translocation 10
Path 2
Term Annotations click to browse term
  biological_process 28558
    localization 5518
      macromolecule localization 3219
        cellular macromolecule localization 2731
          protein localization 2719
            establishment of protein localization 1822
              protein targeting 325
                protein targeting to membrane 125
                  cotranslational protein targeting to membrane 20
                    SRP-dependent cotranslational protein targeting to membrane 19
                      SRP-dependent cotranslational protein targeting to membrane, docking 0
                      SRP-dependent cotranslational protein targeting to membrane, signal sequence processing 0
                      SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition 4
                      SRP-dependent cotranslational protein targeting to membrane, translocation 10
paths to the root