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ONTOLOGY REPORT - ANNOTATIONS


Term:SRP-dependent cotranslational protein targeting to membrane
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Accession:GO:0006614 term browser browse the term
Definition:The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
Synonyms:exact_synonym: SRP-dependent cotranslational membrane targeting;   SRP-dependent cotranslational protein-membrane targeting
 broad_synonym: ER translocation


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SRP-dependent cotranslational protein targeting to membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC102151683 signal recognition particle 14 kDa protein-like involved_in IEA InterPro GO_REF:0000002 NCBI chr18:29,652,810...29,653,502 JBrowse link
G SEC61A1 SEC61 translocon subunit alpha 1 acts_upstream_of_or_within ISO (PMID:22375059) MGI PMID:22375059 NCBI chr20:2,070,739...2,087,790
Ensembl chr20:2,070,248...2,087,789
JBrowse link
G SEC63 SEC63 homolog, protein translocation regulator acts_upstream_of_or_within ISO (MGI:5494355|PMID:22375059)
(PMID:22375059)
MGI PMID:22375059 MGI:5494355 NCBI chr12:64,983,442...65,028,573 JBrowse link
G SRP14 signal recognition particle 14 involved_in IEA InterPro GO_REF:0000002 NCBI chr30:7,256,467...7,259,080
Ensembl chr30:7,256,170...7,259,146
JBrowse link
G SRP68 signal recognition particle 68 involved_in IEA InterPro GO_REF:0000002 NCBI chr 9:4,567,613...4,604,230
Ensembl chr 9:4,567,628...4,604,229
JBrowse link
G SRP72 signal recognition particle 72 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:48,688,295...48,717,826
Ensembl chr13:48,688,295...48,717,824
JBrowse link
G SRP9 signal recognition particle 9 involved_in IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr 7:39,012,142...39,023,009
Ensembl chr 7:39,013,806...39,022,991
JBrowse link
G SRPRA SRP receptor subunit alpha involved_in IEA InterPro GO_REF:0000002 NCBI chr 5:8,247,608...8,253,411
Ensembl chr 5:8,224,416...8,254,792
JBrowse link
G SSR3 signal sequence receptor subunit 3 involved_in IEA InterPro GO_REF:0000002 NCBI chr23:50,136,591...50,150,424
Ensembl chr23:50,138,909...50,150,415
JBrowse link
SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SRP19 signal recognition particle 19 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:239,651...245,078
Ensembl chr 3:239,652...245,078
JBrowse link
G SRP54 signal recognition particle 54 involved_in IMP (PMID:16469117) UniProt PMID:16469117 NCBI chr 8:13,800,275...13,837,799
Ensembl chr 8:13,677,760...13,837,722
JBrowse link
SRP-dependent cotranslational protein targeting to membrane, translocation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SEC61A1 SEC61 translocon subunit alpha 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr20:2,070,739...2,087,790
Ensembl chr20:2,070,248...2,087,789
JBrowse link
G SEC61B SEC61 translocon subunit beta involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr11:56,279,564...56,298,593
Ensembl chr11:56,251,636...56,286,291
JBrowse link
G SRP54 signal recognition particle 54 involved_in IBA
IDA
(PMID:21873635)
(PMID:8521805)
GO_Central
UniProt
PMID:8521805 PMID:21873635 NCBI chr 8:13,800,275...13,837,799
Ensembl chr 8:13,677,760...13,837,722
JBrowse link
G TRAM1 translocation associated membrane protein 1 involved_in IDA (PMID:8698819) WB PMID:8698819 NCBI chr29:19,669,622...19,703,707
Ensembl chr29:19,669,628...19,703,669
JBrowse link
G TRAM1L1 translocation associated membrane protein 1 like 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr32:36,487,648...36,489,596
Ensembl chr32:36,488,434...36,489,546
JBrowse link
G ZFAND2B zinc finger AN1-type containing 2B acts_upstream_of_or_within ISO (PMID:24160817) MGI PMID:24160817 NCBI chr37:25,757,454...25,760,366
Ensembl chr37:25,757,669...25,760,132
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 13863
    localization 5399
      cellular localization 2581
        intracellular transport 1245
          intracellular protein transport 700
            protein targeting 250
              protein targeting to ER 29
                SRP-dependent cotranslational protein targeting to membrane 15
                  SRP-dependent cotranslational protein targeting to membrane, docking 0
                  SRP-dependent cotranslational protein targeting to membrane, signal sequence processing 0
                  SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition 2
                  SRP-dependent cotranslational protein targeting to membrane, translocation 6
Path 2
Term Annotations click to browse term
  biological_process 13863
    localization 5399
      macromolecule localization 2515
        protein localization 2157
          establishment of protein localization 1339
            protein transport 1214
              intracellular protein transport 700
                protein targeting 250
                  protein targeting to membrane 93
                    cotranslational protein targeting to membrane 16
                      SRP-dependent cotranslational protein targeting to membrane 15
                        SRP-dependent cotranslational protein targeting to membrane, docking 0
                        SRP-dependent cotranslational protein targeting to membrane, signal sequence processing 0
                        SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition 2
                        SRP-dependent cotranslational protein targeting to membrane, translocation 6
paths to the root