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ONTOLOGY REPORT - ANNOTATIONS


Term:creatine biosynthetic process
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Accession:GO:0006601 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle.
Synonyms:exact_synonym: creatine anabolism;   creatine biosynthesis;   creatine formation;   creatine synthesis



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creatine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gamt guanidinoacetate N-methyltransferase acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
IEA
TAS
MGI:3044282 (MGI:3043413|PMID:15028668)
PMID:21873635
(PMID:8651275)
GO_REF:0000041
RGD
UniProt
PMID:8651275 PMID:15028668 PMID:15533043 PMID:21873635 PMID:12079381 GO_REF:0000041 MGI:3043413, RGD:1359081, RGD:13792537, RGD:632754 NCBI chr 7:9,448,590...9,451,778
Ensembl chr 7:9,448,628...9,451,778
JBrowse link
G Gatm glycine amidinotransferase involved_in
acts_upstream_of_or_within
TAS
IBA
IEA
ISO
PMID:21873635
GO_REF:0000041
(PMID:9218780)
UniProt
RGD
PMID:9218780 PMID:8021264 PMID:21873635 GO_REF:0000041, RGD:70746, RGD:13792537 NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    metabolic process 11824
      cellular metabolic process 10719
        cellular modified amino acid metabolic process 203
          creatine metabolic process 2
            creatine biosynthetic process 2
Path 2
Term Annotations click to browse term
  biological_process 19497
    cellular process 18359
      cellular metabolic process 10719
        organic acid metabolic process 1013
          oxoacid metabolic process 982
            carboxylic acid metabolic process 961
              monocarboxylic acid metabolic process 659
                monocarboxylic acid biosynthetic process 200
                  creatine biosynthetic process 2
paths to the root