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ONTOLOGY REPORT - ANNOTATIONS

Term:creatine biosynthetic process
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Accession:GO:0006601 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle.
Synonyms:exact_synonym: creatine anabolism;   creatine biosynthesis;   creatine formation;   creatine synthesis


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creatine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gamt guanidinoacetate N-methyltransferase involved_in
acts_upstream_of_or_within		 IDA
TAS
IEA
ISO
IBA		 GO_REF:0000041
(PMID:8651275)
GO_REF:0000033
MGI:3044282 (PMID:15028668)		 UniProt
RGD
GO_Central		 PMID:8651275 PMID:15028668 PMID:15533043 PMID:12079381 GO_REF:0000033 GO_REF:0000041, RGD:1359081, RGD:632754 NCBI chr 7:9,448,590...9,451,413
Ensembl chr 7:9,448,628...9,451,778 		JBrowse link
G Gatm glycine amidinotransferase acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 (PMID:9218780)
GO_REF:0000041
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:9218780 GO_REF:0000033 GO_REF:0000041 NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    metabolic process 12289
      biosynthetic process 8418
        cellular modified amino acid biosynthetic process 41
          creatine biosynthetic process 2
Path 2
Term Annotations click to browse term
  biological_process 20115
    metabolic process 12289
      small molecule metabolic process 1902
        organic acid metabolic process 1033
          oxoacid metabolic process 1022
            carboxylic acid metabolic process 1007
              monocarboxylic acid metabolic process 730
                monocarboxylic acid biosynthetic process 221
                  creatine biosynthetic process 2
paths to the root