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ONTOLOGY REPORT - ANNOTATIONS


Term:creatine biosynthetic process
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Accession:GO:0006601 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle.
Synonyms:exact_synonym: creatine anabolism;   creatine biosynthesis;   creatine formation;   creatine synthesis


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creatine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gamt guanidinoacetate N-methyltransferase IDA
ISO
IBA
IEA
TAS
MGI:3044282 (MGI:3043413|PMID:15028668)
PMID:21873635
(PMID:8651275)
GO_REF:0000041
RGD
UniProt
PMID:8651275, PMID:15028668, PMID:15533043, PMID:21873635, PMID:12079381 GO_REF:0000041, MGI:3043413, RGD:1359081, RGD:13792537, RGD:632754 NCBI chr 7:12,314,848...12,317,998
Ensembl chr 7:12,314,848...12,317,998
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G Gatm glycine amidinotransferase TAS
ISO
IEA
IBA
(PMID:9218780)
GO_REF:0000041
PMID:21873635
RGD
UniProt
PMID:9218780, PMID:8021264, PMID:21873635 GO_REF:0000041, RGD:70746, RGD:13792537 NCBI chr 3:114,711,570...114,728,155
Ensembl chr 3:114,711,562...114,728,410
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      cellular metabolic process 11073
        cellular modified amino acid metabolic process 190
          creatine metabolic process 2
            creatine biosynthetic process 2
Path 2
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      organic substance metabolic process 11643
        organic acid metabolic process 1008
          oxoacid metabolic process 970
            carboxylic acid metabolic process 951
              monocarboxylic acid metabolic process 651
                monocarboxylic acid biosynthetic process 200
                  creatine biosynthetic process 2
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