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Pathways

ONTOLOGY REPORT - ANNOTATIONS


Term:melanin metabolic process
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Accession:GO:0006582 term browser browse the term
Definition:The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
Synonyms:exact_synonym: melanin metabolism



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melanin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IEA
MGI:2156165 (MGI:2154874|PMID:11709185)
GO_REF:0000107
RGD
Ensembl
PMID:11709185 GO_REF:0000107 MGI:2154874 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Myo5a myosin VA acts_upstream_of_or_within ISO MGI:1856004 (MGI:1202196|PMID:9548375) RGD PMID:9548375 MGI:1202196 NCBI chr 8:75,811,985...75,980,049
Ensembl chr 8:75,812,412...75,975,918
JBrowse link
G Tyrp1 tyrosinase-related protein 1 acts_upstream_of_or_within ISO MGI:1855960 (MGI:1202196|PMID:9548375) RGD PMID:9548375 MGI:1202196 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor acts_upstream_of_or_within ISO MGI:2136645 (MGI:5429122|PMID:22627278) RGD PMID:22627278 MGI:5429122 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377
JBrowse link
melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asip agouti signaling protein acts_upstream_of_or_within
involved_in
ISO
ISS
IEA
MGI:1855937 (MGI:76308|PMID:7665913)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:7665913 GO_REF:0000024 GO_REF:0000107 MGI:76308 NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171
JBrowse link
G Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:4412464|PMID:11434569)
UniProt
RGD
PMID:11434569 GO_REF:0000024 MGI:4412464 NCBI chr  X:67,350,376...67,355,072
Ensembl chr  X:67,350,373...67,355,162
JBrowse link
G Dct dopachrome tautomerase acts_upstream_of_or_within ISO MGI:1856379 (MGI:76308|PMID:7665913) RGD PMID:7665913 MGI:76308 NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836
JBrowse link
G Ddt D-dopachrome tautomerase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:12,884,216...12,886,687
Ensembl chr20:12,884,243...12,888,482
JBrowse link
G Mc1r melanocortin 1 receptor acts_upstream_of_or_within ISO MGI:1856028 (MGI:76308|PMID:7665913) RGD PMID:7665913 MGI:76308 NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192
JBrowse link
G Myo5a myosin VA acts_upstream_of_or_within ISO MGI:1856004 (MGI:76308|PMID:7665913) RGD PMID:7665913 MGI:76308 NCBI chr 8:75,811,985...75,980,049
Ensembl chr 8:75,812,412...75,975,918
JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein acts_upstream_of_or_within
involved_in
ISO
IBA
MGI:1856114 (MGI:1202196|PMID:9548375), (MGI:76308|PMID:7665913)
PMID:21873635
RGD PMID:7665913 PMID:9548375 PMID:21873635 MGI:1202196 MGI:76308, RGD:13792537 NCBI chr 1:107,116,278...107,446,093
Ensembl chr 1:107,116,278...107,446,074
JBrowse link
G Pmel premelanosome protein acts_upstream_of_or_within ISO MGI:1857040 (MGI:76308|PMID:7665913) RGD PMID:7665913 MGI:76308 NCBI chr 7:1,138,202...1,148,735
Ensembl chr 7:1,138,586...1,148,746
JBrowse link
G Slc24a5 solute carrier family 24 member 5 acts_upstream_of ISO (MGI:3775882|PMID:18166528) RGD PMID:18166528 MGI:3775882 NCBI chr 3:112,319,349...112,338,889
Ensembl chr 3:112,319,308...112,339,231
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:8126111)
Ensembl
RGD
PMID:8126111 GO_REF:0000107 NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276
JBrowse link
G Tyr tyrosinase involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1855976|MGI:1855978 (MGI:1202196|PMID:9548375), (MGI:76308|PMID:7665913)
(PMID:8126111)
RGD PMID:7665913 PMID:8126111 PMID:9548375 PMID:21873635 MGI:1202196 MGI:76308, RGD:13792537 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
G Tyrp1 tyrosinase-related protein 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
JBrowse link
melanin biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dct dopachrome tautomerase involved_in ISO (MGI:3690794|PMID:2169885), (MGI:6827472|PMID:33100333) RGD PMID:2169885 PMID:33100333 MGI:3690794 MGI:6827472 NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836
JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein involved_in ISO (PMID:25513726), (PMID:32966160) RGD PMID:25513726 PMID:32966160 NCBI chr 1:107,116,278...107,446,093
Ensembl chr 1:107,116,278...107,446,074
JBrowse link
G Slc45a2 solute carrier family 45, member 2 involved_in ISO (PMID:32966160)
(MGI:7338895|PMID:35469906)
RGD PMID:32966160 PMID:35469906 MGI:7338895 NCBI chr 2:59,963,599...59,996,408
Ensembl chr 2:59,963,706...59,996,317
JBrowse link
negative regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mfsd12 major facilitator superfamily domain containing 12 involved_in ISO (MGI:5912387|PMID:29025994) RGD PMID:29025994 MGI:5912387 NCBI chr 7:8,345,171...8,354,050
Ensembl chr 7:8,347,314...8,353,988
JBrowse link
G Opn3 opsin 3 involved_in ISO (PMID:31097585) RGD PMID:31097585 NCBI chr13:87,589,333...87,619,847
Ensembl chr13:87,589,333...87,619,847
JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:5499726|PMID:16272156)
UniProt
RGD
PMID:16272156 GO_REF:0000024 MGI:5499726 NCBI chr 2:164,207,513...164,322,157
Ensembl chr 2:164,207,513...164,244,247
JBrowse link
G Slc24a5 solute carrier family 24 member 5 acts_upstream_of_or_within ISO (MGI:3775882|PMID:18166528) RGD PMID:18166528 MGI:3775882 NCBI chr 3:112,319,349...112,338,889
Ensembl chr 3:112,319,308...112,339,231
JBrowse link
G Wnt5a Wnt family member 5A involved_in ISO
IEA
(MGI:5619434|PMID:23569434)
GO_REF:0000107
RGD
Ensembl
PMID:23569434 GO_REF:0000107 MGI:5619434 NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234
JBrowse link
positive regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISO (PMID:21291857) RGD PMID:21291857 NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692
JBrowse link
G Asip agouti signaling protein involved_in IBA
IEA
PMID:21873635
GO_REF:0000107
Ensembl PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171
JBrowse link
G Atp7a ATPase copper transporting alpha involved_in ISS
ISO
GO_REF:0000024
(PMID:11092760)
UniProt
RGD
PMID:11092760 GO_REF:0000024 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Cdh3 cadherin 3 involved_in ISO (PMID:23334344) RGD PMID:23334344 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:21291857)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:21291857 GO_REF:0000024 GO_REF:0000107 NCBI chr19:24,474,291...24,487,083
Ensembl chr19:24,453,123...24,486,997
JBrowse link
G Opn3 opsin 3 involved_in ISO (PMID:28842328) RGD PMID:28842328 NCBI chr13:87,589,333...87,619,847
Ensembl chr13:87,589,333...87,619,847
JBrowse link
G Pmel premelanosome protein involved_in ISO (MGI:5294257|PMID:21949658) RGD PMID:21949658 MGI:5294257 NCBI chr 7:1,138,202...1,148,735
Ensembl chr 7:1,138,586...1,148,746
JBrowse link
G Rab38 RAB38, member RAS oncogene family IMP RGD PMID:17043139 RGD:152025192 NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924
JBrowse link
G Tyrp1 tyrosinase-related protein 1 involved_in ISO (PMID:21996312)
UniProtKB:Q03288|UniProtKB:Q60696 (MGI:5294257|PMID:21949658)
RGD PMID:21949658 PMID:21996312 MGI:5294257 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
JBrowse link
regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter involved_in ISO (PMID:22649030) RGD PMID:22649030 NCBI chr10:57,801,551...57,817,213
Ensembl chr10:57,801,456...57,817,120
JBrowse link
G Mfsd12 major facilitator superfamily domain containing 12 involved_in ISO (PMID:33208952)
(MGI:6492453|PMID:33208952)
(PMID:31117290)
RGD PMID:31117290 PMID:33208952 MGI:6492453 NCBI chr 7:8,345,171...8,354,050
Ensembl chr 7:8,347,314...8,353,988
JBrowse link
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO MGI:1857061 (MGI:3588610|PMID:16037214) RGD PMID:16037214 MGI:3588610 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19553
    metabolic process 11538
      secondary metabolic process 69
        melanin metabolic process 26
          melanin biosynthetic process + 24
          melanin catabolic process 0
          melanization defense response + 0
Path 2
Term Annotations click to browse term
  biological_process 19553
    metabolic process 11538
      cellular metabolic process 10124
        cellular aromatic compound metabolic process 5773
          phenol-containing compound metabolic process 132
            melanin metabolic process 26
              melanin biosynthetic process + 24
              melanin catabolic process 0
              melanization defense response + 0
paths to the root