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ONTOLOGY REPORT - ANNOTATIONS

Term:melanin metabolic process
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Accession:GO:0006582 term browser browse the term
Definition:The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
Synonyms:exact_synonym: melanin metabolism


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melanin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within ISO MGI:2156165 (PMID:11709185) RGD PMID:11709185 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Myo5a myosin VA acts_upstream_of_or_within ISO MGI:1856004 (PMID:9548375) RGD PMID:9548375 NCBI chr 8:75,811,985...75,980,049
Ensembl chr 8:75,812,412...75,975,918 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 acts_upstream_of_or_within ISO
IEA 		MGI:1855960 (PMID:9548375)
GO_REF:0000107 		RGD
Ensembl		 PMID:9548375 GO_REF:0000107 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor acts_upstream_of_or_within ISO
IEA 		MGI:2136645 (PMID:22627278)
GO_REF:0000107 		RGD
Ensembl		 PMID:22627278 GO_REF:0000107 NCBI chr 4:148,328,099...148,334,992
Ensembl chr 4:146,772,468...146,779,377 		JBrowse link
melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asip agouti signaling protein involved_in
acts_upstream_of_or_within 		IEA
ISO
ISS 		GO_REF:0000107
(PMID:8449404)
MGI:1855937 (PMID:7665913)
GO_REF:0000024 		Ensembl
RGD
UniProt		 PMID:7665913 PMID:8449404 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171 		JBrowse link
G Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:11434569) 		UniProt
RGD		 PMID:11434569 GO_REF:0000024 NCBI chr  X:67,350,376...67,355,072
Ensembl chr  X:67,350,373...67,355,162 		JBrowse link
G Dct dopachrome tautomerase acts_upstream_of_or_within
involved_in 		ISO
IEA 		MGI:1856379 (PMID:7665913)
GO_REF:0000043
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:7665913 GO_REF:0000043 GO_REF:0000107 NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836 		JBrowse link
G Ddt D-dopachrome tautomerase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:12,884,216...12,886,687
Ensembl chr20:12,884,243...12,888,482 		JBrowse link
G Mc1r melanocortin 1 receptor acts_upstream_of_or_within ISO
IEA 		MGI:1856028 (PMID:7665913)
GO_REF:0000107 		RGD
Ensembl		 PMID:7665913 GO_REF:0000107 NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192 		JBrowse link
G Myo5a myosin VA acts_upstream_of_or_within ISO MGI:1856004 (PMID:7665913) RGD PMID:7665913 NCBI chr 8:75,811,985...75,980,049
Ensembl chr 8:75,812,412...75,975,918 		JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein acts_upstream_of_or_within
involved_in 		ISO
IEA
IBA 		MGI:1856114 (PMID:7665913), (PMID:9548375)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:7665913 PMID:9548375 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:107,116,278...107,446,093
Ensembl chr 1:107,116,278...107,446,074 		JBrowse link
G Pmel premelanosome protein acts_upstream_of_or_within ISO
IEA 		MGI:1857040 (PMID:7665913)
GO_REF:0000107 		RGD
Ensembl		 PMID:7665913 GO_REF:0000107 NCBI chr 7:1,138,202...1,148,735
Ensembl chr 7:1,138,586...1,148,746 		JBrowse link
G Slc24a5 solute carrier family 24 member 5 acts_upstream_of ISO
IEA 		(PMID:18166528)
GO_REF:0000107 		RGD
Ensembl		 PMID:18166528 GO_REF:0000107 NCBI chr 3:112,319,349...112,338,889
Ensembl chr 3:112,319,308...112,339,231 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:8126111) 		Ensembl
RGD		 PMID:8126111 GO_REF:0000107 NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276 		JBrowse link
G Tyr tyrosinase involved_in
acts_upstream_of_or_within 		ISO
IEA
IBA 		(PMID:8126111)
GO_REF:0000043
GO_REF:0000107
MGI:1855976|MGI:1855978 (PMID:7665913), (PMID:9548375)
GO_REF:0000033 		RGD
UniProt
Ensembl
GO_Central		 PMID:7665913 PMID:8126111 PMID:9548375 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
melanin biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dct dopachrome tautomerase involved_in ISO
IEA
IBA 		(PMID:2169885), (PMID:33100333)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:2169885 PMID:33100333 GO_REF:0000033 GO_REF:0000107 NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836 		JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein involved_in ISO
IEA 		(PMID:25513726), (PMID:32966160)
GO_REF:0000107 		RGD
Ensembl		 PMID:25513726 PMID:32966160 GO_REF:0000107 NCBI chr 1:107,116,278...107,446,093
Ensembl chr 1:107,116,278...107,446,074 		JBrowse link
G Slc45a2 solute carrier family 45, member 2 involved_in ISO
IEA 		(PMID:32966160)
GO_REF:0000107
(PMID:35469906) 		RGD
Ensembl		 PMID:32966160 PMID:35469906 GO_REF:0000107 NCBI chr 2:59,963,599...59,996,408
Ensembl chr 2:59,963,706...59,996,317 		JBrowse link
negative regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mfsd12 major facilitator superfamily domain containing 12 involved_in ISO
IEA 		(PMID:29025994)
GO_REF:0000107 		RGD
Ensembl		 PMID:29025994 GO_REF:0000107 NCBI chr 7:8,345,171...8,354,050
Ensembl chr 7:8,347,314...8,353,988 		JBrowse link
G Opn3 opsin 3 involved_in ISO
IEA 		(PMID:31097585)
GO_REF:0000107 		RGD
Ensembl		 PMID:31097585 GO_REF:0000107 NCBI chr13:87,589,333...87,619,847
Ensembl chr13:87,589,333...87,619,847 		JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 involved_in ISS
ISO 		GO_REF:0000024
(PMID:16272156) 		UniProt
RGD		 PMID:16272156 GO_REF:0000024 NCBI chr 2:164,207,513...164,322,157
Ensembl chr 2:164,207,513...164,244,247 		JBrowse link
G Slc24a5 solute carrier family 24 member 5 acts_upstream_of_or_within ISO
IEA 		(PMID:18166528)
GO_REF:0000107 		RGD
Ensembl		 PMID:18166528 GO_REF:0000107 NCBI chr 3:112,319,349...112,338,889
Ensembl chr 3:112,319,308...112,339,231 		JBrowse link
G Wnt5a Wnt family member 5A involved_in IEA
ISO 		GO_REF:0000107
(PMID:23569434) 		Ensembl
RGD		 PMID:23569434 GO_REF:0000107 NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
positive regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISO (PMID:21291857) RGD PMID:21291857 NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692 		JBrowse link
G Asip agouti signaling protein involved_in IEA
ISO 		GO_REF:0000107
UniProtKB:P07147|UniProtKB:Q60696 (PMID:21949658) 		Ensembl
RGD		 PMID:21949658 GO_REF:0000107 NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171 		JBrowse link
G Atp7a ATPase copper transporting alpha involved_in ISS
ISO 		GO_REF:0000024
(PMID:11092760) 		UniProt
RGD		 PMID:11092760 GO_REF:0000024 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Cdh3 cadherin 3 involved_in ISO (PMID:23334344) RGD PMID:23334344 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084 		JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:21291857)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:21291857 GO_REF:0000024 GO_REF:0000107 NCBI chr19:24,474,291...24,487,083
Ensembl chr19:24,453,123...24,486,997 		JBrowse link
G Opn3 opsin 3 involved_in ISO
IEA 		(PMID:28842328)
GO_REF:0000107 		RGD
Ensembl		 PMID:28842328 GO_REF:0000107 NCBI chr13:87,589,333...87,619,847
Ensembl chr13:87,589,333...87,619,847 		JBrowse link
G Pmel premelanosome protein involved_in ISO
IEA 		(PMID:21949658)
GO_REF:0000107 		RGD
Ensembl		 PMID:21949658 GO_REF:0000107 NCBI chr 7:1,138,202...1,148,735
Ensembl chr 7:1,138,586...1,148,746 		JBrowse link
G Rab38 RAB38, member RAS oncogene family IMP RGD PMID:17043139 RGD:152025192 NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 involved_in ISO
IEA 		(PMID:21996312)
UniProtKB:Q03288|UniProtKB:Q60696 (PMID:21949658)
GO_REF:0000107 		RGD
Ensembl		 PMID:21949658 PMID:21996312 GO_REF:0000107 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter involved_in ISO (PMID:22649030) RGD PMID:22649030 NCBI chr10:57,801,551...57,817,213
Ensembl chr10:57,801,456...57,817,120 		JBrowse link
G Mfsd12 major facilitator superfamily domain containing 12 involved_in ISO
IEA
IBA 		(PMID:33208952)
GO_REF:0000107
GO_REF:0000033
(PMID:31117290) 		RGD
Ensembl
GO_Central		 PMID:31117290 PMID:33208952 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:8,345,171...8,354,050
Ensembl chr 7:8,347,314...8,353,988 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO MGI:1857061 (PMID:16037214) RGD PMID:16037214 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      metabolic process 12158
        phenol-containing compound metabolic process 136
          melanin metabolic process 26
            melanin biosynthetic process + 24
            melanin catabolic process 0
            melanization defense response + 0
paths to the root