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ONTOLOGY REPORT - ANNOTATIONS


Term:L-serine metabolic process
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Accession:GO:0006563 term browser browse the term
Definition:The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.
Synonyms:exact_synonym: L-serine metabolism


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L-serine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase ISO
ISS
(PMID:19010420)
GO_REF:0000024
RGD
UniProt
PMID:19010420 GO_REF:0000024 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Phgdh phosphoglycerate dehydrogenase ISO MGI:3769591 (MGI:3835979|PMID:19114063) RGD PMID:19114063 MGI:3835979 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Psph phosphoserine phosphatase ISO
ISS
(PMID:15291819)
GO_REF:0000024
RGD
UniProt
PMID:15291819 GO_REF:0000024 NCBI chr12:30,514,128...30,526,551
Ensembl chr12:30,514,112...30,526,557
JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 TAS
ISO
(PMID:24698160) RGD PMID:24698160, PMID:15671219 RGD:1359815 NCBI chr10:47,030,813...47,059,216
Ensembl chr10:47,031,050...47,059,216
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 TAS
ISO
(PMID:25619277), (PMID:29180469) RGD PMID:25619277, PMID:29180469, PMID:15671219 RGD:1359815 NCBI chr 7:70,824,718...70,829,822
Ensembl chr 7:70,824,715...70,829,815
JBrowse link
G Srr serine racemase IDA
ISO
IBA
PMID:20106978
(MGI:1347751|PMID:10557334), (MGI:2183617|PMID:12021263), (MGI:3529732|PMID:15710237), (MGI:3769629|PMID:16517698)
PMID:21873635
(PMID:11054547), (PMID:15193426), (PMID:20106978)
RGD PMID:10557334, PMID:11054547, PMID:12021263, PMID:15193426, PMID:15710237, PMID:16517698, PMID:20106978, PMID:20106978, PMID:21873635 MGI:1347751, MGI:2183617, MGI:3529732, MGI:3769629, RGD:8554326, RGD:13792537 NCBI chr10:61,756,138...61,772,327
Ensembl chr10:61,756,138...61,772,293
JBrowse link
cysteine biosynthetic process from serine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase TAS RGD PMID:9359866 RGD:1359024 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
glycine biosynthetic process from serine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Shmt1 serine hydroxymethyltransferase 1 IDA
IBA
in the presence of tetrahydrofolate
PMID:21873635
RGD
GO_Central
PMID:3110140, PMID:21873635 RGD:2300383, RGD:13792537 NCBI chr10:47,030,813...47,059,216
Ensembl chr10:47,031,050...47,059,216
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 IDA
IBA
in the presence of tetrahydrofolate
PMID:21873635
RGD
GO_Central
PMID:3110140, PMID:21873635 RGD:2300383, RGD:13792537 NCBI chr 7:70,824,718...70,829,822
Ensembl chr 7:70,824,715...70,829,815
JBrowse link
L-serine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Phgdh phosphoglycerate dehydrogenase IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Psat1 phosphoserine aminotransferase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941
JBrowse link
G Psph phosphoserine phosphatase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:30,514,128...30,526,551
Ensembl chr12:30,514,112...30,526,557
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 IDA RGD PMID:10457370 RGD:2300380 NCBI chr 7:70,824,718...70,829,822
Ensembl chr 7:70,824,715...70,829,815
JBrowse link
L-serine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase ISO (PMID:18776696) RGD PMID:18776696 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Sds serine dehydratase IEA
ISO
GO_REF:0000107
(PMID:15689518), (PMID:18342636)
Ensembl
RGD
PMID:15689518, PMID:18342636 GO_REF:0000107 NCBI chr12:41,620,429...41,627,741
Ensembl chr12:41,620,393...41,627,741
JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 ISO
IBA
(PMID:17482557)
PMID:21873635
RGD PMID:17482557, PMID:21873635 RGD:13792537 NCBI chr10:47,030,813...47,059,216
Ensembl chr10:47,031,050...47,059,216
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:70,824,718...70,829,822
Ensembl chr 7:70,824,715...70,829,815
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      primary metabolic process 10900
        cellular amino acid metabolic process 268
          alpha-amino acid metabolic process 190
            serine family amino acid metabolic process 40
              L-serine metabolic process 8
                L-serine biosynthetic process 4
                L-serine catabolic process 4
                cysteine biosynthetic process from serine 1
                glycine biosynthetic process from serine 2
Path 2
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      cellular metabolic process 11073
        organic acid metabolic process 1008
          oxoacid metabolic process 970
            carboxylic acid metabolic process 951
              cellular amino acid metabolic process 268
                alpha-amino acid metabolic process 190
                  serine family amino acid metabolic process 40
                    L-serine metabolic process 8
                      L-serine biosynthetic process 4
                      L-serine catabolic process 4
                      cysteine biosynthetic process from serine 1
                      glycine biosynthetic process from serine 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.