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ONTOLOGY REPORT - ANNOTATIONS


Term:proline biosynthetic process
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Accession:GO:0006561 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
Synonyms:exact_synonym: proline anabolism;   proline biosynthesis;   proline formation;   proline synthesis
 xref: MetaCyc:PROSYN-PWY;   MetaCyc:PWY-3341


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proline biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 ISO (PMID:11092761), (PMID:26297558) RGD PMID:11092761 PMID:26297558 NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425
Ensembl chr 1:259,641,676...259,674,425
JBrowse link
G Pycr1 pyrroline-5-carboxylate reductase 1 ISO (PMID:16730026) RGD PMID:16730026 NCBI chr10:109,817,300...109,822,218
Ensembl chr10:109,818,177...109,821,807
JBrowse link
G Pycr2 pyrroline-5-carboxylate reductase 2 ISO
ISS
(PMID:23024808)
GO_REF:0000024
RGD
UniProt
PMID:23024808 GO_REF:0000024 NCBI chr13:99,184,624...99,188,418
Ensembl chr13:99,184,564...99,188,431
JBrowse link
L-proline biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425
Ensembl chr 1:259,641,676...259,674,425
JBrowse link
G LOC108348083 delta-1-pyrroline-5-carboxylate synthase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:259,057,407...259,089,727
Ensembl chr 1:259,057,402...259,089,642
JBrowse link
G Noxred1 NADP-dependent oxidoreductase domain containing 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:111,243,232...111,271,107
Ensembl chr 6:111,243,228...111,267,734
JBrowse link
G Oat ornithine aminotransferase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Pycr1 pyrroline-5-carboxylate reductase 1 IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr10:109,817,300...109,822,218
Ensembl chr10:109,818,177...109,821,807
JBrowse link
G Pycr2 pyrroline-5-carboxylate reductase 2 IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr13:99,184,624...99,188,418
Ensembl chr13:99,184,564...99,188,431
JBrowse link
G Pycr3 pyrroline-5-carboxylate reductase 3 IEA
IBA
ISS
ISO
GO_REF:0000041
PMID:21873635
GO_REF:0000024
(PMID:23024808)
UniProt
RGD
PMID:23024808, PMID:21873635 GO_REF:0000024 GO_REF:0000041, RGD:13792537 NCBI chr 7:116,949,882...116,955,150
Ensembl chr 7:116,949,879...116,955,148
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20030
    metabolic process 12185
      primary metabolic process 10778
        cellular amino acid metabolic process 268
          cellular amino acid biosynthetic process 64
            proline biosynthetic process 7
              L-proline biosynthetic process 7
              negative regulation of proline biosynthetic process 0
              proline salvage 0
              regulation of proline biosynthetic process + 0
Path 2
Term Annotations click to browse term
  biological_process 20030
    metabolic process 12185
      cellular metabolic process 10964
        organic acid metabolic process 1007
          oxoacid metabolic process 969
            carboxylic acid metabolic process 950
              cellular amino acid metabolic process 268
                alpha-amino acid metabolic process 190
                  glutamine family amino acid metabolic process 75
                    glutamine family amino acid biosynthetic process 18
                      proline biosynthetic process 7
                        L-proline biosynthetic process 7
                        negative regulation of proline biosynthetic process 0
                        proline salvage 0
                        regulation of proline biosynthetic process + 0
paths to the root