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ONTOLOGY REPORT - ANNOTATIONS


Term:proline metabolic process
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Accession:GO:0006560 term browser browse the term
Definition:The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
Synonyms:exact_synonym: proline metabolism



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proline metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH4A1 aldehyde dehydrogenase 4 family member A1 involved_in TAS (PMID:8621661) PINC PMID:8621661 NCBI chr 1:18,871,430...18,902,555
Ensembl chr 1:18,871,430...18,902,724
JBrowse link
G PRODH proline dehydrogenase 1 involved_in TAS (PMID:9385373) PINC PMID:9385373 NCBI chr22:18,912,781...18,936,553
Ensembl chr22:18,912,777...18,936,553
JBrowse link
arginine catabolic process to proline via ornithine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G OAT ornithine aminotransferase involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976
JBrowse link
L-proline biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AL117348.2 novel protein involved_in IEA UniProt GO_REF:0000041 Ensembl chr 1:225,886,696...225,924,278 JBrowse link
G ALDH18A1 aldehyde dehydrogenase 18 family member A1 involved_in IEA UniProt GO_REF:0000041 NCBI chr10:95,605,938...95,656,901
Ensembl chr10:95,605,941...95,656,711
JBrowse link
G NOXRED1 NADP dependent oxidoreductase domain containing 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:77,394,021...77,426,013
Ensembl chr14:77,394,021...77,423,517
JBrowse link
G OAT ornithine aminotransferase involved_in IEA UniProt GO_REF:0000041 NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976
JBrowse link
G PYCR1 pyrroline-5-carboxylate reductase 1 involved_in IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000041 NCBI chr17:81,932,391...81,937,300
Ensembl chr17:81,932,384...81,942,412
JBrowse link
G PYCR2 pyrroline-5-carboxylate reductase 2 involved_in IBA
IEA
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000041 NCBI chr 1:225,919,878...225,924,250
Ensembl chr 1:225,919,877...225,924,340
JBrowse link
G PYCR3 pyrroline-5-carboxylate reductase 3 involved_in IEA
IBA
IDA
(PMID:21873635)
(PMID:23024808)
UniProt
GO_Central
PMID:21873635 PMID:23024808 GO_REF:0000041 NCBI chr 8:143,603,210...143,609,575
Ensembl chr 8:143,603,210...143,609,773
JBrowse link
proline biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH18A1 aldehyde dehydrogenase 18 family member A1 involved_in IMP (PMID:11092761), (PMID:26297558) UniProt PMID:11092761 PMID:26297558 NCBI chr10:95,605,938...95,656,901
Ensembl chr10:95,605,941...95,656,711
JBrowse link
G NOXRED1 NADP dependent oxidoreductase domain containing 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr14:77,394,021...77,426,013
Ensembl chr14:77,394,021...77,423,517
JBrowse link
G PYCR1 pyrroline-5-carboxylate reductase 1 involved_in IDA
IEA
(PMID:16730026) UniProt
InterPro
PMID:16730026 GO_REF:0000002 NCBI chr17:81,932,391...81,937,300
Ensembl chr17:81,932,384...81,942,412
JBrowse link
G PYCR2 pyrroline-5-carboxylate reductase 2 involved_in IDA
IEA
(PMID:23024808) UniProt
InterPro
PMID:23024808 GO_REF:0000002 NCBI chr 1:225,919,878...225,924,250
Ensembl chr 1:225,919,877...225,924,340
JBrowse link
G PYCR3 pyrroline-5-carboxylate reductase 3 involved_in IEA InterPro GO_REF:0000002 NCBI chr 8:143,603,210...143,609,575
Ensembl chr 8:143,603,210...143,609,773
JBrowse link
proline catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH4A1 aldehyde dehydrogenase 4 family member A1 involved_in TAS (PMID:8621661) PINC PMID:8621661 NCBI chr 1:18,871,430...18,902,555
Ensembl chr 1:18,871,430...18,902,724
JBrowse link
G DAO D-amino acid oxidase involved_in IDA
IBA
(PMID:16616139)
(PMID:21873635)
UniProt
GO_Central
PMID:16616139 PMID:21873635 NCBI chr12:108,880,030...108,901,043
Ensembl chr12:108,858,932...108,901,043
JBrowse link
G PRODH proline dehydrogenase 1 involved_in IEA
TAS
InterPro
Reactome
GO_REF:0000002 Reactome:R-HSA-70688 NCBI chr22:18,912,781...18,936,553
Ensembl chr22:18,912,777...18,936,553
JBrowse link
G PRODH2 proline dehydrogenase 2 involved_in IEA
TAS
InterPro
Reactome
GO_REF:0000002 Reactome:R-HSA-70688 NCBI chr19:35,799,988...35,812,845
Ensembl chr19:35,799,988...35,813,299
JBrowse link
proline catabolic process to glutamate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH4A1 aldehyde dehydrogenase 4 family member A1 involved_in IEA UniProt GO_REF:0000041 NCBI chr 1:18,871,430...18,902,555
Ensembl chr 1:18,871,430...18,902,724
JBrowse link
G PRODH proline dehydrogenase 1 involved_in IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000041 NCBI chr22:18,912,781...18,936,553
Ensembl chr22:18,912,777...18,936,553
JBrowse link
G PRODH2 proline dehydrogenase 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr19:35,799,988...35,812,845
Ensembl chr19:35,799,988...35,813,299
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18539
    metabolic process 11872
      primary metabolic process 10546
        cellular amino acid metabolic process 302
          alpha-amino acid metabolic process 221
            glutamine family amino acid metabolic process 83
              proline metabolic process 11
                arginine catabolic process to proline + 1
                negative regulation of proline metabolic process + 0
                nopaline catabolic process to proline 0
                octopine catabolic process to proline 0
                ornithine catabolic process via proline 0
                positive regulation of proline metabolic process + 0
                proline biosynthetic process + 7
                proline catabolic process + 4
                regulation of proline metabolic process + 0
Path 2
Term Annotations click to browse term
  biological_process 18539
    metabolic process 11872
      cellular metabolic process 10812
        organic acid metabolic process 1039
          oxoacid metabolic process 1011
            carboxylic acid metabolic process 982
              cellular amino acid metabolic process 302
                alpha-amino acid metabolic process 221
                  glutamine family amino acid metabolic process 83
                    proline metabolic process 11
                      arginine catabolic process to proline + 1
                      negative regulation of proline metabolic process + 0
                      nopaline catabolic process to proline 0
                      octopine catabolic process to proline 0
                      ornithine catabolic process via proline 0
                      positive regulation of proline metabolic process + 0
                      proline biosynthetic process + 7
                      proline catabolic process + 4
                      regulation of proline metabolic process + 0
paths to the root