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ONTOLOGY REPORT - ANNOTATIONS


Term:proline metabolic process
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Accession:GO:0006560 term browser browse the term
Definition:The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
Synonyms:exact_synonym: proline metabolism



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L-proline biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PYCR3 pyrroline-5-carboxylate reductase 3 involved_in ISO (PMID:23024808) UniProt PMID:23024808 NCBI chr 8:140,356,586...140,362,972
Ensembl chr 8:143,371,748...143,378,032
JBrowse link
proline biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH18A1 aldehyde dehydrogenase 18 family member A1 involved_in ISO (PMID:11092761), (PMID:26297558) UniProt PMID:11092761 PMID:26297558 NCBI chr10:92,216,639...92,267,525
Ensembl chr10:95,723,099...95,774,095
JBrowse link
G PYCR1 pyrroline-5-carboxylate reductase 1 involved_in ISO (PMID:16730026) UniProt PMID:16730026 NCBI chr17:76,337,991...76,348,207
Ensembl chr17:82,040,824...82,045,686
JBrowse link
G PYCR2 pyrroline-5-carboxylate reductase 2 involved_in ISO (PMID:23024808) UniProt PMID:23024808 NCBI chr 1:201,381,270...201,385,703 JBrowse link
proline catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DAO D-amino acid oxidase involved_in ISO (PMID:16616139) UniProt PMID:16616139 NCBI chr12:106,453,807...106,475,409
Ensembl chr12:109,849,995...109,870,065
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12661
    metabolic process 7934
      primary metabolic process 6983
        cellular amino acid metabolic process 190
          alpha-amino acid metabolic process 141
            glutamine family amino acid metabolic process 52
              proline metabolic process 5
                arginine catabolic process to proline + 0
                negative regulation of proline metabolic process + 0
                nopaline catabolic process to proline 0
                octopine catabolic process to proline 0
                ornithine catabolic process via proline 0
                positive regulation of proline metabolic process + 0
                proline biosynthetic process + 4
                proline catabolic process + 1
                regulation of proline metabolic process + 0
Path 2
Term Annotations click to browse term
  biological_process 12661
    metabolic process 7934
      cellular metabolic process 7256
        organic acid metabolic process 700
          oxoacid metabolic process 677
            carboxylic acid metabolic process 665
              cellular amino acid metabolic process 190
                alpha-amino acid metabolic process 141
                  glutamine family amino acid metabolic process 52
                    proline metabolic process 5
                      arginine catabolic process to proline + 0
                      negative regulation of proline metabolic process + 0
                      nopaline catabolic process to proline 0
                      octopine catabolic process to proline 0
                      ornithine catabolic process via proline 0
                      positive regulation of proline metabolic process + 0
                      proline biosynthetic process + 4
                      proline catabolic process + 1
                      regulation of proline metabolic process + 0
paths to the root