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ONTOLOGY REPORT - ANNOTATIONS


Term:proline metabolic process
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Accession:GO:0006560 term browser browse the term
Definition:The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
Synonyms:exact_synonym: proline metabolism


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arginine catabolic process to proline via ornithine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oat ornithine aminotransferase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
L-proline biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425
Ensembl chr 1:259,641,676...259,674,425
JBrowse link
G LOC108348083 delta-1-pyrroline-5-carboxylate synthase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:259,057,407...259,089,727
Ensembl chr 1:259,057,402...259,089,642
JBrowse link
G Noxred1 NADP-dependent oxidoreductase domain containing 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:111,243,232...111,271,107
Ensembl chr 6:111,243,228...111,267,734
JBrowse link
G Oat ornithine aminotransferase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Pycr1 pyrroline-5-carboxylate reductase 1 IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr10:109,817,300...109,822,218
Ensembl chr10:109,818,177...109,821,807
JBrowse link
G Pycr2 pyrroline-5-carboxylate reductase 2 IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr13:99,184,624...99,188,418
Ensembl chr13:99,184,564...99,188,431
JBrowse link
G Pycr3 pyrroline-5-carboxylate reductase 3 IEA
IBA
ISS
ISO
GO_REF:0000041
PMID:21873635
GO_REF:0000024
(PMID:23024808)
UniProt
RGD
PMID:23024808, PMID:21873635 GO_REF:0000024, GO_REF:0000041, RGD:13792537 NCBI chr 7:116,949,882...116,955,150
Ensembl chr 7:116,949,879...116,955,148
JBrowse link
proline biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 ISO (PMID:11092761), (PMID:26297558) RGD PMID:11092761, PMID:26297558 NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425
Ensembl chr 1:259,641,676...259,674,425
JBrowse link
G Pycr1 pyrroline-5-carboxylate reductase 1 ISO (PMID:16730026) RGD PMID:16730026 NCBI chr10:109,817,300...109,822,218
Ensembl chr10:109,818,177...109,821,807
JBrowse link
G Pycr2 pyrroline-5-carboxylate reductase 2 ISO
ISS
(PMID:23024808)
GO_REF:0000024
RGD
UniProt
PMID:23024808 GO_REF:0000024 NCBI chr13:99,184,624...99,188,418
Ensembl chr13:99,184,564...99,188,431
JBrowse link
proline catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dao D-amino-acid oxidase IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:16616139)
Ensembl
RGD
PMID:16616139, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr12:48,353,691...48,373,647
Ensembl chr12:48,354,196...48,365,784
JBrowse link
G Prodh2 proline dehydrogenase 2 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:88,955,125...88,968,501
Ensembl chr 1:88,955,135...88,968,501
JBrowse link
proline catabolic process to glutamate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:158,090,238...158,115,725
Ensembl chr 5:158,042,587...158,135,733
JBrowse link
G Iffo2 intermediate filament family orphan 2 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:158,042,587...158,083,311
Ensembl chr 5:158,042,587...158,135,733
JBrowse link
G Prodh1 proline dehydrogenase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:87,058,478...87,075,785
Ensembl chr11:87,058,616...87,075,785
JBrowse link
G Prodh2 proline dehydrogenase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:88,955,125...88,968,501
Ensembl chr 1:88,955,135...88,968,501
JBrowse link
G Tas1r2 taste 1 receptor member 2 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:158,119,894...158,135,733
Ensembl chr 5:158,042,587...158,135,733
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    cellular process 18791
      cellular metabolic process 11064
        heterocycle metabolic process 5634
          proline metabolic process 13
            arginine catabolic process to proline + 1
            negative regulation of proline metabolic process + 0
            nopaline catabolic process to proline 0
            octopine catabolic process to proline 0
            ornithine catabolic process via proline 0
            positive regulation of proline metabolic process + 0
            proline biosynthetic process + 7
            proline catabolic process + 6
            regulation of proline metabolic process + 0
Path 2
Term Annotations click to browse term
  biological_process 20017
    metabolic process 12256
      cellular metabolic process 11064
        organic acid metabolic process 1089
          oxoacid metabolic process 1060
            carboxylic acid metabolic process 1004
              cellular amino acid metabolic process 274
                alpha-amino acid metabolic process 198
                  glutamine family amino acid metabolic process 75
                    proline metabolic process 13
                      arginine catabolic process to proline + 1
                      negative regulation of proline metabolic process + 0
                      nopaline catabolic process to proline 0
                      octopine catabolic process to proline 0
                      ornithine catabolic process via proline 0
                      positive regulation of proline metabolic process + 0
                      proline biosynthetic process + 7
                      proline catabolic process + 6
                      regulation of proline metabolic process + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.