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ONTOLOGY REPORT - ANNOTATIONS

Term:methionine metabolic process
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Accession:GO:0006555 term browser browse the term
Definition:The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
Synonyms:exact_synonym: methionine metabolism
 broad_synonym: methionine and threonine metabolic process;   methionine and threonine metabolism
 xref: UM-BBD_pathwayID:met


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methionine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adi1 acireductone dioxygenase 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:28,725,206...28,732,174
Ensembl chr12:28,725,230...28,732,174 		JBrowse link
G Gnmt glycine N-methyltransferase acts_upstream_of_or_within IMP (PMID:17937387) MGI PMID:17937387 NCBI chr17:47,036,590...47,040,091
Ensembl chr17:47,036,590...47,040,094 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase involved_in IMP (MGI:5621260|PMID:23190757)
(PMID:23190757)		 BHF-UCL PMID:23190757 MGI:5621260 NCBI chr12:76,301,180...76,366,594
Ensembl chr12:76,302,072...76,366,577 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase involved_in ISO MGI
GO_Central		 GO_REF:0000119 MGI:4834177 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in ISO RGD
GO_Central
MGI		 PMID:21121936 GO_REF:0000096 MGI:4417868 RGD:7207080 NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999 		JBrowse link
'de novo' L-methionine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bhmt betaine-homocysteine methyltransferase involved_in ISO MGI
GO_Central		 GO_REF:0000119 MGI:4834177 NCBI chr13:93,753,399...93,774,266
Ensembl chr13:93,753,183...93,774,469 		JBrowse link
G Bhmt1b betaine--homocysteine S-methyltransferase 1B involved_in ISO MGI
GO_Central		 GO_REF:0000119 MGI:4834177 NCBI chr18:87,774,411...87,776,278
Ensembl chr18:87,774,410...87,776,275 		JBrowse link
L-methionine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bhmt betaine-homocysteine methyltransferase involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr13:93,753,399...93,774,266
Ensembl chr13:93,753,183...93,774,469 		JBrowse link
G Bhmt1b betaine--homocysteine S-methyltransferase 1B involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr18:87,774,411...87,776,278
Ensembl chr18:87,774,410...87,776,275 		JBrowse link
G Bhmt2 betaine-homocysteine methyltransferase 2 involved_in ISO
IBA
IEA		 MGI
GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 MGI:4834177 NCBI chr13:93,792,605...93,810,810
Ensembl chr13:93,792,228...93,810,810 		JBrowse link
L-methionine salvage from methylthioadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adi1 acireductone dioxygenase 1 involved_in ISO
IEA
ISS		 MGI
UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000041 GO_REF:0000119 MGI:4834177 NCBI chr12:28,725,206...28,732,174
Ensembl chr12:28,725,230...28,732,174 		JBrowse link
G Apip APAF1 interacting protein involved_in ISO
ISS
IEA
IBA		 MGI
UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000119 MGI:4834177 NCBI chr 2:102,904,020...102,922,994
Ensembl chr 2:102,904,020...102,922,989 		JBrowse link
G Enoph1 enolase-phosphatase 1 involved_in ISO
IBA
ISS
IEA		 MGI
GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000119 MGI:4834177 NCBI chr 5:100,186,887...100,216,784
Ensembl chr 5:100,187,844...100,216,619 		JBrowse link
G Mri1 methylthioribose-1-phosphate isomerase 1 involved_in IBA
IEA		 GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000041 NCBI chr 8:84,977,205...84,983,953
Ensembl chr 8:84,976,535...84,983,955 		JBrowse link
G Mtap methylthioadenosine phosphorylase involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:89,055,607...89,099,327
Ensembl chr 4:89,055,359...89,099,318 		JBrowse link
L-methionine salvage from S-adenosylmethionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apip APAF1 interacting protein involved_in IEA UniProt GO_REF:0000104 NCBI chr 2:102,904,020...102,922,994
Ensembl chr 2:102,904,020...102,922,989 		JBrowse link
G Enoph1 enolase-phosphatase 1 involved_in IEA UniProt GO_REF:0000104 NCBI chr 5:100,186,887...100,216,784
Ensembl chr 5:100,187,844...100,216,619 		JBrowse link
G Mri1 methylthioribose-1-phosphate isomerase 1 involved_in IEA UniProt GO_REF:0000104 NCBI chr 8:84,977,205...84,983,953
Ensembl chr 8:84,976,535...84,983,955 		JBrowse link
methionine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adi1 acireductone dioxygenase 1 acts_upstream_of_or_within IEA UniProt GO_REF:0000043 MGI:1354194 NCBI chr12:28,725,206...28,732,174
Ensembl chr12:28,725,230...28,732,174 		JBrowse link
G Apip APAF1 interacting protein acts_upstream_of_or_within IEA UniProt GO_REF:0000043 MGI:1354194 NCBI chr 2:102,904,020...102,922,994
Ensembl chr 2:102,904,020...102,922,989 		JBrowse link
G Bhmt betaine-homocysteine methyltransferase involved_in
acts_upstream_of_or_within		 ISO
IDA		 (PMID:15217352) RGD
GO_Central
MGI		 PMID:15217352 PMID:15845641 GO_REF:0000096 MGI:4417868 RGD:1359026 NCBI chr13:93,753,399...93,774,266
Ensembl chr13:93,753,183...93,774,469 		JBrowse link
G Bhmt1b betaine--homocysteine S-methyltransferase 1B involved_in ISO MGI
GO_Central		 GO_REF:0000096 MGI:4417868 NCBI chr18:87,774,411...87,776,278
Ensembl chr18:87,774,410...87,776,275 		JBrowse link
G Bhmt2 betaine-homocysteine methyltransferase 2 acts_upstream_of_or_within ISO (PMID:11087663) MGI PMID:11087663 NCBI chr13:93,792,605...93,810,810
Ensembl chr13:93,792,228...93,810,810 		JBrowse link
G Enoph1 enolase-phosphatase 1 acts_upstream_of_or_within IEA UniProt GO_REF:0000043 MGI:1354194 NCBI chr 5:100,186,887...100,216,784
Ensembl chr 5:100,187,844...100,216,619 		JBrowse link
G Mri1 methylthioribose-1-phosphate isomerase 1 acts_upstream_of_or_within IEA UniProt GO_REF:0000043 MGI:1354194 NCBI chr 8:84,977,205...84,983,953
Ensembl chr 8:84,976,535...84,983,955 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase involved_in ISO
IEA		 MGI
Ensembl		 GO_REF:0000107 GO_REF:0000119 MGI:4834177 NCBI chr12:76,301,180...76,366,594
Ensembl chr12:76,302,072...76,366,577 		JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like acts_upstream_of_or_within
involved_in		 IEA UniProt GO_REF:0000043 MGI:1354194 NCBI chr 5:91,078,704...91,169,227
Ensembl chr 5:91,078,976...91,169,227 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:15217352) MGI
GO_Central		 PMID:15217352 GO_REF:0000033 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in
acts_upstream_of_or_within		 ISO
IBA
IMP		 (PMID:11158293) RGD
GO_Central
MGI		 PMID:11158293 PMID:11730351 PMID:15845641 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:1359026 RGD:1601423 NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in IMP
IBA
ISO		 (MGI:3710265|PMID:17369066)
(PMID:17369066)		 BHF-UCL
GO_Central
MGI		 PMID:17369066 GO_REF:0000033 GO_REF:0000119 MGI:3710265 MGI:4834177 NCBI chr13:68,708,897...68,730,273
Ensembl chr13:68,708,899...68,730,268 		JBrowse link
methionine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mat1a methionine adenosyltransferase 1A involved_in ISO
ISS		 MGI
GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 MGI:4834177 NCBI chr14:40,826,969...40,846,385
Ensembl chr14:40,826,992...40,846,369 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28753
    cellular process 18453
      metabolic process 11890
        sulfur compound metabolic process 355
          sulfur amino acid metabolic process 32
            methionine metabolic process 15
              methionine biosynthetic process + 13
              methionine catabolic process + 1
Path 2
Term Annotations click to browse term
  biological_process 28753
    cellular process 18453
      metabolic process 11890
        small molecule metabolic process 1932
          organic acid metabolic process 1053
            oxoacid metabolic process 1046
              carboxylic acid metabolic process 1024
                alpha-amino acid metabolic process 222
                  L-amino acid metabolic process 193
                    aspartate family amino acid metabolic process 44
                      methionine metabolic process 15
                        methionine biosynthetic process + 13
                        methionine catabolic process + 1
paths to the root