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ONTOLOGY REPORT - ANNOTATIONS

Term:methionine metabolic process
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Accession:GO:0006555 term browser browse the term
Definition:The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
Synonyms:exact_synonym: methionine metabolism
 broad_synonym: methionine and threonine metabolic process;   methionine and threonine metabolism
 xref: UM-BBD_pathwayID:met


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methionine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADI1 acireductone dioxygenase 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:3,497,366...3,519,531
Ensembl chr 2:3,497,366...3,519,531 		JBrowse link
G GNMT glycine N-methyltransferase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17937387) Ensembl
MGI		 PMID:17937387 GO_REF:0000107 NCBI chr 6:42,960,754...42,963,880
Ensembl chr 6:42,960,754...42,963,880 		JBrowse link
G MSRA methionine sulfoxide reductase A involved_in TAS (PMID:10452521) PINC PMID:10452521 NCBI chr 8:10,054,292...10,428,891
Ensembl chr 8:10,054,292...10,428,891 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISS
IEA		 BHF-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr14:64,388,353...64,460,025
Ensembl chr14:64,388,031...64,463,457 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase involved_in IGI
IEA		 (PMID:10551815) BHF-UCL
InterPro		 PMID:10551815 GO_REF:0000002 NCBI chr 1:11,785,723...11,805,964
Ensembl chr 1:11,785,723...11,806,455 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:21121936 RGD:7207080 NCBI chr 1:236,795,281...236,903,981
Ensembl chr 1:236,795,260...236,921,278 		JBrowse link
G SMS spermine synthase involved_in TAS (PMID:7546290) PINC PMID:7546290 NCBI chr  X:21,940,709...21,994,837
Ensembl chr  X:21,940,709...21,994,837 		JBrowse link
'de novo' L-methionine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BHMT betaine--homocysteine S-methyltransferase involved_in IMP (PMID:10529246) UniProt PMID:10529246 NCBI chr 5:79,111,809...79,132,288
Ensembl chr 5:79,111,809...79,132,288 		JBrowse link
L-methionine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BHMT betaine--homocysteine S-methyltransferase involved_in IDA
IBA		 (PMID:18230605) BHF-UCL
GO_Central		 PMID:18230605 GO_REF:0000033 NCBI chr 5:79,111,809...79,132,288
Ensembl chr 5:79,111,809...79,132,288 		JBrowse link
G BHMT2 betaine--homocysteine S-methyltransferase 2 involved_in IDA
IBA		 (PMID:18230605) BHF-UCL
GO_Central		 PMID:18230605 GO_REF:0000033 NCBI chr 5:79,069,767...79,090,069
Ensembl chr 5:79,069,767...79,090,069 		JBrowse link
L-methionine salvage from methylthioadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADI1 acireductone dioxygenase 1 involved_in IDA
IEA		 (PMID:15938715) UniProt
InterPro		 PMID:15938715 GO_REF:0000002 GO_REF:0000041 GO_REF:0000104 NCBI chr 2:3,497,366...3,519,531
Ensembl chr 2:3,497,366...3,519,531 		JBrowse link
G APIP APAF1 interacting protein involved_in IEA
IBA
IMP		 (PMID:22837397), (PMID:23285211) UniProt
GO_Central
InterPro		 PMID:22837397 PMID:23285211 GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 NCBI chr11:34,882,295...34,916,379
Ensembl chr11:34,853,094...34,916,379 		JBrowse link
G ENOPH1 enolase-phosphatase 1 involved_in IEA
IBA
IDA		 (PMID:15843022) UniProt
GO_Central
InterPro		 PMID:15843022 GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 NCBI chr 4:82,430,590...82,461,177
Ensembl chr 4:82,430,590...82,461,177 		JBrowse link
G MRI1 methylthioribose-1-phosphate isomerase 1 involved_in TAS
IBA
IEA		 Reactome
GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000041 Reactome:R-HSA-1237112 NCBI chr19:13,764,522...13,774,282
Ensembl chr19:13,764,522...13,774,282 		JBrowse link
G MTAP methylthioadenosine phosphorylase involved_in IEA
IBA		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000041 GO_REF:0000104 NCBI chr 9:21,802,636...21,941,115
Ensembl chr 9:21,802,636...21,937,651 		JBrowse link
L-methionine salvage from S-adenosylmethionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APIP APAF1 interacting protein involved_in IEA UniProt GO_REF:0000104 NCBI chr11:34,882,295...34,916,379
Ensembl chr11:34,853,094...34,916,379 		JBrowse link
G ENOPH1 enolase-phosphatase 1 involved_in IEA UniProt GO_REF:0000104 NCBI chr 4:82,430,590...82,461,177
Ensembl chr 4:82,430,590...82,461,177 		JBrowse link
G MRI1 methylthioribose-1-phosphate isomerase 1 involved_in IEA UniProt GO_REF:0000104 NCBI chr19:13,764,522...13,774,282
Ensembl chr19:13,764,522...13,774,282 		JBrowse link
methionine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADI1 acireductone dioxygenase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 2:3,497,366...3,519,531
Ensembl chr 2:3,497,366...3,519,531 		JBrowse link
G APIP APAF1 interacting protein involved_in IEA UniProt GO_REF:0000043 NCBI chr11:34,882,295...34,916,379
Ensembl chr11:34,853,094...34,916,379 		JBrowse link
G BHMT betaine--homocysteine S-methyltransferase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15217352) RGD
MGI
UniProt
InterPro		 PMID:15217352 PMID:15845641 GO_REF:0000002 GO_REF:0000117 RGD:1359026 NCBI chr 5:79,111,809...79,132,288
Ensembl chr 5:79,111,809...79,132,288 		JBrowse link
G BHMT2 betaine--homocysteine S-methyltransferase 2 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000117 NCBI chr 5:79,069,767...79,090,069
Ensembl chr 5:79,069,767...79,090,069 		JBrowse link
G ENOPH1 enolase-phosphatase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:82,430,590...82,461,177
Ensembl chr 4:82,430,590...82,461,177 		JBrowse link
G MRI1 methylthioribose-1-phosphate isomerase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr19:13,764,522...13,774,282
Ensembl chr19:13,764,522...13,774,282 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in IMP (PMID:25633902) BHF-UCL PMID:25633902 NCBI chr14:64,388,353...64,460,025
Ensembl chr14:64,388,031...64,463,457 		JBrowse link
G MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:74,114,560...74,303,099
Ensembl chr 4:74,114,174...74,303,099 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:15217352) GO_Central
MGI		 PMID:15217352 GO_REF:0000033 NCBI chr 1:11,785,723...11,805,964
Ensembl chr 1:11,785,723...11,806,455 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA
IMP		 (PMID:11158293)
(PMID:23825108)		 RGD
MGI
Ensembl
GO_Central
UniProt
InterPro
BHF-UCL		 PMID:11158293 PMID:11730351 PMID:15845641 PMID:23825108 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 GO_REF:0000117 RGD:1359026 RGD:1601423 NCBI chr 1:236,795,281...236,903,981
Ensembl chr 1:236,795,260...236,921,278 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in IDA
IBA
IEA		 (PMID:11466310) BHF-UCL
GO_Central
UniProt		 PMID:11466310 GO_REF:0000033 GO_REF:0000043 NCBI chr 5:7,850,859...7,901,113
Ensembl chr 5:7,851,186...7,906,025 		JBrowse link
methionine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAT1A methionine adenosyltransferase 1A involved_in IMP (PMID:10677294) UniProt PMID:10677294 NCBI chr10:80,271,820...80,289,658
Ensembl chr10:80,271,820...80,289,658 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19787
    cellular process 18956
      metabolic process 13080
        sulfur compound metabolic process 369
          sulfur amino acid metabolic process 36
            methionine metabolic process 16
              methionine biosynthetic process + 12
              methionine catabolic process + 1
Path 2
Term Annotations click to browse term
  biological_process 19787
    cellular process 18956
      metabolic process 13080
        small molecule metabolic process 1994
          organic acid metabolic process 1053
            oxoacid metabolic process 1045
              carboxylic acid metabolic process 1022
                alpha-amino acid metabolic process 238
                  L-amino acid metabolic process 206
                    aspartate family amino acid metabolic process 45
                      methionine metabolic process 16
                        methionine biosynthetic process + 12
                        methionine catabolic process + 1
paths to the root