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ONTOLOGY REPORT - ANNOTATIONS

Term:methionine metabolic process
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Accession:GO:0006555 term browser browse the term
Definition:The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
Synonyms:exact_synonym: methionine metabolism
 broad_synonym: methionine and threonine metabolic process;   methionine and threonine metabolism
 xref: UM-BBD_pathwayID:met


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methionine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNMT glycine N-methyltransferase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17937387) Ensembl
MGI		 PMID:17937387 GO_REF:0000107 NCBI chr12:11,500,363...11,503,075
Ensembl chr12:11,500,392...11,503,481 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO (MGI:5621260|PMID:23190757)
(PMID:23190757)		 BHF-UCL PMID:23190757 MGI:5621260 NCBI chr 8:38,831,672...38,889,607
Ensembl chr 8:38,831,860...38,889,453 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:21121936 RGD:7207080 NCBI chr 4:3,219,851...3,328,000
Ensembl chr 4:3,215,090...3,328,115 		JBrowse link
'de novo' L-methionine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BHMT betaine--homocysteine S-methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:27,732,381...27,752,168
Ensembl chr 3:27,734,108...27,752,046 		JBrowse link
L-methionine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BHMT betaine--homocysteine S-methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:27,732,381...27,752,168
Ensembl chr 3:27,734,108...27,752,046 		JBrowse link
G BHMT2 betaine--homocysteine S-methyltransferase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:27,775,779...27,804,603
Ensembl chr 3:27,776,084...27,789,960 		JBrowse link
L-methionine salvage from methylthioadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADI1 acireductone dioxygenase 1 involved_in IEA UniProt
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000104 GO_REF:0000107 NCBI chr17:2,087,107...2,095,576 JBrowse link
G APIP APAF1 interacting protein involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000041 NCBI chr18:33,012,049...33,033,453
Ensembl chr18:33,011,121...33,033,435 		JBrowse link
G ENOPH1 enolase-phosphatase 1 involved_in IEA InterPro
Ensembl
UniProt		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000107 NCBI chr32:6,408,778...6,451,606
Ensembl chr32:6,407,460...6,450,790 		JBrowse link
G MRI1 methylthioribose-1-phosphate isomerase 1 involved_in IEA UniProt GO_REF:0000041 NCBI chr20:48,648,987...48,658,231
Ensembl chr20:48,653,152...48,658,160 		JBrowse link
G MTAP methylthioadenosine phosphorylase involved_in IEA UniProt GO_REF:0000041 GO_REF:0000104 NCBI chr11:41,148,389...41,200,635
Ensembl chr11:41,148,404...41,264,504 		JBrowse link
L-methionine salvage from S-adenosylmethionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APIP APAF1 interacting protein involved_in IEA UniProt GO_REF:0000104 NCBI chr18:33,012,049...33,033,453
Ensembl chr18:33,011,121...33,033,435 		JBrowse link
G ENOPH1 enolase-phosphatase 1 involved_in IEA UniProt GO_REF:0000104 NCBI chr32:6,408,778...6,451,606
Ensembl chr32:6,407,460...6,450,790 		JBrowse link
G MRI1 methylthioribose-1-phosphate isomerase 1 involved_in IEA UniProt GO_REF:0000104 NCBI chr20:48,648,987...48,658,231
Ensembl chr20:48,653,152...48,658,160 		JBrowse link
methionine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADI1 acireductone dioxygenase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr17:2,087,107...2,095,576 JBrowse link
G APIP APAF1 interacting protein involved_in IEA UniProt GO_REF:0000043 NCBI chr18:33,012,049...33,033,453
Ensembl chr18:33,011,121...33,033,435 		JBrowse link
G BHMT betaine--homocysteine S-methyltransferase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15217352) RGD
MGI
InterPro		 PMID:15217352 PMID:15845641 GO_REF:0000002 RGD:1359026 NCBI chr 3:27,732,381...27,752,168
Ensembl chr 3:27,734,108...27,752,046 		JBrowse link
G BHMT2 betaine--homocysteine S-methyltransferase 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr 3:27,775,779...27,804,603
Ensembl chr 3:27,776,084...27,789,960 		JBrowse link
G ENOPH1 enolase-phosphatase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr32:6,408,778...6,451,606
Ensembl chr32:6,407,460...6,450,790 		JBrowse link
G MRI1 methylthioribose-1-phosphate isomerase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr20:48,648,987...48,658,231
Ensembl chr20:48,653,152...48,658,160 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO (PMID:25633902) BHF-UCL PMID:25633902 NCBI chr 8:38,831,672...38,889,607
Ensembl chr 8:38,831,860...38,889,453 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase acts_upstream_of_or_within ISO (PMID:15217352) MGI PMID:15217352 NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11158293) RGD
MGI
Ensembl
InterPro
UniProt		 PMID:11158293 PMID:11730351 PMID:15845641 GO_REF:0000002 GO_REF:0000043 GO_REF:0000107 RGD:1359026 RGD:1601423 NCBI chr 4:3,219,851...3,328,000
Ensembl chr 4:3,215,090...3,328,115 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in IEA Ensembl
UniProt		 GO_REF:0000043 GO_REF:0000107 NCBI chr34:6,068,572...6,119,580
Ensembl chr34:6,070,046...6,098,312 		JBrowse link
methionine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAT1A methionine adenosyltransferase 1A involved_in ISO (PMID:10677294) UniProt PMID:10677294 NCBI chr 4:29,450,857...29,467,251
Ensembl chr 4:29,452,601...29,466,929 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17088
    cellular process 16614
      metabolic process 10876
        sulfur compound metabolic process 301
          sulfur amino acid metabolic process 29
            methionine metabolic process 13
              methionine biosynthetic process + 11
              methionine catabolic process + 1
Path 2
Term Annotations click to browse term
  biological_process 17088
    cellular process 16614
      metabolic process 10876
        small molecule metabolic process 1704
          organic acid metabolic process 906
            oxoacid metabolic process 899
              carboxylic acid metabolic process 884
                alpha-amino acid metabolic process 209
                  L-amino acid metabolic process 184
                    aspartate family amino acid metabolic process 37
                      methionine metabolic process 13
                        methionine biosynthetic process + 11
                        methionine catabolic process + 1
paths to the root