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ONTOLOGY REPORT - ANNOTATIONS

Term:methionine metabolic process
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Accession:GO:0006555 term browser browse the term
Definition:The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
Synonyms:exact_synonym: methionine metabolism
 broad_synonym: methionine and threonine metabolic process;   methionine and threonine metabolism
 xref: UM-BBD_pathwayID:met


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methionine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adi1 acireductone dioxygenase 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:51,035,267...51,042,229
Ensembl chr 6:51,034,931...51,042,855 		JBrowse link
G Gnmt glycine N-methyltransferase acts_upstream_of_or_within ISO MGI:3842652 (PMID:17937387) RGD PMID:17937387 NCBI chr 9:21,752,235...21,756,368
Ensembl chr 9:21,752,266...21,755,692 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in
acts_upstream_of 		IEA
ISO 		GO_REF:0000117
(PMID:23190757) 		UniProt
RGD		 PMID:23190757 GO_REF:0000117 NCBI chr 6:100,713,510...100,781,013
Ensembl chr 6:100,713,681...100,781,957 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase involved_in ISO
IEA 		UniProtKB:P53128 (PMID:10551815)
GO_REF:0000117
GO_REF:0000002
GO_REF:0000107 		RGD
UniProt
InterPro
Ensembl		 PMID:10551815 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IMP RGD PMID:21121936 RGD:7207080 NCBI chr17:62,911,705...62,996,544
Ensembl chr17:62,911,771...62,996,541 		JBrowse link
L-methionine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mat1a methionine adenosyltransferase 1A involved_in ISO
ISS 		(PMID:10677294)
GO_REF:0000024 		RGD
UniProt		 PMID:10677294 GO_REF:0000024 NCBI chr16:17,017,168...17,035,368
Ensembl chr16:17,016,030...17,035,367 		JBrowse link
L-methionine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bhmt betaine-homocysteine S-methyltransferase involved_in ISO
IBA
IEA 		(PMID:18230605)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:18230605 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:26,594,852...26,614,429
Ensembl chr 2:26,594,854...26,614,715 		JBrowse link
G Bhmt2 betaine-homocysteine S-methyltransferase 2 involved_in ISO
IEA
IBA 		(PMID:18230605)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:18230605 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:24,895,525...24,912,475
Ensembl chr 2:26,630,510...26,651,326 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr17:62,911,705...62,996,544
Ensembl chr17:62,911,771...62,996,541 		JBrowse link
L-methionine salvage from methylthioadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adi1 acireductone dioxygenase 1 involved_in ISO
IEA
ISS 		(PMID:15938715)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000104
GO_REF:0000041
GO_REF:0000024 		RGD
Ensembl
InterPro
UniProt		 PMID:15938715 GO_REF:0000002 GO_REF:0000024 GO_REF:0000041 GO_REF:0000104 GO_REF:0000107 NCBI chr 6:51,035,267...51,042,229
Ensembl chr 6:51,034,931...51,042,855 		JBrowse link
G Apip APAF1 interacting protein involved_in ISO
IEA
IBA 		(PMID:22837397), (PMID:23285211)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000104
GO_REF:0000041
GO_REF:0000033 		RGD
Ensembl
InterPro
UniProt
GO_Central		 PMID:22837397 PMID:23285211 GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000104 GO_REF:0000107 NCBI chr 3:89,431,964...89,458,000
Ensembl chr 3:109,886,953...109,915,862 		JBrowse link
G Enoph1 enolase-phosphatase 1 involved_in ISO
IEA
IBA
ISS 		(PMID:15843022)
GO_REF:0000002
GO_REF:0000104
GO_REF:0000041
GO_REF:0000033
GO_REF:0000024 		RGD
InterPro
UniProt
GO_Central		 PMID:15843022 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000104 NCBI chr14:9,531,336...9,557,797
Ensembl chr14:9,835,627...9,873,668 		JBrowse link
G Mri1 methylthioribose-1-phosphate isomerase 1 involved_in IEA
IBA 		GO_REF:0000041
GO_REF:0000104
GO_REF:0000033 		UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000041 GO_REF:0000104 NCBI chr19:23,907,327...23,913,721
Ensembl chr19:40,812,094...40,822,607 		JBrowse link
G Mtap methylthioadenosine phosphorylase involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000104
GO_REF:0000041 		GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000041 GO_REF:0000104 NCBI chr 5:108,990,270...109,036,494
Ensembl chr 5:108,988,830...109,055,214 		JBrowse link
methionine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adi1 acireductone dioxygenase 1 involved_in IEA GO_REF:0000043
GO_REF:0000117 		UniProt GO_REF:0000043 GO_REF:0000117 NCBI chr 6:51,035,267...51,042,229
Ensembl chr 6:51,034,931...51,042,855 		JBrowse link
G Apip APAF1 interacting protein involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:89,431,964...89,458,000
Ensembl chr 3:109,886,953...109,915,862 		JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase involved_in
acts_upstream_of_or_within 		IDA
IEA
ISO 		GO_REF:0000002
GO_REF:0000117
(PMID:15217352) 		InterPro
UniProt
RGD		 PMID:15217352 PMID:15845641 GO_REF:0000002 GO_REF:0000117, RGD:1359026 NCBI chr 2:26,594,852...26,614,429
Ensembl chr 2:26,594,854...26,614,715 		JBrowse link
G Bhmt2 betaine-homocysteine S-methyltransferase 2 involved_in IEA GO_REF:0000117
GO_REF:0000002 		UniProt
InterPro		 GO_REF:0000002 GO_REF:0000117 NCBI chr 2:24,895,525...24,912,475
Ensembl chr 2:26,630,510...26,651,326 		JBrowse link
G Enoph1 enolase-phosphatase 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr14:9,531,336...9,557,797
Ensembl chr14:9,835,627...9,873,668 		JBrowse link
G Mri1 methylthioribose-1-phosphate isomerase 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr19:23,907,327...23,913,721
Ensembl chr19:40,812,094...40,822,607 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in
acts_upstream_of 		IEA
ISO 		GO_REF:0000043
(PMID:25633902) 		UniProt
RGD		 PMID:25633902 GO_REF:0000043 NCBI chr 6:100,713,510...100,781,013
Ensembl chr 6:100,713,681...100,781,957 		JBrowse link
G Mthfd1-ps1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1, pseudogene 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:116,195,791...116,198,973 JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr14:17,374,139...17,455,508
Ensembl chr14:17,374,144...17,454,322 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase acts_upstream_of_or_within
involved_in 		ISO
IBA 		MGI:2385823 (PMID:15217352)
GO_REF:0000033 		RGD
GO_Central		 PMID:15217352 GO_REF:0000033 NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in
acts_upstream_of_or_within 		IDA
IEA
IBA
ISO 		GO_REF:0000107
GO_REF:0000002
GO_REF:0000043
GO_REF:0000033
PMID:20424322
MGI:2180496 (PMID:11158293)
(PMID:23825108) 		Ensembl
InterPro
UniProt
GO_Central
RGD		 PMID:11158293 PMID:23825108 PMID:15845641 PMID:20424322 PMID:11730351 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107, RGD:1359026, RGD:10054082, RGD:1601423 NCBI chr17:62,911,705...62,996,544
Ensembl chr17:62,911,771...62,996,541 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISO
IEA
IBA 		(PMID:11466310)
GO_REF:0000117
GO_REF:0000033
GO_REF:0000043
(PMID:17369066) 		RGD
UniProt
GO_Central		 PMID:11466310 PMID:17369066 GO_REF:0000033 GO_REF:0000043 GO_REF:0000117 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:36,695,460...36,727,807 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20668
    cellular process 19605
      metabolic process 12252
        sulfur compound metabolic process 302
          sulfur amino acid metabolic process 33
            methionine metabolic process 15
              L-methionine catabolic process + 1
              methionine biosynthetic process + 13
Path 2
Term Annotations click to browse term
  biological_process 20668
    cellular process 19605
      metabolic process 12252
        small molecule metabolic process 1977
          organic acid metabolic process 1082
            oxoacid metabolic process 1068
              carboxylic acid metabolic process 1053
                alpha-amino acid metabolic process 229
                  L-amino acid metabolic process 196
                    aspartate family amino acid metabolic process 50
                      methionine metabolic process 15
                        L-methionine catabolic process + 1
                        methionine biosynthetic process + 13
paths to the root